Development of Selective Carbohydrate Immunomodulators Targeting C-type Lectin Receptors on Antigen Presenting Cells

Rezultaty

Library of β-glucans, α-mannans rhamnans, fucoidans polyN-acetylglucosamines (PNAG) and lipomannans synthesized by automated solid-phase synthesis

Murine and human CLRs

Recombinant expression of murine and human CLRs, expression cloning of new CLRs

Glycodendrimers

(Fluorescent) glycan functionalized dendritic scaffolds prepared

Neoglycoproteins

BSA and OVA-glycoconjugates prepared, GFP-neoglycoproteins expressed

Cell surface binding

Classification of cell surface lectins by their in vitro binding capacity

Glycan binding of CLRs

Determine the glycan binding specificities of recombinant CLRs expressed in WP1

Website online

Design and develop network website, regular updates on network progress and events

Publikacje

Facile access to pseudo-thio - 1,2 - dimannoside, a new glycomimetic DC-SIGN antagonist

Autorzy: Alice Tamburrini, Silvia Achilli, Francesca Vasile, Sara Sattin, Corinne Vivès, Cinzia Colombo, Franck Fieschi, Anna Bernardi
Opublikowane w: Bioorganic & Medicinal Chemistry, Numer 25/19, 2017, Strona(/y) 5142-5147, ISSN 0968-0896
Wydawca: Pergamon Press Ltd.
DOI: 10.1016/j.bmc.2017.03.046

Specific anti-glycan antibodies are sustained during and after parasite clearance in Schistosoma japonicum-infected rhesus macaques

Autorzy: Y. Y. Michelle Yang, Xiao Hong Li, Katarzyna Brzezicka, Niels-Christian Reichardt, R. Alan Wilson, Angela van Diepen, Cornelis H. Hokke
Opublikowane w: PLOS Neglected Tropical Diseases, Numer 11/2, 2017, Strona(/y) e0005339, ISSN 1935-2735
Wydawca: Public Library of Science
DOI: 10.1371/journal.pntd.0005339

C-Type Lectin Receptor (CLR)–Fc Fusion Proteins As Tools to Screen for Novel CLR/Bacteria Interactions: An Exemplary Study on Preselected Campylobacter jejuni Isolates

Autorzy: Sabine Mayer, Rebecca Moeller, João T. Monteiro, Kerstin Ellrott, Christine Josenhans, Bernd Lepenies
Opublikowane w: Frontiers in Immunology, Numer 9, 2018, ISSN 1664-3224
Wydawca: Frontiers
DOI: 10.3389/fimmu.2018.00213

Rapid and efficient synthesis of α(1–2)mannobiosides

Autorzy: José J. Reina, Antonio Di Maio, Javier Ramos-Soriano, Rute C. Figueiredo, Javier Rojo
Opublikowane w: Org. Biomol. Chem., Numer 14/10, 2016, Strona(/y) 2873-2882, ISSN 1477-0520
Wydawca: Royal Society of Chemistry
DOI: 10.1039/C6OB00083E

Chemoenzymatic Synthesis of N-glycan Positional Isomers and Evidence for Branch Selective Binding by Monoclonal Antibodies and Human C-type Lectin Receptors

Autorzy: Begoña Echeverria, Sonia Serna, Silvia Achilli, Corinne Vivès, Julie Pham, Michel Thépaut, Cornelis H. Hokke, Franck Fieschi, Niels-Christian Reichardt
Opublikowane w: ACS Chemical Biology, 2018, ISSN 1554-8929
Wydawca: American Chemical Society
DOI: 10.1021/acschembio.8b00431

ABO Antigens Active Tri- and Disaccharides Microarray to Evaluate C-type Lectin Receptor Binding Preferences

Autorzy: Chethan D. Shanthamurthy, Prashant Jain, Sharon Yehuda, João T. Monteiro, Shani Leviatan Ben-Arye, Balamurugan Subramani, Bernd Lepenies, Vered Padler-Karavani, Raghavendra Kikkeri
Opublikowane w: Scientific Reports, Numer 8/1, 2018, ISSN 2045-2322
Wydawca: Nature Publishing Group
DOI: 10.1038/s41598-018-24333-y

Fucosylated Antigens in Cancer: An Alliance toward Tumor Progression, Metastasis, and Resistance to Chemotherapy

Autorzy: Athanasios Blanas, Neha M. Sahasrabudhe, Ernesto Rodríguez, Yvette van Kooyk, Sandra J. van Vliet
Opublikowane w: Frontiers in Oncology, Numer 8, 2018, ISSN 2234-943X
Wydawca: Frontiers Media S. A.
DOI: 10.3389/fonc.2018.00039

Automated glycan assembly as an enabling technology

Autorzy: Alonso Pardo-Vargas, Martina Delbianco, Peter H Seeberger
Opublikowane w: Current Opinion in Chemical Biology, Numer 46, 2018, Strona(/y) 48-55, ISSN 1367-5931
Wydawca: Elsevier BV
DOI: 10.1016/j.cbpa.2018.04.007

On-Chip Screening of a Glycomimetic Library with C-Type Lectins Reveals Structural Features Responsible for Preferential Binding of Dectin-2 over DC-SIGN/R and Langerin

Autorzy: Laura Medve, Silvia Achilli, Sonia Serna, Fabio Zuccotto, Norbert Varga, Michel Thépaut, Monica Civera, Corinne Vivès, Franck Fieschi, Niels Reichardt, Anna Bernardi
Opublikowane w: Chemistry - A European Journal, Numer 24/54, 2018, Strona(/y) 14448-14460, ISSN 0947-6539
Wydawca: John Wiley & Sons Ltd.
DOI: 10.1002/chem.201802577

C-type lectin receptor DCIR modulates immunity to tuberculosis by sustaining type I interferon signaling in dendritic cells

Autorzy: Anthony Troegeler, Ingrid Mercier, Céline Cougoule, Danilo Pietretti, André Colom, Carine Duval, Thien-Phong Vu Manh, Florence Capilla, Renaud Poincloux, Karine Pingris, Jérôme Nigou, Jörg Rademann, Marc Dalod, Frank A. W. Verreck, Talal Al Saati, Geanncarlo Lugo-Villarino, Bernd Lepenies, Denis Hudrisier, Olivier Neyrolles
Opublikowane w: Proceedings of the National Academy of Sciences, Numer 114/4, 2017, Strona(/y) E540-E549, ISSN 0027-8424
Wydawca: National Academy of Sciences
DOI: 10.1073/pnas.1613254114

CD169+ Macrophages Capture and Dendritic Cells Instruct: The Interplay of the Gatekeeper and the General of the Immune System

Autorzy: Joanna Grabowska, Miguel A. Lopez-Venegas, Alsya J. Affandi, Joke M. M. den Haan
Opublikowane w: Frontiers in Immunology, Numer 9, 2018, ISSN 1664-3224
Wydawca: Frontiers
DOI: 10.3389/fimmu.2018.02472

Modulation of Immune Tolerance via Siglec-Sialic Acid Interactions

Autorzy: Joyce Lübbers, Ernesto Rodríguez, Yvette van Kooyk
Opublikowane w: Frontiers in Immunology, Numer 9, 2018, ISSN 1664-3224
Wydawca: FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2018.02807

Glycopeptides as Targets for Dendritic Cells: Exploring MUC1 Glycopeptides Binding Profile toward Macrophage Galactose-Type Lectin (MGL) Orthologs

Autorzy: Gerard Artigas, João T. Monteiro, Hiroshi Hinou, Shin-Ichiro Nishimura, Bernd Lepenies, Fayna Garcia-Martin
Opublikowane w: Journal of Medicinal Chemistry, Numer 60/21, 2017, Strona(/y) 9012-9021, ISSN 0022-2623
Wydawca: American Chemical Society
DOI: 10.1021/acs.jmedchem.7b01242

Pseudo-Mannosylated DC-SIGN Ligands as Immunomodulants

Autorzy: Angela Berzi, Stefania Ordanini, Ben Joosten, Daria Trabattoni, Alessandra Cambi, Anna Bernardi, Mario Clerici
Opublikowane w: Scientific Reports, Numer 6, 2016, Strona(/y) 35373, ISSN 2045-2322
Wydawca: Nature Publishing Group
DOI: 10.1038/srep35373

Opportunities for glyconanomaterials in personalized medicine

Autorzy: Niels-Christian Reichardt, Manuel Martín-Lomas, Soledad Penadés
Opublikowane w: Chem. Commun., Numer 52/92, 2016, Strona(/y) 13430-13439, ISSN 1359-7345
Wydawca: Royal Society of Chemistry
DOI: 10.1039/C6CC04445J

Microbe-focused glycan array screening platform

Autorzy: Andreas Geissner, Anika Reinhardt, Christoph Rademacher, Timo Johannssen, João Monteiro, Bernd Lepenies, Michel Thépaut, Franck Fieschi, Jana Mrázková, Michaela Wimmerova, Frank Schuhmacher, Sebastian Götze, Dan Grünstein, Xiaoqiang Guo, Heung Sik Hahm, Jeyakumar Kandasamy, Daniele Leonori, Christopher E. Martin, Sharavathi G. Parameswarappa, Sandip Pasari, Mark K. Schlegel, Hidenori Tanaka,
Opublikowane w: Proceedings of the National Academy of Sciences, Numer 116/6, 2019, Strona(/y) 1958-1967, ISSN 0027-8424
Wydawca: National Academy of Sciences
DOI: 10.1073/pnas.1800853116

Influence of Core β-1,2-Xylosylation on Glycoprotein Recognition by Murine C-type Lectin Receptors and Its Impact on Dendritic Cell Targeting

Autorzy: Katarzyna Brzezicka, Uwe Vogel, Sonia Serna, Timo Johannssen, Bernd Lepenies, Niels-Christian Reichardt
Opublikowane w: ACS Chemical Biology, Numer 11/8, 2016, Strona(/y) 2347-2356, ISSN 1554-8929
Wydawca: American Chemical Society
DOI: 10.1021/acschembio.6b00265

Myeloid C-Type Lectin Receptors in Viral Recognition and Antiviral Immunity

Autorzy: João Monteiro, Bernd Lepenies
Opublikowane w: Viruses, Numer 9/3, 2017, Strona(/y) 59, ISSN 1999-4915
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v9030059

Fluoroacetamide Moieties as NMR Spectroscopy Probes for the Molecular Recognition of GlcNAc-Containing Sugars: Modulation of the CH-π Stacking Interactions by Different Fluorination Patterns

Autorzy: Luca Unione, Maria Alcalá, Begoña Echeverria, Sonia Serna, Ana Ardá, Antonio Franconetti, F. Javier Cañada, Tammo Diercks, Niels Reichardt, Jesús Jiménez-Barbero
Opublikowane w: Chemistry - A European Journal, Numer 23/16, 2017, Strona(/y) 3957-3965, ISSN 0947-6539
Wydawca: John Wiley & Sons Ltd.
DOI: 10.1002/chem.201605573

NMR and Molecular Recognition of N-Glycans: Remote Modifications of the Saccharide Chain Modulate Binding Features

Autorzy: Ana Gimeno, Niels-Christian Reichardt, F. Javier Cañada, Lukas Perkams, Carlo Unverzagt, Jesús Jiménez-Barbero, Ana Ardá
Opublikowane w: ACS Chemical Biology, Numer 12/4, 2017, Strona(/y) 1104-1112, ISSN 1554-8929
Wydawca: American Chemical Society
DOI: 10.1021/acschembio.6b01116

Multivalent Lectin-Glycan Interactions in the Immune System

Autorzy: Joao T. Monteiro and Bernd Lepenies
Opublikowane w: Multivalency: Concepts, Research and Applications, 2017, Strona(/y) 325-344
Wydawca: Wiley

Rezultaty

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