Obiettivo DNA, if damaged, cannot be replaced. If not replaceable, it must be repaired. The so-called “DNA damage response” (DDR) is a coordinate set of evolutionary conserved events that arrest the cell-cycle (DNA damage checkpoint function) in proliferating cells and attempts DNA repair. Until DNA damage has not been repaired in full, cell proliferation is not resumed in normal cells.DNA damage is a physiological event. Ageing and cancer are both associated with DNA damage accumulation. In the past, we contribute to better understand the mechanisms and the consequences of DNA damage generation and DDR activation in both settings.We have recently identified a completely hitherto undiscovered level of control of DDR activation, so far considered a proteinaceous only signaling cascade. We have discovered that short RNA species are detectable at DNA damage sites and are necessary for DDR activation at DNA lesions. These RNA species are generated by an evolutionary-conserved RNA processing machinery. However, they serve purposes never reported before.We believe that our findings change radically our understanding of DDR modulation in mammals and disclose a fertile unspoilt ground for exciting investigations. Campo scientifico natural sciencesbiological sciencesgeneticsDNAmedical and health sciencesclinical medicineoncologynatural sciencesbiological sciencesgeneticsRNAnatural sciencesbiological scienceszoologymammalogy Programma(i) FP7-IDEAS-ERC - Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Argomento(i) ERC-AG-LS1 - ERC Advanced Grant - Molecular and Structural Biology and Biochemistry Invito a presentare proposte ERC-2012-ADG_20120314 Vedi altri progetti per questo bando Meccanismo di finanziamento ERC-AG - ERC Advanced Grant Istituzione ospitante IFOM-ISTITUTO FONDAZIONE DI ONCOLOGIA MOLECOLARE ETS Contributo UE € 2 329 200,00 Indirizzo VIA ADAMELLO 16 20139 Milano Italia Mostra sulla mappa Regione Nord-Ovest Lombardia Milano Tipo di attività Research Organisations Contatto amministrativo Carlo Raimondi Cominesi (Dr.) Ricercatore principale Fabrizio D'adda Di Fagagna (Dr.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato Beneficiari (1) Classifica in ordine alfabetico Classifica per Contributo UE Espandi tutto Riduci tutto IFOM-ISTITUTO FONDAZIONE DI ONCOLOGIA MOLECOLARE ETS Italia Contributo UE € 2 329 200,00 Indirizzo VIA ADAMELLO 16 20139 Milano Mostra sulla mappa Regione Nord-Ovest Lombardia Milano Tipo di attività Research Organisations Contatto amministrativo Carlo Raimondi Cominesi (Dr.) Ricercatore principale Fabrizio D'adda Di Fagagna (Dr.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato