Cel DNA, if damaged, cannot be replaced. If not replaceable, it must be repaired. The so-called “DNA damage response” (DDR) is a coordinate set of evolutionary conserved events that arrest the cell-cycle (DNA damage checkpoint function) in proliferating cells and attempts DNA repair. Until DNA damage has not been repaired in full, cell proliferation is not resumed in normal cells.DNA damage is a physiological event. Ageing and cancer are both associated with DNA damage accumulation. In the past, we contribute to better understand the mechanisms and the consequences of DNA damage generation and DDR activation in both settings.We have recently identified a completely hitherto undiscovered level of control of DDR activation, so far considered a proteinaceous only signaling cascade. We have discovered that short RNA species are detectable at DNA damage sites and are necessary for DDR activation at DNA lesions. These RNA species are generated by an evolutionary-conserved RNA processing machinery. However, they serve purposes never reported before.We believe that our findings change radically our understanding of DDR modulation in mammals and disclose a fertile unspoilt ground for exciting investigations. Dziedzina nauki natural sciencesbiological sciencesgeneticsDNAmedical and health sciencesclinical medicineoncologynatural sciencesbiological sciencesgeneticsRNAnatural sciencesbiological scienceszoologymammalogy Program(-y) FP7-IDEAS-ERC - Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Temat(-y) ERC-AG-LS1 - ERC Advanced Grant - Molecular and Structural Biology and Biochemistry Zaproszenie do składania wniosków ERC-2012-ADG_20120314 Zobacz inne projekty w ramach tego zaproszenia System finansowania ERC-AG - ERC Advanced Grant Instytucja przyjmująca IFOM-ISTITUTO FONDAZIONE DI ONCOLOGIA MOLECOLARE ETS Wkład UE € 2 329 200,00 Adres VIA ADAMELLO 16 20139 Milano Włochy Zobacz na mapie Region Nord-Ovest Lombardia Milano Rodzaj działalności Research Organisations Kontakt administracyjny Carlo Raimondi Cominesi (Dr.) Kierownik naukowy Fabrizio D'adda Di Fagagna (Dr.) Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Koszt całkowity Brak danych Beneficjenci (1) Sortuj alfabetycznie Sortuj według wkładu UE Rozwiń wszystko Zwiń wszystko IFOM-ISTITUTO FONDAZIONE DI ONCOLOGIA MOLECOLARE ETS Włochy Wkład UE € 2 329 200,00 Adres VIA ADAMELLO 16 20139 Milano Zobacz na mapie Region Nord-Ovest Lombardia Milano Rodzaj działalności Research Organisations Kontakt administracyjny Carlo Raimondi Cominesi (Dr.) Kierownik naukowy Fabrizio D'adda Di Fagagna (Dr.) Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Koszt całkowity Brak danych