Obiettivo Current interest in neural stem cells derives from the prospect of using them in brain repair strategies, but also to understand neurodevelopmental pathologies. This will require, however, a significant improvement of our understanding of the gene expression programs associated with their maintenance and differentiation, and how these are regulated. Recently, several lines of evidence suggest a regulatory function for the zinc-finger transcription factor ZEB1, both in embryonic neural stem/progenitor cells, and in human tumours of neural origin. Here we propose to use a multidisciplinary approach, combining mouse genetics and genomics, to characterize the function of ZEB1 in neural development. A thorough phenotypic analysis of ZEB1 loss-of-function mouse models will be performed, with a special focus on its role in neural progenitors. This will be complemented with the genome-wide characterization of its transcriptional network, using a combination of genomic location analysis with expression profiling. Moreover, a detailed comparison of the ZEB1 transcriptional programs in human foetal- and glioma-derived stem cells will be carried out, providing important insights into ZEB1 function in tumour initiation and development. Campo scientifico scienze naturaliscienze biologicheneurobiologiascienze naturaliscienze biologichegeneticascienze mediche e della salutebiotecnologia medicatecnologie cellularicellule staminaliscienze mediche e della salutemedicina di basepatologia Programma(i) FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Argomento(i) FP7-PEOPLE-2011-CIG - Marie-Curie Action: "Career Integration Grants" Invito a presentare proposte FP7-PEOPLE-2011-CIG Vedi altri progetti per questo bando Meccanismo di finanziamento MC-CIG - Support for training and career development of researcher (CIG) Coordinatore FUNDACAO CALOUSTE GULBENKIAN Indirizzo Avenida berna 45a 1067-001 Lisboa Portogallo Mostra sulla mappa Regione Continente Área Metropolitana de Lisboa Área Metropolitana de Lisboa Tipo di attività Research Organisations Contatto amministrativo José Mario Leite (Mr.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Contributo UE € 100 000,00
