Cel Two main types of diseases based on iron accumulation will be studied:1) Chronic systemic iron over-load diseases.They comprise:i)HFE Haemochromatosis, which is one of the most frequent hereditary recessive diseases in Europe. It affects female/male subjects both in their quality of life and/or their vital prognosis. It should be emphasized that only a limited percentage (especially for females) of the individuals carrying the genetic hallmark predisposing to the disease (homozygosity for the C282Y mutation) will develop an overt disease, raising the issue of the involvement, beside acquired factors, of genetic factors accounting for this important global and gender phenotypic variability.ii) Non HFE Hereditary Iron Overload, such as Juvenile Haemochromatosis, Transferrin Receptor2 Haemochromatosis, or the Ferroportin Disease.2) The Anemia of Chronic Disease, which is the second most common form of anemia worldwide, source of important disability and related to local macrophagic iron accumulation. For both types of diseases, recent data have shed light on the key pathogenic role of hepcidin dysregulation.The aims of our project are to dissect the mechanisms, both at the genetic and molecular levels, accounting for the development of these body iron misdistributions and for their phenotypic variability. The fact that these two types of situations can be, on a pathophysiological viewpoint, considered as "mirror" conditions constitute a major advantage for our integrated methodological approach which will rest upon animal and cellular models using innovative methodologies as well as upon the study of groups of highly selected patients. The expected improvement in our knowledge of the genetic control of the pathogenesis of these specific diseases should not only provide novel diagnostic markers and new potential therapeutic targets, but also indirectly benefit to the understanding and management of other types of diseases based on disorders of iron metabolism. Dziedzina nauki natural sciencesbiological sciencesbiochemistrybiomoleculesproteinsnatural sciencesbiological sciencesgeneticsmutationmedical and health sciencesclinical medicinehematologymedical and health sciencesbasic medicinephysiologyhomeostasismedical and health sciencesclinical medicinegastroenterology Program(-y) FP6-LIFESCIHEALTH - Life sciences, genomics and biotechnology for health: Thematic Priority 1 under the Focusing and Integrating Community Research programme 2002-2006. Temat(-y) LIFESCIHEALTH - Life sciences, genomics and biotechnology for health Zaproszenie do składania wniosków FP6-2005-LIFESCIHEALTH-6 Zobacz inne projekty w ramach tego zaproszenia System finansowania STREP - Specific Targeted Research Project Koordynator UNIVERSITY OF RENNES1 Wkład UE Brak danych Adres 2 RUE DU THABOR RENNES Francja Zobacz na mapie Linki Strona internetowa Opens in new window Koszt całkowity Brak danych Uczestnicy (10) Sortuj alfabetycznie Sortuj według wkładu UE Rozwiń wszystko Zwiń wszystko KINGS COLLEGE LONDON Zjednoczone Królestwo Wkład UE Brak danych Adres Strand LONDON Zobacz na mapie Linki Strona internetowa Opens in new window Koszt całkowity Brak danych THE HEBREW UNIVERSITY OF JERUSALEM Izrael Wkład UE Brak danych Adres The Authority for Research and Development, Edmond J. Safra Campus, Givat Ram JERUSALEM Zobacz na mapie Linki Strona internetowa Opens in new window Koszt całkowity Brak danych UNIVERSITA' VITA-SALUTE SAN RAFFAELE' Włochy Wkład UE Brak danych Adres Via Olgettina 58 MILAN Zobacz na mapie Linki Strona internetowa Opens in new window Koszt całkowity Brak danych EUROPEAN MOLECULAR BIOLOGY LABORATORY Niemcy Wkład UE Brak danych Adres Meyerhofstr. 1 HEIDELBERG Zobacz na mapie Linki Strona internetowa Opens in new window Koszt całkowity Brak danych MEDICAL UNIVERSITY OF INNSBRUCK Austria Wkład UE Brak danych Adres Christoph Propst Place 1 INNSBRUCK Zobacz na mapie Linki Strona internetowa Opens in new window Koszt całkowity Brak danych PARTNERCHIP Francja Wkład UE Brak danych Adres Bat G2 -2 rue Gaston Cremieux EVRY Zobacz na mapie Linki Strona internetowa Opens in new window Koszt całkowity Brak danych INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MEDICALE Francja Wkład UE Brak danych Adres 101 Rue de Tolbiac PARIS Zobacz na mapie Linki Strona internetowa Opens in new window Koszt całkowity Brak danych UNIVERSITÀ DEGLI STUDI DI BRESCIA Włochy Wkład UE Brak danych Adres Piazza del Mercato 15 BRESCIA Zobacz na mapie Linki Strona internetowa Opens in new window Koszt całkowity Brak danych UNIVERSITÀ DEGLI STUDI DI MODENA E REGGIO EMILIA Włochy Wkład UE Brak danych Adres Via Università n.4 MODENA Zobacz na mapie Linki Strona internetowa Opens in new window Koszt całkowity Brak danych UNIVERSITÄTSKLINIKUM HEIDELBERG Niemcy Wkład UE Brak danych Adres Im Neuenheimer Feld 672 HEIDELBERG Zobacz na mapie Linki Strona internetowa Opens in new window Koszt całkowity Brak danych
