Objective
The introduction of antibiotics in the medical practice has drastically reduced illness and death from infectious diseases. However, bacteria have exhibited a remarkable capacity to become resistant to commonly used antibacterial compounds. In parallel to efforts aimed at better understanding the strikingly diverse mechanisms they use, it is important to design strategies which will allow to counteract them and to search for new targets, ideally essential and specific to bacterial physiology. Our approach i s based on the well established facts that peptidoglycan biosynthesis and cell morphogenesis are related phenomena and that they are totally specific to bacterial cells, without even remotely equivalent processes in eukaryotic cells. By attempting to int erfere with these processes by inhibiting enzyme activities or perturbing protein-protein interactions, one should be able to design new antibacterial compounds active against pathogenic organisms such as streptococci, staphylococci, enterococci or chlamyd iae. Five workpackages will provide converging approaches to the same general goal. 1 The study and the design of inhibitors for penicillin-resistant transpeptidases. 2 The development of inhibitors of the glycosyltransferase domain of class A penicillin-binding proteins. 3 The study and the design of inhibitors for the synthesis and transport steps of cell wall subunits located at the plasma membrane. 4 The study and the design of inhibitors for the synthesis of soluble peptidoglycan precursors. 5 The s tudy of cell morphogenesis and of its regulation and the design of compounds which might interfere with these processes. This ambitious project will lead to new insights into bacterial physiology and might have a pronounced impact in other areas includin g biotechnology, and bacterial pathogenesis. Indeed, this project will create renewed interest in these key areas and pave the way to innovative for fighting resistance to antibiotics.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules proteins proteomics
- medical and health sciences health sciences infectious diseases
- medical and health sciences basic medicine pharmacology and pharmacy pharmaceutical drugs antibiotics
- medical and health sciences basic medicine physiology
- medical and health sciences basic medicine pharmacology and pharmacy drug resistance antibiotic resistance
You need to log in or register to use this function
We are sorry... an unexpected error occurred during execution.
You need to be authenticated. Your session might have expired.
Thank you for your feedback. You will soon receive an email to confirm the submission. If you have selected to be notified about the reporting status, you will also be contacted when the reporting status will change.
Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2003-LIFESCIHEALTH-I
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
LIÈGE
Belgium
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.