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CORDIS - EU research results
CORDIS

ERA-NET for establishing synergies between the Joint Programming on Neurodegenerative Diseases Research and Horizon 2020

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Organization of a symposium for the dissemination of the results of JPco-fuND-funded research (opens in new window)

Organization of a symposium for the dissemination of the results of JPcofuNDfunded research by ZonMw and ITMOH Month 30 60

Publications

Tdp-25 Routing to Autophagy and Proteasome Ameliorates its Aggregation in Amyotrophic Lateral Sclerosis Target Cells (opens in new window)

Author(s): Cicardi, Maria Elena; Cristofani, Riccardo; Rusmini, Paola; Meroni, Marco; Ferrari, Veronica; Vezzoli, Giulia; Tedesco, Barbara; Piccolella, Margherita; Messi, Elio; Galbiati, Mariarita; Boncoraglio, Alessandra; Carra, Serena; Crippa, Valeria; Poletti, Angelo
Published in: Scientific Reports, Issue 2, 2018, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-018-29658-2

Modeling Parkinson’s disease in midbrain-like organoids (opens in new window)

Author(s): Smits, L.M., Reinhardt, L., Reinhardt, P. et al.
Published in: npj Parkinsons Dis., 2019, ISSN 2373-8057
Publisher: Springer Nature
DOI: 10.1038/s41531-019-0078-4

The blood-brain barrier is disrupted in Machado-Joseph disease/spinocerebellar ataxia type 3: evidence from transgenic mice and human post-mortem samples (opens in new window)

Author(s): Duarte Lobo D, Nobre RJ, Oliveira Miranda C, Pereira D, Castelhano J, Sereno J, Koeppen A, Castelo-Branco M, Pereira de Almeida L.
Published in: Acta neuropathologica communications, 2020, ISSN 2051-5960
Publisher: BioMed Central
DOI: 10.1186/s40478-020-00955-0

Bri2 BRICHOS client specificity and chaperone activity are governed by assembly state (opens in new window)

Author(s): Chen G, Abelein A, Nilsson H, Leppert A, Andrade-Talavera Y, Tambaro S, Hemmingsson L, Roshan F, Landreh M, Biverstål H, Koeck P, Presto J, Hebert H, Fisahn A, Johansson J,
Published in: Nature communications, 2017, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-017-02056-4

Repeated Mesenchymal Stromal Cell Treatment Sustainably Alleviates Machado-Joseph Disease (opens in new window)

Author(s): Oliveira Miranda C, Marcelo A, Silva TP, Barata J, Vasconcelos-Ferreira A, Pereira D, Nóbrega C, Duarte S, Barros I, Alves J, Sereno J, Petrella LI, Castelhano J, Paiva VH, Rodrigues-Santos P, Alves V, Nunes-Correia I, Nobre RJ, Gomes C, Castelo-Branco M, Pereira de Almeida L.
Published in: Molecular Therapy, 2018, ISSN 1525-0016
Publisher: Nature Publishing Group
DOI: 10.1016/j.ymthe.2018.07.007

The ability of liposomes, tailored for blood-brain barrier targeting, to reach the brain is dramatically affected by the disease state (opens in new window)

Author(s): Magro RD, Cox A, Zambelli V, Mancini S, Masserini M, Re F.
Published in: Nanomedicine (Lond), 2018, ISSN 1743-5889
Publisher: Future Medicine Ltd.
DOI: 10.2217/nnm-2017-0317

A variant near DHCR24 associates with microstructural properties of white matter and peripheral lipid metabolism in adolescents (opens in new window)

Author(s): Sliz E., Shin J., Syme C., Patel Y., Parker N., Richer L., Gaudet D., Bennett S., Paus T., Pausova Z.
Published in: Molecular psychiatry, 2021, ISSN 1359-4184
Publisher: Nature Publishing Group
DOI: 10.1038/s41380-019-0640-9

Neuronal DNA Methyltransferases: Epigenetic Mediators between Synaptic Activity and Gene Expression? (opens in new window)

Author(s): Gonca Bayraktar, Michael R. Kreutz
Published in: The Neuroscientist, 2017, ISSN 1073-8584
Publisher: Sage Science Press
DOI: 10.1177/1073858417707457

The Role of the Heat Shock Protein B8 (HSPB8) in Motoneuron Diseases (opens in new window)

Author(s): Paola Rusmini; Riccardo Cristofani; Mariarita Galbiati; Maria E. Cicardi; Marco Meroni; Veronica Ferrari; Giulia Vezzoli; Barbara Tedesco; Elio Messi; Margherita Piccolella; Serena Carra; Valeria Crippa; Valeria Crippa; Angelo Poletti; Angelo Poletti
Published in: Frontiers in Molecular Neuroscience, Vol 10 (2017), Issue 2, 2017, ISSN 1662-5099
Publisher: Frontiers Research Foundation
DOI: 10.3389/fnmol.2017.00176

Survival Associations Using Perfusion and Diffusion Magnetic Resonance Imaging in Patients With Histologic and Genetic Defined Diffuse Glioma World Health Organization Grades II and III (opens in new window)

Author(s): Latysheva A, Emblem KE, Server A, Brandal P, Meling TR, Pahnke J, Hald JK.
Published in: Journal of computer assisted tomography, 2018, ISSN 0363-8715
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/rct.0000000000000742

High-yield Production of Amyloid-β Peptide Enabled by a Customized Spider Silk Domain. (opens in new window)

Author(s): Axel Abelein; Gefei Chen; Kristīne Kitoka; Rihards Aleksis; Filips Oleskovs; Médoune Sarr; Michael Landreh; Jens Pahnke; Kerstin Nordling; Nina Kronqvist; Kristaps Jaudzems; Anna Rising; Anna Rising; Jan Johansson; Henrik Biverstål
Published in: Scientific Reports, Issue Vol 10, Iss 1,, 2020, Page(s) Pp 1-10, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-019-57143-x

Validation of behavioral phenotypes in the BACHD rat model (opens in new window)

Author(s): Novati A, Manfré G, Flunkert S, Van der Harst JE, Homberg JR, Wronski R, Nguyen HP.
Published in: Behavioural Brain Research, 2020, ISSN 0166-4328
Publisher: Elsevier BV
DOI: 10.1016/j.bbr.2020.112783

In vivo Phenotyping of Human Parkinson’s Disease-Specific Stem Cells Carrying the LRRK2-G2019S Mutation Reveals Increased a-Synuclein Levels but Absence of Spreading (opens in new window)

Author(s): Kathrin Hemmer, Lisa M. Smits, Silvia Bolognin, Jens Schwamborn
Published in: Opera Medica et Physiologica, 2018, ISSN 2500-2295
Publisher: Opera Medica et Physiologica
DOI: 10.1101/140178

Golgi-Cox impregnation combined with fluorescence staining of amyloid plaques reveals local spine loss in an Alzheimer mouse model (opens in new window)

Author(s): Kartalou GI, Endres T, Lessmann V, Gottmann K.
Published in: Journal of Neuroscience Methods, 2020, ISSN 0165-0270
Publisher: Elsevier BV
DOI: 10.1016/j.jneumeth.2020.108797

Environment-dependent striatal gene expression in the BACHD rat model for Huntington disease (opens in new window)

Author(s): Novati, Arianna; Hentrich, Thomas; Wassouf, Zinah; Weber, Jonasz J.; Yu-Taeger, Libo; Déglon, Nicole; Nguyen, Huu Phuc; Schulze-Hentrich, Julia M.
Published in: Scientific reports,, Issue vol. 8, no. 1, 2018, Page(s) 5803, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-018-24243-z

Glymphatic distribution of CSF-derived apoE into brain is isoform specific and suppressed during sleep deprivation. (opens in new window)

Author(s): Achariyar TM, Li B, Peng W, Verghese PB, Shi Y, McConnell E, Benraiss A, Kasper T, Song W, Takano T, Holtzman DM, Nedergaard M, Deane R.
Published in: Molecular Neurodegeneration, 2017, ISSN 1750-1326
Publisher: BioMed Central
DOI: 10.1186/s13024-016-0147-7

Defective ribosomal products challenge nuclear function by impairing nuclear condensate dynamics and immobilizing ubiquitin (opens in new window)

Author(s): Mediani, Laura; Guillén‐Boixet, Jordina; Vinet, Jonathan; Franzmann, Titus M; Bigi, Ilaria; Mateju, Daniel; Carrà, Arianna D; Morelli, Federica F; Tiago, Tatiana; Poser, Ina; Alberti, Simon; Carra, Serena
Published in: The EMBO Journal, Issue 1, 2019, ISSN 0261-4189
Publisher: Nature Publishing Group
DOI: 10.15252/embj.2018101341

The Regulation of the Small Heat Shock Protein B8 in Misfolding Protein Diseases Causing Motoneuronal and Muscle Cell Death (opens in new window)

Author(s): Riccardo Cristofani; Paola Rusmini; Mariarita Galbiati; Maria Elena Cicardi; Veronica Ferrari; Barbara Tedesco; Elena Casarotto; Marta Chierichetti; Elio Messi; Margherita Piccolella; Serena Carra; Valeria Crippa; Angelo Poletti; Angelo Poletti
Published in: Frontiers in Neuroscience, Vol 13 (2019), 2019, ISSN 1662-4548
Publisher: Frontiers Research Foundation
DOI: 10.3389/fnins.2019.00796

Generation of a human induced pluripotent stem cell line (LL008 1.4) from a familial Alzheimer's disease patient carrying a double KM670/671NL (Swedish) mutation in APP gene. (opens in new window)

Author(s): Oksanen, Minna; Hyötyläinen, Ida; Voutilainen, Jenni; Puttonen, Katja A.; Hämäläinen, Riikka H.; Graff, Caroline; Lehtonen, Šárka; Koistinaho, Jari
Published in: Stem Cell Research, Vol 31, Iss , Pp 181-185 (2018), 2018, ISSN 1873-5061
Publisher: Elsevier
DOI: 10.1016/j.scr.2018.07.024

Directing neuronal cell fate in vitro: Achievements and challenges (opens in new window)

Author(s): R.J.M.Riemensabc, D.L.A.van den Hovecd, M.Estelleraef, R.Delgado-Moralesac
Published in: Progress in Neurobiology, 2018, ISSN 0301-0082
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.pneurobio.2018.04.003

Global and regional development of the human cerebral cortex: Molecular acrchitecture and occupational aptitudes. (opens in new window)

Author(s): Shin, J., Ma, S., Hofer, E., Patel, Y., Vosberg, D. E., Tilley, S., Roshchupkin, G. V., Sousa, A. M. M., Jian, X., Gottesman, R., Mosley, T. H., Fornage, M., Saba, Y., Pirpamer, L., Schmidt, R., Schmidt, H., Carrion Castillo, A., Crivello, F., Mazoyer, B., Bis, J. C., Li, S., Yang, Q., Luciano, M., Karama, S., Lewis, L., Bastin, M. E., Harris, M. A., Wardlaw, J. M., Deary, I. E., Scholz, M., Loeff
Published in: Cerebral Cortex, 2020, ISSN 1047-3211
Publisher: Oxford University Press
DOI: 10.1093/cercor/bhaa035

Long-term depression at hippocampal mossy fiber-CA3 synapses involves BDNF but is not mediated by p75NTR signaling (opens in new window)

Author(s): Garad M, Edelmann E, Lessmann V.
Published in: Scientific Reports, 2021, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-021-87769-9

Loss of zebrafish Ataxin-7, a SAGA subunit responsible for SCA7 retinopathy, causes ocular coloboma and malformation of photoreceptors (opens in new window)

Author(s): Samantha Carrillo-Rosas, Chantal Weber, Lorraine Fievet, Nadia Messaddeq, Alice Karam, Yvon Trottier;
Published in: Human molecular genetics, 2019, ISSN 0964-6906
Publisher: Oxford University Press
DOI: 10.1093/hmg/ddy401

A Molecular Grammar Governing the Driving Forces for Phase Separation of Prion-like RNA Binding Proteins (opens in new window)

Author(s): Wang, Jie; Choi, Jeong-Mo; Holehouse, Alex S.; Lee, Hyun O.; Zhang, Xiaojie; Jahnel, Marcus; Maharana, Shovamayee; Lemaitre, Régis; Pozniakovsky, Andrei; Drechsel, David; Poser, Ina; Pappu, Rohit V.; Alberti, Simon; Hyman, Anthony A.
Published in: Cells, 2018, ISSN 0092-8674
Publisher: Cell Press
DOI: 10.1016/j.cell.2018.06.006

A kinetic model for Brain-Derived Neurotrophic Factor mediated spike timing-dependent LTP (opens in new window)

Author(s): Solinas SMG, Edelmann E, Leßmann V, Migliore M.
Published in: Plos Computational Biology, 2019, ISSN 1553-734X
Publisher: Public Library of Science
DOI: 10.1371/journal.pcbi.1006975

Mitochondria in the signaling pathways that control longevity and health span. (opens in new window)

Author(s): Akbari M, Kirkwood TBL, Bohr VA.
Published in: Ageing Research Reviews, 2019, ISSN 1568-1637
Publisher: Elsevier BV
DOI: 10.1016/j.arr.2019.100940

Can markers of biological age predict dependency in old age? (opens in new window)

Author(s): Jylhävä J, Jiang M, Foebel AD, Pedersen NL, Hägg S.
Published in: Biogerontology, 2019, ISSN 1389-5729
Publisher: Kluwer Academic Publishers
DOI: 10.1007/s10522-019-09795-5

Impairment of macroautophagy in dopamine neurons has opposing effects on Parkinsonian pathology and behavior. (opens in new window)

Author(s): Hunn BHM, Vingill S, Threlfell S, Alegre-Abarrategui J, Magdelyns M, Deltheil T, Bengoa-Vergniory N, Oliver PL, Cioroch M, Doig NM, Bannerman DM, Cragg SJ and Wade-Martins R.
Published in: Cell reports, 2019, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2019.09.029

Gene Deregulation and Underlying Mechanisms in Spinocerebellar Ataxias With Polyglutamine Expansion (opens in new window)

Author(s): Niewiadomska-Cimicka A, Hache A, Trottier Y.
Published in: Frontiers in neuroscience, 2020, ISSN 1662-4548
Publisher: Frontiers Research Foundation
DOI: 10.3389/fnins.2020.00571

ST Pipeline: an automated pipeline for spatial mapping of unique transcripts. (opens in new window)

Author(s): Navarro JF, Sjöstrand J, Salmén F, Lundeberg J, Ståhl PL.
Published in: Bioinformatics, 2017, ISSN 1367-4811
Publisher: Oxford Academic
DOI: 10.1093/bioinformatics/btx211

Expression of endogenous mouse APP modulates β-amyloid deposition in hAPP-transgenic mice (opens in new window)

Author(s): Steffen, J., Krohn, M., Schwitlick, C. et al.
Published in: acta neuropathol commun, Issue 5, 2017, Page(s) 49, ISSN 2051-5960
Publisher: BioMed Central
DOI: 10.1186/s40478-017-0448-2

The Emerging Role of Mechanics in Synapse Formation and Plasticity (opens in new window)

Author(s): Kilinc D
Published in: Front. Cell. Neurosci, Issue 12, 2018, Page(s) 483, ISSN 1662-5102
Publisher: Frontiers Research Foundation
DOI: 10.3389/fncel.2018.00483

Differential Membrane Binding and Seeding of Distinct α-Synuclein Fibrillar Polymorphs (opens in new window)

Author(s): Shrivastava AN, Bousset L, Renner M, Redeker V, Savistchenko J, Triller A, Melki R
Published in: Biophysical journal, 2020, ISSN 0006-3495
Publisher: Biophysical Society
DOI: 10.1016/j.bpj.2020.01.022

Genetic and lifestyle risk factors for MRI-defined brain infarcts in a population-based setting (opens in new window)

Author(s): Ganesh Chauhan, Hieab H H Adams, Claudia L Satizabal, Joshua C Bis, Alexander Teumer, Muralidharan Sargurupremraj, Edith Hofer, Stella Trompet, Saima Hilal, Albert Vernon Smith, Xueqiu Jian, Rainer Malik, Matthew Traylor, Sara L Pulit, Philippe Amouyel, Bernard Mazoyer, Yi-Cheng Zhu, Sara Kaffashian, Sabrina Schilling, Gary W Beecham, Thomas J Montine, Gerard D Schellenberg, Olafur Kjartansson, Vi
Published in: Neurology, 2019, ISSN 0028-3878
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1212/wnl.0000000000006851

Selection of Reference Genes for Normalization of Gene Expression Data in Blood of Machado-Joseph Disease/Spinocerebellar Ataxia Type 3 (MJD/SCA3) Subjects (opens in new window)

Author(s): Ferreira, A.F., Raposo, M., Vasconcelos, J. et al.
Published in: Journal of Molecular Neuroscience, Issue 69, 2019, Page(s) 450–455, ISSN 0895-8696
Publisher: Humana Press, Inc.
DOI: 10.1007/s12031-019-01374-0

FACS-Assisted CRISPR-Cas9 Genome Editing Facilitates Parkinson's Disease Modeling (opens in new window)

Author(s): Jonathan Arias-Fuenzalida, JavierJarazo, Xiaobing Qing, Jonas Walter, Gemma Gomez-Giro, Sarah Louise Nickels, HolmZaehres45Hans Robert Schöler, Jens Christian Schwamborn
Published in: Stem Cell Reports, 2017, ISSN 2213-6711
Publisher: Cell Press
DOI: 10.1016/j.stemcr.2017.08.026

Dual Inhibition of GSK3β and CDK5 Protects the Cytoskeleton of Neurons from Neuroinflammatory-Mediated Degeneration In Vitro and In Vivo (opens in new window)

Author(s): Reinhardt L, Kordes S, Reinhardt P, Glatza M, Baumann M, Drexler HCA, Menninger S, Zischinsky G, Eickhoff J, Fröb C, Bhattarai P, Arulmozhivarman G, Marrone L, Janosch A, Adachi K, Stehling M, Anderson EN, Abo-Rady M, Bickle M, Pandey UB, Reimer MM, Kizil C, Schöler HR, Nussbaumer P, Klebl B, and Sterneckert JL.
Published in: Stem Cell Reports, 2019, ISSN 2213-6711
Publisher: Cell Press
DOI: 10.1016/j.stemcr.2019.01.015

The L444P Gba1 mutation enhances alpha-synuclein induced loss of nigral dopaminergic neurons in mice (opens in new window)

Author(s): Migdalska-Richards A, Wegrzynowicz M, Rusconi R, Deangeli G, Di Monte DA, Spillantini MG, Schapira AHV.
Published in: Brain, 2017, ISSN 0006-8950
Publisher: Oxford University Press
DOI: 10.1093/brain/awx221

Glycation in Huntington's Disease: A Possible Modifier and Target for Intervention (opens in new window)

Author(s): Brás IC, König A, Outeiro TF.
Published in: Journal of Huntington's Disease, 2019, ISSN 1879-6397
Publisher: IOS Press
DOI: 10.3233/jhd-190366

Lactate-Induced Glucose Output Is Unchanged by Metformin at a Therapeutic Concentration - A Mass Spectrometry Imaging Study of the Perfused Rat Liver. (opens in new window)

Author(s): Giulio Calza; Elisabeth Nyberg; Elisabeth Nyberg; Matias Mäkinen; Rabah Soliymani; Annunziata Cascone; Dan Lindholm; Dan Lindholm; Emanuele Barborini; Marc Baumann; Maciej Lalowski; Ove Eriksson
Published in: Frontiers in Pharmacology, Vol 9 (2018), 2018, ISSN 1663-9812
Publisher: Frontiers Media S.A.
DOI: 10.3389/fphar.2018.00141

Using a qPCR device to screen for modulators of ABC transporter activity: A step-by-step protocol (opens in new window)

Author(s): Luisa Möhle; Luisa Möhle; Barbora Schwarzová; Markus Krohn; Sven Marcel Stefan; Jens Pahnke
Published in: Journal of Pharmacological and Toxicological Methods, Issue 1, 2020, ISSN 1056-8719
Publisher: Elsevier BV
DOI: 10.1016/j.vascn.2020.106882

A comparative study on pathological features of transgenic rat lines expressing either three or four repeat misfolded tau (opens in new window)

Author(s): Valachova B, Brezovakova V, Bugos O, Jadhav S, Smolek T, Novak P, Zilka N.
Published in: Journal of Comparative Neurology, 2018, ISSN 0021-9967
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/cne.24447

Key Aging-Associated Alterations in Primary Microglia Response to Beta-Amyloid Stimulation (opens in new window)

Author(s): Caldeira C, Cunha C, Vaz AR, Falcão AS, Barateiro A, Seixas E, Fernandes A, Brites D.
Published in: Frontiers in ageing neuroscience, 2017, ISSN 1663-4365
Publisher: Frontiers Research Foundation
DOI: 10.3389/fnagi.2017.00277

Evaluation of Lymphocyte Response to the Induced Oxidative Stress in a Cohort of Ageing Subjects, including Semisupercentenarians and Their Offspring (opens in new window)

Author(s): Sizzano, F., Collino, S., Cominetti, O., Monti, D., Garagnani, P., Ostan, R., Pirazzini, C., Bacalini, M.G., Mari, D., Passarino, G.,…Franceschi C., et al.
Published in: Mediators of Inflammation, 2018, ISSN 0962-9351
Publisher: Hindawi Publishing Corporation
DOI: 10.1155/2018/7109312

Ibuprofen enhances synaptic function and neural progenitors proliferation markers and improves neuropathology and motor coordination in Machado-Joseph disease models (opens in new window)

Author(s): Mendonça LS, Nóbrega C, Tavino S, Brinkhaus M, Matos C, Tomé S, Moreira R, Henriques D, Kaspar BK, Pereira de Almeida L.
Published in: Human Molecular Genetics, 2019, ISSN 0964-6906
Publisher: Oxford University Press
DOI: 10.1093/hmg/ddz097

Revisiting rodent models: Octodon degus as Alzheimer's disease model? (opens in new window)

Author(s): Steffen J, Krohn M, Paarmann K, Schwitlick C, Bruning T, Marreiros R, Muller- Schiffmann A, Korth C, Braun K, Pahnke J
Published in: Acta neuropathologica communications, 2016, ISSN 2051-5960
Publisher: BioMed Central
DOI: 10.1186/s40478-016-0363-y

Inhibition of copper transporter 1 prevents α-synuclein pathology and alleviates nigrostriatal degeneration in AAV-based mouse model of Parkinson's disease (opens in new window)

Author(s): Gou DH, Huang TT, Li W, Gao XD, Haikal C, Wang XH, Song DY, Liang X, Zhu L, Tang Y, Ding C, Li JY.
Published in: Redox Biology, 2021, ISSN 2213-2317
Publisher: Elsevier BV
DOI: 10.1016/j.redox.2020.101795

Inhibiting pathologically active ADAM10 rescues synaptic and cognitive decline in Huntington's disease (opens in new window)

Author(s): Vezzoli E, Caron I, Talpo F, Besusso D, Conforti P, Battaglia E, Sogne E, Falqui A, Petricca L, Verani M, Martufi P, Caricasole A, Bresciani A, Cecchetti O, Rivetti di Val Cervo P, Sancini G, Riess O, Nguyen H, Seipold L, Saftig P, Biella G, Cattaneo E, Zuccato C.
Published in: Journal of Clinical Investigation, 2019, ISSN 0021-9738
Publisher: American Society for Clinical Investigation
DOI: 10.1172/jci120616

CRISPR/Cas9 and piggyBac-mediated footprint-free LRRK2-G2019S knock-in reveals neuronal complexity phenotypes and α-Synuclein modulation in dopaminergic neurons (opens in new window)

Author(s): Xiaobing Qing 1, Jonas Walter 1, Javier Jarazo 1, Jonathan Arias-Fuenzalida 1, Anna-Lena Hillje 1, Jens C Schwamborn 2
Published in: Stem Cell Res, 2018, ISSN 1873-5061
Publisher: Elsevier
DOI: 10.1016/j.scr.2017.08.013

The Continuum of Aging and Age-Related Diseases: Common Mechanisms but Different Rates (opens in new window)

Author(s): Claudio Franceschi 1, Paolo Garagnani 2 3 4 5, Cristina Morsiani 2, Maria Conte 2, Aurelia Santoro 2 6, Andrea Grignolio 7, Daniela Monti 8, Miriam Capri 2 6, Stefano Salvioli
Published in: Front Med (Lausanne), 2018, ISSN 2296-858X
Publisher: Frontiers Media SA
DOI: 10.3389/fmed.2018.00061

Alpha-synuclein and the prion hypothesis in Parkinson's disease (opens in new window)

Author(s): Melki R.
Published in: Revue neurologique (Paris), 2018, ISSN 0035-3787
Publisher: Elsevier Masson
DOI: 10.1016/j.neurol.2018.08.002

Neural Correlates of the Dual-Pathway Model for ADHD in Adolescents (opens in new window)

Author(s): Chun Shen, M.Sc., Qiang Luo, Ph.D., Tianye Jia, Ph.D., Qi Zhao, M.Sc., Sylvane Desrivières, Ph.D., Erin Burke Quinlan, Ph.D., Tobias Banaschewski, M.D., Ph.D., Sabina Millenet, D.Psych., Arun L.W. Bokde, Ph.D., Christian Büchel, M.D., Herta Flor, Ph.D., Vincent Frouin, Ph.D., Hugh Garavan, Ph.D., Penny Gowland, Ph.D., Andreas Heinz, M.D., Ph.D., Bernd Ittermann, Ph.D., Jean-Luc Martinot, M.D., P
Published in: American journal of psychiatry, 2020, ISSN 0002-953X
Publisher: American Psychiatric Publishing, Inc.
DOI: 10.1176/appi.ajp.2020.19020183

3D Cultures of Parkinson's Disease-Specific Dopaminergic Neurons for High Content Phenotyping and Drug Testing (opens in new window)

Author(s): Silvia Bolognin 1 2, Marie Fossépré 1 2, Xiaobing Qing 1, Javier Jarazo 1, Janez Ščančar 3, Edinson Lucumi Moreno 1, Sarah L Nickels 1, Kobi Wasner 1, Nassima Ouzren 1, Jonas Walter 1 2, Anne Grünewald 1 4, Enrico Glaab 1, Luis Salamanca 1, Ronan M T Fleming 1, Paul M A Antony 1, Jens C Schwamborn
Published in: Adv Sci, 2019, ISSN 2198-3844
Publisher: Wiley-VCH GmbH, Weinheim
DOI: 10.1002/advs.201800927

Secretome from SH-SY5Y APP Swe cells trigger time-dependent CHME3 microglia activation phenotypes, ultimately leading to miR-21 exosome shuttling (opens in new window)

Author(s): Fernandes A, Ribeiro AR, Monteiro M, Garcia G, Vaz AR, Brites D
Published in: Biochimie, 2018, ISSN 0300-9084
Publisher: Elsevier BV
DOI: 10.1016/j.biochi.2018.05.015

Increased Immune Activation by Pathologic α-Synuclein in Parkinson's Disease (opens in new window)

Author(s): Grozdanov V, Bousset L, Hoffmeister M, Bliederhaeuser C, Meier C, Madiona K, Pieri L, Kiechle M, McLean PJ, Kassubek J, Behrends C, Ludolph AC, Weishaupt JH, Melki R, Danzer KM
Published in: Annals of neurology, 2019, ISSN 0364-5134
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/ana.25557

FTY720 treatment starting after onset of symptoms reverses synaptic and memory deficits in an AD mouse model. (opens in new window)

Author(s): Kartalou G-I, Salgueiro Pereira SP, Endres T, Lesnikova A, Casarotto P, Pousinha P, Delanoe K, Edelmann E, Castrén E, Gottmann K, Marie H, Lessmann V.
Published in: BioRxiv, 2019, ISSN 2692-8205
Publisher: BioRxiv
DOI: 10.1101/2019.12.15.868026

Human iPSC-Derived Hippocampal Spheroids: An Innovative Tool for Stratifying Alzheimer Disease Patient-Specific Cellular Phenotypes and Developing Therapies (opens in new window)

Author(s): Pomeshchik Y, Klementieva O, Gil J, Martinsson I, Hansen MG, de Vries T, Sancho-Balsells A, Russ K, Savchenko E, Collin A, Vaz AR, Bagnoli S, Nacmias B, Rampon C, Sorbi S, Brites D, Marko-Varga G, Kokaia Z, Rezeli M, Gouras GK, Roybon L.
Published in: Stem Cell Reports, 2020, ISSN 2213-6711
Publisher: Cell Press
DOI: 10.1016/j.stemcr.2020.06.001

Quality Control of Membraneless Organelles. (opens in new window)

Author(s): Simon Alberti; Serena Carra
Published in: Journal of Molecular Biology, 2018, ISSN 0022-2836
Publisher: Academic Press
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"Brain-Derived Neurotrophic Factor and Vascular Endothelial Growth Factor: ""Siamese Twins"" in Antidepressant Action" (opens in new window)

Author(s): Lima-Ojeda JM, Castrén E.
Published in: Biological psychiatry, 2019, ISSN 0006-3223
Publisher: Elsevier BV
DOI: 10.1016/j.biopsych.2019.05.003

Transcranial optical imaging reveals a pathway for optimizing the delivery of immunotherapeutics to the brain. (opens in new window)

Author(s): Plog BA, Mestre H, Olveda GE, Sweeney AM, Kenney HM, Cove A, Dholakia KY, Tithof J, Nevins TD, Lundgaard I, Du T, Kelley DH, Nedergaard M.
Published in: JCI insight, 2018, ISSN 2379-3708
Publisher: The American Society for Clinical Investigation
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The prion protein is an agonistic ligand of the G protein-coupled receptor Adgrg6 (opens in new window)

Author(s): Küffer, A., Lakkaraju, A., Mogha, A. et al.
Published in: Nature, Issue 536, 2016, Page(s) 464–468, ISSN 0028-0836
Publisher: Nature Publishing Group
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Cell biology and dynamics of Neuronal Na +/K +-ATPase in health and diseases (opens in new window)

Author(s): Shrivastava AN, Triller A, Melki R.
Published in: Neuropharmacology, 2020, ISSN 0028-3908
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.neuropharm.2018.12.008

The Amyloid Precursor Protein C-Terminal Domain Alters CA1 Neuron Firing, Modifying Hippocampus Oscillations and Impairing Spatial Memory Encoding. (opens in new window)

Author(s): Pousinha, Paula A.; Mouska, Xavier; Bianchi, Daniela; Temido-Ferreira, Mariana; Rajão-Saraiva, Joana; Gomes, Rui; Fernandez, Sebastian P.; Salgueiro-Pereira, Ana Rita; Gandin, Carine; Raymond, Elisabeth F.; Barik, Jacques; Goutagny, Romain; Bethus, Ingrid; Lopes, Luisa V.; Migliore, Michele; Marie, Hélène
Published in: Cell reports, Issue 1, 2019, ISSN 2211-1247
Publisher: Cell Press
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Genetics of Human Longevity Within an Eco-Evolutionary Nature-Nurture Framework. (opens in new window)

Author(s): Giuliani C, Garagnani P, Franceschi C.
Published in: Circulation Research, 2018, ISSN 0009-7330
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/circresaha.118.312562

Derivation of Human Midbrain-Specific Organoids from Neuroepithelial Stem Cells (opens in new window)

Author(s): Anna S Monzel 1, Lisa M Smits 1, Kathrin Hemmer 1, Siham Hachi 2, Edinson Lucumi Moreno 2, Thea van Wuellen 1, Javier Jarazo 1, Jonas Walter 1, Inga Brüggemann 1, Ibrahim Boussaad 3, Emanuel Berger 1, Ronan M T Fleming 2, Silvia Bolognin 1, Jens C Schwamborn 4
Published in: Stem Cell Reports, 2017, ISSN 2213-6711
Publisher: Cell Press
DOI: 10.1016/j.stemcr.2017.03.010

ɑ-Synuclein strains and seeding in Parkinson's disease, incidental Lewy body disease, dementia with Lewy bodies and multiple system atrophy: similarities and differences (opens in new window)

Author(s): Peelaerts W, Bousset L, Baekelandt V, Melki R.
Published in: Cell and Tissue Research, 2018, ISSN 0302-766X
Publisher: Springer Verlag
DOI: 10.1007/s00441-018-2839-5

Protein Phase Separation as a Stress Survival Strategy (opens in new window)

Author(s): Franzmann TM, Alberti S
Published in: Cold Spring Harbor Perspectives in Biology, 2019, ISSN 1943-0264
Publisher: Cold Spring Harbor Laboratory Press
DOI: 10.1101/cshperspect.a034058

Inhibition of Stat3-mediated astrogliosis ameliorates pathology in an Alzheimer's disease model. (opens in new window)

Author(s): Reichenbach, Nicole; Delekate, Andrea; Plescher, Monika; Schmitt, Franziska; Krauss, Sybille; Blank, Nelli; Halle, Annett; Petzold, Gabor C
Published in: EMBO Molecular Medicine, Vol 11, Iss 2, Pp n/a-n/a (2019), Issue 2, 2019, ISSN 1757-4676
Publisher: John Wiley & Sons Ltd.
DOI: 10.15252/emmm.201809665

Glucocerebrosidase activity, cathepsin D and monomeric α-synuclein interactions in a stem cell derived neuronal model of a PD associated GBA1 mutation (opens in new window)

Author(s): Shi-Yu Yang, Matthew Gegg , David Chau, Anthony Schapira
Published in: Neurobiology of Disease, 2019, ISSN 0969-9961
Publisher: Academic Press
DOI: 10.1016/j.nbd.2019.104620

Molecular subtypes of Alzheimer's disease (opens in new window)

Author(s): Di Fede G, Catania M, Maderna E, Ghidoni R, Benussi L, Tonoli E, Giaccone G, Moda F, Paterlini A, Campagnani I, Sorrentino S, Colombo L, Kubis A, Bistaffa E, Ghetti B, Tagliavini F.
Published in: Scientific reports, 2018, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-018-21641-1

Endocytic vesicle rupture is a conserved mechanism of cellular invasion by amyloid proteins (opens in new window)

Author(s): Flavin WP, Bousset L, Green ZC, Chu Y, Skarpathiotis S, Chaney MJ, Kordower JH, Melki R, Campbell EM.
Published in: Acta neuropathologica, 2017, ISSN 0001-6322
Publisher: Springer Verlag
DOI: 10.1007/s00401-017-1722-x

Brain Distribution of Dual ABCB1/ABCG2 Substrates Is Unaltered in a Beta-Amyloidosis Mouse Model. (opens in new window)

Author(s): Thomas Wanek; Viktoria Zoufal; Mirjam Brackhan; Markus Krohn; Severin Mairinger; Thomas Filip; Michael Sauberer; Johann Stanek; Thomas Pekar; Jens Pahnke; Jens Pahnke; Jens Pahnke; Oliver Langer; Oliver Langer
Published in: International Journal of Molecular Sciences, 2020, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21218245

Evaluation of the Performance of AmpliSeq and SureSelect Exome Sequencing Libraries for Ion Proton (opens in new window)

Author(s): Gampawar P, Saba Y, Werner U, Schmidt R, Müller-Myhsok B, Schmidt H.
Published in: Frontiers in Genetics, 2019, ISSN 1664-8021
Publisher: Frontiers Media
DOI: 10.3389/fgene.2019.00856

High-quality draft genome sequence of Sphaerisporangium cinnabarinum (opens in new window)

Author(s): Christensen LFB, Otzen DE, Dueholm MS
Published in: Genome announcements, 2018, ISSN 2169-8287
Publisher: American Society for Microbiology
DOI: 10.1128/genomea.00456-18

Trehalose induces autophagy via lysosomal-mediated TFEB activation in models of motoneuron degeneration (opens in new window)

Author(s): "Rusmini, P.; Cortese, K.; Crippa, V.; Cristofani, R.; Cicardi, M.E.; Ferrari, V.; Vezzoli, G.; Tedesco, B.; Meroni, M.; Messi, E.; Piccolella, M.; Galbiati, M.; Garrè , M.; Morelli, E.; Vaccari, T.; Poletti, A."
Published in: Autophagy, Issue 1, 2018, ISSN 1554-8627
Publisher: Landes Bioscience
DOI: 10.1080/15548627.2018.1535292

Age-Related Changes of Peak Width Skeletonized Mean Diffusivity (PSMD) Across the Adult Lifespan: A Multi-Cohort Study (opens in new window)

Author(s): Beaudet G, Tsuchida A, Petit L, Tzourio C, Caspers S, Schreiber J, Pausova Z, Patel Y, Paus T, Schmidt R, Pirpamer L, Sachdev P, Wen W, Armstrong N, Deary IJ, Bastin ME, Wardlaw JM, Munõz Maniega S, Witte V, Villringer A, Duering M, Debette S, Mazoyer B.
Published in: Frontiers in psychiatry, 2020, ISSN 1664-0640
Publisher: Frontiers Research Foundation
DOI: 10.3389/fpsyt.2020.00342

Diminished OPA1 expression and impaired mitochondrial morphology and homeostasis in Aprataxin-deficient cells. (opens in new window)

Author(s): Zheng J, Croteau DL, Bohr VA, Akbari M.
Published in: Nucleic acids research, 2019, ISSN 1362-4962
Publisher: Oxford Academic
DOI: 10.1093/nar/gkz083

Longitudinal changes in the genetic and environmental influences on the epigenetic clocks across old age: Evidence from two twin cohorts. (opens in new window)

Author(s): Jylhävä J, Hjelmborg J, Soerensen M, Munoz E, Tan Q, Kuja-Halkola R, Mengel-From J, Christensen K, Christiansen L, Hägg S, Pedersen NL, Reynolds CA.
Published in: EBioMedicine, 2019, ISSN 2352-3964
Publisher: Elsevier BV
DOI: 10.1016/j.ebiom.2019.01.040

Voluntary running enhances glymphatic influx in awake behaving, young mice. (opens in new window)

Author(s): Holstein-Rathlou S, Petersen NC, Nedergaard M.
Published in: Neuroscience Letters, 2018, ISSN 0304-3940
Publisher: Elsevier BV
DOI: 10.1016/j.neulet.2017.10.035

Improved method for cannula fixation for long-term intracerebral brain infusion (opens in new window)

Author(s): Ádám Sike, Jonas Wengenroth, Jolanta Upīte, Thomas Brüning, Iván Eiriz, Petra Sántha, Henrik Biverstål, Baiba Jansone, Håvard Jostein Haugen, Markus Krohn, Jens Pahnke
Published in: Journal of Neuroscience Methods, Issue 290, 2017, Page(s) 145-150, ISSN 0165-0270
Publisher: Elsevier BV
DOI: 10.1016/j.jneumeth.2017.07.026

Diabetes Mellitus as a Risk Factor for Parkinson’s Disease: a Molecular Point of View. (opens in new window)

Author(s): Biosa, A., Outeiro, T.F., Bubacco, L. et al.
Published in: Molecular Neurobiology, Issue 55, 2018, Page(s) 8754–8763, ISSN 0893-7648
Publisher: Humana Press, Inc.
DOI: 10.1007/s12035-018-1025-9

Age-Dependent Alpha-Synuclein Accumulation and Phosphorylation in the Enteric Nervous System in a Transgenic Mouse Model of Parkinson’s Disease (opens in new window)

Author(s): Zhong, CB., Chen, QQ., Haikal, C. et al.
Published in: Translational Neurodegeneration, 2018, ISSN 2047-9158
Publisher: BioMed Central Ltd
DOI: 10.1007/s12264-017-0179-1

Clinical Significance of Magnetic Resonance Imaging Markers of Vascular Brain Injury: A Systematic Review and Meta-analysis (opens in new window)

Author(s): Debette S, Schilling S, Duperron MG, Larsson SC, Markus HS.
Published in: JAMA Neurology, 2019, ISSN 2168-6149
Publisher: American Medical Association
DOI: 10.1001/jamaneurol.2018.3122

Age dependency of cerebral P-glycoprotein function in wild-type and APPPS1 mice measured with PET (opens in new window)

Author(s): Zoufal V, Wanek T, Krohn M, Mairinger S, Filip T, Sauberer M, Stanek J, Pekar T, Bauer M, Pahnke J, Langer O,
Published in: Journal of Cerebral Blood Flow & Metabolism, 2020, ISSN 0271-678X
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1177/0271678x18806640

Prion-like seeding and nucleation of intracellular amyloid-β (opens in new window)

Author(s): Olsson TT, Klementieva O, Gouras GK.
Published in: Neurobiology of disease, 2018, ISSN 0969-9961
Publisher: Academic Press
DOI: 10.1016/j.nbd.2018.01.015

Stress granules sense metabolic stress at the plasma membrane and potentiate recovery by storing active Pkc1 (opens in new window)

Author(s): Triana Amen and Daniel Kaganovich
Published in: Science Signaling, 2020, ISSN 1945-0877
Publisher: American Association for the Advancement of Science
DOI: 10.1126/scisignal.aaz6339

Genetic Burden for Late-Life Neurodegenerative Disease and Its Association With Early-Life Lipids, Brain, Behavior, and Cognition (opens in new window)

Author(s): Sander Lamballais; Ryan L. Muetzel; Ryan L. Muetzel; Mohammad Arfan Ikram; Henning Tiemeier; Henning Tiemeier; Meike W. Vernooij; Meike W. Vernooij; Tonya White; Tonya White; Hieab H. H. Adams; Hieab H. H. Adams; Hieab H. H. Adams
Published in: Frontiers in Psychiatry, 11, 2020, ISSN 1664-0640
Publisher: Frontiers Research Foundation
DOI: 10.3389/fpsyt.2020.00033

The synergistic effect of chlorotoxin-mApoE in boosting drug-loaded liposomes across the BBB (opens in new window)

Author(s): Formicola B, Dal Magro R, Montefusco-Pereira CV, Lehr CM, Koch M, Russo L, Grasso G, Deriu MA, Danani A, Bourdoulous S, Re F.
Published in: Journal of nanobiotechnology, 2019, ISSN 1477-3155
Publisher: BioMed Central
DOI: 10.1186/s12951-019-0546-3

Short-Term Effects of Microglia-Specific Mitochondrial Dysfunction on Amyloidosis in Transgenic Models of Alzheimer's Disease (opens in new window)

Author(s): Steffen J, Stenzel J, Ibrahim S, Pahnke J,
Published in: Journal of Alzheimer's Disease, 2018, ISSN 1387-2877
Publisher: IOS Press
DOI: 10.3233/jad-180395

Stratifying the presymptomatic phase of genetic frontotemporal dementia by serum NfL and pNfH: a longitudinal multicentre study (opens in new window)

Author(s): Wilke, Carlo; Reich, Selina; Swieten, John C.; Borroni, Barbara; Sanchez‐Valle, Raquel; Moreno, Fermin; Laforce, Robert; Graff, Caroline; Galimberti, Daniela; Rowe, James B.; Masellis, Mario; Tartaglia, Maria C.; Finger, Elizabeth; Vandenberghe, Rik; De Mendonça, Alexandre; Tagliavini, Fabrizio; Santana, Isabel; Ducharme, Simon; Butler, Chris R.; Gerhard, Alexander; Levin, Johannes; Danek, Adri
Published in: Annals of Neurology, 2021, ISSN 0364-5134
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/ana.26265

Novel tau filament fold in chronic traumatic encephalopathy encloses hydrophobic molecules (opens in new window)

Author(s): Falcon B, Zivanov J, Zhang W,Murzin A, Garringer H, Vidal R, Crowther A, Newell K, Ghetti B, Goedert M and Scheres S.
Published in: Nature, 2019, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-019-1026-5

Neuroinflammatory responses in Alzheimer's disease. (opens in new window)

Author(s): Dansokho C, Heneka MT.
Published in: Journal of Neural Transmission, 2018, ISSN 0300-9564
Publisher: Springer Verlag
DOI: 10.1007/s00702-017-1831-7

Leukocyte Derived Microvesicles as Disease Progression Biomarkers in Slow Progressing Amyotrophic Lateral Sclerosis Patients. (opens in new window)

Author(s): Daisy Sproviero; Sabrina La Salvia; Federico Colombo; Susanna Zucca; Orietta Pansarasa; Luca Diamanti; Luca Diamanti; Alfredo Costa; Alfredo Costa; Luca Lova; Luca Lova; Marta Giannini; Marta Giannini; Stella Gagliardi; Eliana Lauranzano; Michela Matteoli; Michela Matteoli; Mauro Ceroni; Mauro Ceroni; Andrea Malaspina; Cristina Cereda
Published in: Frontiers in Neuroscience, Vol 13 (2019), 2019, ISSN 1662-4548
Publisher: Frontiers Research Foundation
DOI: 10.3389/fnins.2019.00344

LRP1 Has a Predominant Role in Production over Clearance of Aβ in a Mouse Model of Alzheimer's Disease (opens in new window)

Author(s): Van Gool B, Storck SE, Reekmans SM, Lechat B, Gordts PLSM, Pradier L, Pietrzik CU, Roebroek AJM,
Published in: Molecular neurobiology, 2019, ISSN 0893-7648
Publisher: Humana Press, Inc.
DOI: 10.1007/s12035-019-1594-2

A Surveillance Function of the HSPB8-BAG3-HSP70 Chaperone Complex Ensures Stress Granule Integrity and Dynamism (opens in new window)

Author(s): Massimo Ganassi, Daniel Mateju, Ilaria Bigi, Laura Mediani, Ina Poser, Hyun O.Lee, Samuel J.Seguin, Federica, F. Morelli, Jonathan Vinet, Giuseppina Leo, Orietta Pansarasa, Cristina Cereda, Angelo Poletti, SimonAlberti, SerenaCarra16
Published in: Molecular Cell, Issue 63, 2016, Page(s) 796–810, ISSN 1097-2765
Publisher: Cell Press
DOI: 10.1016/j.molcel.2016.07.021

Small-molecule induction of Aβ-42 peptide production in human cerebral organoids to model Alzheimer's disease associated phenotypes (opens in new window)

Author(s): Pavoni S, Jarray R, Nassor F, Guyot AC, Cottin S, Rontard J, Mikol J, Mabondzo A, Deslys JP, Yates F.
Published in: PLoS One, 2018, ISSN 1932-6203
Publisher: Public Library of Science
DOI: 10.1371/journal.pone.0209150

A High Output Method to Isolate Cerebral Pericytes from Mouse (opens in new window)

Author(s): Mehra A., Dehouck L., Vandenhaute E., Fatar M., Fenart L., Gosselet F.
Published in: Journal of visualized experiments, 2020, ISSN 1940-087X
Publisher: MYJoVE Corporation
DOI: 10.3791/60588

Pathological Proteins Are Transported by Extracellular Vesicles of Sporadic Amyotrophic Lateral Sclerosis Patients. (opens in new window)

Author(s): Daisy Sproviero; Sabrina La Salvia; Marta Giannini; Marta Giannini; Valeria Crippa; Stella Gagliardi; Stefano Bernuzzi; Luca Diamanti; Luca Diamanti; Mauro Ceroni; Mauro Ceroni; Orietta Pansarasa; Angelo Poletti; Cristina Cereda
Published in: Frontiers in Neuroscience,, Issue Vol 12, 2018, ISSN 1662-4548
Publisher: Frontiers Research Foundation
DOI: 10.3389/fnins.2018.00487

Effects of ambroxol on the autophagy-lysosome pathway and mitochondria in primary cortical neurons. (opens in new window)

Author(s): Magalhaes, J; Gegg, ME; Migdalska-Richards, A; Schapira, AH;
Published in: Scientific Reports, 2018, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-018-19479-8

The Genetic Variability of APOE in Different Human Populations and Its Implications for Longevity (opens in new window)

Author(s): Paolo Abondio 1, Marco Sazzini 2, Paolo Garagnani 3, Alessio Boattini 4, Daniela Monti 5, Claudio Franceschi 6, Donata Luiselli 7, Cristina Giuliani
Published in: Genes (Basel), 2019, ISSN 2073-4425
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/genes10030222

Generation and characterization of an ABCC1 humanized mouse model (HABCC1<sup>FLX/FLX</sup>) with knockout capability (opens in new window)

Author(s): Krohn, Markus; Zoufal, Viktoria; Mairinger, Severin; Wanek, Thomas; Paarmann, Kristin; Brüning, Thomas; Eiriz Delgado, Iván; Brackhan, Mirjam; Langer, Oliver; Pahnke, Jens
Published in: Molecular Pharmacology, 2019, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.1124/mol.119.115824

Evolution of prodromal parkinsonian features in a cohort of GBA mutation-positive individuals: a 6-year longitudinal study (opens in new window)

Author(s): Avenali M, Toffoli M, Mullin S, McNeil A, Hughes DA, Mehta A, Blandini F, Schapira AHV.
Published in: Journal of Neurology Neurosurgery and Psychiatry, 2019, ISSN 0022-3050
Publisher: BMJ Publishing Group
DOI: 10.1136/jnnp-2019-320394

Overdominant Effect of a CHRNA4 Polymorphism on Cingulo-Opercular Network Activity and Cognitive Control (opens in new window)

Author(s): Sadaghiani S, Ng B, [...], Paus T, Poustka L, Millenet , Fröhner JH, Smolka MN, Walter H, Whelan R, Schumann G, Napolioni V, Greicius M
Published in: Journal of Neuroscience, 2017, ISSN 0270-6474
Publisher: Society for Neuroscience
DOI: 10.1523/jneurosci.0991-17.2017

DJ-1 (Park7) affects the gut microbiome, metabolites and the development of innate lymphoid cells (ILCs). (opens in new window)

Author(s): Yogesh Singh, Christoph Trautwein, Achal Dhariwal, Madhuri S. Salker, Md Alauddin, Laimdota Zizmare, Lisann Pelzl, Martina Feger, Jakob Admard, Nicolas Casadei, Michael Föller, Vivek Pachauri, David S. Park, Tak W. Mak, Julia-Stefanie Frick, Diethelm Wallwiener, Sara Y. Brucker, Florian Lang and Olaf Riess
Published in: Scientific Reports, 2020, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-020-72903-w

NLRP3 Is Involved in the Maintenance of Cerebral Pericytes (opens in new window)

Author(s): Quan W, Luo Q, Tang Q, Furihata T, Li D, Fassbender K, and Liu Y
Published in: Frontiers in cellular neuroscience, 2020, ISSN 1662-5102
Publisher: Frontiers Research Foundation
DOI: 10.3389/fncel.2020.00276

Epigenetic mechanisms during ageing and neurogenesis as novel therapeutic avenues in human brain disorders (opens in new window)

Author(s): Raul Delgado-Morales; Roberto Carlos Agis-Balboa; Manel Esteller; Manel Esteller; María Berdasco
Published in: Clinical Epigenics, 2017, ISSN 1868-7075
Publisher: Springer Verlag
DOI: 10.1186/s13148-017-0365-z

The Exosomal/Total α-Synuclein Ratio in Plasma Is Associated With Glucocerebrosidase Activity and Correlates With Measures of Disease Severity in PD Patients (opens in new window)

Author(s): Silvia Cerri1*, Cristina Ghezzi1, Maria Sampieri1, Francesca Siani1, Micol Avenali2,3, Gianluca Dornini4, Roberta Zangaglia5, Brigida Minafra5 and Fabio Blandini1
Published in: Frontiers in Cellular Neuroscience, 2018, ISSN 1662-5102
Publisher: Frontiers Research Foundation
DOI: 10.3389/fncel.2018.00125

Clinical and neuropathological phenotype associated with the novel V189I mutation in the prion protein gene (opens in new window)

Author(s): Di Fede G, Catania M, Atzori C, Moda F, Pasquali C, Indaco A, Grisoli M, Zuffi M, Guaita MC, Testi R, Taraglio S, Sessa M, Gusmaroli G, Spinelli M, Salzano G, Legname G, Tarletti R, Godi L, Pocchiari M, Tagliavini F, Imperiale D, Giaccone G.
Published in: acta neuropathologica communications, 2019, ISSN 2051-5960
Publisher: BioMed Central
DOI: 10.1186/s40478-018-0656-4

Granulostasis: Protein Quality Control of RNP Granules (opens in new window)

Author(s): Alberti, Simon; Mateju, Daniel; Mediani, Laura; Carra, Serena
Published in: Frontiers in molecular Neuroscience, Issue 2, 2017, ISSN 1662-5099
Publisher: Frontiers Research Foundation
DOI: 10.3389/fnmol.2017.00084

Inhibition of retrograde transport modulates misfolded protein accumulation and clearance in motoneuron diseases. (opens in new window)

Author(s): Cristofani R., Crippa V., Rusmini P., Cicardi M.E., Meroni M., Licata N.V., Sala G., Giorgetti E., Grunseich C., Galbiati M., Piccolella M., Messi E., Ferrarese C., Carra S, Poletti A.
Published in: Autophagy, 2017, ISSN 1554-8627
Publisher: Landes Bioscience
DOI: 10.1080/15548627.2017.1308985

Understanding Dopaminergic Cell Death Pathways in Parkinson Disease (opens in new window)

Author(s): Patrick P. Michel, Etienne C. Hirsch, Stephane Hunot
Published in: Neuron, Issue Volume 90, Issue 4, 2016, Page(s) Pages 675-691, ISSN 0896-6273
Publisher: Cell Press
DOI: 10.1016/j.neuron.2016.03.038

Soluble Aβ oligomers and protofibrils induce NLRP3 inflammasome activation in microglia (opens in new window)

Author(s): Lučiūnaitė A, McManus RM, Jankunec M, Rácz I, Dansokho C, Dalgėdienė I, Schwartz S, Brosseron F, Heneka MT.
Published in: Journal of neurochemistry, 2020, ISSN 0022-3042
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/jnc.14945

Impairment of Glycolysis-Derived l-Serine Production in Astrocytes Contributes to Cognitive Deficits in Alzheimer’s Disease

Author(s): Le Douce, Juliette; Maugard, Marianne; Veran, Julien; Matos, Marco; Jégo, Pierrick; Vigneron, Pierre-Antoine; Faivre, Emilie; Toussay, Xavier; Vandenberghe, Michel; Balbastre, Yaël; Piquet, Juliette; Guiot, Elvire; Tran, Nguyet Thuy; Taverna, Myriam; Marinesco, Stéphane; Koyanagi, Ayumi; Furuya, Shigeki; Gaudin-Guérif, Mylène; Goutal, Sébastien; Ghettas, Aurélie; Pruvost, Alain; Bemelmans,
Published in: Cell Metabolism, 2020, Page(s) pp.503-517, ISSN 0893-7648
Publisher: Humana Press, Inc.

Intravenous treatment with human recombinant ApoA-I Milano reduces beta amyloid cerebral deposition in the APP23-transgenic mouse model of Alzheimer's disease (opens in new window)

Author(s): Fernández-de Retana S, Montañola A, Marazuela P, De La Cuesta M, Batlle A, Fatar M, Grudzenski S, Montaner J, Hernández-Guillamon M.
Published in: Neurobiology of aging, 2017, ISSN 0197-4580
Publisher: Elsevier BV
DOI: 10.1016/j.neurobiolaging.2017.08.028

Genome-wide pleiotropy between depression and body mass index (opens in new window)

Author(s): Garvert, L., Roshchupkin, G.V., Völzke, H., Nauck, M., Milaneschi, Y., Grabe, J., Van der Auwera, S.
Published in: Pharmacopsychiatry, 2020, ISSN 0176-3679
Publisher: Georg Thieme Verlag
DOI: 10.1055/s-0039-3403015

A User's Guide for Phase Separation Assays with Purified Proteins. (opens in new window)

Author(s): Simon Alberti; Shambaditya Saha; Jeffrey B. Woodruff; Titus M. Franzmann; Jie Wang; Anthony A. Hyman
Published in: Journal of Molecular Biology, 2018, ISSN 0022-2836
Publisher: Academic Press
DOI: 10.1016/j.jmb.2018.06.038

Neurological effects of glucocerebrosidase gene mutations (opens in new window)

Author(s): Mullin S, Hughes D, Mehta A, Schapira AHV.
Published in: European Journal of Neurology, 2019, ISSN 1351-5101
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/ene.13837

Brain Peak Width of Skeletonized Mean Diffusivity (PSMD) and Cognitive Function in Later Life (opens in new window)

Author(s): Deary IJ, Ritchie SJ, Muñoz Maniega S, Cox SR, Valdés Hernández MC, Luciano M, Starr JM, Wardlaw JM, Bastin ME.
Published in: Frontiers in Psychiatry, 2019, ISSN 1664-0640
Publisher: Frontiers Research Foundation
DOI: 10.3389/fpsyt.2019.00524

Faulty neuronal determination and cell polarization are reverted by modulating HD early phenotypes (opens in new window)

Author(s): Conforti P, Besusso D, Bocchi VD, Faedo A, Cesana E, Rossetti G, Ranzani V, Svendsen CN, Thompson LM, Toselli M, Biella G, Pagani M, Cattaneo E.
Published in: PNAS, 2018, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.1715865115

Considerations and Challenges in Studying Liquid-Liquid Phase Separation and Biomolecular Condensates (opens in new window)

Author(s): Alberti S, Gladfelter A, Mittag T
Published in: Cell, 2019, ISSN 0092-8674
Publisher: Cell Press
DOI: 10.1016/j.cell.2018.12.035

Tau/DDX6 interaction increases microRNA activity (opens in new window)

Author(s): Alban Chauderlier; Melissa Gilles; Andrea Spolcova; Raphaëlle Caillierez; Maggy Chwastyniak; Michel Kress; Hervé Drobecq; Eliette Bonnefoy; Florence Pinet; Dominique Weil; Luc Buée; Marie-Christine Galas; Bruno Lefebvre
Published in: Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, Issue Volume 1861, Issue 8, August 2018,, 2018, Page(s) 762-772, ISSN 1874-9399
Publisher: Elsevier BV
DOI: 10.1016/j.bbagrm.2018.06.006

Measurement of cerebral ABCC1 transport activity in wild-type and APP/PS1-21 mice with positron emission tomography (opens in new window)

Author(s): Zoufal V, Mairinger S, Krohn M, Wanek T, Filip T, Sauberer M, Stanek J, Kuntner C, Pahnke J, Langer O,
Published in: Journal of Cerebral Blood Flow & Metabolism, 2020, ISSN 0271-678X
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1177/0271678x19854541

Preclinical Evaluation of a Lentiviral Vector for Huntingtin Silencing (opens in new window)

Author(s): Karine Cambon, Virginie Zimmer, Sylvain Martineau, Marie-Claude Gaillard, Margot Jarrige, Aurore Bugi, Jana Miniarikova, Maria Rey, Raymonde Hassig, Noelle Dufour, Gwenaelle Auregan, Philippe Hantraye, Anselme L. Perrier, Nicole Déglon
Published in: Molecular Therapy - Methods & Clinical Development, Issue Volume 5, 2017, Page(s) 259-276, ISSN 2329-0501
Publisher: The American Society of Gene and Cell Therapy. Elsevier
DOI: 10.1016/j.omtm.2017.05.001

How the shapes of seeds can influence pathology (opens in new window)

Author(s): Melki R.
Published in: Neurobiology of Disease, 2018, ISSN 0969-9961
Publisher: Academic Press
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Expression of the Parkinson’s Disease-Associated Gene Alpha-Synuclein is Regulated by the Neuronal Cell Fate Determinant TRIM32 (opens in new window)

Author(s): Maria Angeliki S. Pavlou, Nicoló Colombo, Sandra Fuertes-Alvarez, Sarah Nicklas, Laura Gonzalez Cano, Maria C. Marín, Jorge Goncalves, Jens C. Schwamborn
Published in: Mol Neurobiol, 2017, ISSN 0893-7648
Publisher: Humana Press, Inc.
DOI: 10.1007/s12035-016-9989-9

Antidepressants act by binding to the cholesterolinteraction site at TrkB neurotrophin receptor (opens in new window)

Author(s): Casarotto PC, M.Girych, S.M. Fred, R. Moliner, G. Enkavi, C. Biojone, C.Cannarozzo, C.A.Brunello, A.Steinzeig, F.Winkel, S.Patil, S.Vestring, T.Serchov, V.Kovaleva, C.Diniz, L.Laukkanen, I.Cardon, H.Antila, T.Rog, M.Saarma, C.R.Bramham, C.Normann, S.E.Lauri, I.Vattulainen, Eero Castrén.
Published in: BioRxiv, 2019, ISSN 2692-8205
Publisher: BioRxiv
DOI: 10.1101/757989

The Role of Sex and Sex Hormones in Neurodegenerative Diseases (opens in new window)

Author(s): Vegeto E., Villa A., Della Torre S., Crippa V. Rusmini P., Cristofani R., Galbiati M., Maggi A., Poletti A.
Published in: Endocrine Reviews, 2020, ISSN 0163-769X
Publisher: The Endocrine Society
DOI: 10.1210/endrev/bnz005

Knocking out C9ORF72 Exacerbates Axonal Trafficking Defects Associated with Hexanucleotide Repeat Expansion and Reduces Levels of Heat Shock Proteins (opens in new window)

Author(s): Abo-Rady, Masin; Kalmbach, Norman; Pal, Arun; Schludi, Carina; Janosch, Antje; Richter, Tanja; Freitag, Petra; Bickle, Marc; Kahlert, Anne-Karin; Petri, Susanne; Stefanov, Stefan; Glass, Hannes; Staege, Selma; Just, Walter; Bhatnagar, Rajat; Edbauer, Dieter; Hermann, Andreas; Wegner, Florian; Sterneckert, Jared L.
Published in: Stem Cell Reports, Vol 14, Iss 3, Pp 390-405 (2020), 2020, ISSN 2213-6711
Publisher: Cell Press
DOI: 10.1016/j.stemcr.2020.01.010

