Obiettivo Compulsivity is characterized by a repetitive, irresistible urge to perform a behavior, the experience of loss of voluntary control over this intense urge, the diminished ability to delay or inhibit thoughts or behaviors, and the tendency to perform repetitive acts in a habitual or stereotyped manner. Compulsivity is a cross-disorder trait underlying phenotypically distinct psychiatric disorders that emerge in childhood (autism spectrum disorder, ASD; obsessive-compulsive disorder, OCD) or adolescence (substance abuse). Our approach integrates clinical data sets for ‘addictive’ (ADHD high risk for substance use), ‘anxious’ (OCD) and ‘stereotypical’ (ASD) compulsive behaviors with highly predictive animal models for new pharmacotherapy. In a series of ‘proof-of-concept’ studies, the cohesion of structural neuroimaging studies (MRI/DTI), neurochemistry (MRS/microdialysis), behavior, genetics (GWAS), proteomics and (Bayesian) machine learning tools in both male and female paediatric clinical populations and behavioral animal models will seek to better understand underlying mechanisms related to glutamate dysfunction in frontostriatal circuits and its remediation / prevention by early intervention studies with glutamate-based (riluzole and memantine) clinically used drugs. The leading drug-based interventions will be tested in pilot Phase IIb-like studies for ‘proof-of-principle’ efficacy in paediatric OCD and ASD populations. This approach will 1) establish predictive neural, genetic and molecular markers of compulsivity in pediatric populations; 2) provide evidence of disorder modifying pharmacologic strategies as a therapeutic approach; 3) develop a novel animal model for pharmaceutical screening and proof of concept studies, 4) build and valorize a translational biomarker compulsivity database and 5) provide pilot efficacy and safety data in paediatric clinical populations to support future large scale clinical trials according to these strategies. Campo scientifico medical and health sciencesclinical medicinepsychiatryobsessive-compulsive disordernatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsproteomicsmedical and health scienceshealth sciencessubstance abusemedical and health sciencesclinical medicinepaediatricsnatural sciencescomputer and information sciencesartificial intelligencemachine learning Programma(i) FP7-HEALTH - Specific Programme "Cooperation": Health Argomento(i) HEALTH-2011.2.2.1-3 - Addictive and/or compulsive behaviour in children and adolescents: translating pre-clinical results into therapies Invito a presentare proposte FP7-HEALTH-2011-two-stage Vedi altri progetti per questo bando Meccanismo di finanziamento CP-FP - Small or medium-scale focused research project Coordinatore STICHTING RADBOUD UNIVERSITEIT Contributo UE € 3 103 063,00 Indirizzo HOUTLAAN 4 6525 XZ Nijmegen Paesi Bassi Mostra sulla mappa Regione Oost-Nederland Gelderland Arnhem/Nijmegen Tipo di attività Higher or Secondary Education Establishments Contatto amministrativo Maarten Van Langen (Mr.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato Partecipanti (11) Classifica in ordine alfabetico Classifica per Contributo UE Espandi tutto Riduci tutto KING'S COLLEGE LONDON Regno Unito Contributo UE € 418 000,00 Indirizzo STRAND WC2R 2LS London Mostra sulla mappa Regione London Inner London — West Westminster Tipo di attività Higher or Secondary Education Establishments Contatto amministrativo Paul Labbett (Mr.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato ZENTRALINSTITUT FUER SEELISCHE GESUNDHEIT Germania Contributo UE € 383 480,00 Indirizzo Square J 5 68159 Mannheim Mostra sulla mappa Regione Baden-Württemberg Karlsruhe Mannheim, Stadtkreis Tipo di attività Higher or Secondary Education Establishments Contatto amministrativo Simone Fuchs Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato TEL AVIV UNIVERSITY Israele Contributo UE € 214 800,00 Indirizzo RAMAT AVIV 69978 Tel Aviv Mostra sulla mappa Tipo di attività Higher or Secondary Education Establishments Contatto amministrativo Lea Pais (Ms.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato UNIVERSITY COLLEGE CORK - NATIONAL UNIVERSITY OF IRELAND, CORK Irlanda Contributo UE € 252 181,00 Indirizzo WESTERN ROAD T12 YN60 Cork Mostra sulla mappa Regione Ireland Southern South-East Tipo di attività Higher or Secondary Education Establishments Contatto amministrativo David O'connel (Dr.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato THE GENERAL HOSPITAL CORPORATION Stati Uniti Contributo UE € 325 137,00 Indirizzo FRUIT STREET 55 02114 Boston Ma Mostra sulla mappa Tipo di attività Other Contatto amministrativo John Hureau (Mr.) Collegamenti Contatta l’organizzazione Opens in new window Costo totale Nessun dato UNIVERSITAIR MEDISCH CENTRUM UTRECHT Paesi Bassi Contributo UE € 782 734,00 Indirizzo HEIDELBERGLAAN 100 3584 CX Utrecht Mostra sulla mappa Regione West-Nederland Utrecht Utrecht Tipo di attività Higher or Secondary Education Establishments Contatto amministrativo Sarah Durston (Prof.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato WOCKHARDT UK LTD Partecipazione conclusa Regno Unito Contributo UE Nessun dato Indirizzo ASH ROAD NORTH, WREXHAM INDUSTRIAL ESTATE LL139UF WREXHAM Mostra sulla mappa Tipo di attività Private for-profit entities (excluding Higher or Secondary Education Establishments) Contatto amministrativo Gordon Urquhart (Mr.) Collegamenti Contatta l’organizzazione Opens in new window Costo totale Nessun dato GENOWAY Francia Contributo UE € 100 605,00 Indirizzo 31 RUE SAINT JEAN DE DIEU TECHNOPARK 2 69007 Lyon Mostra sulla mappa Regione Auvergne-Rhône-Alpes Rhône-Alpes Rhône Tipo di attività Private for-profit entities (excluding Higher or Secondary Education Establishments) Contatto amministrativo Angelique Heckmann (Dr.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE Regno Unito Contributo UE € 120 000,00 Indirizzo TRINITY LANE THE OLD SCHOOLS CB2 1TN Cambridge Mostra sulla mappa Regione East of England East Anglia Cambridgeshire CC Tipo di attività Higher or Secondary Education Establishments Contatto amministrativo Renata Schaeffer (Ms.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato CONCENTRIS RESEARCH MANAGEMENT GMBH Germania Contributo UE € 300 000,00 Indirizzo Ludwigstr. 4 82256 FURSTENFELDBRUCK Mostra sulla mappa Regione Bayern Oberbayern Fürstenfeldbruck Tipo di attività Private for-profit entities (excluding Higher or Secondary Education Establishments) Contatto amministrativo Ameli Schwalber (Ms.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato H. LUNDBECK AS Danimarca Contributo UE Nessun dato Indirizzo OTTILIAVEJ 7-9 2500 Valby Mostra sulla mappa Regione Danmark Hovedstaden Byen København Tipo di attività Private for-profit entities (excluding Higher or Secondary Education Establishments) Contatto amministrativo Philippe Auby (Dr.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato