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Capture, dissemination and analysis of multiscale cell migration data for biological and clinical applications (MULTIMOT)

Objetivo

This proposal addresses the call topic ‘Advancing bioinformatics to meet biomedical and clinical needs’ (PHC-32-2014), with the focus on the standardization, dissemination and meta-analysis of cell migration data. Cell migration is the fundamental process in medically highly relevant topics, including morphogenesis, immune function, wound healing, and cancer metastasis, and the study of cell migration thus has a direct impact on major clinical applications, especially regarding personalized treatment and diagnosis. Over the last few years, cell migration research has benefited enormously from advances in methodology and instrumentation, allowing multiplexing and multi-parameter post-processing of cell migration analyses to become widely used. As cell migration studies have thus de facto become both a high-content as well as a high-throughput science, an urgent yet largely unmet bioinformatics need has emerged in the form of intra- and inter-lab data management solutions, standardization and dissemination infrastructure, and novel approaches and algorithms for meta-analysis. The central goal of this project is therefore to construct a comprehensive, open and free data exchange ecosystem for cell migration data, based on the development of extensible community standards and a robust, future-proof repository that collects, annotates and disseminates these data in the standardized formats. The standards and repository will be supported by freely available and open source tools for data management, submission, extraction and analysis. Importantly, we will also demonstrate the application of large-scale integrative data analysis from cell migration studies through two proof-of-concept studies: guiding personalized cancer treatment from patient organoids, and providing patient-specific diagnosis based on peripheral blood leukocyte motility. This work will also establish the foundation for a cell migration science-based ELIXIR Node.

Ámbito científico

  • /ciencias naturales/informática y ciencias de la información/ciencia de datos/intercambio de datos
  • /ciencias naturales/informática y ciencias de la información/ciencia de datos/análisis de datos

Convocatoria de propuestas

H2020-PHC-2014-two-stage
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Régimen de financiación

RIA - Research and Innovation action

Coordinador

VIB VZW
Dirección
Rijvisschestraat 120
9052 Zwijnaarde - Gent
Bélgica
Tipo de actividad
Research Organisations
Aportación de la UE
€ 576 750

Participantes (9)

WEIZMANN INSTITUTE OF SCIENCE
Israel
Aportación de la UE
€ 490 680
Dirección
Herzl Street 234
7610001 Rehovot
Tipo de actividad
Higher or Secondary Education Establishments
UNIVERSITEIT GENT
Bélgica
Aportación de la UE
€ 144 052,75
Dirección
Sint Pietersnieuwstraat 25
9000 Gent
Tipo de actividad
Higher or Secondary Education Establishments
STICHTING KATHOLIEKE UNIVERSITEIT
Países Bajos
Aportación de la UE
€ 420 812,50
Dirección
Geert Grooteplein Noord 9
6525 EZ Nijmegen
Tipo de actividad
Higher or Secondary Education Establishments
KAROLINSKA INSTITUTET
Suecia
Aportación de la UE
€ 340 750
Dirección
Nobels Vag 5
17177 Stockholm
Tipo de actividad
Higher or Secondary Education Establishments
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
United Kingdom
Aportación de la UE
€ 118 375
Dirección
Wellington Square University Offices
OX1 2JD Oxford
Tipo de actividad
Higher or Secondary Education Establishments
UNIVERSITY OF DUNDEE
United Kingdom
Aportación de la UE
€ 364 520
Dirección
Nethergate
DD1 4HN Dundee
Tipo de actividad
Higher or Secondary Education Establishments
UNIVERSITAETSKLINIKUM ESSEN
Alemania
Aportación de la UE
€ 347 038,75
Dirección
Hufelandstrasse 55
45147 Essen
Tipo de actividad
Higher or Secondary Education Establishments
Idea Bio-Medical Ltd.
Israel
Aportación de la UE
€ 62 625
Dirección
Prof. Bergman St. 2
76705 Rehovot
Tipo de actividad
Private for-profit entities (excluding Higher or Secondary Education Establishments)
THE FRANCIS CRICK INSTITUTE LIMITED
United Kingdom
Aportación de la UE
€ 133 750
Dirección
1 Midland Road
NW1 1AT London
Tipo de actividad
Research Organisations