Obiettivo Excitotoxicity contributes significantly to neuronal cell death in a number of neurological conditions including stroke, head trauma, and Huntington's disease. The recent discovery of the proteins that anchor and interact with glutamate receptors opens for a new strategical approach to cytoprotective therapy. The present project aims at exploiting this conceptual advance to provide a platform for cytoprotective therapies that do not interfere unduly with synaptic transmission.Glutamate receptor interacting proteins (interactors) serve dual purpose. They determine the level and site of glutamate receptor expression within the cells and connect the receptors to specific intracellular signalling pathways. Both roles are interesting from a therapeutical perspective. Thus, excitotoxicity might be alleviated by modulation of the surface expression of glutamate receptors, as well as by interfering with their downstream signalling.The first part of the project aims at providing a more complete picture of the functional roles of interactors (WP1-3). It is envisaged that we will be able to identify novel interactors and that we will be in a position to understand, at a molecular level, how the different interactors connect with glutamate receptors and with each other. This part of the project will also elucidate the principles that govern the turnover and surface expression of glutamate receptors and the mechanisms that couple the individual receptors to specific downstream effectors of excitotoxicity.The second part (WP4 and 5) aims at exploiting the increased insight obtained through the first part of the project to design ways to alleviate excitotoxicity in different model systems. In designing these experiments the complex of glutamate receptor interacting proteins will be viewed as a 'nodal point' in orchestrating the surface expression of receptors and in activating appropriate and inappropriate (excitotoxic) signalling pathways. Campo scientifico natural sciencesbiological sciencesneurobiologynatural sciencesbiological sciencescell biologycell signalingnatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsmedical and health sciencesbasic medicineneurologystroke Parole chiave CREB glutamate receptors interacting proteins ischemia pro-survival genes Programma(i) FP6-LIFESCIHEALTH - Life sciences, genomics and biotechnology for health: Thematic Priority 1 under the Focusing and Integrating Community Research programme 2002-2006. Argomento(i) LSH-2003-2.1.3-6 - Excitotoxic neuronal cell death Invito a presentare proposte FP6-2003-LIFESCIHEALTH-I Vedi altri progetti per questo bando Meccanismo di finanziamento STREP - Specific Targeted Research Project Coordinatore UNIVERSITY OF OSLO Contributo UE Nessun dato Indirizzo Problemveien 57 1073 OSLO Norvegia Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato Partecipanti (7) Classifica in ordine alfabetico Classifica per Contributo UE Espandi tutto Riduci tutto UNIVERSITY OF BRISTOL Regno Unito Contributo UE Nessun dato Indirizzo Senate House, Tyndall Avenue BRISTOL Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato NEUROSEARCH A/S Danimarca Contributo UE Nessun dato Indirizzo Pederstrupvej 93 BALLERUP Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato INSTYTUT BIOLOGII DOSWIADCZALNEJ IM. M. NENCKIEGO PAN Polonia Contributo UE Nessun dato Indirizzo Pasteura 3 WARSAW Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato RUPRECHT-KARLS-UNIVERSITÄT HEIDELBERG Germania Contributo UE Nessun dato Indirizzo Seminarstr. 2 HEIDELBERG Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato FLUOFARMA SA Francia Contributo UE Nessun dato Indirizzo 2, Rue Robert Escarpit PESSAC Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato UNIVERSITY OF SOUTHERN DENMARK Danimarca Contributo UE Nessun dato Indirizzo Campusvej 55 ODENSE M Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE Francia Contributo UE Nessun dato Indirizzo 3 rue Michel Ange PARIS Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato