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Nanotherapeutics to Treat Antibiotic Resistant Gram-Negative Pneumonia Infections

Ziel

The main objective of PneumoNP is the development of a theragnostic system for the treatment of lung Gram-negative bacterial infections. As a proof of concept PneumoNP will focus the attention on Klebsiella pneumoniae caused infections. A diagnostic kit will be developed to enable a rapid and precise identification of the bacteria strain causing the infection and avoid the use of wide spectrum antibiotics. For the treatment a nanotherapeutic based inhalable antibiotic will be developed. The therapeutic nanosystem will be based on a nanocarrier combined with an antimicrobial peptide. 3 different types of NCs will be tested with 2 AMPs to be able to obtain a novel effective inhalable antimicrobial NS. Nanotherapeutics offers many advantages in pulmonary drug-delivery, due to the huge surface area available in the lungs and their potential to achieve uniform distribution of drug dose among the alveoli. To improve this delivery to the lungs an aerosol system will also be developed. Due to the characteristics related to pulmonary delivery of NCs, topical and systemic bioavailabilities are envisaged. A diagnostic kit will be generated to monitor the efficacy and efficiency of the therapy. Once this treatment is proved to be effective, it could then be applied to any Gram-negative lung bacterial infection.
The number of antibiotic resistant bacteria strains is increasing rapidly, new types of therapy are urgently required to avoid the use of standard antibiotics. Gram-negative bacteria that cause pneumonia are one of the main sources of nosocomial infections, mainly in people with a weakened immune system. Apart from pneumonia they can cause bacteremia and other infections. Early detection of the infection source combined with the development of appropriate and effective NSs to treat multi-drug resistant (MDR) bacteria caused infections will definitely radically improve the healing process of patients and avoid complications for people in hospital.

Aufforderung zur Vorschlagseinreichung

FP7-NMP-2013-LARGE-7
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FUNDACION CIDETEC
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Paseo Miramon 196 Parque Tecnologico De Miramon
20014 San Sebastian
Spanien
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ADENIUM BIOTECH APS
Dänemark
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€ 416 300
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2200 Kobenhavn
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ASOCIACION CENTRO DE INVESTIGACION COOPERATIVA EN BIOMATERIALES- CIC biomaGUNE
Spanien
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€ 555 990,80
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Paseo Miramon 182, Parque Tecnologico De San Sebastian Edificio Empresarial C
20009 San Sebastian
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ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM
Niederlande
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€ 975 861,20
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Dr Molewaterplein 40
3015 GD Rotterdam
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Higher or Secondary Education Establishments
EURICE EUROPEAN RESEARCH AND PROJECT OFFICE GMBH
Deutschland
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€ 332 340
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Heinrich-hertz-allee 1
66386 St Ingbert
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FRAUNHOFER GESELLSCHAFT ZUR FORDERUNG DER ANGEWANDTEN FORSCHUNG EV
Deutschland
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Hansastrasse 27C
80686 Munchen
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INGENIATRICS TECNOLOGIAS SL
Spanien
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Calle Camino Mozarabe 41 Parque Industrial Parque Plata Camas
41900 Sevilla
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PATHOFINDER BV
Niederlande
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6229 EG Maastricht
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Italien
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Frankreich
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Avenue De La Resistance 104 112
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UNIVERSITEIT UTRECHT
Niederlande
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