Sorting of Self

Informations projet

SOS

N° de convention de subvention: 640087

DOI

10.3030/640087

Projet clôturé

Date de signature de la CE 1 Avril 2015

Date de début 1 Mai 2015

Date de fin 30 Avril 2020

Financé au titre de

• EXCELLENT SCIENCE - European Research Council (ERC)

Coût total

€ 1 479 781,00

Contribution de l’UE

€ 1 479 781,00

Coordonné par

UNIVERSITATSKLINIKUM ERLANGEN
Germany

Periodic Reporting for period 4 - SOS (Sorting of Self)

Période du rapport: 2019-11-01 au 2020-04-30

Résumé du contexte et des objectifs généraux du projet

Clearance of dying cells by phagocytes is important to remove cell-derived autoantigens during the steady state and during inflammation. A failure during this process can result in autoimmunity and autoimmune-disease. During our project we want to better understand the processes underlying this clearance process and identify involved phagocate subsets as well as responsible molecular mechanisms. Insights into these issues will help to better understand the pathogenesis of autoimmune diseases and to identify novel therapeutic targets.

Travail effectué depuis le début du projet jusqu’à la fin de la période considérée dans le rapport et principaux résultats atteints jusqu’à présent

We identified tissue resident macrophages as Major cells responsible for the clearance of dying cells. Moreover we defined Special transcription factors such as NR4A1 that are involved in the non-immunogenic clearance of dying cells and for the maintenance of self-tolerance.

Progrès au-delà de l’état des connaissances et impact potentiel prévu (y compris l’impact socio-économique et les conséquences sociétales plus larges du projet jusqu’à présent)

We developed novel techniques that allow us to track the clearance of dying cells in vivo and follow the involved phagocytes during their Differentiation process. We expect to utilize These developments to study the clearance of dying cells during models of autoimmune disease as well as within the Tumor Environment.

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