Development of Selective Carbohydrate Immunomodulators Targeting C-type Lectin Receptors on Antigen Presenting Cells

Informazioni relative al progetto

IMMUNOSHAPE

ID dell’accordo di sovvenzione: 642870

DOI

10.3030/642870

Progetto chiuso

Data della firma CE 12 Dicembre 2014

Data di avvio 1 Gennaio 2015

Data di completamento 31 Dicembre 2018

Finanziato da

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Costo totale

€ 3 811 581,00

Contributo UE

€ 3 811 581,00

Coordinato da

ASOCIACION CENTRO DE INVESTIGACION COOPERATIVA EN BIOMATERIALES- CIC biomaGUNE
Spain

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Documents, reports (6)

Glycan antigen library

Library of β-glucans, α-mannans rhamnans, fucoidans polyN-acetylglucosamines (PNAG) and lipomannans synthesized by automated solid-phase synthesis

Murine and human CLRs

Recombinant expression of murine and human CLRs, expression cloning of new CLRs

Glycodendrimers

(Fluorescent) glycan functionalized dendritic scaffolds prepared

Neoglycoproteins

BSA and OVA-glycoconjugates prepared, GFP-neoglycoproteins expressed

Cell surface binding

Classification of cell surface lectins by their in vitro binding capacity

Glycan binding of CLRs

Determine the glycan binding specificities of recombinant CLRs expressed in WP1

Websites, patent fillings, videos etc. (1)

Website online

Design and develop network website, regular updates on network progress and events

Pubblicazioni

Peer reviewed articles (20)

Facile access to pseudo-thio - 1,2 - dimannoside, a new glycomimetic DC-SIGN antagonist

Autori: Alice Tamburrini, Silvia Achilli, Francesca Vasile, Sara Sattin, Corinne Vivès, Cinzia Colombo, Franck Fieschi, Anna Bernardi
Pubblicato in: Bioorganic & Medicinal Chemistry, Numero 25/19, 2017, Pagina/e 5142-5147, ISSN 0968-0896
Editore: Pergamon Press Ltd.
DOI: 10.1016/j.bmc.2017.03.046

Specific anti-glycan antibodies are sustained during and after parasite clearance in Schistosoma japonicum-infected rhesus macaques

Autori: Y. Y. Michelle Yang, Xiao Hong Li, Katarzyna Brzezicka, Niels-Christian Reichardt, R. Alan Wilson, Angela van Diepen, Cornelis H. Hokke
Pubblicato in: PLOS Neglected Tropical Diseases, Numero 11/2, 2017, Pagina/e e0005339, ISSN 1935-2735
Editore: Public Library of Science
DOI: 10.1371/journal.pntd.0005339

C-Type Lectin Receptor (CLR)–Fc Fusion Proteins As Tools to Screen for Novel CLR/Bacteria Interactions: An Exemplary Study on Preselected Campylobacter jejuni Isolates

Autori: Sabine Mayer, Rebecca Moeller, João T. Monteiro, Kerstin Ellrott, Christine Josenhans, Bernd Lepenies
Pubblicato in: Frontiers in Immunology, Numero 9, 2018, ISSN 1664-3224
Editore: Frontiers
DOI: 10.3389/fimmu.2018.00213

Rapid and efficient synthesis of α(1–2)mannobiosides

Autori: José J. Reina, Antonio Di Maio, Javier Ramos-Soriano, Rute C. Figueiredo, Javier Rojo
Pubblicato in: Org. Biomol. Chem., Numero 14/10, 2016, Pagina/e 2873-2882, ISSN 1477-0520
Editore: Royal Society of Chemistry
DOI: 10.1039/C6OB00083E

Chemoenzymatic Synthesis of N-glycan Positional Isomers and Evidence for Branch Selective Binding by Monoclonal Antibodies and Human C-type Lectin Receptors

Autori: Begoña Echeverria, Sonia Serna, Silvia Achilli, Corinne Vivès, Julie Pham, Michel Thépaut, Cornelis H. Hokke, Franck Fieschi, Niels-Christian Reichardt
Pubblicato in: ACS Chemical Biology, 2018, ISSN 1554-8929
Editore: American Chemical Society
DOI: 10.1021/acschembio.8b00431

ABO Antigens Active Tri- and Disaccharides Microarray to Evaluate C-type Lectin Receptor Binding Preferences

Autori: Chethan D. Shanthamurthy, Prashant Jain, Sharon Yehuda, João T. Monteiro, Shani Leviatan Ben-Arye, Balamurugan Subramani, Bernd Lepenies, Vered Padler-Karavani, Raghavendra Kikkeri
Pubblicato in: Scientific Reports, Numero 8/1, 2018, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-018-24333-y

Fucosylated Antigens in Cancer: An Alliance toward Tumor Progression, Metastasis, and Resistance to Chemotherapy

Autori: Athanasios Blanas, Neha M. Sahasrabudhe, Ernesto Rodríguez, Yvette van Kooyk, Sandra J. van Vliet
Pubblicato in: Frontiers in Oncology, Numero 8, 2018, ISSN 2234-943X
Editore: Frontiers Media S. A.
DOI: 10.3389/fonc.2018.00039

Automated glycan assembly as an enabling technology

Autori: Alonso Pardo-Vargas, Martina Delbianco, Peter H Seeberger
Pubblicato in: Current Opinion in Chemical Biology, Numero 46, 2018, Pagina/e 48-55, ISSN 1367-5931
Editore: Elsevier BV
DOI: 10.1016/j.cbpa.2018.04.007

On-Chip Screening of a Glycomimetic Library with C-Type Lectins Reveals Structural Features Responsible for Preferential Binding of Dectin-2 over DC-SIGN/R and Langerin

Autori: Laura Medve, Silvia Achilli, Sonia Serna, Fabio Zuccotto, Norbert Varga, Michel Thépaut, Monica Civera, Corinne Vivès, Franck Fieschi, Niels Reichardt, Anna Bernardi
Pubblicato in: Chemistry - A European Journal, Numero 24/54, 2018, Pagina/e 14448-14460, ISSN 0947-6539
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/chem.201802577

C-type lectin receptor DCIR modulates immunity to tuberculosis by sustaining type I interferon signaling in dendritic cells

Autori: Anthony Troegeler, Ingrid Mercier, Céline Cougoule, Danilo Pietretti, André Colom, Carine Duval, Thien-Phong Vu Manh, Florence Capilla, Renaud Poincloux, Karine Pingris, Jérôme Nigou, Jörg Rademann, Marc Dalod, Frank A. W. Verreck, Talal Al Saati, Geanncarlo Lugo-Villarino, Bernd Lepenies, Denis Hudrisier, Olivier Neyrolles
Pubblicato in: Proceedings of the National Academy of Sciences, Numero 114/4, 2017, Pagina/e E540-E549, ISSN 0027-8424
Editore: National Academy of Sciences
DOI: 10.1073/pnas.1613254114

CD169+ Macrophages Capture and Dendritic Cells Instruct: The Interplay of the Gatekeeper and the General of the Immune System

Autori: Joanna Grabowska, Miguel A. Lopez-Venegas, Alsya J. Affandi, Joke M. M. den Haan
Pubblicato in: Frontiers in Immunology, Numero 9, 2018, ISSN 1664-3224
Editore: Frontiers
DOI: 10.3389/fimmu.2018.02472

Modulation of Immune Tolerance via Siglec-Sialic Acid Interactions

Autori: Joyce Lübbers, Ernesto Rodríguez, Yvette van Kooyk
Pubblicato in: Frontiers in Immunology, Numero 9, 2018, ISSN 1664-3224
Editore: FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2018.02807

Glycopeptides as Targets for Dendritic Cells: Exploring MUC1 Glycopeptides Binding Profile toward Macrophage Galactose-Type Lectin (MGL) Orthologs

