Sorting of Self

Informazioni relative al progetto

SOS

ID dell’accordo di sovvenzione: 640087

DOI

10.3030/640087

Progetto chiuso

Data della firma CE 1 Aprile 2015

Data di avvio 1 Maggio 2015

Data di completamento 30 Aprile 2020

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale

€ 1 479 781,00

Contributo UE

€ 1 479 781,00

Coordinato da

UNIVERSITATSKLINIKUM ERLANGEN
Germany

Periodic Reporting for period 4 - SOS (Sorting of Self)

Periodo di rendicontazione: 2019-11-01 al 2020-04-30

Sintesi del contesto e degli obiettivi generali del progetto

Clearance of dying cells by phagocytes is important to remove cell-derived autoantigens during the steady state and during inflammation. A failure during this process can result in autoimmunity and autoimmune-disease. During our project we want to better understand the processes underlying this clearance process and identify involved phagocate subsets as well as responsible molecular mechanisms. Insights into these issues will help to better understand the pathogenesis of autoimmune diseases and to identify novel therapeutic targets.

Lavoro eseguito dall’inizio del progetto fino alla fine del periodo coperto dalla relazione e principali risultati finora ottenuti

We identified tissue resident macrophages as Major cells responsible for the clearance of dying cells. Moreover we defined Special transcription factors such as NR4A1 that are involved in the non-immunogenic clearance of dying cells and for the maintenance of self-tolerance.

Progressi oltre lo stato dell’arte e potenziale impatto previsto (incluso l’impatto socioeconomico e le implicazioni sociali più ampie del progetto fino ad ora)

We developed novel techniques that allow us to track the clearance of dying cells in vivo and follow the involved phagocytes during their Differentiation process. We expect to utilize These developments to study the clearance of dying cells during models of autoimmune disease as well as within the Tumor Environment.

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