Obiettivo Nature is able to carry out numerous parallel reactions transforming countless chemical compounds in a single cell. For the stereoselective synthesis of complex, biologically relevant molecules, such as pharmaceuticals and agrochemicals, chemists both in academia and industry typically still use “stop and go” procedures with all its disadvantages, such as the isolation and purification of intermediates after each step causing a lot of waste and high costs.Since around the turn of the millennium, the research area of organocatalysis has grown with a breathtaking speed and can now be seen as a third pillar of catalysis beside bio- and metal catalysis. Very recently, organocatalytic multi-component domino reactions came into the focus of synthetic chemistry by mimicking Nature’s enzymatic cascades.Based on our pioneering contributions in this field of asymmetric organodomino catalysis we aim at developing novel simple, triple, quadruple and even more complex organocascade protocols as well as sequential one-pot-procedures thereby significantly advancing the strategic arsenal for the synthesis of complex biologically active enantiopure compounds bearing multiple stereocenters. Spectroscopic and kinetic studies, especially high resolution ESI-MS measurements which opens an insight into a running domino reaction and accompanying theoretical calculations (in cooperation) will allow a deep mechanistic understanding. The combination of organocatalysis with metal, especially gold catalysis will pave the way for completely new environmentally benign and “green” enantioselective multi-component one-pot techniques scalable for future industrial applications. Campo scientifico medical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsnatural scienceschemical sciencescatalysisnatural sciencesmathematicsapplied mathematicsmathematical model Programma(i) FP7-IDEAS-ERC - Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Argomento(i) ERC-AG-PE5 - ERC Advanced Grant - Materials and Synthesis Invito a presentare proposte ERC-2012-ADG_20120216 Vedi altri progetti per questo bando Meccanismo di finanziamento ERC-AG - ERC Advanced Grant Istituzione ospitante RHEINISCH-WESTFAELISCHE TECHNISCHE HOCHSCHULE AACHEN Contributo UE € 2 435 600,00 Indirizzo TEMPLERGRABEN 55 52062 Aachen Germania Mostra sulla mappa Regione Nordrhein-Westfalen Köln Städteregion Aachen Tipo di attività Higher or Secondary Education Establishments Ricercatore principale Dieter Enders (Dr.) Contatto amministrativo Ernst Schmachtenberg (Prof.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato Beneficiari (1) Classifica in ordine alfabetico Classifica per Contributo UE Espandi tutto Riduci tutto RHEINISCH-WESTFAELISCHE TECHNISCHE HOCHSCHULE AACHEN Germania Contributo UE € 2 435 600,00 Indirizzo TEMPLERGRABEN 55 52062 Aachen Mostra sulla mappa Regione Nordrhein-Westfalen Köln Städteregion Aachen Tipo di attività Higher or Secondary Education Establishments Ricercatore principale Dieter Enders (Dr.) Contatto amministrativo Ernst Schmachtenberg (Prof.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato