Sorting of Self

Información del proyecto

SOS

Identificador del acuerdo de subvención: 640087

DOI

10.3030/640087

Proyecto cerrado

Fecha de la firma de la CE 1 Abril 2015

Fecha de inicio 1 Mayo 2015

Fecha de finalización 30 Abril 2020

Financiado con arreglo a

• EXCELLENT SCIENCE - European Research Council (ERC)

Coste total

€ 1 479 781,00

Aportación de la UE

€ 1 479 781,00

Coordinado por

UNIVERSITATSKLINIKUM ERLANGEN
Germany

Periodic Reporting for period 4 - SOS (Sorting of Self)

Período documentado: 2019-11-01 hasta 2020-04-30

Resumen del contexto y de los objetivos generales del proyecto

Clearance of dying cells by phagocytes is important to remove cell-derived autoantigens during the steady state and during inflammation. A failure during this process can result in autoimmunity and autoimmune-disease. During our project we want to better understand the processes underlying this clearance process and identify involved phagocate subsets as well as responsible molecular mechanisms. Insights into these issues will help to better understand the pathogenesis of autoimmune diseases and to identify novel therapeutic targets.

Trabajo realizado desde el comienzo del proyecto hasta el final del período abarcado por el informe y los principales resultados hasta la fecha

We identified tissue resident macrophages as Major cells responsible for the clearance of dying cells. Moreover we defined Special transcription factors such as NR4A1 that are involved in the non-immunogenic clearance of dying cells and for the maintenance of self-tolerance.

Avances que van más allá del estado de la técnica e impacto potencial esperado (incluida la repercusión socioeconómica y las implicaciones sociales más amplias del proyecto hasta la fecha)

We developed novel techniques that allow us to track the clearance of dying cells in vivo and follow the involved phagocytes during their Differentiation process. We expect to utilize These developments to study the clearance of dying cells during models of autoimmune disease as well as within the Tumor Environment.

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