Objectif The innate immune system provides an immediate response to infection and injury. It relies on the detection of pathogen-associated molecular patterns (PAMPs), molecular hallmarks of infection which are shared amongst different pathogens but are absent from healthy host cells. The detection of intracellular DNA as PAMP has emerged a key event in the innate immune response to DNA viruses, retroviruses and intracellular bacteria. In some circumstances the body’s own DNA can also be also detected as a danger-associated molecular pattern (DAMP), e.g. when DNA from dying cells is not cleared effectively, and this can play a role in the development of autoimmune conditions such as systemic lupus erythematosus.One of the responses to foreign DNA is the secretion of interferons and pro-inflammatory cytokines, which then help to establish an antiviral state in the infected cell and its neighbours, and alert more specialised immune cells to the danger. Several proteins have been proposed to act as interferon-inducing DNA receptors, including most recently the enzyme cyclic GMP-AMP synthase, which provides a particularly elegant signalling pathway through production of cyclic GMP-AMP as second messenger. However, it is no yet know whether other receptor proteins also utilise this signalling pathway, how signalling is regulated, and how foreign DNA is distinguished from the cell's own genome.The objectives of this project are:1.) To test the involvement of DNA receptors in the recognition of DNA as 'stranger' and 'danger' signal in human cells2.) To examine the interplay between DNA receptor candidates3.) To identify novel regulators of the DNA-induced signalling pathway4.) To define the nature of the DNA ligand that is recognised by innate immune receptorsBy elucidating the molecular mechanisms of DNA sensing by the innate immune system, this project has great scientific and medical relevance for the fields of infection, vaccination and autoimmunity. Champ scientifique natural sciencesbiological sciencesmicrobiologyvirologynatural sciencesbiological sciencesgeneticsDNAmedical and health sciencesbasic medicineimmunologymedical and health scienceshealth sciencesinfectious diseasesDNA virusesnatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsenzymes Programme(s) FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Thème(s) FP7-PEOPLE-2013-CIG - Marie-Curie Action: "Career Integration Grants" Appel à propositions FP7-PEOPLE-2013-CIG Voir d’autres projets de cet appel Régime de financement MC-CIG - Support for training and career development of researcher (CIG) Coordinateur UNIVERSITY OF LANCASTER Contribution de l’UE € 70 833,33 Adresse BAILRIGG LA1 4YW Lancaster Royaume-Uni Voir sur la carte Région North West (England) Lancashire Lancaster and Wyre Type d’activité Higher or Secondary Education Establishments Contact administratif Toni Elsworth-Ross Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée Participants (1) Trier par ordre alphabétique Trier par contribution de l’UE Tout développer Tout réduire UNIVERSITY OF DUNDEE Participation terminée Royaume-Uni Contribution de l’UE € 29 166,67 Adresse Nethergate DD1 4HN Dundee Voir sur la carte Région Scotland Eastern Scotland Angus and Dundee City Type d’activité Higher or Secondary Education Establishments Contact administratif James Mcgregor (Mr.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée
