Objectif Human milk is universally considered as the best nutrition for the new born infant and recent research has revealed that, in addition to its nutritional value, it represents a constant supply of commensal, non-pathogenic and potential probiotic bacteria to the infant gastrointestinal tract. Milk is also a rich source of human milk oligosaccharides (HMOs), which have been shown to interrupt the attachment of enteric pathogens to the intestinal mucosa and to act as prebiotic substrates within the infant intestine, where they can promote the growth of certain beneficial bacteria. Therefore human milk may strongly influence the composition of the new born intestinal microbiota, known to be closely related to survivorship. The rationale behind this multidisciplinary and cooperative project is that human milk composition may have evolved differentially under various environmental pressures. Thus, a single “normal” or healthy milk composition would not exist, but instead it would be conditioned by a combination of evolutionary and socio-ecological factors. The applicant will investigate how selected population-specific factors can contribute to variation of two main human milk components, i.e. HMOs and milk microbiota. In addition, this project will provide further insights on the consequences that these variations may pose to the infant fecal microbiota. To achieve these goals the applicant will use conventional HMOs determination methodologies and will develop a new high-throughput variant of traditional molecular fingerprinting methods, which will significantly improve the existing ability to characterize complex microbial communities. Finally, socioecological data will be collected and analyzed on the studied populations, in order to gain insight on the environmental and evolutionary factors conditioning milk variation. Results obtained will be of great value to the European scientific community and will influence the way “normal” human milk composition is regarded. Champ scientifique natural sciencesbiological sciencesmicrobiologybacteriologymedical and health scienceshealth sciencesnutritionnatural sciencesbiological sciencesecologyecosystems Programme(s) FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Thème(s) FP7-PEOPLE-2013-IEF - Marie-Curie Action: "Intra-European fellowships for career development" Appel à propositions FP7-PEOPLE-2013-IEF Voir d’autres projets de cet appel Régime de financement MC-IEF - Intra-European Fellowships (IEF) Coordinateur UNIVERSIDAD COMPLUTENSE DE MADRID Contribution de l’UE € 166 336,20 Adresse AVENIDA DE SENECA 2 28040 Madrid Espagne Voir sur la carte Région Comunidad de Madrid Comunidad de Madrid Madrid Type d’activité Higher or Secondary Education Establishments Contact administratif Rodríguez Villa María Isabel (Mrs.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée