Final Report Summary - H4H (Exploring the therapeutic potential of homoarginine in experimental models of ischemia reperfusion injury and chronic heart failure)
During her Fellowship, the Fellow has generated a substantial amount of data following the project hypothesis. The Fellow received extensive training and transferable skills in experimental models of HF, in vivo imaging and LV catheterization. Along with this, the Fellow was trained in single cell experiments in order to study calcium-handling in cardiomyocytes. For mechanistic studies, the Fellow furthermore performed a broad range of cutting edge biochemical assays such as the biotin switch assay and NOS activity assay as well as NO bioavailability, biopterin and superoxide quantification measurements.
This interdisciplinary project brought together the Fellow’s (Germany) specific expertise in pharmacology and detailed knowledge of the homoarginine research field with the unique opportunity to receive extensive in vivo training in an array of cutting-edge murine cardiac phenotyping techniques developed by the scientist in charge and collaborators on-site (Oxford, UK). In conclusion this project 1) paved the road to develop scientific independence for the Fellow, 2) fostered intra-European collaboration, 3) provided a basis for further funding, and 4) provided novel insights into CVD pathophysiology including potential therapeutic options to the scientific community and to the general public.
Dr. Dorothee Atzler, email: email@example.com
Prof. Craig Lygate, email: firstname.lastname@example.org