Associations between sleep apnea and advanced brain aging in a large-scale population study (opens in new window)

Author(s): Antoine Weihs, Stefan Frenzel, Katharina Wittfeld, Anne Obst, Beate Stubbe, Mohamad Habes, András Szentkirályi, Klaus Berger, Ingo Fietze, Thomas Penzel, Norbert Hosten, Ralf Ewert, Henry Völzke, Helena U Zacharias, Hans J Grabe
Published in: Sleep, 2021, ISSN 0161-8105
Publisher: The American Academy of Sleep Medicine
DOI: 10.1093/sleep/zsaa204

Spatial Transcriptomics Reveals Genes Associated with Dysregulated Mitochondrial Functions and Stress Signaling in Alzheimer Disease. (opens in new window)

Author(s): José Fernández Navarro; Deborah L. Croteau; Aleksandra Jurek; Zaneta Andrusivova; Beimeng Yang; Yue Wang; Benjamin Ogedegbe; Tahira Riaz; Mari Støen; Claus Desler; Lene Juel Rasmussen; Tone Tønjum; Marie-Christine Galas; Joakim Lundeberg; Vilhelm A. Bohr; Vilhelm A. Bohr
Published in: iScience, Issue 1, 2020, ISSN 2589-0042
Publisher: Elsevier Inc.
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PDGF-B Is Required for Development of the Glymphatic System. (opens in new window)

Author(s): Munk, Anne Sofie; Wang, Wei; Bechet, Nicholas Burdon; Eltanahy, Ahmed M.; Cheng, Anne Xiaoan; Sigurdsson, Bjorn; Benraiss, Abdellatif; Mäe, Maarja Andaloussi; Kress, Benjamin Travis; Kelley, Douglas H.; Betsholtz, Christer; Mollgard, Kjeld; Meissner, Anja; Nedergaard, Maiken; Lundgaard, Iben
Published in: Cell Reports, Issue vol. 26, 2019, Page(s) 11, ISSN 2211-1247
Publisher: Cell Press
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Neural circuitry underlying sustained attention in healthy adolescents and in ADHD symptomatology (opens in new window)

Author(s): Laura O'Halloran, Zhipeng Cao, Kathy Ruddy, Lee Jollans, Matthew D Albaugh, Andrea Aleni, Alexandra S Potter, Nigel Vahey, Tobias Banaschewski, Sarah Hohmann, Arun L W Bokde, Uli Bromberg, Christian Büchel, Erin Burke Quinlan, Sylvane Desrivières, Herta Flor, Vincent Frouin, Penny Gowland, Andreas Heinz, Bernd Ittermann, Frauke Nees, Dimitri Papadopoulos Orfanos, Tomáš Paus, Michael N Smolka,
Published in: Neuroimage, 2018, ISSN 2666-9560
Publisher: New York Elsevier Inc
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Transcriptional induction of the heat shock protein B8 mediates the clearance of misfolded proteins responsible for motor neuron diseases. (opens in new window)

Author(s): Crippa V., D'Agostino V.G., Cristofani R., Rusmini P., Cicardi M.E., Messi E., Loffredo R., Pancher M., Piccolella M., Galbiati M., Meroni M., Cereda C., Carra S., Provenzani A., Poletti A.
Published in: Scientific Reports, 2016, ISSN 2045-2322
Publisher: Nature Publishing Group
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Genome-wide identification of genic and intergenic neuronal DNA regions bound by Tau protein under physiological and stress conditions. (opens in new window)

Author(s): Benhelli-Mokrani, Houda; Mansuroglu, Zeyni; Chauderlier, Alban; Albaud, Benoit; Gentien, David; Sommer, Sabrina; Schirmer, Claire; Laqueuvre, Lucie; Josse, Thibaut; Buée, Luc; Lefebvre, Bruno; Galas, Marie-Christine; Souès, Sylvie; Bonnefoy, Eliette
Published in: Nucleic Acids Research, 2018, ISSN 0305-1048
Publisher: Oxford University Press
DOI: 10.1093/nar/gky929

The IMAGEN study: a decade of imaging genetics in adolescents (opens in new window)

Author(s): Lea Mascarell Maričić, Henrik Walter, Annika Rosenthal, Stephan Ripke, Erin Burke Quinlan, Tobias Banaschewski, Gareth J. Barker, Arun L. W. Bokde, Uli Bromberg, Christian Büchel, Sylvane Desrivières, Herta Flor, Vincent Frouin, Hugh Garavan, Bernd Itterman, Jean-Luc Martinot, Marie-Laure Paillère Martinot, Frauke Nees, Dimitri Papadopoulos Orfanos, Tomáš Paus, Luise Poustka, Sarah Hohmann,
Published in: Molecular psychiatry, 2020, ISSN 1359-4184
Publisher: Nature Publishing Group
DOI: 10.1038/s41380-020-0822-5

Linking Neuroinflammation and Neurodegeneration in Parkinson's Disease. (opens in new window)

Author(s): Gelders G, Baekelandt V, Van der Perren A.
Published in: Journal of immunology research, 2018, ISSN 2314-8861
Publisher: Hindawi Publishing Corporation
DOI: 10.1155/2018/4784268

Cell-Type-Specific Gene Expression Profiling in Adult Mouse Brain Reveals Normal and Disease-State Signatures (opens in new window)

Author(s): Nicolas Merienne, Cécile Meunier, Anne Schneider, Jonathan Seguin, Satish S Nair, Anne B Rocher, Stéphanie Le Gras, Céline Keime, Richard Faull, Luc Pellerin, Jean-Yves Chatton, Christian Neri, Karine Merienne, Nicole Déglon;
Published in: Cell reports, 2019, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2019.02.003

Sexual behavior and testis morphology in the BACHD rat model. (opens in new window)

Author(s): Novati, Arianna; Yu-Taeger, Libo; Gonzalez Menendez, Irene; Quintanilla Martinez, Leticia; Nguyen, Huu Phuc
Published in: PLoS ONE, 2018, ISSN 1932-6203
Publisher: Public Library of Science
DOI: 10.1371/journal.pone.0198338

Psychosisassociated DNA methylomic variation in Alzheimer's disease cortex. (opens in new window)

Author(s): Pishva E, Creese B, Smith AR, Viechtbauer W, Proitsi P, van den Hove DLA, Ballard C, Mill J, Lunnon K.
Published in: Neurobiology of Aging, 2020, ISSN 0197-4580
Publisher: Elsevier BV
DOI: 10.1016/j.neurobiolaging.2020.01.001

Whole exome sequencing study identifies novel rare and common Alzheimer's-Associated variants involved in immune response and transcriptional regulation. (opens in new window)

Author(s): Bis JC, Jian X, Kunkle BW, Chen Y, Hamilton-Nelson KL, Bush WS, Salerno WJ, Lancour D, Ma Y, Renton AE, Marcora E, Farrell JJ, Zhao Y, Qu L, Ahmad S, Amin N, Amouyel P, Beecham GW, Below JE, Campion D, Cantwell L, Charbonnier C, Chung J, Crane PK, Cruchaga C, Cupples LA, Dartigues JF, Debette S, Deleuze JF, Fulton L, Gabriel SB, Genin E, Gibbs RA, Goate A, Grenier-Boley B, Gupta N, Haines JL, Havu
Published in: Molecular psychiatry, 2020, ISSN 1359-4184
Publisher: Nature Publishing Group
DOI: 10.1038/s41380-018-0112-7

The Self-Inactivating KamiCas9 System for the Editing of CNS Disease Genes (opens in new window)

Author(s): Nicolas Merienne , Gabriel Vachey , Lucie de Longprez , Cécile Meunier , Virginie Zimmer , Guillaume Perriard , Mathieu Canales , Amandine Mathias , Lucas Herrgott , Tim Beltraminelli , Axelle Maulet , Thomas Dequesne , Catherine Pythoud , Maria Rey , Luc Pellerin , Emmanuel Brouillet , Anselme L Perrier, Renaud du Pasquier , Nicole Déglon;
Published in: Cell reports, 2017, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2017.08.075

In Vivo Transient and Partial Cell Reprogramming to Pluripotency as a Therapeutic Tool for Neurodegenerative Diseases (opens in new window)

Author(s): Tamanini, S., Comi, G.P. & Corti, S.
Published in: Molecular Neurobiology, Issue 55, 2018, Page(s) 6850–6862, ISSN 0893-7648
Publisher: Humana Press, Inc.
DOI: 10.1007/s12035-018-0888-0

Reconstituting Corticostriatal Network on-a-Chip Reveals the Contribution of the Presynaptic Compartment to Huntington's Disease (opens in new window)

Author(s): Virlogeux A, Moutaux E, Christaller W, Genoux A, Bruyère J, Fino E, Charlot B, Cazorla M, Saudou F.
Published in: Cell Reports, 2018, ISSN 2211-1247
Publisher: Cell Press
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Chondroitinase and antidepressants promote plasticity by releasing TRKB from dephosphorylating control of PTPσ in parvalbumin neurons (opens in new window)

Author(s): Lesnikova, A., Casarotto, P. C., Fred, S. M., Voipio, M., WInkel, F., Steinzeig, A., Antila, H., Umemori, J., Biojone, C., Castrén, E.
Published in: BioRxiv, 2020, ISSN 2692-8205
Publisher: BioRxiv
DOI: 10.1101/2020.08.13.249615

The small heat shock protein B8 (HSPB8) efficiently removes aggregating species of dipeptides produced in C9ORF72-related neurodegenerative diseases (opens in new window)

Author(s): Cristofani, Riccardo; Crippa, Valeria; Vezzoli, Giulia; Rusmini, Paola; Galbiati, Mariarita; Cicardi, Maria Elena; Meroni, Marco; Ferrari, Veronica; Tedesco, Barbara; Piccolella, Margherita; Messi, Elio; Carra, Serena; Poletti, Angelo
Published in: Cell Stress & Chaperones, Issue 2, 2018, ISSN 1355-8145
Publisher: Cell Stress Society International
DOI: 10.1007/s12192-017-0806-9

Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes (opens in new window)

Author(s): Malik R, Chauhan G, Traylor M, Sargurupremraj M, Okada Y, Mishra A, Rutten-Jacobs L, Giese AK, van der Laan SW, Gretarsdottir S, Anderson CD, Chong M, Adams HHH, Ago T, Almgren P, Amouyel P, […], Ikram MA, [...], Schmidt R [...], Tzourio C, [...], Stefansson K, Worrall BB, Kittner J, Seshadri S, Fornage M, Markus HS, Howson JMM, Kamatani Y, Debette S*, Dichgans M*.
Published in: Nature Genetics, 2018, ISSN 1061-4036
Publisher: Nature Publishing Group
DOI: 10.1038/s41588-018-0058-3

Dihydromyricetin and Salvianolic acid B inhibit alpha-synuclein aggregation and enhance chaperone-mediated autophagy. (opens in new window)

Author(s): Wu JZ, Ardah M, Haikal C, Svanbergsson A, Diepenbroek M, Vaikath NN, Li W, Wang ZY, Outeiro TF, El-Agnaf OM, Li JY.
Published in: Translational Neurodegeneration, 2019, ISSN 2047-9158
Publisher: BioMed Central Ltd.
DOI: 10.1186/s40035-019-0159-7

Inflammaging 2018: An update and a model (opens in new window)

Author(s): Claudio Franceschi 1, Alexey Zaikin 2, Susanna Gordleeva 3, Mikhail Ivanchenko 3, Francesca Bonifazi 4, Gianluca Storci 5, Massimiliano Bonafè
Published in: Semin Immunol, 2018, ISSN 1044-5323
Publisher: Academic Press
DOI: 10.1016/j.smim.2018.10.008

Chronic inflammation in the etiology of disease across the life span (opens in new window)

Author(s): Furman D, Campisi J, Verdin E, Carrera-Bastos P, Targ S, Franceschi C, Ferrucci L, Gilroy DW, Fasano A, Miller GW, Miller AH, Mantovani A, Weyand CM, Barzilai N, Goronzy JJ, Rando TA, Effros RB, Lucia A, Kleinstreuer N, Slavich GM.
Published in: Nature Medicine., 2019, ISSN 1078-8956
Publisher: Nature Publishing Group
DOI: 10.1038/s41591-019-0675-0

Molecular Mechanisms and Therapeutic Strategies in Spinocerebellar Ataxia Type 7 (opens in new window)

Author(s): Karam A, Trottier Y.
Published in: Advances in Experimental Medicine and Biology, 2018, ISSN 0065-2598
Publisher: Kluwer Academic/Plenum Publishers
DOI: 10.1007/978-3-319-71779-1_9

RNA Interference Therapy for Machado-Joseph Disease: Long-Term Safety Profile of Lentiviral Vectors Encoding Short Hairpin RNAs Targeting Mutant Ataxin-3 (opens in new window)

Author(s): Nóbrega C, Codêsso JM, Mendonça L, Pereira de Almeida L.
Published in: Human Gene Therapy, 2019, ISSN 1043-0342
Publisher: Mary Ann Liebert Inc.
DOI: 10.1089/hum.2018.157

Altered Brain Endothelial Cell Phenotype from a Familial Alzheimer Mutation and Its Potential Implications for Amyloid Clearance and Drug Delivery (opens in new window)

Author(s): Lotta E. Oikari; Rucha Pandit; Romal Stewart; Carla Cuni-Lopez; Hazel Quek; Ratneswary Sutharsan; Ratneswary Sutharsan; Laura M. Rantanen; Minna Oksanen; Šárka Lehtonen; Šárka Lehtonen; Carmela Maria de Boer; Carmela Maria de Boer; Jose M. Polo; Jose M. Polo; Jose M. Polo; Jürgen Götz; Jari Koistinaho; Jari Koistinaho; Anthony R. White
Published in: Stem Cell reports, Issue 1, 2020, ISSN 2213-6711
Publisher: Cell Press
DOI: 10.1016/j.stemcr.2020.03.011

Stroke target identification guided by astrocyte transcriptome analysis (opens in new window)

Author(s): Rakers C, Schleif M, Blank N, Matušková H, Ulas T, Händler K, Torres SV, Schumacher T, Tai K, Schultze JL, Jackson WS, Petzold GC.
Published in: Glia, 2019, ISSN 0894-1491
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/glia.23544

Antisense oligonucleotide therapeutics in neurodegenerative diseases: the case of polyglutamine disorders (opens in new window)

Author(s): Silva AC, Lobo DD, Martins IM, Lopes SM, Henriques C, Duarte SP, Dodart JC, Nobre RJ, Pereira de Almeida L.
Published in: Brain, 2020, ISSN 2632-1297
Publisher: Oxford Academy
DOI: 10.1093/brain/awz328

The Extent of Human Apolipoprotein A-I Lipidation Strongly Affects the β-Amyloid Efflux Across the Blood-Brain Barrier in vitro (opens in new window)

Author(s): Dal Magro R, Simonelli S, Cox A, Formicola B, Corti R, Cassina V, Nardo L, Mantegazza F, Salerno D, Grasso G, Deriu MA, Danani A, Calabresi L, Re F.
Published in: Frontiers in neuroscience, 2019, ISSN 1662-4548
Publisher: Frontiers Research Foundation
DOI: 10.3389/fnins.2019.00419

First-in-Rat Study of Human Alzheimer's Disease Tau Propagation (opens in new window)

Author(s): Smolek T, Jadhav S, Brezovakova V, Cubinkova V, Valachova B, Novak P, Zilka N.
Published in: Molecular Neurobiology, 2019, ISSN 0893-7648
Publisher: Humana Press, Inc.
DOI: 10.1007/s12035-018-1102-0

In vivo imaging of early signs of dopaminergic neuronal death in an animal model of Parkinson's disease (opens in new window)

Author(s): Rizzi N, Brunialti E, Cerri S, Cermisoni G, Levandis G, Cesari N, Maggi A, Blandini F, Ciana P.
Published in: Neurobiology of Disease, 2018, ISSN 0969-9961
Publisher: Academic Press
DOI: 10.1016/j.nbd.2018.02.005

PPARβ/δ-agonist GW0742 ameliorates dysfunction in fatty acid oxidation in PSEN1ΔE9 astrocytes (opens in new window)

Author(s): Konttinen H, Gureviciene I, Oksanen M, Grubman A, Loppi S, Huuskonen MT, Korhonen P, Lampinen R, Keuters M, Belaya I, Tanila H, Kanninen KM, Goldsteins G, Landreth G, Koistinaho J, Malm T.
Published in: Glia, 2019, ISSN 0894-1491
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/glia.23534

Comprehensive longitudinal study of epigenetic mutations in aging. (opens in new window)

Author(s): Wang Y, Karlsson R, Jylhävä J, Hedman ÅK, Almqvist C, Karlsson IK, Pedersen NL, Almgren M, Hägg S.
Published in: Clinical Epigenetics, 2019, ISSN 1868-7075
Publisher: Springer Verlag
DOI: 10.1186/s13148-019-0788-9

Age-related epigenetic changes in hippocampal subregions of four animal models of Alzheimer's disease (opens in new window)

Author(s): Roy Lardenoije, Daniël L.A. van den Hove, Monique Havermans, Anne van Casteren, Kevin X. Le, Roberta Palmour, Cynthia A. Lemere, Bart P.F. Rutten
Published in: Molecular and Cellular Neuroscience, Issue Volume 86, 2018, Page(s) Pages 1-15, ISSN 1044-7431
Publisher: Academic Press
DOI: 10.1016/j.mcn.2017.11.002

Accelerated bio-cognitive aging in Down syndrome: State of the art and possible deceleration strategies (opens in new window)

Author(s): Claudio Franceschi , Paolo Garagnani, Noémie Gensous, Maria Giulia Bacalini, Maria Conte , Stefano Salvioli
Published in: Ageing Cell, 2019, ISSN 1474-9718
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/acel.12903

Genetic correlations and genome-wide associations of cortical structure in general population samples of 22,824 adults. (opens in new window)

Author(s): Hofer E , Roshchupkin G , Adams HHH , Knol M , Lin H, Li S, Zare H , Ahmad S, Armstrong N , Satizabal C , Bernard M , Bis J , Gillespie N, Luciano M, Mishra A, Scholz M, Teumer A, Xia R, Jian X, Mosley T, Saba Y, Pirpamer L , Seiler S, Becker J, Carmichael O, Rotter J, Psaty B, Lopez O, Amin N , van der Lee S, Yang Q, Himali J, Maillard P, Beiser A, DeCarli C, Karama S, Lewis L, Bastin M, Deary I,
Published in: Nature communications, 2020, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-020-18367-y

Tau Stabilizes Chromatin Compaction. (opens in new window)

Author(s): Thomas Rico; Melissa Gilles; Alban Chauderlier; Thomas Comptdaer; Romain Magnez; Maggy Chwastyniak; Hervé Drobecq; Florence Pinet; Xavier Thuru; Luc Buée; Marie-Christine Galas; Bruno Lefebvre
Published in: "Frontiers in Cell and Developmental Biology, Frontiers media, 2021, 9, pp.740550. ⟨10.3389/fcell.2021.740550⟩", Issue 1, 2021, ISSN 2296-634X
Publisher: Frontiers media
DOI: 10.3389/fcell.2021.740550

The genetic architecture of the human cerebral cortex (opens in new window)

Author(s): Grasby KL, Jahanshad N, Painter JN, Colodro-Conde L, Bralten J, Hibar DP, Lind PA, Pizzagalli F, Ching CRK, McMahon MAB, Shatokhina N, Zsembik LCP, Thomopoulos SI, Zhu AH, Strike LT, Agartz I, Alhusaini S, Almeida MAA, Alnæs D, Amlien IK, Andersson M, Ard T, Armstrong NJ, Ashley-Koch A, Atkins JR, Bernard M, Brouwer RM, Buimer EEL, Bülow R, Bürger C, Cannon DM, Chakravarty M, Chen Q, Cheung JW,
Published in: Science, 2020, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.aay6690

Efficient protein production inspired by how spiders make silk (opens in new window)

Author(s): Kronqvist N, Sarr M, Lindqvist A, Nordling K, Otikovs M, Venturi L, Pioselli B, Purhonen P, Landreh M, Biverstål H, Toleikis Z, Sjöberg L, Robinson CV, Pelizzi N, Jörnvall H, Hebert H, Jaudzems K, Curstedt T, Rising A, Johansson J.
Published in: Nature communications, 2017, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/ncomms15504

Synapse-to-nucleus communication: from developmental disorders to Alzheimer's disease (opens in new window)

Author(s): Marcello E, Di Luca M, Gardoni F
Published in: Current opinion in neurobiology, 2018, ISSN 0959-4388
Publisher: Elsevier BV
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HSC70 expression is reduced in lymphomonocytes of sporadic ALS patients and contributes to TDP-43 accumulation. (opens in new window)

Author(s): Arosio A., Cristofani R., Pansarasa O., Crippa V., Riva C., Sirtori R., Menendez V., Riva N., Gerardi F., Lunetta C., Cereda C., Poletti A., Ferrarese C., Tremolizzo L., Sala G.
Published in: Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, 2020, ISSN 2167-8421
Publisher: Informa Healthcare
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PSEN1 Mutant iPSC-Derived Model Reveals Severe Astrocyte Pathology in Alzheimer's Disease. (opens in new window)

Author(s): Oksanen, M; Petersen, AJ; Naumenko, N; Puttonen, K; Lehtonen, S; Olive, MG; Shakirzyanova, A; Leskela, S; Sarajarvi, T; Viitanen, M; Rinne, JO; Hiltunen, M; Haapasalo, A; Giniatullin, R; Tavi, P; Zhang, SC; Kanninen, KM; Hamalainen, RH; Koistinaho, J; Koistinaho, J
Published in: Stem Cell Reports, Issue Vol 9, Iss 6,, 2017, Page(s) 1885-1897, ISSN 2213-6711
Publisher: Cell Press
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Simple and Fast SEC-Based Protocol to Isolate Human Plasma-Derived Extracellular Vesicles for Transcriptional Research (opens in new window)

Author(s): Gaspar L, Santana MM, Henriques C, Ribeiro-Rodrigues T, Girão H, Nobre RJ, Pereira de Almeida L.
Published in: Molecular Therapy - Methods and Clinical Development, 2020, ISSN 2329-0501
Publisher: CellPress
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Sideritis spp. Extracts Enhance Memory and Learning in Alzheimer's β-Amyloidosis Mouse Models and Aged C57Bl/6 Mice (opens in new window)

Author(s): Hofrichter J, Krohn M, Schumacher T, Lange C, Feistel B, Walbroel B, Pahnke J
Published in: Journal of Alzheimer's Disease, 2016, ISSN 1387-2877
Publisher: IOS Press
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Genetic architecture of subcortical brain structures in 38,851 individuals (opens in new window)

Author(s): Claudia L. Satizabal, Hieab H. H. Adams, Derrek P. Hibar, Charles C. White, Maria J. Knol, Jason L. Stein, Markus Scholz, Muralidharan Sargurupremraj, Neda Jahanshad, Gennady V. Roshchupkin, Albert V. Smith, Joshua C. Bis, Xueqiu Jian, Michelle Luciano, Edith Hofer, Alexander Teumer, Sven J. van der Lee, Jingyun Yang, Lisa R. Yanek, Tom V. Lee, Shuo Li, Yanhui Hu, Jia Yu Koh, John D. Eicher, Sylva
Published in: Nature Genetics, 2019, ISSN 1061-4036
Publisher: Nature Publishing Group
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Developmental Expression of 4-Repeat-Tau Induces Neuronal Aneuploidy in Drosophila Tauopathy Models (opens in new window)

Author(s): Nicolas Malmanche; Nicolas Malmanche; Nicolas Malmanche; Pierre Dourlen; Pierre Dourlen; Pierre Dourlen; Marc Gistelinck; Florie Demiautte; Florie Demiautte; Florie Demiautte; Nichole Link; Cloé Dupont; Cloé Dupont; Cloé Dupont; Lies Vanden Broeck; Elisabeth Werkmeister; Philippe Amouyel; Philippe Amouyel; Philippe Amouyel; Antonino Bongiovanni; Hélène Bauderlique; Dieder Moechars; Anne Royou
Published in: SCIENTIFIC REPORTS, Issue 1, 2017, ISSN 2045-2322
Publisher: Nature Publishing Group
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Reporter-Based Screens for the Ubiquitin/Proteasome System (opens in new window)

Author(s): Gierisch, M.1, T.A. Giovannucci1, Nico P. Dantuma
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Publisher: Blackwell Publishing Inc.
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Protocol for the Characterization of the Cytosine-Adenine-Guanine Tract and Flanking Polymorphisms in Machado-Joseph Disease: Impact on Diagnosis and Development of Gene-Based Therapies (opens in new window)

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Publisher: American Society for Investigative Pathology
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PSEN1ΔE9, APPswe, and APOE4 Confer Disparate Phenotypes in Human iPSC-Derived Microglia (opens in new window)

Author(s): Konttinen H, Cabral-da-Silva MEC, Ohtonen S, Wojciechowski S, Shakirzyanova A, Caligola S, Giugno R, Ishchenko Y, Hernández D, Fazaludeen MF, Eamen S, Budia MG,Fagerlund I, Scoyni F, Korhonen P, Huber N, Haapasalo A, Hewitt AW, Vickers J, Smith GC, Oksanen M, Graff C, Kanninen KM, Lehtonen S, Propson N, Schwartz MP, Pébay A, Koistinaho J, Ooi L, Malm T.
Published in: Stem cell reports, 2019, ISSN 2213-6711
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The BACHD rat model of Huntington disease shows slowed learning in a Go/No-Go-like test of visual discrimination (opens in new window)

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An aberrant phase transition of stress granules triggered by misfolded protein and prevented by chaperone function (opens in new window)

Author(s): Mateju, Daniel; Franzmann, Titus M; Patel, Avinash; Kopach, Andrii; Boczek, Edgar E; Maharana, Shovamayee; Lee, Hyun O; Carra, Serena; Hyman, Anthony A; Alberti, Simon
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Publisher: Nature Publishing Group
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A Biomarker for Alzheimer's Disease Based on Patterns of Regional Brain Atrophy (opens in new window)

Author(s): Frenzel S., Wittfeld K., Habes M., Klinger-König J., Bülow R., Völzke H., Grabe HJ.
Published in: Frontiers in Psychiatry, 2020, ISSN 1664-0640
Publisher: Frontiers Research Foundation
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Inflammaging: a new immune–metabolic viewpoint for age-related diseases (opens in new window)

Author(s): Franceschi, C., Garagnani, P., Parini, P. et al.
Published in: Nat Rev Endocrinol, 2018, ISSN 1759-5029
Publisher: Nature Publishing Group
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C@PA: Computer-Aided Pattern Analysis to Predict Multitarget ABC Transporter Inhibitors. (opens in new window)

Author(s): Vigneshwaran Namasivayam; Katja Silbermann; Michael Wiese; Jens Pahnke; Sven Marcel Stefan; Sven Marcel Stefan; Sven Marcel Stefan
Published in: Journal of Medicinal Chemistry, 2021, ISSN 0022-2623
Publisher: American Chemical Society
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Burden of Dilated Perivascular Spaces, an Emerging Marker of Cerebral Small Vessel Disease, Is Highly Heritable (opens in new window)

Author(s): Duperron MG, Tzourio C, Sargurupremraj M, Mazoyer B, Soumaré A, Schilling S, Amouyel P, Chauhan G, Zhu YC, Debette S.
Published in: Stroke, 2018, ISSN 0039-2499
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iPlasticity: Induced juvenile-like plasticity in the adult brain as a mechanism of antidepressants (opens in new window)

Author(s): Umemori, J., Winkel, F., Didio, G., Llach Pou, M., Castren, E.
Published in: Psychiatry and Clinical Neurosciences, 2018, ISSN 1323-1316
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Extracellular vesicles: Novel promising delivery systems for therapy of brain diseases (opens in new window)

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Published in: Journal of Controlled Release, Issue Volume 262, 2017, Page(s) Pages 247-258, ISSN 0168-3659
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Quantitating denaturation by formic acid: imperfect repeats are essential to the stability of the functional amyloid protein FapC (opens in new window)

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Glucocerebrosidase mutations and synucleinopathies: Toward a model of precision medicine. (opens in new window)

Author(s): Fabio Blandini MD, Roberto Cilia MD, Silvia Cerri PhD, Gianni Pezzoli MD, Anthony H.V. Schapira MD, Stephen Mullin PhD, José L. Lanciego MD, PhD
Published in: Movement Disorders, 2019, ISSN 0885-3185
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Protein Phase Separation: A New Phase in Cell Biology (opens in new window)

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Impact of Chronic BDNF Depletion on GABAergic Synaptic Transmission in the Lateral Amygdala (opens in new window)

Author(s): Meis S, Endres T, Munsch T, Lessmann V.
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Peripheral Inflammation Regulates CNS Immune Surveillance Through the Recruitment of Inflammatory Monocytes Upon Systemic α-Synuclein Administration (opens in new window)

Author(s): Peralta Ramos J, Iribarren P, Bousset L, Melki R, Baekelandt V, Van der Perren A.
Published in: Frontiers in immunology, 2019, ISSN 1664-3224
Publisher: Lausanne Frontiers Media S.A.
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Allele-Specific Methylation of SPDEF: A Novel Moderator of Psychosocial Stress and Substance Abuse (opens in new window)

Author(s): Nicole Tay, M.Sc., Christine Macare, Ph.D., Yun Liu, Ph.D., Barbara Ruggeri, Ph.D., Tianye Jia, Ph.D., Congying Chu, Ph.D., Francesca Biondo, Ph.D., Alex Ing, Ph.D., Qiang Luo, Ph.D., Daniil Sarkysian, Ph.D., Tobias Banaschewski, M.D., Ph.D., Gareth J. Barker, Ph.D., Arun L.W. Bokde, Ph.D., Uli Bromberg, Ph.D., Christian Büchel, M.D., Erin Burke Quinlan, Ph.D., Sylvane Desrivières, Ph.D., Herta
Published in: The American Journal of Psychiatry, 2019, ISSN 0002-953X
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FUS pathology in ALS is linked to alterations in multiple ALS-associated proteins and rescued by drugs stimulating autophagy (opens in new window)

Author(s): Marrone L, Drexler HCA, Wang J, Tripathi P, Distler T, Heisterkamp P, Anderson EN, Kour S, Moraiti A, Maharana S, Bhatnagar R, Belgard TG, Tripathy V, Kalmbach N, Hosseinzadeh Z, Crippa V, Abo-Rady M, Wegner F, Poletti A, Troost D, Aronica E, Busskamp V, Weis J, Pandey UB, Hyman AA, Alberti S, Goswami A, Sterneckert J
Published in: Acta Neuropathologica, 2019, ISSN 1432-0533
Publisher: Springer
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Structural studies of amyloid-β peptides: Unlocking the mechanism of aggregation and the associated toxicity (opens in new window)

Author(s): Aleksis R, Oleskovs F, Jaudzems K, Pahnke J, Biverstal H,
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Genetically Elevated LDL Associates with Lower Risk of Intracerebral Hemorrhage (opens in new window)

Author(s): Guido J. Falcone MD, ScD, MPH,Elayna Kirsch BA,Julian N. Acosta MD,Rommell B. Noche MS,Audrey Leasure BS,Sandro Marini MD,Jaeyoon Chung PhD,Magdy Selim MD, PhD,James F. Meschia MD,Devin L. Brown MD, MS,Bradford B. Worrall MD, MSc,David L. Tirschwell MD, MSc,Jeremiasz M. Jagiella MD, PhD,Helena Schmidt MD,Jordi Jimenez-Conde MD, PhD,Israel Fernandez-Cadenas PhD,Arne Lindgren MD,Agnieszka Slowik MD,
Published in: Annals of Neurology, 2020, ISSN 0364-5134
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Impairment of the glymphatic system after diabetes. (opens in new window)

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Published in: Journal of Cerebral Blood Flow and Metabolism, 2016, ISSN 0271-678X
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TrkB-ICD Fragment, Originating From BDNF Receptor Cleavage, Is Translocated to Cell Nucleus and Phosphorylates Nuclear and Axonal Proteins (opens in new window)

Author(s): Fonseca-Gomes, J., Jerónimo-Santos, A., Lesnikova, A., Casarotto, P., Castrén, E., Sebastião, A. M., and Diógenes, M. J.
Published in: Frontiers in Molecular Neuroscience, 2019, ISSN 1662-5099
Publisher: Frontiers Research Foundation
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A tool for analysis and visualization of spatial transcriptomics datasets. (opens in new window)

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Published in: Bioinformatics, 2019, ISSN 1367-4811
Publisher: Oxford Academic
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Transforming growth factor beta 1 signaling is altered in the spinal cord and muscle of amyotrophic lateral sclerosis mice and patients. (opens in new window)

Author(s): Meroni M., Crippa V., Cristofani R., Rusmini P., Cicardi M.E., Messi E., Piccolella M., Tedesco B., Ferrari V., Sorarù G., M., Pennuto M, Poletti A., Galbiati M.
Published in: Neurobiology of Disease, 2019, ISSN 0969-9961
Publisher: Academic Press
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Vesicular ATP-binding cassette transporters in human disease: relevant aspects of their organization for future drug development (opens in new window)

Author(s): Katja Stefan; Lionel Yi Wen Leck; Lionel Yi Wen Leck; Vigneshwaran Namasivayam; Pablo Bascuñana; Michael L.-H. Huang; Patrick J. Riss; Jens Pahnke; Patric J. Jansson; Patric J. Jansson; Sven Marcel Stefan
Published in: Future Science, 2020, ISSN 1756-8919
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Protease resistance of infectious prions is suppressed by removal of a single atom in the cellular prion protein (opens in new window)

Author(s): Henning Leske, Simone Hornemann, Uli Simon Herrmann, Caihong Zhu, Paolo Dametto, Bei Li, Florent Laferriere, Magdalini Polymenidou, Pawel Pelczar, Regina Rose Reimann, Petra Schwarz, Elisabeth Jane Rushing, Kurt Wüthrich , Adriano Aguzzi
Published in: PLOS ONE, 2017, ISSN 1932-6203
Publisher: Public Library of Science
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Inflammatory markers and imaging patterns of advanced brain aging in the general population (opens in new window)

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Published in: Brain Imaging and Behavior, 2020, ISSN 1931-7557
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Parallel profiling of DNA methylation and hydroxymethylation highlights neuropathology-associated epigenetic variation in Alzheimer's disease (opens in new window)

Author(s): Smith, Adam R.; Smith, Rebecca G.; Pishva, Ehsan; Hannon, Eilis; Roubroeks, Janou A. Y.; Burrage, Joe; Troakes, Claire; Al-Sarraj, Safa; Sloan, Carolyn; Mill, Jonathan; van den Hove, Daniel L.; Lunnon, Katie
Published in: Clinical epigenetics, Issue vol. 11, 2019, ISSN 1868-7075
Publisher: Springer Verlag
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The structural differences between patient-derived α-synuclein strains dictate characteristics of Parkinson's disease, multiple system atrophy and dementia with Lewy bodies (opens in new window)

Author(s): Van der Perren A, Gelders G, Fenyi A, Bousset L, Brito F, Peelaerts W, Van den Haute C, Gentleman S, Melki R, Baekelandt V
Published in: Acta neuropathologica, 2020, ISSN 0001-6322
Publisher: Springer Verlag
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The SAC1 domain in synaptojanin is required for autophagosome maturation at presynaptic terminals (opens in new window)

Author(s): Roeland Vanhauwaert 1 2, Sabine Kuenen 1 2, Roy Masius 3, Adekunle Bademosi 4, Julia Manetsberger 1 2, Nils Schoovaerts 1 2, Laura Bounti 1 2, Serguei Gontcharenko 1 2, Jef Swerts 1 2, Sven Vilain 1 2, Marina Picillo 5, Paolo Barone 5, Shashini T Munshi 6, Femke Ms de Vrij 6, Steven A Kushner 6, Natalia V Gounko 1 2 7, Wim Mandemakers 3, Vincenzo Bonifati 3, Frederic A Meunier 4, Sandra-Fausia Sou
Published in: EMBO J, 2017, ISSN 0261-4189
Publisher: Nature Publishing Group
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Long Term Gene Expression in Human Induced Pluripotent Stem Cells and Cerebral Organoids to Model a Neurodegenerative Disease. (opens in new window)

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Published in: Front. Cell. Neurosci, 2020, ISSN 1662-5102
Publisher: Frontiers Research Foundation
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Richness and ecosystem development across faecal snapshots of the gut microbiota (opens in new window)

Author(s): Falony G, Vieira-Silva S, Raes J.
Published in: Nature microbiology, 2018, ISSN 2058-5276
Publisher: Nature microbiology
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Identification of neurobehavioural symptom groups based on shared brain mechanisms (opens in new window)

Author(s): Alex Ing, Philipp G Sämann, Congying Chu, Nicole Tay, Francesca Biondo, Gabriel Robert, Tianye Jia, Thomas Wolfers, Sylvane Desrivières, Tobias Banaschewski, Arun L W Bokde, Uli Bromberg, Christian Büchel, Patricia Conrod, Tahmine Fadai, Herta Flor, Vincent Froui, Hugh Garavan, Philip A Spechler, Penny Gowland, Yvonne Grimmer, Andreas Heinz, Bernd Ittermann, Viola Kappel, Jean-Luc Martinot, And
Published in: Nature human behaviour, 2019, ISSN 2397-3374
Publisher: Nature human behaviour
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Psychosocial Stress and Brain Function in Adolescent Psychopathology (opens in new window)

Author(s): Erin Burke Quinlan, Ph.D., Anna Cattrell, Ph.D., Tianye Jia, Ph.D., Eric Artiges, M.D., Ph.D., Tobias Banaschewski, M.D., Ph.D, Gareth Barker, Ph.D., Arun L.W. Bokde, Ph.D., Uli Bromberg, Dipl.-Psych., Christian Büchel, M.D., Rüdiger Brühl, Ph.D., Patricia J. Conrod, Ph.D., Sylvane Desrivieres, Ph.D., Herta Flor, Ph.D., Vincent Frouin, Ph.D., Jürgen Gallinat, M.D., Hugh Garavan, Ph.D., Penny G
Published in: The american journal of psychiatry, 2017, ISSN 0002-953X
Publisher: American Psychiatric Publishing, Inc.
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The autophagy-enhancing drug carbamazepine improves neuropathology and motor impairment in mouse models of Machado–Joseph disease (opens in new window)

Author(s): Ana Vasconcelos-Ferreira; Sara Carmo-Silva; José Miguel Codêsso; Patrick Silva; Alberto R. M. Martinez; Marcondes C. França; Clévio Nóbrega; Luís Pereira de Almeida
Published in: Neuropathology and Applied Neurobiology, Issue 2, 2022, ISSN 0305-1846
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Cultivation and characterization of human midbrain organoids in sensor integrated microfluidic chips (opens in new window)

Author(s): Spitz S., Zanetti C., Bolognin S., Muwanigwa M.N., Smits L., Berger E., Jäger C., Harasek M., Schwamborn J.C., Peter Ertl
Published in: bioRxiv, 2019, ISSN 2692-8205
Publisher: bioRxiv
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Reducing pericyte-derived scarring promotes recovery after spinal cord injury. (opens in new window)

Author(s): Oliveira Dias D, Kim H, Holl D, Werne Solnestam B, Lundeberg J, Carlén M, Göritz C* and Frisén J*.
Published in: Cell, 2018, ISSN 0092-8674
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Alzheimer’s disease-associated (hydroxy)methylomic changes in the brain and blood (opens in new window)

Author(s): Lardenoije, Roy; Roubroeks, Janou A. Y.; Pishva, Ehsan; Leber, Markus; Wagner, Holger; Iatrou, Artemis; Smith, Adam R.; Smith, Rebecca G.; Eijssen, Lars M. T.; Kleineidam, Luca; Kawalia, Amit; Hoffmann, Per; Luck, Tobias; Riedel-Heller, Steffi; Jessen, Frank; Maier, Wolfgang; Wagner, Michael; Hurlemann, René; Kenis, Gunter; Ali, Muhammad; del Sol, Antonio; Mastroeni, Diego; Delvaux, Elaine; Colem
Published in: Clinical epigenetics, 2019, ISSN 1868-7075
Publisher: Springer Verlag
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Biological Age Predictors (opens in new window)

Author(s): Jylhävä J, Pedersen NL, Hägg S
Published in: EBioMedicine, 2017, ISSN 2352-3964
Publisher: Elsevier BV
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Epigenome-wide meta-analysis of blood DNA methylation and its association with subcortical volumes: findings from the ENIGMA Epigenetics Working Group (opens in new window)

Author(s): Tianye Jia, Congying Chu, Yun Liu, Jenny van Dongen, Evangelos Papastergios, Nicola J. Armstrong, Mark E. Bastin, Tania Carrillo-Roa, Anouk den Braber, Mathew Harris, Rick Jansen, Jingyu Liu, Michelle Luciano, Anil P. S. Ori, Roberto Roiz Santiañez, Barbara Ruggeri, Daniil Sarkisyan, Jean Shin, Kim Sungeun, Diana Tordesillas Gutiérrez, Dennis van’t Ent, David Ames, Eric Artiges, Georgy Bakalki
Published in: Molecular psychiatry, 2021, ISSN 1359-4184
Publisher: Nature Publishing Group
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Physico-Pathologic Mechanisms Involved in Neurodegeneration: Misfolded Protein-Plasma Membrane Interactions (opens in new window)

Author(s): Shrivastava AN, Aperia A, Melki R, Triller A.
Published in: Neuron, 2017, ISSN 0896-6273
Publisher: Cell Press
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Neurobehavioural characterisation and stratification of reinforcement-related behaviour (opens in new window)

Author(s): Tianye Jia, Alex Ing, Erin Burke Quinlan, Nicole Tay, Qiang Luo, Biondo Francesca, Tobias Banaschewski, Gareth J. Barker, Arun L. W. Bokde, Uli Bromberg, Christian Büchel, Sylvane Desrivières, Jianfeng Feng, Herta Flor, Antoine Grigis, Hugh Garavan, Penny Gowland, Andreas Heinz, Bernd Ittermann, Jean-Luc Martinot, Marie-Laure Paillère Martinot, Frauke Nees, Dimitri Papadopoulos Orfanos, Tomáš
Published in: Nature Human Behaviour, 2020, ISSN 2397-3374
Publisher: Nature Human Behaviour
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"Corrigendum to ""Morphometric analysis of the cerebral expression of ATP-binding cassette transporter protein ABCB1 in chronic schizophrenia: Circumscribed deficits in the habenula"" [Schizophr. Res. 2016 Nov;177(1-3):52-58]" (opens in new window)

Author(s): Bernstein HG, Hildebrandt J, Dobrowolny H, Steiner J, Bogerts B, Pahnke J,
Published in: Schizophrenia Research, 2018, ISSN 0920-9964
Publisher: Elsevier BV
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Fibroblasts of Machado Joseph Disease patients reveal autophagy impairmen (opens in new window)

Author(s): Isabel Onofre1,2,*, Nuno Mendonça1,3,4,*, Sara Lopes1,5, Rui Nobre1,5, Joana Barbosa de Melo1,4,6, Isabel Marques Carreira1,4,6, Cristina Januário3,4, António Freire Gonçalves3,4 & Luis Pereira de Almeida1,2
Published in: Scientifc Reports, 2016, ISSN 2045-2322
Publisher: Nature Publishing Group
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Machine Learning-Supported Analyses Improve Quantitative Histological Assessments of Amyloid-β Deposits and Activated Microglia (opens in new window)

Author(s): Bascunana P, Brackhan M, Pahnke J,
Published in: Journal of Alzheimer's Disease, 2021, ISSN 1387-2877
Publisher: IOS Press
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Differential overexpression of SERPINA3 in human prion diseases (opens in new window)

Author(s): Vanni, S., Moda, F., Zattoni, M. et al.
Published in: Scientific Reports, Issue 7, 2017, Page(s) 15637, ISSN 2045-2322
Publisher: Nature Publishing Group
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Leukocyte Telomere Length Is Related to Brain Parenchymal Fraction and Attention/Speed in the Elderly: Results of the Austrian Stroke Prevention Study. (opens in new window)

Author(s): Piyush Gampawar; Reinhold Schmidt; Helena Schmidt
Published in: Frontiers in Psychiatry, Vol 11 (2020), 2020, ISSN 1664-0640
Publisher: Frontiers Research Foundation
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Targeting Neuroinflammation to Treat Alzheimer's Disease (opens in new window)

Author(s): Ardura-Fabregat A, Boddeke EWGM, Boza-Serrano A, Brioschi S, Castro-Gomez S, Ceyzériat K, Dansokho C, Dierkes T, Gelders G, Heneka MT, Hoeijmakers L, Hoffmann A, Iaccarino L, Jahnert S, Kuhbandner K, Landreth G, Lonnemann N, Löschmann PA, McManus RM, Paulus A, Reemst K, Sanchez-Caro JM, Tiberi A, Van der Perren A, Vautheny A, Venegas C, Webers A, Weydt P, Wijasa TS, Xiang X, Yang Y
Published in: CNS Drugs, 2017, ISSN 1172-7047
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Millifluidic culture improves human midbrain organoid vitality and differentiation (opens in new window)

Author(s): Emanuel Berger,aChiara Magliaro,bNicole Paczia,cAnna S. Monzel,aPaul Antony,dCarole L. Linster,cSilvia Bolognin,aArti Ahluwaliaband Jens C. Schwamborn
Published in: Lab Chip, 2018, ISSN 1473-0197
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Are rodent models of Parkinson's disease behaving as they should ? (opens in new window)

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Dynamic Arc SUMOylation and Selective Interaction with F-Actin-Binding Protein Drebrin A in LTP Consolidation In Vivo (opens in new window)

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Published in: Frontiers in Synaptic Neuroscience, 2017, ISSN 1663-3563
Publisher: Frontiers Research Foundation
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Fingolimod as a Treatment in Neurologic Disorders Beyond Multiple Sclerosis (opens in new window)

Author(s): Pablo Bascuñana; Luisa Möhle; Mirjam Brackhan; Jens Pahnke
Published in: Drugs in R&D, 2020, ISSN 1174-5886
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Gut microbiota changes in the extreme decades of human life: a focus on centenarians (opens in new window)

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Published in: Cellular and Molecular Life Sciences, Issue 75, 2018, Page(s) 129–148, ISSN 1420-682X
Publisher: Birkhauser Verlag
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Unravelling Endogenous MicroRNA System Dysfunction as a New Pathophysiological Mechanism in Machado-Joseph Disease (opens in new window)

Author(s): Vitor Carmona,Janete Cunha-Santos, Isabel Onofre,Ana Teresa Simões,Udaya Vijayakumar,Beverly L. Davidson, and Luís Pereira de Almeida
Published in: Molecular therapy, 2017, ISSN 1525-0016
Publisher: Nature Publishing Group
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RNA buffers the phase separation behavior of prion-like RNA binding proteins (opens in new window)

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Published in: Science, Issue 1, 2018, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
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Amplifying mitochondrial function rescues adult neurogenesis in a mouse model of Alzheimer's disease (opens in new window)

Author(s): Richetin K, Moulis M, Millet A, Arràzola MS, Andraini T, Hua J, Davezac N, Roybon L, Belenguer P, Miquel MC, Rampon C.
Published in: Neurobiology of Disease, Issue Volume 102, 2017, Page(s) 113-124, ISSN 0969-9961
Publisher: Academic Press
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Nanomedicine for the Treatment of Alzheimer's Disease (opens in new window)

Author(s): Formicola B, Cox A, Dal Magro R, Masserini M, Re F.
Published in: Journal of biomedical nanotechnology, 2019, ISSN 1550-7033
Publisher: American Scientific Publishers
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Intrinsic Xenobiotic Resistance of the Intestinal Stem Cell Niche (opens in new window)

Author(s): Yuemin Celina Chee; Jens Pahnke; Jens Pahnke; Jens Pahnke; Ralph M. Bunte; Vikrant A. Adsool; Babita Madan; David M. Virshup; David M. Virshup
Published in: Developmental Cell, 2018, ISSN 1534-5807
Publisher: Cell Press
DOI: 10.1016/j.devcel.2018.07.023

CNS-Specific Synthesis of Interleukin 23 Induces a Progressive Cerebellar Ataxia and the Accumulation of Both T and B Cells in the Brain: Characterization of a Novel Transgenic Mouse Model. (opens in new window)

Author(s): Nitsch L, Zimmermann J, Krauthausen M, Hofer MJ, Saggu R, Petzold GC, Heneka MT, Getts DR, Becker A, Campbell IL, Müller M.
Published in: MOL NEUROBIOL, 2019, ISSN 0893-7648
Publisher: Humana Press, Inc.
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Prion-like low-complexity sequences: Key regulators of protein solubility and phase behavior (opens in new window)

Author(s): Franzmann T, Alberti S
Published in: Journal of Biological Chemistry, 2018, ISSN 0021-9258
Publisher: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1074/jbc.tm118.001190

There Is an Inclusion for That: Material Properties of Protein Granules Provide a Platform for Building Diverse Cellular Functions (opens in new window)

Author(s): Daniel Kaganovich
Published in: Trends in Biochemical Sciences, 2017, ISSN 0968-0004
Publisher: Elsevier BV
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Early Cognitive Training Rescues Remote Spatial Memory but Reduces Cognitive Flexibility in Alzheimer's Disease Mice. (opens in new window)

Author(s): Surya Prakash Rai; Markus Krohn; Markus Krohn; Jens Pahnke
Published in: Journal of Alzheimers Disease & Parkinsonism., Issue 1, 2020, ISSN 1387-2877
Publisher: IOS Press
DOI: 10.3233/jad-200161

Restoring brain cholesterol turnover improves autophagy and has therapeutic potential in mouse models of spinocerebellar ataxia. (opens in new window)

Author(s): Nóbrega, Clévio; Mendonça, Liliana; Marcelo, Adriana; Lamazière, Antonin; Tomé, Sandra; Despres, Gaetan; Matos, Carlos A.; Mechmet, Fatich; Langui, Dominique; den Dunnen, Wilfred; de Almeida, Luis Pereira; Cartier, Nathalie; Alves, Sandro
Published in: Acta neuropothologica, 2019, ISSN 0001-6322
Publisher: Springer Verlag
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Genetic variation underlying cognition and its relation with neurological outcomes and brain imaging. (opens in new window)

Author(s): Maria J. Knol; Alis Heshmatollah; Lotte G.M. Cremers; M. Kamran Ikram; André G. Uitterlinden; Cornelia M. van Duijn; Wiro J. Niessen; Wiro J. Niessen; Meike W. Vernooij; M. Arfan Ikram; Hieab H.H. Adams
Published in: Aging, 2019, ISSN 2589-9589
Publisher: Impact Journals LLC
DOI: 10.18632/aging.101844

The choroid plexus in health and in disease: dialogues into and out of the brain (opens in new window)

Author(s): Marques F, Sousa JC, Brito MA, Pahnke J, Santos C, Correia-Neves M, Palha JA,
Published in: Neurobiology of disease, 2017, ISSN 0969-9961
Publisher: Academic Press
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Age-related ultrastructural changes of the basement membrane in the mouse blood-brain barrier (opens in new window)

Author(s): Ceafalan, Laura Cristina; Fertig, Tudor Emanuel; Gheorghe, Teodora Cristina; Hinescu, Mihail Eugen; Popescu, Bogdan Ovidiu; Pahnke, Jens; Gherghiceanu, Mihaela
Published in: Journal of Cellular and Molecular Medicine, 2018, ISSN 1582-1838
Publisher: Wiley-Blackwell
DOI: 10.1111/jcmm.13980

The small heat shock protein B8 (HSPB8) modulates proliferation and migration of breast cancer cells (opens in new window)

Author(s): Piccolella M., Crippa V., Cristofani R., Rusmini P., Galbiati M., Cicardi M.E., Meroni M., Ferri N., Morelli F.F., Carra S., Messi E., Poletti A.
Published in: Oncotarget, 2017, ISSN 1949-2553
Publisher: Impact Journals
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Detection and Prediction of Mild Cognitive Impairment in Alzheimer's Disease Mice. (opens in new window)

Author(s): Surya Prakash Rai; Pablo Bascuñana; Mirjam Brackhan; Markus Krohn; Luisa Möhle; Kristin Paarmann; Jens Pahnke
Published in: J Alzheimers Dis, Issue 2, 2020, ISSN 1387-2877
Publisher: IOS Press
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Evaluating β-amyloidosis progression in Alzheimer's disease with Mueller polarimetry (opens in new window)

Author(s): Borovkova M, Bykov A, Popov A, Pierangelo A, Novikova T, Pahnke J, Meglinski I
Published in: Biomedical Optics Express, 2020, ISSN 2156-7085
Publisher: The Optical Society
DOI: 10.1364/boe.396294

From Stroke to Dementia: a Comprehensive Review Exposing Tight Interactions Between Stroke and Amyloid-β Formation (opens in new window)

Author(s): Goulay R, Mena Romo L, Hol EM, Dijkhuizen RM.
Published in: Translational stroke research, 2020, ISSN 1868-4483
Publisher: Springer Pub. Co.,
DOI: 10.1007/s12975-019-00755-2

The concerted amyloid-beta clearance of LRP1 and ABCB1/P-gp across the blood-brain barrier is linked by PICALM (opens in new window)

Author(s): Storck SE, Hartz AMS, Bernard J, Wolf A, Kachlmeier A, Mahringer A, Weggen S, Pahnke J, Pietrzik CU
Published in: Brain, Behavior, and Immunity, 2018, ISSN 0889-1591
Publisher: Academic Press
DOI: 10.1016/j.bbi.2018.07.017

Differential Exchange of Multifunctional Liposomes Between Glioblastoma Cells and Healthy Astrocytes via Tunneling Nanotubes (opens in new window)

Author(s): Formicola B, D'Aloia A, Dal Magro R, Stucchi S, Rigolio R, Ceriani M, Re F.
Published in: Frontiers in bioengineering and biotechnology, 2019, ISSN 2296-4185
Publisher: Lausanne: Frontiers Media S.A.
DOI: 10.3389/fbioe.2019.00403

SCA7 Mouse Cerebellar Pathology Reveals Preferential Downregulation of Key Purkinje Cell-Identity Genes and Shared Disease Signature with SCA1 and SCA2 (opens in new window)

Author(s): Niewiadomska-Cimicka A, Doussau F, Perot JB, Roux MJ, Keime C, Hache A, Piguet F, Novati A, Weber C, Yalcin B, Meziane H, Champy MF, Grandgirard E, Karam A, Messaddeq N, Eisenmann A, Brouillet E, Nguyen HHP, Flament J, Isope P and Trottier Y.
Published in: The journal of neuroscience, 2021, ISSN 0270-6474
Publisher: Society for Neuroscience
DOI: 10.1523/jneurosci.1882-20.2021

Prying into the Prion Hypothesis for Parkinson's Disease (opens in new window)

Author(s): Brundin P, Melki R
Published in: The Journal of Neuroscience, 2017, ISSN 0270-6474
Publisher: Society for Neuroscience
DOI: 10.1523/jneurosci.1788-16.2017

Endothelial LRP1 - A Potential Target for the Treatment of Alzheimer's Disease : Theme: Drug Discovery, Development and Delivery in Alzheimer's Disease Guest Editor: Davide Brambilla (opens in new window)

Author(s): Storck SE, Pietrzik CU
Published in: Pharmaceutical research, 2017, ISSN 0724-8741
Publisher: Kluwer Academic/Plenum Publishers
DOI: 10.1007/s11095-017-2267-3

The physiology of regulated BDNF release (opens in new window)

Author(s): Brigadski T, Leßmann V.
Published in: Cell and Tissue Research | Home, 2020, ISSN 1432-0878
Publisher: Springer
DOI: 10.1007/s00441-020-03253-2

Evolution of Nanoparticle Protein Corona across the Blood-Brain Barrier (opens in new window)

Author(s): Cox A, Andreozzi P, Dal Magro R, Fiordaliso F, Corbelli A, Talamini L, Chinello C, Raimondo F, Magni F, Tringali M, Krol S, Jacob Silva P, Stellacci F, Masserini M, Re F.
Published in: ACS nano, 2018, ISSN 1936-0851
Publisher: American Chemical Society
DOI: 10.1021/acsnano.8b03500

3D human brain cell models: New frontiers in disease understanding and drug discovery for neurodegenerative diseases (opens in new window)

Author(s): Korhonen P, Malm T and White A R. White AR.
Published in: Neurochemistry international, 2018, ISSN 0197-0186
Publisher: Elsevier BV
DOI: 10.1016/j.neuint.2018.08.012

Humanization of the Blood-Brain Barrier Transporter ABCB1 in Mice Disrupts Genomic Locus - Lessons from Three Unsuccessful Approaches (opens in new window)

Author(s): Krohn M, Wanek T, Menet MC, Noack A, Decleves X, Langer O, Loscher W, Pahnke J,
Published in: European journal of microbiology and immunology, 2018, ISSN 2062-509X
Publisher: European journal of microbiology & immunology
DOI: 10.1556/1886.2018.00008

Neuroticism as a predictor of frailty in old age: a genetically informative approach (opens in new window)

Author(s): Hilda Bjork Danielsdottir, Juulia Jylhävä, Sara Hägg, Yi Lu, Lucía Colodro-Conde, Nicholas G. Martin, Nancy L. Pedersen, Miriam A. Mosing, Kelli Lehto
Published in: Psychosomatic Medicine, 2019, ISSN 0033-3174
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/psy.0000000000000742

Spatial Transcriptomics and In Situ Sequencing to Study Alzheimer's Disease. (opens in new window)

Author(s): Chen WT, Lu A, Craessaerts K, Pavie B, Sala Frigerio C, Corthout N, Qian X, Laláková J, Kühnemund M, Voytyuk I, Wolfs L, Mancuso R, Salta E, Balusu S, Snellinx A, Munck S, Jurek A, Fernandez Navarro J, Saido TC, Huitinga I, Lundeberg J, Fiers M, De Strooper B.
Published in: Cell, 2020, ISSN 0092-8674
Publisher: Cell Press
DOI: 10.1016/j.cell.2020.06.038

Hippocampal tau oligomerization early in tau pathology coincides with a transient alteration of mitochondrial homeostasis and DNA repair in a mouse model of tauopathy (opens in new window)

Author(s): Zheng, Jin; Akbari, Mansour; Schirmer, Claire; Reynaert, Marie-Line; Loyens, Anne; Lefebvre, Bruno; Buée, Luc; Croteau, Deborah L.; Galas, Marie-Christine; Bohr, Vilhelm A.
Published in: Acta Neuropathologica Communications, Issue Vol 8, Iss 1, 2020, Page(s) Pp 1-23, ISSN 2051-5960
Publisher: BioMed Central
DOI: 10.1186/s40478-020-00896-8

Teaming up to tackle neurodegenerative diseases (opens in new window)

Author(s): Editorial
Published in: The Lancet Neurology, 2015, ISSN 1474-4422
Publisher: The Lancet Publishing Group
DOI: 10.1016/s1474-4422(15)70029-3

Cerebral small vessel disease genomics and its implications across the lifespan (opens in new window)

Author(s): Sargurupremraj M, Suzuki H, Jian X, Sarnowski C, Evans TE, Bis JC, Eiriksdottir G, Sakaue S, Terzikhan N, Habes M, Zhao W, Armstrong NJ, Hofer E, Yanek LR, Hagenaars SP, Kumar RB, van den Akker EB, McWhirter RE, Trompet S, Mishra A, Saba Y, Satizabal CL, Beaudet G, Petit L, Tsuchida A, Zago L, Schilling S, Sigurdsson S, Gottesman RF, Lewis CE, Aggarwal NT, Lopez OL, Smith JA, Valdés Hernández MC
Published in: Nature communication, 2020, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-020-19111-2

Activation of Mitochondrial Complex II-Dependent Respiration Is Beneficial for α-Synucleinopathies (opens in new window)

Author(s): Frohlich C, Zschiebsch K, Groger V, Paarmann K, Steffen J, Thurm C, Schropp EM, Bruning T, Gellerich F, Radloff M, Schwabe R, Lachmann I, Krohn M, Ibrahim S, Pahnke J,
Published in: Molecular neurobiology, 2016, ISSN 0893-7648
Publisher: Humana Press, Inc.
DOI: 10.1007/s12035-015-9399-4

LRRK2 modifies α-syn pathology and spread in mouse models and human neurons (opens in new window)

Author(s): Bieri G, Brahic M, Bousset L, Couthouis J, Kramer NJ, Ma R, Nakayama L, Monbureau M, Defensor E, Schüle B, Shamloo M, Melki R, Gitler AD.
Published in: Acta neuropathologica, 2019, ISSN 0001-6322
Publisher: Springer Verlag
DOI: 10.1007/s00401-019-01995-0

Recent advances in applying mass spectrometry and systems biology to determine brain dynamics (opens in new window)

Author(s): Scifo E*, Calza G*, Fuhrmann M, Soliymani R, Baumann M, Lalowski M,
Published in: Expert Review of Proteomics, 2017, ISSN 1478-9450
Publisher: Future Drugs Ltd.
DOI: 10.1080/14789450.2017.1335200

Corticosteroids and Regional Variations in Thickness of the Human Cerebral Cortex across the Lifespan (opens in new window)

