Development of Selective Carbohydrate Immunomodulators Targeting C-type Lectin Receptors on Antigen Presenting Cells

Livrables

Library of β-glucans, α-mannans rhamnans, fucoidans polyN-acetylglucosamines (PNAG) and lipomannans synthesized by automated solid-phase synthesis

Murine and human CLRs

Recombinant expression of murine and human CLRs, expression cloning of new CLRs

Glycodendrimers

(Fluorescent) glycan functionalized dendritic scaffolds prepared

Neoglycoproteins

BSA and OVA-glycoconjugates prepared, GFP-neoglycoproteins expressed

Cell surface binding

Classification of cell surface lectins by their in vitro binding capacity

Glycan binding of CLRs

Determine the glycan binding specificities of recombinant CLRs expressed in WP1

Website online

Design and develop network website, regular updates on network progress and events

Publications

Facile access to pseudo-thio - 1,2 - dimannoside, a new glycomimetic DC-SIGN antagonist

Auteurs: Alice Tamburrini, Silvia Achilli, Francesca Vasile, Sara Sattin, Corinne Vivès, Cinzia Colombo, Franck Fieschi, Anna Bernardi
Publié dans: Bioorganic & Medicinal Chemistry, Numéro 25/19, 2017, Page(s) 5142-5147, ISSN 0968-0896
Éditeur: Pergamon Press Ltd.
DOI: 10.1016/j.bmc.2017.03.046

Specific anti-glycan antibodies are sustained during and after parasite clearance in Schistosoma japonicum-infected rhesus macaques

Auteurs: Y. Y. Michelle Yang, Xiao Hong Li, Katarzyna Brzezicka, Niels-Christian Reichardt, R. Alan Wilson, Angela van Diepen, Cornelis H. Hokke
Publié dans: PLOS Neglected Tropical Diseases, Numéro 11/2, 2017, Page(s) e0005339, ISSN 1935-2735
Éditeur: Public Library of Science
DOI: 10.1371/journal.pntd.0005339

C-Type Lectin Receptor (CLR)–Fc Fusion Proteins As Tools to Screen for Novel CLR/Bacteria Interactions: An Exemplary Study on Preselected Campylobacter jejuni Isolates

Auteurs: Sabine Mayer, Rebecca Moeller, João T. Monteiro, Kerstin Ellrott, Christine Josenhans, Bernd Lepenies
Publié dans: Frontiers in Immunology, Numéro 9, 2018, ISSN 1664-3224
Éditeur: Frontiers
DOI: 10.3389/fimmu.2018.00213

Rapid and efficient synthesis of α(1–2)mannobiosides

Auteurs: José J. Reina, Antonio Di Maio, Javier Ramos-Soriano, Rute C. Figueiredo, Javier Rojo
Publié dans: Org. Biomol. Chem., Numéro 14/10, 2016, Page(s) 2873-2882, ISSN 1477-0520
Éditeur: Royal Society of Chemistry
DOI: 10.1039/C6OB00083E

Chemoenzymatic Synthesis of N-glycan Positional Isomers and Evidence for Branch Selective Binding by Monoclonal Antibodies and Human C-type Lectin Receptors

Auteurs: Begoña Echeverria, Sonia Serna, Silvia Achilli, Corinne Vivès, Julie Pham, Michel Thépaut, Cornelis H. Hokke, Franck Fieschi, Niels-Christian Reichardt
Publié dans: ACS Chemical Biology, 2018, ISSN 1554-8929
Éditeur: American Chemical Society
DOI: 10.1021/acschembio.8b00431

ABO Antigens Active Tri- and Disaccharides Microarray to Evaluate C-type Lectin Receptor Binding Preferences

Auteurs: Chethan D. Shanthamurthy, Prashant Jain, Sharon Yehuda, João T. Monteiro, Shani Leviatan Ben-Arye, Balamurugan Subramani, Bernd Lepenies, Vered Padler-Karavani, Raghavendra Kikkeri
Publié dans: Scientific Reports, Numéro 8/1, 2018, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/s41598-018-24333-y

Fucosylated Antigens in Cancer: An Alliance toward Tumor Progression, Metastasis, and Resistance to Chemotherapy

Auteurs: Athanasios Blanas, Neha M. Sahasrabudhe, Ernesto Rodríguez, Yvette van Kooyk, Sandra J. van Vliet
Publié dans: Frontiers in Oncology, Numéro 8, 2018, ISSN 2234-943X
Éditeur: Frontiers Media S. A.
DOI: 10.3389/fonc.2018.00039

Automated glycan assembly as an enabling technology

Auteurs: Alonso Pardo-Vargas, Martina Delbianco, Peter H Seeberger
Publié dans: Current Opinion in Chemical Biology, Numéro 46, 2018, Page(s) 48-55, ISSN 1367-5931
Éditeur: Elsevier BV
DOI: 10.1016/j.cbpa.2018.04.007

On-Chip Screening of a Glycomimetic Library with C-Type Lectins Reveals Structural Features Responsible for Preferential Binding of Dectin-2 over DC-SIGN/R and Langerin

Auteurs: Laura Medve, Silvia Achilli, Sonia Serna, Fabio Zuccotto, Norbert Varga, Michel Thépaut, Monica Civera, Corinne Vivès, Franck Fieschi, Niels Reichardt, Anna Bernardi
Publié dans: Chemistry - A European Journal, Numéro 24/54, 2018, Page(s) 14448-14460, ISSN 0947-6539
Éditeur: John Wiley & Sons Ltd.
DOI: 10.1002/chem.201802577

C-type lectin receptor DCIR modulates immunity to tuberculosis by sustaining type I interferon signaling in dendritic cells

Auteurs: Anthony Troegeler, Ingrid Mercier, Céline Cougoule, Danilo Pietretti, André Colom, Carine Duval, Thien-Phong Vu Manh, Florence Capilla, Renaud Poincloux, Karine Pingris, Jérôme Nigou, Jörg Rademann, Marc Dalod, Frank A. W. Verreck, Talal Al Saati, Geanncarlo Lugo-Villarino, Bernd Lepenies, Denis Hudrisier, Olivier Neyrolles
Publié dans: Proceedings of the National Academy of Sciences, Numéro 114/4, 2017, Page(s) E540-E549, ISSN 0027-8424
Éditeur: National Academy of Sciences
DOI: 10.1073/pnas.1613254114

CD169+ Macrophages Capture and Dendritic Cells Instruct: The Interplay of the Gatekeeper and the General of the Immune System

Auteurs: Joanna Grabowska, Miguel A. Lopez-Venegas, Alsya J. Affandi, Joke M. M. den Haan
Publié dans: Frontiers in Immunology, Numéro 9, 2018, ISSN 1664-3224
Éditeur: Frontiers
DOI: 10.3389/fimmu.2018.02472

Modulation of Immune Tolerance via Siglec-Sialic Acid Interactions

Auteurs: Joyce Lübbers, Ernesto Rodríguez, Yvette van Kooyk
Publié dans: Frontiers in Immunology, Numéro 9, 2018, ISSN 1664-3224
Éditeur: FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2018.02807

Glycopeptides as Targets for Dendritic Cells: Exploring MUC1 Glycopeptides Binding Profile toward Macrophage Galactose-Type Lectin (MGL) Orthologs

Auteurs: Gerard Artigas, João T. Monteiro, Hiroshi Hinou, Shin-Ichiro Nishimura, Bernd Lepenies, Fayna Garcia-Martin
Publié dans: Journal of Medicinal Chemistry, Numéro 60/21, 2017, Page(s) 9012-9021, ISSN 0022-2623
Éditeur: American Chemical Society
DOI: 10.1021/acs.jmedchem.7b01242

