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Sphingolipid homeostasis: from basic biology to applications

Obiettivo

SPHINGONET was inspired by a common vision of its partners on the training of researchers in the field of sphingolipid homeostasis and body-wide sphingolipid signaling networks using innovative technological approaches. Dysregulation of sphingolipid balances contributes to a broad range of pathological processes, spanning neurodegeneration, asthma, autoimmune disease, insuline resistance, obesity and cancer progression. Key to defining proper sites for therapeutic intervention is a comprehensive understanding of the mechanisms of sphingolipid homeostasis and how sphingolipid-mediated signaling pathways are interconnected. In spite of its many clinical implications, progress in this field is curbed by a lack of appropriate tools to monitor, quantify and manipulate sphingolipid pools in live cells. SPHINGONET’S training program is designed to close these gaps in knowledge and technology by transferring the complementary expertise of its partners to a future generation of scientists who will take a leading role in decoding the full regulatory potential of the sphingolipid signaling network and maximize its therapeutic use. By merging seven academic partners working at the forefront of sphingolipid, chemical and systems biology with three (pro)drug discovery-oriented SMEs, SPHINGONET will create a challenging interdisciplinary and clinically-relevant research environment with ample opportunities for structuring industrial projects, commercial exploitation of results, entrepreneurship and complementary education adapted to the personal needs. Thus, SPHINGONET will provide its trainees with a rounded education that, besides enhancing their career perspectives, will enable them to choose a career path in Europe’s academia or industry, and be successful at it while retaining ties between both these bodies.

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FP7-PEOPLE-2011-ITN
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Coordinatore

UNIVERSITAET OSNABRUECK
Indirizzo
Neuer Graben/schloss 29
49074 Osnabrueck
Germania
Tipo di attività
Higher or Secondary Education Establishments
Contributo UE
€ 903 489,80
Contatto amministrativo
Joost Cm Holthuis (Prof.)

Partecipanti (9)

WEIZMANN INSTITUTE OF SCIENCE
Israele
Contributo UE
€ 244 602,60
Indirizzo
Herzl Street 234
7610001 Rehovot
Tipo di attività
Higher or Secondary Education Establishments
Contatto amministrativo
Talia Tzahor (Ms.)
UNIVERSITE DE GENEVE
Svizzera
Contributo UE
€ 249 180,80
Indirizzo
Rue Du General Dufour 24
1211 Geneve
Tipo di attività
Higher or Secondary Education Establishments
Contatto amministrativo
Howard Riezman (Prof.)
UCL Elizabeth Garrett Anderson Institute for Women’s Health
United Kingdom
Contributo UE
€ 265 600,51
Indirizzo
Gower Street
WC1E 6BT London
Tipo di attività
Higher or Secondary Education Establishments
Contatto amministrativo
Greta Borg-Carbott (Ms.)
ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE
Svizzera
Contributo UE
€ 714 413,70
Indirizzo
Batiment Ce 3316 Station 1
1015 Lausanne
Tipo di attività
Higher or Secondary Education Establishments
Contatto amministrativo
Kai Johnsson (Prof.)
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
United Kingdom
Contributo UE
€ 265 600,51
Indirizzo
Wellington Square University Offices
OX1 2JD Oxford
Tipo di attività
Higher or Secondary Education Establishments
Contatto amministrativo
Stephen Conway (Dr.)
EUROPEAN MOLECULAR BIOLOGY LABORATORY
Germania
Contributo UE
€ 231 026,40
Indirizzo
Meyerhofstrasse 1
69117 Heidelberg
Tipo di attività
Research Organisations
Contatto amministrativo
Phil Irving (Dr.)
Dualsystems Biotech AG

Partecipazione conclusa

Svizzera
Indirizzo
Grabenstrasse 11A
8952 Zurich-schlieren
Tipo di attività
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contatto amministrativo
Mandana Rezwan (Dr.)
INTANA BIOSCIENCE GMBH
Germania
Contributo UE
€ 199 862,30
Indirizzo
Lochhamer Strasse 29 A
82152 Planegg Martinsried
Tipo di attività
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contatto amministrativo
Stefan Hannus (Dr.)
UNIVERSITEIT UTRECHT
Paesi Bassi
Contributo UE
€ 262 418,32
Indirizzo
Heidelberglaan 8
3584 CS Utrecht
Tipo di attività
Higher or Secondary Education Establishments
Contatto amministrativo
Joos Cm Holthuis (Dr.)