Author(s): Parker N, Vidal-Pineiro D, French L, Shin J, Adams HHH, Cox SR, Deary IJ, Fjell AM, Frenzel S, Grabe, HJ, Hosten N, Ikram MA, Jiang J, Knol MJ, Mazoyer B, Mishra A, Sachdev PS, Salum G, Schmidt H, Schmidt R, Seshadri S, Schumann G, Völzke H, Walhovd KB, Wei W, Wittfeld K, Yang Q, Debette S, Pausova Z, Paus T.
Published in: Cerebral cortex, 2020, ISSN 1047-3211
Publisher: Oxford University Press
DOI: 10.1093/cercor/bhz108

CSF clearance in Alzheimer Disease measured with dynamic PET. (opens in new window)

Author(s): de Leon MJ, Li Y, Okamura N, Tsui WH, Saint Louis LA, Glodzik L, Osorio RS, Fortea J, Butler T, Pirraglia E, Fossati S, Kim HJ, Carare RO, Nedergaard M, Benveniste H, Rusinek H.
Published in: Journal of Nuclear Medicine, 2017, ISSN 0161-5505
Publisher: Kexue Chubaneshe/Science Press
DOI: 10.2967/jnumed.116.187211

Development of Disordered Eating Behaviors and Comorbid Depressive Symptoms in Adolescence: Neural and Psychopathological Predictors (opens in new window)

Author(s): Zuo Zhang, Lauren Robinson, Tianye Jia, Erin Burke Quinlan, Nicole Tay, Congying Chu, Edward D Barker, Tobias Banaschewski, Gareth J Barker, Arun L W Bokde, Herta Flor, Antoine Grigis, Hugh Garavan, Penny Gowland, Andreas Heinz, Bernd Ittermann, Jean-Luc Martinot, Argyris Stringaris, Jani Penttilä, Betteke van Noort, Yvonne Grimmer, Marie-Laure Paillère Martinot, Corinna Isensee, Andreas Becker,
Published in: Biological psychiatry, 2021, ISSN 0006-3223
Publisher: Elsevier BV
DOI: 10.1016/j.biopsych.2020.06.003

Common Genetic Variation Indicates Separate Causes for Periventricular and Deep White Matter Hyperintensities (opens in new window)

Author(s): Nicola J. Armstrong, Karen A. Mather, Muralidharan Sargurupremraj, Maria J. Knol, Rainer Malik, Claudia L. Satizabal, Lisa R. Yanek, Wei Wen, Vilmundur G. Gudnason, Nicole D. Dueker, Lloyd T. Elliott, Edith Hofer, Joshua Bis, Neda Jahanshad, Shuo Li, Mark A. Logue, Michelle Luciano, Markus Scholz, Albert V. Smith, Stella Trompet, Dina Vojinovic, Rui Xia, Fidel Alfaro-Almagro, David Ames, Najaf Ami
Published in: Stroke, 2020, ISSN 0039-2499
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/strokeaha.119.027544

Thickness of the cerebral cortex shows positive association with blood levels of triacylglycerols carrying 18-carbon fatty acids (opens in new window)

Author(s): Sliz E., Shin E., Syme C., Black S., Seshadri S., Paus T., Pausova Z.
Published in: Communications biology, 2020, ISSN 2399-3642
Publisher: Springer Nature
DOI: 10.1038/s42003-020-01189-5

Measurement of Rapid Protein Diffusion in the Cytoplasm by Photo-Converted Intensity Profile Expansion (opens in new window)

Author(s): Rotem Gura Sadovsky, Shlomi Brielle, Daniel Kaganovich, Jeremy L. England
Published in: Molecular Cell, 2016, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2017.02.063

Posttranslational modification impact on the mechanism by which amyloid-β induces synaptic dysfunction (opens in new window)

Author(s): Katarzyna M Grochowska PingAn Yuanxiang Julia Bär Rajeev Raman Gemma Brugal Giriraj Sahu Michaela Schweizer Arthur Bikbaev Stephan Schilling Hans-Ulrich Demuth Michael R Kreutz
Published in: EMBO reports, 2017, ISSN 1469-221X
Publisher: Nature Publishing Group
DOI: 10.15252/embr.201643519

BACHD rats expressing full-length mutant huntingtin exhibit differences in social behavior compared to wild-type littermates (opens in new window)

Author(s): Giuseppe Manfré, Arianna Novati, Ilaria Faccini, Andrea C Rossetti, Kari Bosch, Raffaella Molteni, Marco A Riva, Johanneke E Van der Harst, Huu Phuc Nguyen, Judith R Homberg;
Published in: Plos One, 2017, ISSN 1932-6203
Publisher: Public Library of Science
DOI: 10.1371/journal.pone.0192289

Cellular correlates of cortical thinning throughout the lifespan (opens in new window)

Author(s): Didac Vidal-Pineiro, Nadine Parker, Jean Shin, Leon French, Håkon Grydeland, Andrea P. Jackowski, Athanasia M. Mowinckel, Yash Patel, Zdenka Pausova, Giovanni Salum, Øystein Sørensen, Kristine B. Walhovd, Tomas Paus, Anders M. Fjell, and the Alzheimer’s Disease Neuroimaging Initiative and the Australian Imaging Biomarkers and Lifestyle flagship study of ageing
Published in: Scientific reports, 2020, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-020-78471-3

Reducing the amyloidogenicity of functional amyloid FapC increases its ability to inhibit a-synuclein fibrillation (opens in new window)

Author(s): Christensen LFB, Jensen KF, Nielsen J, Vad BS, Christiansen G, Otzen DE,
Published in: ACS Omega, 2019, ISSN 2470-1343
Publisher: American Chemical Society omega
DOI: 10.1021/acsomega.8b03590

A genome-wide association study identifies genetic loci associated with specific lobar brain volumes (opens in new window)

Author(s): Lee, S.J. van der; Knol, M.J.; Chauhan, G.; Satizabal, C.L.; Smith, A.V.; Hofer, E.; Bis, J.C.; Hibar, D.P.; Hilal, S.; Akker, E.B. van den; Arfanakis, K.; Bernard, M.; Yanek, L.R.; Amin, N.; Crivello, F.; Cheung, J.W.; Harris, T.B.; Saba, Y.; Lopez, O.L.; Li, S.; Grond, J. van der; Yu, L.; Paus, T.; Roshchupkin, G.V.; Amouyel, P.; Jahanshad, N.; Taylor, K.D.; Yang, Q.; Mathias, R.A.; Boehringer,
Published in: Communications Biology, 2019, ISSN 2399-3642
Publisher: Springer Nature
DOI: 10.1038/s42003-019-0537-9

P2Y1 receptor blockade normalizes network dysfunction and cognition in an Alzheimer's disease model. (opens in new window)

Author(s): Reichenbach N, Delekate A, Breithausen B, Keppler K, Poll S, Schulte T, Peter J, Plescher M, Hansen JN, Blank N, Keller A, Fuhrmann M, Henneberger C, Halle A, Petzold GC.
Published in: Journal of Experimental Medicine, 2018, ISSN 0022-1007
Publisher: Rockefeller University Press
DOI: 10.1084/jem.20171487

The new genetic landscape of Alzheimer's disease: from amyloid cascade to genetically driven synaptic failure hypothesis? (opens in new window)

Author(s): Dourlen P, Kilinc D, Malmanche N, Chapuis J, Lambert JC.
Published in: Acta Neuropathol, 2019, ISSN 0001-6322
Publisher: Springer Verlag
DOI: 10.1007/s00401-019-02004-0

The Role of Activity-Dependent DNA Demethylation in the Adult Brain and in Neurological Disorders (opens in new window)

Author(s): Bayraktar G, Kreutz MR
Published in: Frontiers in molecular neuroscience, 2018, ISSN 1662-5099
Publisher: Frontiers Research Foundation
DOI: 10.3389/fnmol.2018.00169

Virtual histology of multi-modal magnetic resonance imaging of cerebral cortex in young men (opens in new window)

Author(s): Yash Patel, Jean Shin, Mark Drakesmith, John Evans, Zdenka Pausova, Tomas Paus
Published in: Neuroimage, 2020, ISSN 2666-9560
Publisher: New York Elsevier Inc.
DOI: 10.1016/j.neuroimage.2020.116968

Alexithymia Is Associated with Altered Cortical Thickness Networks in the General Population (opens in new window)

Author(s): Terock J. · Frenzel S. · Wittfeld K. · Klinger-König J. · Janowitz D. · Bülow R. · Hosten N. · Völzke H. · Grabe H.J.
Published in: Neuropsychobiology, 2020, ISSN 0302-282X
Publisher: S. Karger AG
DOI: 10.1159/000504983

Lack of association between proton pump inhibitor use and brain aging: a cross-sectional study (opens in new window)

Author(s): Nayeon Ahn, Stefan Frenzel, Katharina Wittfeld, Robin Bülow, Henry Völzke, Markus M Lerch, Jean-Francois Chenot, Ulf Schminke, Michael Nolde, Ute Amann, Christa Meisinger, Jakob Linseisen, Sebastian E Baumeister, Hans Jörgen Grabe, Ina-Maria Rückert-Eheberg
Published in: European Journal of Clinical Pharmacology, 2021, ISSN 0031-6970
Publisher: Springer Verlag
DOI: 10.1007/s00228-020-03068-8

The neuroactive potential of the human gut microbiota in quality of life and depression (opens in new window)

Author(s): Mireia Valles-Colomer, Gwen Falony, Youssef Darzi, Ettje F. Tigchelaar, Jun Wang, Raul Y. Tito, Carmen Schiweck, Alexander Kurilshikov, Marie Joossens, Cisca Wijmenga, Stephan Claes, Lukas Van Oudenhove, Alexandra Zhernakova, Sara Vieira-Silva & Jeroen Raes
Published in: Nature microbiology, 2019, ISSN 2058-5276
Publisher: Nature microbiology
DOI: 10.1038/s41564-018-0337-x

Anti-Inflammatory Treatment with FTY720 Starting after Onset of Symptoms Reverses Synaptic Deficits in an AD Mouse Model. (opens in new window)

Author(s): Georgia-Ioanna Kartalou; Georgia-Ioanna Kartalou; Ana Rita Salgueiro-Pereira; Thomas Endres; Angelina Lesnikova; Plinio C. Casarotto; Paula A. Pousinha; Kevin Delanoe; Elke Edelmann; Eero Castrén; Kurt Gottmann; Hélène Marie; Volkmar Lessmann
Published in: International Journal of Molecular Sciences, Issue Issue 23, 2020, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21238957

Creation of a library of induced pluripotent stem cells from Parkinsonian patients (opens in new window)

Author(s): Holmqvist S, Lehtonen Š, Chumarina M, Puttonen KA, Azevedo C, Lebedeva O, Ruponen M, Oksanen M, Djelloul M, Collin A, Goldwurm S, Meyer M, Lagarkova M, Kiselev S, Koistinaho J, Roybon L.
Published in: NPJ Parkinson's Disease, 2016, ISSN 2373-8057
Publisher: Springer Nature
DOI: 10.1038/npjparkd.2016.9

BIN1 recovers tauopathy-induced long-term memory deficits in mice and interacts with Tau through Thr348 phosphorylation (opens in new window)

Author(s): Sartori, M., Mendes, T., Desai, S. et al.
Published in: Acta Neuropathol, 2019, ISSN 0001-6322
Publisher: Springer Verlag
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French maritime pine bark treatment decelerates plaque development and improves spatial memory in Alzheimer's disease mice (opens in new window)

Author(s): Paarmann K, Prakash SR, Krohn M, Mohle L, Brackhan M, Bruning T, Eiriz I, Pahnke J,
Published in: Phytomedicine, 2019, ISSN 0944-7113
Publisher: Elsevier BV
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Immunobiography and the Heterogeneity of Immune Responses in the Elderly: A Focus on Inflammaging and Trained Immunity (opens in new window)

Author(s): Claudio Franceschi, Stefano Salvioli, Paolo Garagnani, Magda de Eguileor, Daniela Monti and Miriam Capri
Published in: Frontiers in Immunology, 2017, ISSN 1664-3224
Publisher: Frontiers Media SA
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Gut Inflammation in Association With Pathogenesis of Parkinson's Disease. (opens in new window)

Author(s): Chen QQ, Haikal C, Li W, Li JY.
Published in: Frontiers in Molecular Neuroscience, 2019, ISSN 1662-5099
Publisher: Frontiers Research Foundation
DOI: 10.3389/fnmol.2019.00218

Pharmacologically diverse antidepressant drugs disrupt the interaction of BDNF receptor TRKB and the endocytic adaptor AP-2 (opens in new window)

Author(s): SM Fred, L Laukkanen, L Vesa, H Goos, I Cardon, R Moliner, T Maritzen, M Varjosalo, PC Casarotto, E Castren
Published in: Journal of Biological Chemistry, 2019, ISSN 0021-9258
Publisher: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1074/jbc.ra119.008837

Iatrogenic early onset cerebral amyloid angiopathy 30 years after cerebral trauma with neurosurgery: vascular amyloid deposits are made up of both Aβ40 and Aβ42 (opens in new window)

Author(s): Giaccone G, Maderna E, Marucci G, Catania M, Erbetta A, Chiapparini L, Indaco A, Caroppo P, Bersano A, Parati E, Di Fede G, Caputi L
Published in: Acta Neuropathologica Communications, 2019, ISSN 2051-5960
Publisher: BioMed Central
DOI: 10.1186/s40478-019-0719-1

Phenotypic Screening Using Mouse and Human Stem Cell-Based Models of Neuroinflammation and Gene Expression Analysis to Study Drug Responses: Methods and Protocols (opens in new window)

Author(s): Abo-Rady M, Bellmann J, Glatza M, Marrone L, Reinhardt L, Tena S, Sterneckert J.
Published in: Methods in molecular biology, 2019, ISSN 1064-3745
Publisher: Humana Press, Inc.
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Neurofilaments as blood biomarkers at the preataxic and ataxic stage of spinocerebellar ataxia type 3: a cross-species analysis in humans and mice. (opens in new window)

Author(s): Wilke C, Haas E, Reetz K, Faber J, Garcia-Moreno H, Santana MM, van de Warrenburg B, Hengel H, Lima M, Filla A, Durr A, Melegh B, Masciullo M, Infante J, Giunti P, Neumann M, de Vries J, Pereira de Almeida L, Rakowicz M, Jacobi H, Schuele R, Kaeser SA, Kuhle J, Klockgether T, Schoels L, SCA3 neurofilament study group, Barro C*, Huebener-Schmid J*, Synofzik M*.
Published in: EMBO Molecular Medicine, 2019, ISSN 1757-4676
Publisher: John Wiley & Sons Ltd.
DOI: 10.1101/19011882

Normal brain aging and Alzheimer's disease are associated with lower cerebral pH: an in vivo histidine 1 H-MR spectroscopy study (opens in new window)

Author(s): Lyros E, Ragoschke-Schumm A, Kostopoulos P, Sehr A, Backens M, Kalampokini S, Decker Y, Lesmeister M, Liu Y, Reith W, Fassbender K.
Published in: Neurobiology of aging, 2020, ISSN 0197-4580
Publisher: Elsevier BV
DOI: 10.1016/j.neurobiolaging.2019.11.012

Brain aging in major depressive disorder: results from the ENIGMA major depressive disorder working group (opens in new window)

Author(s): Laura K M Han, Richard Dinga, Tim Hahn, Christopher R K Ching, Lisa T Eyler, Lyubomir Aftanas, Moji Aghajani, André Aleman, Bernhard T Baune, Klaus Berger, Ivan Brak, Geraldo Busatto Filho, Angela Carballedo, Colm G Connolly, Baptiste Couvy-Duchesne, Kathryn R Cullen, Udo Dannlowski, Christopher G Davey, Danai Dima, Fabio L S Duran, Verena Enneking, Elena Filimonova, Stefan Frenzel, Thomas Frodl,
Published in: Molecular psychiatry, 2020, ISSN 1359-4184
Publisher: Nature Publishing Group
DOI: 10.1038/s41380-020-0754-0

Neuropathology and biochemistry of early onset familial Alzheimer's disease caused by presenilin-1 missense mutation Thr116Asn (opens in new window)

Author(s): Sutovsky S, Smolek T, Turcani P, Petrovic R, Brandoburova P, Jadhav S, Novak P, Attems J, Zilka N.
Published in: Journal of Neural Transmission, 2018, ISSN 0300-9564
Publisher: Springer Verlag
DOI: 10.1007/s00702-018-1850-z

Nucleoli and Promyelocytic Leukemia Protein (PML) bodies are phase separated nuclear protein quality control compartments for misfolded proteins (opens in new window)

Author(s): Mediani L, Guillén-Boixet J, Alberti S, Carra S.
Published in: Molecular & Cellular Oncology, 2019, ISSN 2372-3556
Publisher: Taylor and Francis Ltd
DOI: 10.1080/23723556.2019.1652519

Combinatorial treatment for spinal muscular atrophy: An Editorial for 'Combined treatment with the histone deacetylase inhibitor LBH589 and a splice-switch antisense oligonucleotide enhances SMN2 splicing and SMN expression in Spinal Muscular Atrophy cells' (opens in new window)

Author(s): Poletti A., Fischbeck K.H.
Published in: Journal of Neurochemistry, 2020, ISSN 0022-3042
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/jnc.14974

Deficiency of TLR4 ameliorates hypoperfusion-induced brain pathology (opens in new window)

Author(s): Liu Y, Fassbender K
Published in: Theranostics, 2018, ISSN 1838-7640
Publisher: Ivyspring International Publisher
DOI: 10.7150/thno.30953

ST Spot: a web-based application for automatic spot and tissue detection for spatial Transcriptomics image datasets. (opens in new window)

Author(s): Wong K*, Navarro JF*, Bergenstråhle L, Ståhl PL, Lundeberg J.
Published in: Bioinformatics, 2018, ISSN 1367-4811
Publisher: Oxford Academic
DOI: 10.1093/bioinformatics/bty030

The Blood brain-barrier and its role in Alzheimer’s disease (opens in new window)

Author(s): Steffen E. Storck and Claus U. Pietrzik
Published in: Neuroforum, 2018, ISSN 0947-0875
Publisher: Spektrum Akademischer Verlag GmbH
DOI: 10.1515/nf-2018-a014

TRPV4 channels contribute to calcium transients in astrocytes and neurons during peri-infarct depolarizations in a stroke model (opens in new window)

Author(s): Cordula Rakers, Matthias Schmid, Gabor C. Petzold
Published in: Glia, 2017, ISSN 0894-1491
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/glia.23183

Methylomic profiling in trisomy 21 identifies cognition- and Alzheimer’s disease-related dysregulation (opens in new window)

Author(s): Haertle, Larissa; Müller, Tobias; Lardenoije, Roy; Maierhofer, Anna; Dittrich, Marcus; Riemens, Renzo J. M.; Stora, Samantha; Roche, Mathilde; Leber, Markus; Riedel-Heller, Steffi; Wagner, Michael; Scherer, Martin; Ravel, Aimé; Mircher, Clotilde; Cieuta-Walti, Cecile; Durand, Sophie; van de Hove, Daniel L. A.; Hoffmann, Per; Ramirez, Alfredo; Haaf, Thomas; El Hajj, Nady; Mégarbané, André
Published in: Clinical epigenetics, 11(1):195. BioMed Central Ltd, Issue 1, 2019, ISSN 1868-7075
Publisher: Springer Verlag
DOI: 10.1186/s13148-019-0787-x

PLCG2 protective variant p.P522R modulates tau pathology and disease progression in patients with mild cognitive impairment (opens in new window)

Author(s): Kleineidam L, et al.
Published in: Acta Neuropathologica, 2020, ISSN 0001-6322
Publisher: Springer Verlag
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Obesity in geroscience — is cellular senescence the culprit? (opens in new window)

Author(s): Franceschi, C
Published in: Nat Rev Endocrinol, Issue 13, 2017, Page(s) 76–78, ISSN 1759-5029
Publisher: Nature Publishing Group
DOI: 10.1038/nrendo.2016.213

Trehalose alleviates the phenotype of Machado–Joseph disease mouse models (opens in new window)

Author(s): Santana, M.M., Paixão, S., Cunha-Santos, J. et al.
Published in: Journal of Translational Medicine, 2020, ISSN 1479-5876
Publisher: BioMed Central
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Huntingtin phosphorylation governs BDNF homeostasis and improves the phenotype of Mecp2 knockout mice (opens in new window)

Author(s): Yann Ehinger Julie Bruyère Nicolas Panayotis Yah-Se Abada Emilie Borloz Valérie Matagne Chiara Scaramuzzino Hélène Vitet Benoit Delatour Lydia Saidi Laurent Villard Frédéric Saudou Jean-Christophe Roux
Published in: EMBO Molecular Medicine, 2020, ISSN 1757-4676
Publisher: John Wiley & Sons Ltd.
DOI: 10.15252/emmm.201910889

