Development of Selective Carbohydrate Immunomodulators Targeting C-type Lectin Receptors on Antigen Presenting Cells

Resultado final

Library of β-glucans, α-mannans rhamnans, fucoidans polyN-acetylglucosamines (PNAG) and lipomannans synthesized by automated solid-phase synthesis

Murine and human CLRs

Recombinant expression of murine and human CLRs, expression cloning of new CLRs

Glycodendrimers

(Fluorescent) glycan functionalized dendritic scaffolds prepared

Neoglycoproteins

BSA and OVA-glycoconjugates prepared, GFP-neoglycoproteins expressed

Cell surface binding

Classification of cell surface lectins by their in vitro binding capacity

Glycan binding of CLRs

Determine the glycan binding specificities of recombinant CLRs expressed in WP1

Website online

Design and develop network website, regular updates on network progress and events

Publicaciones

Facile access to pseudo-thio - 1,2 - dimannoside, a new glycomimetic DC-SIGN antagonist

Autores: Alice Tamburrini, Silvia Achilli, Francesca Vasile, Sara Sattin, Corinne Vivès, Cinzia Colombo, Franck Fieschi, Anna Bernardi
Publicado en: Bioorganic & Medicinal Chemistry, Edición 25/19, 2017, Página(s) 5142-5147, ISSN 0968-0896
Editor: Pergamon Press Ltd.
DOI: 10.1016/j.bmc.2017.03.046

Specific anti-glycan antibodies are sustained during and after parasite clearance in Schistosoma japonicum-infected rhesus macaques

Autores: Y. Y. Michelle Yang, Xiao Hong Li, Katarzyna Brzezicka, Niels-Christian Reichardt, R. Alan Wilson, Angela van Diepen, Cornelis H. Hokke
Publicado en: PLOS Neglected Tropical Diseases, Edición 11/2, 2017, Página(s) e0005339, ISSN 1935-2735
Editor: Public Library of Science
DOI: 10.1371/journal.pntd.0005339

C-Type Lectin Receptor (CLR)–Fc Fusion Proteins As Tools to Screen for Novel CLR/Bacteria Interactions: An Exemplary Study on Preselected Campylobacter jejuni Isolates

Autores: Sabine Mayer, Rebecca Moeller, João T. Monteiro, Kerstin Ellrott, Christine Josenhans, Bernd Lepenies
Publicado en: Frontiers in Immunology, Edición 9, 2018, ISSN 1664-3224
Editor: Frontiers
DOI: 10.3389/fimmu.2018.00213

Rapid and efficient synthesis of α(1–2)mannobiosides

Autores: José J. Reina, Antonio Di Maio, Javier Ramos-Soriano, Rute C. Figueiredo, Javier Rojo
Publicado en: Org. Biomol. Chem., Edición 14/10, 2016, Página(s) 2873-2882, ISSN 1477-0520
Editor: Royal Society of Chemistry
DOI: 10.1039/C6OB00083E

Chemoenzymatic Synthesis of N-glycan Positional Isomers and Evidence for Branch Selective Binding by Monoclonal Antibodies and Human C-type Lectin Receptors

Autores: Begoña Echeverria, Sonia Serna, Silvia Achilli, Corinne Vivès, Julie Pham, Michel Thépaut, Cornelis H. Hokke, Franck Fieschi, Niels-Christian Reichardt
Publicado en: ACS Chemical Biology, 2018, ISSN 1554-8929
Editor: American Chemical Society
DOI: 10.1021/acschembio.8b00431

ABO Antigens Active Tri- and Disaccharides Microarray to Evaluate C-type Lectin Receptor Binding Preferences

Autores: Chethan D. Shanthamurthy, Prashant Jain, Sharon Yehuda, João T. Monteiro, Shani Leviatan Ben-Arye, Balamurugan Subramani, Bernd Lepenies, Vered Padler-Karavani, Raghavendra Kikkeri
Publicado en: Scientific Reports, Edición 8/1, 2018, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-018-24333-y

Fucosylated Antigens in Cancer: An Alliance toward Tumor Progression, Metastasis, and Resistance to Chemotherapy

Autores: Athanasios Blanas, Neha M. Sahasrabudhe, Ernesto Rodríguez, Yvette van Kooyk, Sandra J. van Vliet
Publicado en: Frontiers in Oncology, Edición 8, 2018, ISSN 2234-943X
Editor: Frontiers Media S. A.
DOI: 10.3389/fonc.2018.00039

Automated glycan assembly as an enabling technology

Autores: Alonso Pardo-Vargas, Martina Delbianco, Peter H Seeberger
Publicado en: Current Opinion in Chemical Biology, Edición 46, 2018, Página(s) 48-55, ISSN 1367-5931
Editor: Elsevier BV
DOI: 10.1016/j.cbpa.2018.04.007

On-Chip Screening of a Glycomimetic Library with C-Type Lectins Reveals Structural Features Responsible for Preferential Binding of Dectin-2 over DC-SIGN/R and Langerin

Autores: Laura Medve, Silvia Achilli, Sonia Serna, Fabio Zuccotto, Norbert Varga, Michel Thépaut, Monica Civera, Corinne Vivès, Franck Fieschi, Niels Reichardt, Anna Bernardi
Publicado en: Chemistry - A European Journal, Edición 24/54, 2018, Página(s) 14448-14460, ISSN 0947-6539
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/chem.201802577

C-type lectin receptor DCIR modulates immunity to tuberculosis by sustaining type I interferon signaling in dendritic cells

Autores: Anthony Troegeler, Ingrid Mercier, Céline Cougoule, Danilo Pietretti, André Colom, Carine Duval, Thien-Phong Vu Manh, Florence Capilla, Renaud Poincloux, Karine Pingris, Jérôme Nigou, Jörg Rademann, Marc Dalod, Frank A. W. Verreck, Talal Al Saati, Geanncarlo Lugo-Villarino, Bernd Lepenies, Denis Hudrisier, Olivier Neyrolles
Publicado en: Proceedings of the National Academy of Sciences, Edición 114/4, 2017, Página(s) E540-E549, ISSN 0027-8424
Editor: National Academy of Sciences
DOI: 10.1073/pnas.1613254114

CD169+ Macrophages Capture and Dendritic Cells Instruct: The Interplay of the Gatekeeper and the General of the Immune System

Autores: Joanna Grabowska, Miguel A. Lopez-Venegas, Alsya J. Affandi, Joke M. M. den Haan
Publicado en: Frontiers in Immunology, Edición 9, 2018, ISSN 1664-3224
Editor: Frontiers
DOI: 10.3389/fimmu.2018.02472

Modulation of Immune Tolerance via Siglec-Sialic Acid Interactions

Autores: Joyce Lübbers, Ernesto Rodríguez, Yvette van Kooyk
Publicado en: Frontiers in Immunology, Edición 9, 2018, ISSN 1664-3224
Editor: FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2018.02807

Glycopeptides as Targets for Dendritic Cells: Exploring MUC1 Glycopeptides Binding Profile toward Macrophage Galactose-Type Lectin (MGL) Orthologs

Autores: Gerard Artigas, João T. Monteiro, Hiroshi Hinou, Shin-Ichiro Nishimura, Bernd Lepenies, Fayna Garcia-Martin
Publicado en: Journal of Medicinal Chemistry, Edición 60/21, 2017, Página(s) 9012-9021, ISSN 0022-2623
Editor: American Chemical Society
DOI: 10.1021/acs.jmedchem.7b01242

Pseudo-Mannosylated DC-SIGN Ligands as Immunomodulants

Autores: Angela Berzi, Stefania Ordanini, Ben Joosten, Daria Trabattoni, Alessandra Cambi, Anna Bernardi, Mario Clerici
Publicado en: Scientific Reports, Edición 6, 2016, Página(s) 35373, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/srep35373

Opportunities for glyconanomaterials in personalized medicine

Autores: Niels-Christian Reichardt, Manuel Martín-Lomas, Soledad Penadés
Publicado en: Chem. Commun., Edición 52/92, 2016, Página(s) 13430-13439, ISSN 1359-7345
Editor: Royal Society of Chemistry
DOI: 10.1039/C6CC04445J

Microbe-focused glycan array screening platform

Autores: Andreas Geissner, Anika Reinhardt, Christoph Rademacher, Timo Johannssen, João Monteiro, Bernd Lepenies, Michel Thépaut, Franck Fieschi, Jana Mrázková, Michaela Wimmerova, Frank Schuhmacher, Sebastian Götze, Dan Grünstein, Xiaoqiang Guo, Heung Sik Hahm, Jeyakumar Kandasamy, Daniele Leonori, Christopher E. Martin, Sharavathi G. Parameswarappa, Sandip Pasari, Mark K. Schlegel, Hidenori Tanaka,
Publicado en: Proceedings of the National Academy of Sciences, Edición 116/6, 2019, Página(s) 1958-1967, ISSN 0027-8424
Editor: National Academy of Sciences
DOI: 10.1073/pnas.1800853116

Influence of Core β-1,2-Xylosylation on Glycoprotein Recognition by Murine C-type Lectin Receptors and Its Impact on Dendritic Cell Targeting

Autores: Katarzyna Brzezicka, Uwe Vogel, Sonia Serna, Timo Johannssen, Bernd Lepenies, Niels-Christian Reichardt
Publicado en: ACS Chemical Biology, Edición 11/8, 2016, Página(s) 2347-2356, ISSN 1554-8929
Editor: American Chemical Society
DOI: 10.1021/acschembio.6b00265

Myeloid C-Type Lectin Receptors in Viral Recognition and Antiviral Immunity

Autores: João Monteiro, Bernd Lepenies
Publicado en: Viruses, Edición 9/3, 2017, Página(s) 59, ISSN 1999-4915
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v9030059

Fluoroacetamide Moieties as NMR Spectroscopy Probes for the Molecular Recognition of GlcNAc-Containing Sugars: Modulation of the CH-π Stacking Interactions by Different Fluorination Patterns

Autores: Luca Unione, Maria Alcalá, Begoña Echeverria, Sonia Serna, Ana Ardá, Antonio Franconetti, F. Javier Cañada, Tammo Diercks, Niels Reichardt, Jesús Jiménez-Barbero
Publicado en: Chemistry - A European Journal, Edición 23/16, 2017, Página(s) 3957-3965, ISSN 0947-6539
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/chem.201605573

NMR and Molecular Recognition of N-Glycans: Remote Modifications of the Saccharide Chain Modulate Binding Features

Autores: Ana Gimeno, Niels-Christian Reichardt, F. Javier Cañada, Lukas Perkams, Carlo Unverzagt, Jesús Jiménez-Barbero, Ana Ardá
Publicado en: ACS Chemical Biology, Edición 12/4, 2017, Página(s) 1104-1112, ISSN 1554-8929
Editor: American Chemical Society
DOI: 10.1021/acschembio.6b01116

Multivalent Lectin-Glycan Interactions in the Immune System

Autores: Joao T. Monteiro and Bernd Lepenies
Publicado en: Multivalency: Concepts, Research and Applications, 2017, Página(s) 325-344
Editor: Wiley

Resultado final

Publicaciones

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