Skip to main content
European Commission logo
Deutsch Deutsch
CORDIS - Forschungsergebnisse der EU
CORDIS
CORDIS Web 30th anniversary CORDIS Web 30th anniversary
Inhalt archiviert am 2024-06-18

Tumor Infiltrating Myeloid Cell Compartment

Ziel

The ITN TIMCC brings together eight expert teams from different disciplines within Immunology, Genetics and Oncology, to provide substantive and methodological training in the analysis of the role of the Tumor Infiltrating Myeloid Cell Compartment (TIMCC) of the innate immune system. Leukocytes recruited to (pre)malignant tissues are mainly myeloid cells. They can either prevent or functionally contribute to cancer development. However, the mechanisms underlying pro- versus anti-tumor programming of neoplastic tissues by these immune cells remain obscure.
The ITN TIMCC aims to improve anti-tumor therapy by defining general and tumor type specific molecular and cellular immunological pathways (e.g signal transduction and downstream effector pathways) in tumor development and during therapeutic intervention based on an extensive analysis of the infiltrating myeloid cell compartment in human tumor biopsies using a large variety of techniques and functional analysis of the corresponding models of a variety of human tumors, affecting different organs, in a unique cohort of genetically modified mice treated with different types of anti-tumor therapy.
The program will train the appointed researchers in a variety of methodology and technology from genomic technologies and bioinformatics via genetically modified mice to the design and application of therapeutic strategies to understand and manipulate the many interactions of the myeloid cell compartment with developing tumors. By defining underlying molecular and cellular pathways new targets will be identified to be explored by the participating SMEs. The program will deliver young researchers equipped with a broad knowledge in immunology, genetics and oncology and insight in the complexity of translational medicine therefore better prepared to meet new challenges in the field.

Aufforderung zur Vorschlagseinreichung

FP7-PEOPLE-2012-ITN
Andere Projekte für diesen Aufruf anzeigen

Koordinator

ACADEMISCH ZIEKENHUIS LEIDEN
EU-Beitrag
€ 870 434,20
Adresse
ALBINUSDREEF 2
2333 ZA Leiden
Niederlande

Auf der Karte ansehen

Region
West-Nederland Zuid-Holland Agglomeratie Leiden en Bollenstreek
Aktivitätstyp
Higher or Secondary Education Establishments
Kontakt Verwaltung
Ruud Esveld (Mr.)
Links
Gesamtkosten
Keine Daten

Beteiligte (7)