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Rapid development and distribution of statistical tools for high-throughput sequencing data

Ziel

High-throughput sequencing (HTS) is a powerful and rapidly evolving family of technologies with a multitude of applications. They include genetics of rare and common diseases, understanding of disease mechanism and progression through transcriptome and epigenome profiling, cancer stratification, personalised medicine and molecular systems biology of gene regulation. The genome, epigenome, transcriptome and interactome are all intricately connected, and modern HTS technology can probe all of these -omic levels. Statistical analysis is a crucial component of many experiments and studies, and the quality and efficiency of the analysis often determines the success of a project.

In this collaborative project we will develop a range of new statistical analysis tools to solve open problems in HTS data analysis, ranging from low-level processing of sequence reads up to systems-level modelling of disease associated and cellular processes. We will provide to a wide audience an integrated computational framework for HTS data analysis and interpretation that is robust, efficient and user-friendly. We will establish improved procedures for the publishing of statistical software as an integral part of the scientific publication process, within the framework of the Bioconductor project. We will provide tools to benchmark experimental protocols and statistical methods, and we will provide training materials and a extensive training programme to rapidly disseminate these new tools to the broader biomedical community.

SME partners will integrate these new tools within their analysis pipelines with associated user-friendly commercial software providing access to their additional proprietary tools. SMEs will benefit from basic methodology development done in a public, pre-competitive arena and will be able to use these technologies to enhance their products and services.

Aufforderung zur Vorschlagseinreichung

FP7-HEALTH-2012-INNOVATION-1
Andere Projekte für diesen Aufruf anzeigen

Koordinator

THE UNIVERSITY OF MANCHESTER
Adresse
Oxford Road
M13 9PL Manchester
United Kingdom
Aktivitätstyp
Higher or Secondary Education Establishments
EU-Beitrag
€ 635 452
Kontakt Verwaltung
Katherine Boylan (Dr.)

Beteiligte (9)

Genomatix Software GmbH
Deutschland
EU-Beitrag
€ 439 000
Adresse
Bayerstrasse 85A
80335 Muenchen
Aktivitätstyp
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Kontakt Verwaltung
Korbinian Grote (Dr.)
GENOMNIA SRL
Italien
EU-Beitrag
€ 306 059,60
Adresse
Corso Magenta 56
20123 Milano
Aktivitätstyp
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Kontakt Verwaltung
Cinzia Ferraro (Mrs.)
EUROPEAN MOLECULAR BIOLOGY LABORATORY
Deutschland
EU-Beitrag
€ 531 472,20
Adresse
Meyerhofstrasse 1
69117 Heidelberg
Aktivitätstyp
Research Organisations
Kontakt Verwaltung
Virginia Otón García (Ms.)
FONDAZIONE TELETHON
Italien
EU-Beitrag
€ 187 500
Adresse
Via Varese 16/B
00185 Roma
Aktivitätstyp
Research Organisations
Kontakt Verwaltung
Irene Mearelli (Mrs.)
FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA
Italien
EU-Beitrag
€ 256 862,40
Adresse
Via Morego 30
16163 Genova
Aktivitätstyp
Research Organisations
Kontakt Verwaltung
Alessandra Gastaldi (Ms.)
ASSOCIATION POUR LA RECHERCHE ET LE DEVELOPPEMENT DES METHODES ET PROCESSUS INDUSTRIELS - ARMINES
Frankreich
EU-Beitrag
€ 315 428
Adresse
Boulevard Saint-michel
75272 Paris
Aktivitätstyp
Research Organisations
Kontakt Verwaltung
Florence Thépenier (Mrs.)
University of Zurich
Schweiz
EU-Beitrag
€ 356 758
Adresse
Ramistrasse 71
8006 Zurich
Aktivitätstyp
Higher or Secondary Education Establishments
Kontakt Verwaltung
Mark Robinson (Prof.)
THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
United Kingdom
EU-Beitrag
€ 268 776
Adresse
Trinity Lane The Old Schools
CB2 1TN Cambridge
Aktivitätstyp
Higher or Secondary Education Establishments
Kontakt Verwaltung
Renata Shaeffer (Ms.)
THE UNIVERSITY OF SHEFFIELD
United Kingdom
EU-Beitrag
€ 374 941,20
Adresse
Firth Court Western Bank
S10 2TN Sheffield
Aktivitätstyp
Higher or Secondary Education Establishments
Kontakt Verwaltung
Joanne Watson (Ms.)