Sorting of Self

Projektinformationen

SOS

ID Finanzhilfevereinbarung: 640087

DOI

10.3030/640087

Projekt abgeschlossen

EK-Unterschriftsdatum 1 April 2015

Startdatum 1 Mai 2015

Enddatum 30 April 2020

Finanziert unter

• EXCELLENT SCIENCE - European Research Council (ERC)

Gesamtkosten

€ 1 479 781,00

EU-Beitrag

€ 1 479 781,00

Koordiniert durch

UNIVERSITATSKLINIKUM ERLANGEN
Germany

Periodic Reporting for period 4 - SOS (Sorting of Self)

Berichtszeitraum: 2019-11-01 bis 2020-04-30

Zusammenfassung vom Kontext und den Gesamtzielen des Projekts

Clearance of dying cells by phagocytes is important to remove cell-derived autoantigens during the steady state and during inflammation. A failure during this process can result in autoimmunity and autoimmune-disease. During our project we want to better understand the processes underlying this clearance process and identify involved phagocate subsets as well as responsible molecular mechanisms. Insights into these issues will help to better understand the pathogenesis of autoimmune diseases and to identify novel therapeutic targets.

Arbeit, die ab Beginn des Projekts bis zum Ende des durch den Bericht erfassten Berichtszeitraums geleistet wurde, und die wichtigsten bis dahin erzielten Ergebnisse

We identified tissue resident macrophages as Major cells responsible for the clearance of dying cells. Moreover we defined Special transcription factors such as NR4A1 that are involved in the non-immunogenic clearance of dying cells and for the maintenance of self-tolerance.

Fortschritte, die über den aktuellen Stand der Technik hinausgehen und voraussichtliche potenzielle Auswirkungen (einschließlich der bis dato erzielten sozioökonomischen Auswirkungen und weiter gefassten gesellschaftlichen Auswirkungen des Projekts)

We developed novel techniques that allow us to track the clearance of dying cells in vivo and follow the involved phagocytes during their Differentiation process. We expect to utilize These developments to study the clearance of dying cells during models of autoimmune disease as well as within the Tumor Environment.

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