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Capture, dissemination and analysis of multiscale cell migration data for biological and clinical applications (MULTIMOT)

Objectif

This proposal addresses the call topic ‘Advancing bioinformatics to meet biomedical and clinical needs’ (PHC-32-2014), with the focus on the standardization, dissemination and meta-analysis of cell migration data. Cell migration is the fundamental process in medically highly relevant topics, including morphogenesis, immune function, wound healing, and cancer metastasis, and the study of cell migration thus has a direct impact on major clinical applications, especially regarding personalized treatment and diagnosis. Over the last few years, cell migration research has benefited enormously from advances in methodology and instrumentation, allowing multiplexing and multi-parameter post-processing of cell migration analyses to become widely used. As cell migration studies have thus de facto become both a high-content as well as a high-throughput science, an urgent yet largely unmet bioinformatics need has emerged in the form of intra- and inter-lab data management solutions, standardization and dissemination infrastructure, and novel approaches and algorithms for meta-analysis. The central goal of this project is therefore to construct a comprehensive, open and free data exchange ecosystem for cell migration data, based on the development of extensible community standards and a robust, future-proof repository that collects, annotates and disseminates these data in the standardized formats. The standards and repository will be supported by freely available and open source tools for data management, submission, extraction and analysis. Importantly, we will also demonstrate the application of large-scale integrative data analysis from cell migration studies through two proof-of-concept studies: guiding personalized cancer treatment from patient organoids, and providing patient-specific diagnosis based on peripheral blood leukocyte motility. This work will also establish the foundation for a cell migration science-based ELIXIR Node.

Appel à propositions

H2020-PHC-2014-two-stage
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Coordinateur

VIB VZW
Adresse
Rijvisschestraat 120
9052 Zwijnaarde - Gent
Belgique
Type d’activité
Research Organisations
Contribution de l’UE
€ 576 750

Participants (9)

WEIZMANN INSTITUTE OF SCIENCE
Israël
Contribution de l’UE
€ 490 680
Adresse
Herzl Street 234
7610001 Rehovot
Type d’activité
Higher or Secondary Education Establishments
UNIVERSITEIT GENT
Belgique
Contribution de l’UE
€ 144 052,75
Adresse
Sint Pietersnieuwstraat 25
9000 Gent
Type d’activité
Higher or Secondary Education Establishments
STICHTING RADBOUD UNIVERSITEIT
Pays-Bas
Contribution de l’UE
€ 420 812,50
Adresse
Houtlaan 4
6525 XZ Nijmegen
Type d’activité
Higher or Secondary Education Establishments
KAROLINSKA INSTITUTET
Suède
Contribution de l’UE
€ 340 750
Adresse
Nobels Vag 5
17177 Stockholm
Type d’activité
Higher or Secondary Education Establishments
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
United Kingdom
Contribution de l’UE
€ 118 375
Adresse
Wellington Square University Offices
OX1 2JD Oxford
Type d’activité
Higher or Secondary Education Establishments
UNIVERSITY OF DUNDEE
United Kingdom
Contribution de l’UE
€ 364 520
Adresse
Nethergate
DD1 4HN Dundee
Type d’activité
Higher or Secondary Education Establishments
UNIVERSITAETSKLINIKUM ESSEN
Allemagne
Contribution de l’UE
€ 347 038,75
Adresse
Hufelandstrasse 55
45147 Essen
Type d’activité
Higher or Secondary Education Establishments
Idea Bio-Medical Ltd.
Israël
Contribution de l’UE
€ 62 625
Adresse
Prof. Bergman St. 2
76705 Rehovot
Type d’activité
Private for-profit entities (excluding Higher or Secondary Education Establishments)
THE FRANCIS CRICK INSTITUTE LIMITED
United Kingdom
Contribution de l’UE
€ 133 750
Adresse
1 Midland Road
NW1 1AT London
Type d’activité
Research Organisations