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Nanotherapeutics to Treat Antibiotic Resistant Gram-Negative Pneumonia Infections

Obiettivo

The main objective of PneumoNP is the development of a theragnostic system for the treatment of lung Gram-negative bacterial infections. As a proof of concept PneumoNP will focus the attention on Klebsiella pneumoniae caused infections. A diagnostic kit will be developed to enable a rapid and precise identification of the bacteria strain causing the infection and avoid the use of wide spectrum antibiotics. For the treatment a nanotherapeutic based inhalable antibiotic will be developed. The therapeutic nanosystem will be based on a nanocarrier combined with an antimicrobial peptide. 3 different types of NCs will be tested with 2 AMPs to be able to obtain a novel effective inhalable antimicrobial NS. Nanotherapeutics offers many advantages in pulmonary drug-delivery, due to the huge surface area available in the lungs and their potential to achieve uniform distribution of drug dose among the alveoli. To improve this delivery to the lungs an aerosol system will also be developed. Due to the characteristics related to pulmonary delivery of NCs, topical and systemic bioavailabilities are envisaged. A diagnostic kit will be generated to monitor the efficacy and efficiency of the therapy. Once this treatment is proved to be effective, it could then be applied to any Gram-negative lung bacterial infection.
The number of antibiotic resistant bacteria strains is increasing rapidly, new types of therapy are urgently required to avoid the use of standard antibiotics. Gram-negative bacteria that cause pneumonia are one of the main sources of nosocomial infections, mainly in people with a weakened immune system. Apart from pneumonia they can cause bacteremia and other infections. Early detection of the infection source combined with the development of appropriate and effective NSs to treat multi-drug resistant (MDR) bacteria caused infections will definitely radically improve the healing process of patients and avoid complications for people in hospital.

Invito a presentare proposte

FP7-NMP-2013-LARGE-7
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Coordinatore

FUNDACION CIDETEC
Indirizzo
Paseo Miramon 196 Parque Tecnologico De Miramon
20014 San Sebastian
Spagna
Tipo di attività
Research Organisations
Contributo UE
€ 896 660

Partecipanti (10)

ADENIUM BIOTECH APS
Danimarca
Contributo UE
€ 416 300
Indirizzo
Ole Maaloesvej 3
2200 Kobenhavn
Tipo di attività
Private for-profit entities (excluding Higher or Secondary Education Establishments)
ASOCIACION CENTRO DE INVESTIGACION COOPERATIVA EN BIOMATERIALES- CIC biomaGUNE
Spagna
Contributo UE
€ 555 990,80
Indirizzo
Paseo Miramon 182, Parque Tecnologico De San Sebastian Edificio Empresarial C
20009 San Sebastian
Tipo di attività
Research Organisations
ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM
Paesi Bassi
Contributo UE
€ 975 861,20
Indirizzo
Dr Molewaterplein 40
3015 GD Rotterdam
Tipo di attività
Higher or Secondary Education Establishments
EURICE EUROPEAN RESEARCH AND PROJECT OFFICE GMBH
Germania
Contributo UE
€ 332 340
Indirizzo
Heinrich-hertz-allee 1
66386 St Ingbert
Tipo di attività
Private for-profit entities (excluding Higher or Secondary Education Establishments)
FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V.
Germania
Contributo UE
€ 511 251,25
Indirizzo
Hansastrasse 27C
80686 Munchen
Tipo di attività
Research Organisations
INGENIATRICS TECNOLOGIAS SL
Spagna
Contributo UE
€ 454 658
Indirizzo
Calle Camino Mozarabe 41 Parque Industrial Parque Plata Camas
41900 Sevilla
Tipo di attività
Private for-profit entities (excluding Higher or Secondary Education Establishments)
PATHOFINDER BV
Paesi Bassi
Contributo UE
€ 497 681,60
Indirizzo
Randwycksingel 45
6229 EG Maastricht
Tipo di attività
Private for-profit entities (excluding Higher or Secondary Education Establishments)
SETLANCE SRL
Italia
Contributo UE
€ 341 902,40
Indirizzo
Via Fiorentina 1
53100 Siena
Tipo di attività
Private for-profit entities (excluding Higher or Secondary Education Establishments)
UMAPS COMMUNICATION SARL
Francia
Contributo UE
€ 183 520
Indirizzo
Avenue De La Resistance 104 112
93100 Montreuil
Tipo di attività
Private for-profit entities (excluding Higher or Secondary Education Establishments)
UNIVERSITEIT UTRECHT
Paesi Bassi
Contributo UE
€ 516 185,75
Indirizzo
Heidelberglaan 8
3584 CS Utrecht
Tipo di attività
Higher or Secondary Education Establishments