Characterization of nuclear SHP2 function in breast cancer progression and metastasis

Projektinformationen

SHP2N

ID Finanzhilfevereinbarung: 626728

Projekt abgeschlossen

Startdatum 1 März 2015

Enddatum 2 Juli 2017

Finanziert unter

• Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)

Gesamtkosten € 199 317,60

EU-Beitrag € 199 317,60

Koordiniert durch

FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH FONDATION
Switzerland

Ziel

Breast cancer is the most frequently diagnosed cancer in women with ~1.1 million worldwide cases. Despite intense study, in a significant fraction of women, tumor progression and disease relapse is inevitable underscoring a crucial gap in our understanding of these important hallmarks. Currently, little is known about the biochemical networks controlling these processes. The host lab has shown a fundamental role for the protein tyrosine phosphatase, SHP2, in tumor progression and metastasis in two aggressive breast cancer subtypes, human epidermal growth factor 2 (HER2) positive and triple negative breast cancer. Preliminary data in breast cancer cell lines revealed nuclear localization of SHP2 and proteomic analysis identified candidate nuclear substrates including nucleolin. However, whether a nuclear function of SHP2 and how SHP2 and its binding partners (i.e nucleolin) might impact breast cancer progression and metastasis remain unknown. This proposal will take advantage of original, state-of-the art technologies including multiphoton intravital imaging developed by the host laboratory to determine the nuclear function of SHP2 in normal mammary epithelial cells and during breast cancer progression and metastasis. Finally, it will validate nucleolin (and other identified candidates) as a SHP2 nuclear substrate and determine whether it is a critical downstream effector of SHP2 in breast cancer. Elucidation of the mechanisms driving tumor progression and metastasis is paramount for the development of novel therapeutic strategies.

Wissenschaftliches Gebiet (EuroSciVoc)

CORDIS klassifiziert Projekte mit EuroSciVoc, einer mehrsprachigen Taxonomie der Wissenschaftsbereiche, durch einen halbautomatischen Prozess, der auf Verfahren der Verarbeitung natürlicher Sprache beruht.

• Naturwissenschaften › Biowissenschaften › Biochemie › Biomoleküle › Proteine
• Medizin- und Gesundheitswissenschaften › Klinische Medizin › Onkologie › Brustkrebs

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Programm/Programme

• FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)

Thema/Themen

• FP7-PEOPLE-2013-IEF - Marie-Curie Action: "Intra-European fellowships for career development"

Aufforderung zur Vorschlagseinreichung

FP7-PEOPLE-2013-IEF
Andere Projekte für diesen Aufruf anzeigen

Finanzierungsplan

MC-IEF - Intra-European Fellowships (IEF)

Koordinator

FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH FONDATION

• EU-Beitrag: € 199 317,60
• Adresse: FABRIKSTRASSE 2 ; 4056 BASEL ; Schweiz
• Region: Schweiz/Suisse/Svizzera › Nordwestschweiz › Basel-Stadt
• Aktivitätstyp: Research Organisations
• Gesamtkosten: Keine Daten