Pseudo-Mannosylated DC-SIGN Ligands as Immunomodulants

Auteurs: Angela Berzi, Stefania Ordanini, Ben Joosten, Daria Trabattoni, Alessandra Cambi, Anna Bernardi, Mario Clerici
Publié dans: Scientific Reports, Numéro 6, 2016, Page(s) 35373, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/srep35373

Opportunities for glyconanomaterials in personalized medicine

Auteurs: Niels-Christian Reichardt, Manuel Martín-Lomas, Soledad Penadés
Publié dans: Chem. Commun., Numéro 52/92, 2016, Page(s) 13430-13439, ISSN 1359-7345
Éditeur: Royal Society of Chemistry
DOI: 10.1039/C6CC04445J

Microbe-focused glycan array screening platform

Auteurs: Andreas Geissner, Anika Reinhardt, Christoph Rademacher, Timo Johannssen, João Monteiro, Bernd Lepenies, Michel Thépaut, Franck Fieschi, Jana Mrázková, Michaela Wimmerova, Frank Schuhmacher, Sebastian Götze, Dan Grünstein, Xiaoqiang Guo, Heung Sik Hahm, Jeyakumar Kandasamy, Daniele Leonori, Christopher E. Martin, Sharavathi G. Parameswarappa, Sandip Pasari, Mark K. Schlegel, Hidenori Tanaka,
Publié dans: Proceedings of the National Academy of Sciences, Numéro 116/6, 2019, Page(s) 1958-1967, ISSN 0027-8424
Éditeur: National Academy of Sciences
DOI: 10.1073/pnas.1800853116

Influence of Core β-1,2-Xylosylation on Glycoprotein Recognition by Murine C-type Lectin Receptors and Its Impact on Dendritic Cell Targeting

Auteurs: Katarzyna Brzezicka, Uwe Vogel, Sonia Serna, Timo Johannssen, Bernd Lepenies, Niels-Christian Reichardt
Publié dans: ACS Chemical Biology, Numéro 11/8, 2016, Page(s) 2347-2356, ISSN 1554-8929
Éditeur: American Chemical Society
DOI: 10.1021/acschembio.6b00265

Myeloid C-Type Lectin Receptors in Viral Recognition and Antiviral Immunity

Auteurs: João Monteiro, Bernd Lepenies
Publié dans: Viruses, Numéro 9/3, 2017, Page(s) 59, ISSN 1999-4915
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v9030059

Fluoroacetamide Moieties as NMR Spectroscopy Probes for the Molecular Recognition of GlcNAc-Containing Sugars: Modulation of the CH-π Stacking Interactions by Different Fluorination Patterns

Auteurs: Luca Unione, Maria Alcalá, Begoña Echeverria, Sonia Serna, Ana Ardá, Antonio Franconetti, F. Javier Cañada, Tammo Diercks, Niels Reichardt, Jesús Jiménez-Barbero
Publié dans: Chemistry - A European Journal, Numéro 23/16, 2017, Page(s) 3957-3965, ISSN 0947-6539
Éditeur: John Wiley & Sons Ltd.
DOI: 10.1002/chem.201605573

NMR and Molecular Recognition of N-Glycans: Remote Modifications of the Saccharide Chain Modulate Binding Features

Auteurs: Ana Gimeno, Niels-Christian Reichardt, F. Javier Cañada, Lukas Perkams, Carlo Unverzagt, Jesús Jiménez-Barbero, Ana Ardá
Publié dans: ACS Chemical Biology, Numéro 12/4, 2017, Page(s) 1104-1112, ISSN 1554-8929
Éditeur: American Chemical Society
DOI: 10.1021/acschembio.6b01116

Multivalent Lectin-Glycan Interactions in the Immune System

Auteurs: Joao T. Monteiro and Bernd Lepenies
Publié dans: Multivalency: Concepts, Research and Applications, 2017, Page(s) 325-344
Éditeur: Wiley

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