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Mechanisms and parameters controlling cell-to-cell and long-distance movement of plant small RNAs

Obiettivo

Basic processes within individual cells are integrated as part of the development and function of entire multicellular organisms. How this global coordination is achieved is a central question in biology. Plants use silencing small (s)RNA to control physiological and defensive processes at both the cellular and organismal levels by trafficking sRNAs from cell-to-cell through plasmodesmata and over long distances through the phloem. However, the parameters and mechanisms controlling the movement of plant small interfering RNAs (siRNAs) and micro RNAs (miRNAs) remain poorly understood and may well vary extensively depending on the cell types involved, quantities and biochemical nature of sRNAs. Combining biochemical, molecular and genetic approaches, the proposed project aims at deciphering the specific mechanisms underpinning viral, artificial and endogenous sRNA movement. The project is expected to generate a wealth of original information and significantly improve our understanding of RNA silencing in plants and perhaps other organisms.

Invito a presentare proposte

FP7-PEOPLE-2013-IEF
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Coordinatore

EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH
Contributo UE
€ 199 317,60
Indirizzo
Raemistrasse 101
8092 Zuerich
Svizzera

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Regione
Schweiz/Suisse/Svizzera Zürich Zürich
Tipo di attività
Higher or Secondary Education Establishments
Contatto amministrativo
Olivier Voinnet (Prof.)
Collegamenti
Costo totale
Nessun dato