Sorting of Self

Informacje na temat projektu

SOS

Identyfikator umowy o grant: 640087

DOI

10.3030/640087

Projekt został zamknięty

Data podpisania przez KE 1 Kwietnia 2015

Data rozpoczęcia 1 Maja 2015

Data zakończenia 30 Kwietnia 2020

Finansowanie w ramach

• EXCELLENT SCIENCE - European Research Council (ERC)

Koszt całkowity

€ 1 479 781,00

Wkład UE

€ 1 479 781,00

Koordynowany przez

UNIVERSITATSKLINIKUM ERLANGEN
Germany

Periodic Reporting for period 4 - SOS (Sorting of Self)

Okres sprawozdawczy: 2019-11-01 do 2020-04-30

Podsumowanie kontekstu i ogólnych celów projektu

Clearance of dying cells by phagocytes is important to remove cell-derived autoantigens during the steady state and during inflammation. A failure during this process can result in autoimmunity and autoimmune-disease. During our project we want to better understand the processes underlying this clearance process and identify involved phagocate subsets as well as responsible molecular mechanisms. Insights into these issues will help to better understand the pathogenesis of autoimmune diseases and to identify novel therapeutic targets.

Prace wykonane od początku projektu do końca okresu sprawozdawczego oraz najważniejsze dotychczasowe rezultaty

We identified tissue resident macrophages as Major cells responsible for the clearance of dying cells. Moreover we defined Special transcription factors such as NR4A1 that are involved in the non-immunogenic clearance of dying cells and for the maintenance of self-tolerance.

Innowacyjność oraz oczekiwany potencjalny wpływ (w tym dotychczasowe znaczenie społeczno-gospodarcze i szersze implikacje społeczne projektu)

We developed novel techniques that allow us to track the clearance of dying cells in vivo and follow the involved phagocytes during their Differentiation process. We expect to utilize These developments to study the clearance of dying cells during models of autoimmune disease as well as within the Tumor Environment.

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