Autori: Gerard Artigas, João T. Monteiro, Hiroshi Hinou, Shin-Ichiro Nishimura, Bernd Lepenies, Fayna Garcia-Martin
Pubblicato in: Journal of Medicinal Chemistry, Numero 60/21, 2017, Pagina/e 9012-9021, ISSN 0022-2623
Editore: American Chemical Society
DOI: 10.1021/acs.jmedchem.7b01242

Pseudo-Mannosylated DC-SIGN Ligands as Immunomodulants

Autori: Angela Berzi, Stefania Ordanini, Ben Joosten, Daria Trabattoni, Alessandra Cambi, Anna Bernardi, Mario Clerici
Pubblicato in: Scientific Reports, Numero 6, 2016, Pagina/e 35373, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/srep35373

Opportunities for glyconanomaterials in personalized medicine

Autori: Niels-Christian Reichardt, Manuel Martín-Lomas, Soledad Penadés
Pubblicato in: Chem. Commun., Numero 52/92, 2016, Pagina/e 13430-13439, ISSN 1359-7345
Editore: Royal Society of Chemistry
DOI: 10.1039/C6CC04445J

Microbe-focused glycan array screening platform

Autori: Andreas Geissner, Anika Reinhardt, Christoph Rademacher, Timo Johannssen, João Monteiro, Bernd Lepenies, Michel Thépaut, Franck Fieschi, Jana Mrázková, Michaela Wimmerova, Frank Schuhmacher, Sebastian Götze, Dan Grünstein, Xiaoqiang Guo, Heung Sik Hahm, Jeyakumar Kandasamy, Daniele Leonori, Christopher E. Martin, Sharavathi G. Parameswarappa, Sandip Pasari, Mark K. Schlegel, Hidenori Tanaka,
Pubblicato in: Proceedings of the National Academy of Sciences, Numero 116/6, 2019, Pagina/e 1958-1967, ISSN 0027-8424
Editore: National Academy of Sciences
DOI: 10.1073/pnas.1800853116

Influence of Core β-1,2-Xylosylation on Glycoprotein Recognition by Murine C-type Lectin Receptors and Its Impact on Dendritic Cell Targeting

Autori: Katarzyna Brzezicka, Uwe Vogel, Sonia Serna, Timo Johannssen, Bernd Lepenies, Niels-Christian Reichardt
Pubblicato in: ACS Chemical Biology, Numero 11/8, 2016, Pagina/e 2347-2356, ISSN 1554-8929
Editore: American Chemical Society
DOI: 10.1021/acschembio.6b00265

Myeloid C-Type Lectin Receptors in Viral Recognition and Antiviral Immunity

Autori: João Monteiro, Bernd Lepenies
Pubblicato in: Viruses, Numero 9/3, 2017, Pagina/e 59, ISSN 1999-4915
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v9030059

Fluoroacetamide Moieties as NMR Spectroscopy Probes for the Molecular Recognition of GlcNAc-Containing Sugars: Modulation of the CH-π Stacking Interactions by Different Fluorination Patterns

Autori: Luca Unione, Maria Alcalá, Begoña Echeverria, Sonia Serna, Ana Ardá, Antonio Franconetti, F. Javier Cañada, Tammo Diercks, Niels Reichardt, Jesús Jiménez-Barbero
Pubblicato in: Chemistry - A European Journal, Numero 23/16, 2017, Pagina/e 3957-3965, ISSN 0947-6539
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/chem.201605573

NMR and Molecular Recognition of N-Glycans: Remote Modifications of the Saccharide Chain Modulate Binding Features

Autori: Ana Gimeno, Niels-Christian Reichardt, F. Javier Cañada, Lukas Perkams, Carlo Unverzagt, Jesús Jiménez-Barbero, Ana Ardá
Pubblicato in: ACS Chemical Biology, Numero 12/4, 2017, Pagina/e 1104-1112, ISSN 1554-8929
Editore: American Chemical Society
DOI: 10.1021/acschembio.6b01116

Book chapters (1)

Multivalent Lectin-Glycan Interactions in the Immune System

Autori: Joao T. Monteiro and Bernd Lepenies
Pubblicato in: Multivalency: Concepts, Research and Applications, 2017, Pagina/e 325-344
Editore: Wiley