Descrizione del progetto
Virtual Physiological Human
Developing robust, reproducible, interoperable and collaborative hyper-models of diseases and normal physiology is a sine qua non necessity if rational, coherent and comprehensive exploitation of the invaluable information hidden within human multiscale biological data is envisaged. Responding to this imperative in the context of both the broad Virtual Physiological Human (VPH) initiative and the paradigmatic cancer domain, CHIC proposes the development of a suite of tools, services and secure infrastructure that will support accessibility and reusability of VPH mathematical and computational hypermodels. These will include a hypermodelling infrastructure consisting primarily of a hypermodelling editor and a hypermodelling execution environment, an infrastructure for semantic metadata management, a hypermodel repository, a hypermodel-driven clinical data repository, a distributed metadata repository and an in silico trial repository for the storage of executed simulation scenarios. Multiscale models and data will be semantically annotated using the ontological and annotating tools to be developed. An image processing and visualization toolkit, and cloud and virtualization services will also be developed. The CHIC tools, services, infrastructure and repositories will provide the community with a collaborative interface for exchanging knowledge and sharing work in an effective and standardized way. A number of open source features and tools will enhance usability and accessibility. In order to ensure clinical relevance and foster clinical acceptance of hypermodelling in the future, the whole endeavour will be driven by the clinical partners of the consortium. Cancer hypermodels to be collaboratively developed by the consortium cancer modellers will provide the framework and the testbed for the development of the CHIC technologies. Clinical adaptation and partial clinical validation of hypermodels and hypermodel oncosimulators will be undertaken.
Campo scientifico
Argomento(i)
Invito a presentare proposte
FP7-ICT-2011-9
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Meccanismo di finanziamento
CP - Collaborative project (generic)Coordinatore
106 82 ATHINA
Grecia
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Partecipanti (16)
9830 Sint-Martens-Latem
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3000 Leuven
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3012 Bern
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66123 Saarbrucken
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30167 Hannover
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66386 St Ingbert
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710 04 IRAKLEIO
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70013 Irakleio
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40033 Casalecchio Di Reno Bo
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10124 Torino
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5656 AG Eindhoven
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S10 2TN Sheffield
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OX1 2JD Oxford
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LU1 3JU Luton
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WC1E 6BT LONDON
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19104 Philadelphia
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