Skip to main content
European Commission logo print header

Deciphering the ubiquitin code of the TNF receptor signalling complex and its functional role in inflammation and immunity


Tumour necrosis factor (TNF) is a cytokine with important functions in inflammation, immunity and cancer. Signalling processes mediated by ubiquitin are crucial for TNF signalling. The seven lysine (K) residues and the N-terminus of ubiquitin can be used to form ubiquitin chains. Employing a method newly developed in our laboratory we identified the presence of four of these ubiquitin chain linkage types in the native TNF receptor signalling complex (TNF-RSC). Our knowledge of the specific functions of the different ubiquitin linkages is currently very limited. However, their presence in the TNF-RSC, combined with our recent technological advance in dissecting the composition of this protein complex with previously unreached specificity and sensitivity provides a unique opportunity for the proposed research programme: to molecularly and functionally decipher the ubiquitin code. We will aim to achieve this by studying the different ubiquitin chain linkages at the molecular level within the TNF-RSC and by determining how perturbation of specific ubiquitin linkage events impacts the physiological role of TNF in immunity to infection and its pathological function in inflammation-induced cancer.
The specific objectives of this project are:
• to molecularly decipher the ubiquitin code of the TNF-RSC (objective 1),
• to link this code to physiological functions of TNF in immunity to infection (objective 2)
• and to test its pathological impact on cancer-related inflammation (objective 3).

Invito a presentare proposte

Vedi altri progetti per questo bando

Meccanismo di finanziamento

ERC-AG - ERC Advanced Grant


Gower street
WC1E 6BT London

Mostra sulla mappa

Tipo di attività
Higher or Secondary Education Establishments
Ricercatore principale
Henning Walczak (Prof.)
Contatto amministrativo
Giles Machell (Mr.)
Contributo UE
Nessun dato

Beneficiari (2)