Objectif Excitotoxicity contributes significantly to neuronal cell death in a number of neurological conditions including stroke, head trauma, and Huntington's disease. The recent discovery of the proteins that anchor and interact with glutamate receptors opens for a new strategical approach to cytoprotective therapy. The present project aims at exploiting this conceptual advance to provide a platform for cytoprotective therapies that do not interfere unduly with synaptic transmission.Glutamate receptor interacting proteins (interactors) serve dual purpose. They determine the level and site of glutamate receptor expression within the cells and connect the receptors to specific intracellular signalling pathways. Both roles are interesting from a therapeutical perspective. Thus, excitotoxicity might be alleviated by modulation of the surface expression of glutamate receptors, as well as by interfering with their downstream signalling.The first part of the project aims at providing a more complete picture of the functional roles of interactors (WP1-3). It is envisaged that we will be able to identify novel interactors and that we will be in a position to understand, at a molecular level, how the different interactors connect with glutamate receptors and with each other. This part of the project will also elucidate the principles that govern the turnover and surface expression of glutamate receptors and the mechanisms that couple the individual receptors to specific downstream effectors of excitotoxicity.The second part (WP4 and 5) aims at exploiting the increased insight obtained through the first part of the project to design ways to alleviate excitotoxicity in different model systems. In designing these experiments the complex of glutamate receptor interacting proteins will be viewed as a 'nodal point' in orchestrating the surface expression of receptors and in activating appropriate and inappropriate (excitotoxic) signalling pathways. Champ scientifique natural sciencesbiological sciencesneurobiologynatural sciencesbiological sciencescell biologycell signalingnatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsmedical and health sciencesbasic medicineneurologystroke Mots‑clés CREB glutamate receptors interacting proteins ischemia pro-survival genes Programme(s) FP6-LIFESCIHEALTH - Life sciences, genomics and biotechnology for health: Thematic Priority 1 under the Focusing and Integrating Community Research programme 2002-2006. Thème(s) LSH-2003-2.1.3-6 - Excitotoxic neuronal cell death Appel à propositions FP6-2003-LIFESCIHEALTH-I Voir d’autres projets de cet appel Régime de financement STREP - Specific Targeted Research Project Coordinateur UNIVERSITY OF OSLO Contribution de l’UE Aucune donnée Adresse Problemveien 57 1073 OSLO Norvège Voir sur la carte Liens Site web Opens in new window Coût total Aucune donnée Participants (7) Trier par ordre alphabétique Trier par contribution de l’UE Tout développer Tout réduire UNIVERSITY OF BRISTOL Royaume-Uni Contribution de l’UE Aucune donnée Adresse Senate House, Tyndall Avenue BRISTOL Voir sur la carte Liens Site web Opens in new window Coût total Aucune donnée NEUROSEARCH A/S Danemark Contribution de l’UE Aucune donnée Adresse Pederstrupvej 93 BALLERUP Voir sur la carte Liens Site web Opens in new window Coût total Aucune donnée INSTYTUT BIOLOGII DOSWIADCZALNEJ IM. M. NENCKIEGO PAN Pologne Contribution de l’UE Aucune donnée Adresse Pasteura 3 WARSAW Voir sur la carte Liens Site web Opens in new window Coût total Aucune donnée RUPRECHT-KARLS-UNIVERSITÄT HEIDELBERG Allemagne Contribution de l’UE Aucune donnée Adresse Seminarstr. 2 HEIDELBERG Voir sur la carte Liens Site web Opens in new window Coût total Aucune donnée FLUOFARMA SA France Contribution de l’UE Aucune donnée Adresse 2, Rue Robert Escarpit PESSAC Voir sur la carte Liens Site web Opens in new window Coût total Aucune donnée UNIVERSITY OF SOUTHERN DENMARK Danemark Contribution de l’UE Aucune donnée Adresse Campusvej 55 ODENSE M Voir sur la carte Liens Site web Opens in new window Coût total Aucune donnée CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE France Contribution de l’UE Aucune donnée Adresse 3 rue Michel Ange PARIS Voir sur la carte Liens Site web Opens in new window Coût total Aucune donnée