Synthesis of molecular probes for cancer research based on priviliged natural products through a novel enantioselective oxidative arylation technology

Informazioni relative al progetto

Pyrroloindole

ID dell’accordo di sovvenzione: 301895

Progetto chiuso

Data di avvio 1 Settembre 2012

Data di completamento 31 Agosto 2014

Finanziato da

• Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)

Costo totale € 200 371,80

Contributo UE € 200 371,80

Coordinato da

THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
United Kingdom

Obiettivo

Enantioselective catalysis continues to be a necesarily expanding part of Organic Chemistry and Synthesis to be able to provide the enantiopure compounds that Society demands in a straightforward and sustainable way.
This research proposal is aimed at doing so through the development of new enantioselective oxidative arylation reactions a completely unprecedented research field. Moreover, the molecular structures and synthetic targets have been selected in close collaboration with the group of Dr. Murrell at CRUK Cambridge. This collaboration is aimed at understanding the processes of cancer generation and growth at the molecular level through development of small molecule histone methylation and acetylation modulators. To study such processes a priviliged and synthetically challenging familiy of natural products is targeted: the pyrroloindole alkaloids. Development of molecular probes inspired by these products and demonstration of the total synthesis of some members will be accomplished through the development of appropiate chemical tools. The synthesis of these compounds will enable multidisciplinar research to study the particularities of oncogenesis.

Campo scientifico (EuroSciVoc)

CORDIS classifica i progetti con EuroSciVoc, una tassonomia multilingue dei campi scientifici, attraverso un processo semi-automatico basato su tecniche NLP. Cfr.: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.

• scienze naturali › scienze chimiche › chimica organica
• scienze mediche e della salute › medicina clinica › oncologia
• scienze naturali › scienze chimiche › catalisi

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Programma(i)

• FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)

Argomento(i)

• FP7-PEOPLE-2011-IEF - Marie-Curie Action: "Intra-European fellowships for career development"

Invito a presentare proposte

FP7-PEOPLE-2011-IEF
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Meccanismo di finanziamento

MC-IEF - Intra-European Fellowships (IEF)

Coordinatore

THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE

• Contributo UE: € 200 371,80
• Indirizzo: TRINITY LANE THE OLD SCHOOLS ; CB2 1TN Cambridge ; Regno Unito
• Regione: East of England › East Anglia › Cambridgeshire CC
• Tipo di attività: Higher or Secondary Education Establishments
• Costo totale: Nessun dato