Obiettivo Two main types of diseases based on iron accumulation will be studied:1) Chronic systemic iron over-load diseases.They comprise:i)HFE Haemochromatosis, which is one of the most frequent hereditary recessive diseases in Europe. It affects female/male subjects both in their quality of life and/or their vital prognosis. It should be emphasized that only a limited percentage (especially for females) of the individuals carrying the genetic hallmark predisposing to the disease (homozygosity for the C282Y mutation) will develop an overt disease, raising the issue of the involvement, beside acquired factors, of genetic factors accounting for this important global and gender phenotypic variability.ii) Non HFE Hereditary Iron Overload, such as Juvenile Haemochromatosis, Transferrin Receptor2 Haemochromatosis, or the Ferroportin Disease.2) The Anemia of Chronic Disease, which is the second most common form of anemia worldwide, source of important disability and related to local macrophagic iron accumulation. For both types of diseases, recent data have shed light on the key pathogenic role of hepcidin dysregulation.The aims of our project are to dissect the mechanisms, both at the genetic and molecular levels, accounting for the development of these body iron misdistributions and for their phenotypic variability. The fact that these two types of situations can be, on a pathophysiological viewpoint, considered as "mirror" conditions constitute a major advantage for our integrated methodological approach which will rest upon animal and cellular models using innovative methodologies as well as upon the study of groups of highly selected patients. The expected improvement in our knowledge of the genetic control of the pathogenesis of these specific diseases should not only provide novel diagnostic markers and new potential therapeutic targets, but also indirectly benefit to the understanding and management of other types of diseases based on disorders of iron metabolism. Campo scientifico scienze naturaliscienze biologichebiochimicabiomolecoleproteinescienze naturaliscienze biologichegeneticamutazionescienze mediche e della salutemedicina clinicaematologiascienze mediche e della salutemedicina di basefisiologiaomeostasiscienze mediche e della salutemedicina clinicagastroenterologia Programma(i) FP6-LIFESCIHEALTH - Life sciences, genomics and biotechnology for health: Thematic Priority 1 under the Focusing and Integrating Community Research programme 2002-2006. Argomento(i) LIFESCIHEALTH - Life sciences, genomics and biotechnology for health Invito a presentare proposte FP6-2005-LIFESCIHEALTH-6 Vedi altri progetti per questo bando Meccanismo di finanziamento STREP - Specific Targeted Research Project Coordinatore UNIVERSITY OF RENNES1 Indirizzo 2 rue du thabor Rennes Francia Mostra sulla mappa Collegamenti Sito web Opens in new window Contributo UE Nessun dato Partecipanti (10) Classifica in ordine alfabetico Classifica per Contributo UE Espandi tutto Riduci tutto KINGS COLLEGE LONDON Regno Unito Contributo UE € 0,00 Indirizzo Strand London Mostra sulla mappa Collegamenti Sito web Opens in new window Altri finanziamenti Nessun dato THE HEBREW UNIVERSITY OF JERUSALEM Israele Contributo UE € 0,00 Indirizzo The authority for research and development, edmond j. safra campus, givat ram Jerusalem Mostra sulla mappa Collegamenti Sito web Opens in new window Altri finanziamenti Nessun dato UNIVERSITA' VITA-SALUTE SAN RAFFAELE' Italia Contributo UE € 0,00 Indirizzo Via olgettina 58 Milan Mostra sulla mappa Collegamenti Sito web Opens in new window Altri finanziamenti Nessun dato EUROPEAN MOLECULAR BIOLOGY LABORATORY Germania Contributo UE € 0,00 Indirizzo Meyerhofstr. 1 Heidelberg Mostra sulla mappa Collegamenti Sito web Opens in new window Altri finanziamenti Nessun dato MEDICAL UNIVERSITY OF INNSBRUCK Austria Contributo UE € 0,00 Indirizzo Christoph propst place 1 Innsbruck Mostra sulla mappa Collegamenti Sito web Opens in new window Altri finanziamenti Nessun dato PARTNERCHIP Francia Contributo UE € 0,00 Indirizzo Bat g2 -2 rue gaston cremieux Evry Mostra sulla mappa Collegamenti Sito web Opens in new window Altri finanziamenti Nessun dato INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MEDICALE Francia Contributo UE € 0,00 Indirizzo 101 rue de tolbiac Paris Mostra sulla mappa Collegamenti Sito web Opens in new window Altri finanziamenti Nessun dato UNIVERSITÀ DEGLI STUDI DI BRESCIA Italia Contributo UE € 0,00 Indirizzo Piazza del mercato 15 Brescia Mostra sulla mappa Collegamenti Sito web Opens in new window Altri finanziamenti Nessun dato UNIVERSITÀ DEGLI STUDI DI MODENA E REGGIO EMILIA Italia Contributo UE € 0,00 Indirizzo Via università n.4 Modena Mostra sulla mappa Collegamenti Sito web Opens in new window Altri finanziamenti Nessun dato UNIVERSITÄTSKLINIKUM HEIDELBERG Germania Contributo UE € 0,00 Indirizzo Im neuenheimer feld 672 Heidelberg Mostra sulla mappa Collegamenti Sito web Opens in new window Altri finanziamenti Nessun dato