Exome sequencing identifies novel AD-associated genes (opens in new window)

Author(s): Henne Holstege, Marc Hulsman, Camille Charbonnier, Benjamin Grenier-Boley, Olivier Quenez, Detelina Grozeva, Jeroen G.J. van Rooij, Rebecca Sims, Shahzad Ahmad, Najaf Amin, Penny J. Norsworthy, Oriol Dols-Icardo, Holger Hummerich, Amit Kawalia, Philippe Amouyel, Gary W. Beecham, Claudine Berr, Joshua C. Bis, Anne Boland, Paola Bossù, Femke Bouwman, Dominique Campion, Antonio Daniele, Jean-Franço
Published in: Alzheimer’s and Dementia, 2020, ISSN 1552-5260
Publisher: Elsevier BV
DOI: 10.1002/alz.041592

Endocrine influence on neuroinflammation: the use of reporter systems (opens in new window)

Author(s): N. Rizzi, A. Villa, V. Benedusi, E. Brunialti, N. Cesari, P. Ciana, A. Maggi
Published in: Journal of Neuroendocrinology, 2017, ISSN 0953-8194
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/jne.12496

The biological function of the cellular prion protein: an update (opens in new window)

Author(s): Wulf, Marie-Angela; Senatore, Assunta; Aguzzi, Adriano
Published in: BMC Biology, 2017, ISSN 1741-7007
Publisher: BioMed Central
DOI: 10.1186/s12915-017-0375-5

Parkinson’s Disease-Associated Mutant LRRK2-Mediated Inhibition of miRNA Activity is Antagonized by TRIM32 (opens in new window)

Author(s): Gonzalez-Cano, L., Menzl, I., Tisserand, J. et al.
Published in: Mol Neurobiol, Issue 55, 2017, Page(s) 3490–3498, ISSN 0893-7648
Publisher: Humana Press, Inc.
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Functional Neuroimaging Predictors of Self-Reported Psychotic Symptoms in Adolescents (opens in new window)

Author(s): Josiane Bourque, M.Sc., Philip A. Spechler, B.A., Stéphane Potvin, Ph.D., Robert Whelan, Ph.D., Tobias Banaschewski, M.D., Ph.D., Arun L.W. Bokde, Ph.D., Uli Bromberg, Dipl.-Psych., Christian Büchel, M.D., Erin Burke Quinlan, Ph.D., Sylvane Desrivières, Ph.D., Herta Flor, Ph.D., Vincent Frouin, Ph.D., Penny Gowland, Ph.D., Andreas Heinz, M.D., Ph.D., Bernd Ittermann, Ph.D., Jean-Luc Martinot, M
Published in: The american journal of psychiatry, 2017, ISSN 0002-953X
Publisher: American Psychiatric Publishing, Inc.
DOI: 10.1176/appi.ajp.2017.16080897

ABCA7 Downregulation Modifies Cellular Cholesterol Homeostasis and Decreases Amyloid-β Peptide Efflux in an in vitro Model of the Blood-Brain Barrier (opens in new window)

Author(s): Lamartiniere Y, Boucau MC, Dehouck L, Krohn M, Pahnke J, Candela P, Gosselet F, Fenart L
Published in: Journal of Alzheimer's Disease, 2018, ISSN 1387-2877
Publisher: IOS Press
DOI: 10.3233/jad-170883

Analysis of the vasculature by immunohistochemistry in paraffin-embedded brains (opens in new window)

Author(s): Decker Y, Müller A, Németh E, Schulz-Schaeffer WJ, Fatar M, Menger MD, Liu Y, Fassbender K.
Published in: Brain Structure and Function, 2018, ISSN 1863-2653
Publisher: Springer Verlag
DOI: 10.1007/s00429-017-1595-8

An epigenome-wide association study of Alzheimer's disease blood highlights robust DNA hypermethylation in the HOXB6 gene (opens in new window)

Author(s): Roubroeks JAY, Smith AR, Smith RG, Pishva E, Ibrahim Z, Sattlecker M, Hannon EJ, Kłoszewska I, Mecocci P, Soininen H, Tsolaki M, Vellas B, Wahlund LO, Aarsland D, Proitsi P, Hodges A, Lovestone S, Newhouse SJ, Dobson RJB, Mill J, van den Hove DLA, Lunnon K.
Published in: NEUROBIOLOGY OF AGING, 2020, ISSN 0197-4580
Publisher: Elsevier BV
DOI: 10.1016/j.neurobiolaging.2020.06.023

Viral Infections Exacerbate FUS-ALS Phenotypes in iPSC-Derived Spinal Neurons in a Virus Species-Specific Manner. (opens in new window)

Author(s): Jessica Bellmann; Anne Monette; Anne Monette; Vadreenath Tripathy; Anna Sójka; Masin Abo-Rady; Antje Janosh; Rajat Bhatnagar; Marc Bickle; Andrew J. Mouland; Andrew J. Mouland; Jared Sterneckert
Published in: Front. Cell. Neurosci, 2019, ISSN 1662-5102
Publisher: Frontiers Research Foundation
DOI: 10.3389/fncel.2019.00480

The Synaptonuclear Messenger RNF10 Acts as an Architect of Neuronal Morphology (opens in new window)

Author(s): Nicolò Carrano, Tanmoy Samaddar, Electra Brunialti, Luca Franchini, Elena Marcello, Paolo Ciana, Daniela Mauceri, Monica Di Luca and Fabrizio Gardoni
Published in: Molecular Neurobiology, 2019, ISSN 0893-7648
Publisher: Humana Press, Inc.
DOI: 10.1007/s12035-019-1631-1

Successes and Hurdles in Stem Cells Application and Production for Brain Transplantation (opens in new window)

Author(s): Henriques D, Moreira R, Schwamborn J, Pereira de Almeida L, Mendonça LS.
Published in: Frontiers in Neuroscience, 2019, ISSN 1662-4548
Publisher: Frontiers Research Foundation
DOI: 10.3389/fnins.2019.01194

Cerebrospinal and Interstitial Fluid Transport via the Glymphatic Pathway Modeled by Optimal Transport. (opens in new window)

Author(s): Ratner V, Gao Y, Lee H, Elkin R, Nedergaard M, Benveniste H, Tannenbaum A.
Published in: NeuroImage, 2017, ISSN 1053-8119
Publisher: Academic Press
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A nonsynonymous mutation in PLCG2 reduces the risk of Alzheimer's disease, dementia with Lewy bodies and frontotemporal dementia, and increases the likelihood of longevity. (opens in new window)

Author(s): Van der Lee SJ et al,
Published in: Acta Neuropathologica, 2019, ISSN 0001-6322
Publisher: Springer Verlag
DOI: 10.1007/s00401-019-02026-8

Loss of Tau protein affects the structure, transcription and repair of neuronal pericentromeric heterochromatin. (opens in new window)

Author(s): Mansuroglu Z, Benhelli-Mokrani H, Marcato V, Sultan A, Violet M, Chauderlier A, Delattre L, Loyens A, Talahari S, Bégard S, Nesslany F, Colin M, Souès S, Lefebvre B, Buée L, Galas MC, Bonnefoy E.
Published in: Scientifc Reports, 2016, ISSN 2045-2322
Publisher: Nature Publishing Group
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Evolution and clustering of prodromal parkinsonian features in GBA1 carriers (opens in new window)

Author(s): Mullin S, Beavan M, Bestwick J, McNeill A, Proukakis C, Cox T, Hughes D, Mehta A, Zetterberg H, Schapira AHV.
Published in: Movement Disorders, 2019, ISSN 0885-3185
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/mds.27775

Striatal infusion of cholesterol promotes dose-dependent behavioral benefits and exerts disease-modifying effects in Huntington's disease mice (opens in new window)

Author(s): Birolini G, Valenza M, Di Paolo E, Vezzoli E, Talp F, Maniezz C, Caccia C, Leoni V, F Taroni F, Bocchi VD, Conforti P, Sogne E, Petricca L, Cariulo C, Verani M, A Caricasole A, Falqui A, Biella G, Cattaneo E.
Published in: EMBO Molecular Medicine, 2020, ISSN 1757-4676
Publisher: John Wiley & Sons Ltd.
DOI: 10.15252/emmm.202012519

Propagation of α-Synuclein Strains within Human Reconstructed Neuronal Network (opens in new window)

Author(s): Gribaudo S, Tixador P, Bousset L, Fenyi A, Lino P, Melki R, Peyrin JM, Perrier AL.
Published in: Stem Cell Reports, 2019, ISSN 2213-6711
Publisher: Cell Press
DOI: 10.1016/j.stemcr.2018.12.007

NF-E2-related factor 2 activation boosts antioxidant defenses and ameliorates inflammatory and amyloid properties in human Presenilin-1 mutated Alzheimer's disease astrocytes (opens in new window)

Author(s): Oksanen, Minna; Hyötyläinen, Ida; Trontti, Kalevi; Rolova, Taisia; Wojciechowski, Sara; Koskuvi, Marja; Viitanen, Matti; Levonen, Anna‐Liisa; Hovatta, Iiris; Roybon, Laurent; Lehtonen, Šárka; Kanninen, Katja M.; Hämäläinen, Riikka H.; Koistinaho, Jari
Published in: Glia, Issue 1, 2019, ISSN 0894-1491
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/glia.23741

Longitudinal trajectories, correlations and mortality associations of nine biological ages across 20-years follow-up. (opens in new window)

Author(s): Li X, Ploner A, Wang Y, Magnusson PK, Reynolds C, Finkel D, Pedersen NL, Jylhävä J, Hägg S.
Published in: Elife, 2020, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.51507

Caldendrin Directly Couples Postsynaptic Calcium Signals to Actin Remodeling in Dendritic Spines (opens in new window)

Author(s): Mikhaylova M, Bär J, van Bommel B, Schätzle P, YuanXiang P, Raman R, Hradsky J, Konietzny A, Loktionov EY, Reddy PP, Lopez-Rojas J, Spilker C, Kobler O, Raza SA, Stork O, Hoogenraad CC, Kreutz MR
Published in: Neuron, 2018, ISSN 0896-6273
Publisher: Cell Press
DOI: 10.1016/j.neuron.2018.01.046

Assessment of the efficacy of different procedures that remove and disassemble alpha-synuclein, tau and A-beta fibrils from laboratory material and surfaces (opens in new window)

Author(s): Fenyi A, Coens A, Bellande T, Melki R, Bousset L
Published in: Scientific Reports, 2018, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-018-28856-2

Machado-Joseph Disease: A Stress Combating Deubiquitylating Enzyme Changing Sides (opens in new window)

Author(s): Dantuma NP, and Herzog LK.
Published in: Advances in Experimental Medicine and Biology, 2020, ISSN 0065-2598
Publisher: Kluwer Academic/Plenum Publishers
DOI: 10.1007/978-3-030-38266-7_10

Association of variants in HTRA1 and NOTCH3 with MRI-defined extremes of cerebral small vessel disease in older subjects (opens in new window)

Author(s): Mishra A, Chauhan G, Violleau MH, Soumare A, Vojinovic D, Jian X, Bis J, Li S, Saba Y, Yang Q, Bartz T, Hofer E, Zhu Y, Mazoyer B, Lathrop M, Schmidt H, Van Duijn C, Ikram MA, Longstreth WT, Fornage M, Seshadri S, Joutel A, Tzourio C, Debette S.
Published in: Brain, 2019, ISSN 0006-8950
Publisher: Oxford University Press
DOI: 10.1093/brain/awz024

Genetic Background Influences the Propagation of Tau Pathology in Transgenic Rodent Models of Tauopathy (opens in new window)

Author(s): Smolek T, Cubinkova V, Brezovakova V, Valachova B, Szalay P, Zilka N, Jadhav S.
Published in: Frontiers in aging neuroscience, 2019, ISSN 1663-4365
Publisher: Frontiers Research Foundation
DOI: 10.3389/fnagi.2019.00343

Isogenic FUS-eGFP iPSC Reporter Lines Enable Quantification of FUS Stress Granule Pathology that Is Rescued by Drugs Inducing Autophagy (opens in new window)

Author(s): L. Marrone, I. Poser, I. Casci, J. Japtok, P. Reinhardt, A. Janosch, C. Andree, H. O. Lee, C. Moebius, E. Koerner, L. Reinhardt, M. E. Cicardi, K. Hackmann, B. Klink, A. Poletti, S. Alberti, M. Bickle, A. Hermann, U. Pandey, A. A. Hyman, and J. L. Sterneckert
Published in: Stem Cell Reports, 2018, ISSN 2213-6711
Publisher: Cell Press
DOI: 10.1016/j.stemcr.2017.12.018

ALS and FTD: Where RNA metabolism meets protein quality control (opens in new window)

Author(s): Mandrioli J, Mediani L, Alberti S, Carra S
Published in: Seminars in Cell & Developmental Biology, 2019, ISSN 1084-9521
Publisher: Academic Press
DOI: 10.1016/j.semcdb.2019.06.003

Familial Alzheimer’s Disease Lymphocytes Respond Differently Than Sporadic Cells to Oxidative Stress: Upregulated p53-p21 Signaling Linked with Presenilin 1 Mutants (opens in new window)

Author(s): Joanna Wojsiat; Katarzyna Laskowska-Kaszub; Carolina Alquézar; Emilia Bialopiotrowicz; Noemí Esteras; Mykola Zdioruk; Ángeles Martín-Requero; Urszula Wojda
Published in: Molecular Neurobiology, 2017, ISSN 0893-7648
Publisher: Humana Press, Inc.
DOI: 10.1007/s12035-016-0105-y

Human α-synuclein overexpression in a mouse model of Parkinson's disease leads to vascular pathology, blood brain barrier leakage and pericyte activation (opens in new window)

Author(s): Elabi O, Gaceb A, Carlsson R, Padel T, Soylu-Kucharz R, Cortijo I, Li W, Li JY, Paul G.
Published in: Scientific Reports, 2021, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-020-80889-8

Presynaptic Regulation of Tonic Inhibition by Neuromodulatory Transmitters in the Basal Amygdala. (opens in new window)

Author(s): Meis, S., Endres, T., Munsch, T. et al.
Published in: Molecular Neurobiology, Issue 55, 2018, Page(s) 8509–8521, ISSN 0893-7648
Publisher: Humana Press, Inc.
DOI: 10.1007/s12035-018-0984-1

Traditional Japanese Herbal Medicine Yokukansan Targets Distinct but Overlapping Mechanisms in Aged Mice and in the 5xFAD Mouse Model of Alzheimer's Disease (opens in new window)

Author(s): Kaushik R, Morkovin E, Schneeberg J, Confettura AD, Kreutz MR, Senkov O, Dityatev A.
Published in: Frontiers in aging neuroscience, 2018, ISSN 1663-4365
Publisher: Frontiers Research Foundation
DOI: 10.3389/fnagi.2018.00411

SIPA1L2 controls trafficking and local signaling of TrkB-containing amphisomes at presynaptic terminals (opens in new window)

Author(s): Maria Andres-Alonso, Mohamed Raafet Ammar, Ioana Butnaru, Guilherme M Gomes, Gustavo Acuña Sanhueza, Rajeev Raman, PingAn Yuanxiang, Maximilian Borgmeyer, Jeffrey Lopez-Rojas, Syed Ahsan Raza, Nicola Brice, Torben J Hausrat, Tamar Macharadze, Silvia Diaz-Gonzalez, Mark Carlton, Antonio Virgilio Failla, Oliver Stork, Michaela Schweizer, Eckart D Gundelfinger, Matthias Kneussel, Christina Spilker,
Published in: Nature Communications, 2019, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-019-13224-z

Microbiome changes: an indicator of Parkinson's disease? (opens in new window)

Author(s): Haikal C, Chen QQ, Li JY.
Published in: Translational Neurodegeneration, 2019, ISSN 2047-9158
Publisher: BioMed Central
DOI: 10.1186/s40035-019-0175-7

Does Global Astrocytic Calcium Signaling Participate in Awake Brain State Transitions and Neuronal Circuit Function? (opens in new window)

Author(s): Celia Kjaerby, Rune Rasmussen, Mie Andersen & Maiken Nedergaard
Published in: Neurochemical Research, Issue 42, p, 2017, Page(s) ages 1810–1822, ISSN 0364-3190
Publisher: Kluwer Academic/Plenum Publishers
DOI: 10.1007/s11064-017-2195-y

Enriched environmental conditions modify the gut microbiome composition and fecal markers of inflammation in Parkinson’s disease (opens in new window)

Author(s): Yogesh Singh, Mohamed El-Hadidi, Jakob Admard, Zinah Wassouf, Julia Schulze-Hentrich, Ursula Kohlhofer, Leticia Quintanilla-Martinez, Daniel Huson, Olaf Riess, Nicolas Casadei
Published in: Frontiers in neuroscience, 2019, ISSN 1662-4548
Publisher: Frontiers Research Foundation
DOI: 10.3389/fnins.2019.01032

RUES2 hESCs exhibit MGE-biased neuronal differentiation and muHTT-dependent defective specification hinting at SP1 (opens in new window)

Author(s): Conforti P, Besusso D, Brocchetti S, Campus I, Cappadona C, Galimberti M, Laporta A, Iennaco R, Rossi RL, Bocchi VD, Cattaneo E.
Published in: Neurobiology_of_Disease, 2020, ISSN 0969-9961
Publisher: Academic Press
DOI: 10.1016/j.nbd.2020.105140

Transmission of Tau Pathology from Human to Rodent Brain: How to Humanise Animal Models for Alzheimer’s Disease Research (opens in new window)

Author(s): Tomas Smolek, Santosh Jadhav, Bernadeta Valachova, Thomas Vogels, Jaroslav Legath, Petr Novak and Norbert Zilka
Published in: Journal of Alzheimers Disease and Parkinsonism, 2017, ISSN 2161-0460
Publisher: OMICS International Pvt Ltd
DOI: 10.4172/2161-0460.1000400

Neuronal network maturation differently affects secretory vesicles and mitochondria transport in axons (opens in new window)

Author(s): Moutaux E, Christaller W, Scaramuzzino C, Genoux A, Charlot B, Cazorla M, Saudou F.
Published in: Scientific Reports, 2018, ISSN 2045-2322
Publisher: Nature Publishing Group
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Simulation, Implementation and Measurement of Defined Sound Fields for Blood–Brain Barrier Opening in Rats (opens in new window)

Author(s): Saskia Grudzenski; Stefan Heger; Andreas de Jonge; Julia Schipp; Erik Dumont; Benoit Larrat; Lothar Schad; Michael Platten; Marc Fatar
Published in: Ultrasound in Medicine and Biology, 2021, ISSN 0301-5629
Publisher: Elsevier BV
DOI: 10.1016/j.ultrasmedbio.2021.10.003

The Clustering of mApoE Anti-Amyloidogenic Peptide on Nanoparticle Surface Does Not Alter Its Performance in Controlling Beta-Amyloid Aggregation (opens in new window)

Author(s): Corti R, Cox A, Cassina V, Nardo L, Salerno D, Marrano CA, Missana N, Andreozzi P, Silva PJ, Stellacci F, Dal Magro R, Re F, Mantegazza F.
Published in: The International Journal of Molecular Sciences, 2020, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21031066

Effects of pharmacological modulators of α-synuclein and tau aggregation and internalization. (opens in new window)

Author(s): Dominguez-Meijide A, Vasili E, König A, Cima-Omori MS, Ibáñez de Opakua A, Leonov A, Ryazanov S, Zweckstetter M, Griesinger C, Outeiro TF.
Published in: Scientific Reports, 2020, ISSN 2045-2322
Publisher: Nature Publishing Group
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High dilated perivascular space burden: a new MRI marker for risk of intracerebral hemorrhage (opens in new window)

Author(s): Duperron MG, Tzourio C, Schilling S, Zhu YC, Soumaré A, Mazoyer B, Debette S.
Published in: Neurobiology of Ageing, 2019, ISSN 0197-4580
Publisher: Elsevier BV
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Memory enhancement by ferulic acid ester across species. (opens in new window)

Author(s): Michels, Birgit; Zwaka, Hanna; Bartels, Ruth; Lushchak, Oleh; Franke, Katrin; Endres, Thomas; Fendt, Markus; Song, Inseon; Bakr, May; Budragchaa, Tuvshinjargal; Westermann, Bernhard; Mishra, Dushyant; Eschbach, Claire; Schreyer, Stefanie; Lingnau, Annika; Vahl, Caroline; Hilker, Marike; Menzel, Randolf; Kähne, Thilo; Leßmann, Volkmar; Dityatev, Alexander; Wessjohann, Ludger; Gerber, Bertram
Published in: Science advances, 2018, ISSN 2375-2548
Publisher: American Association for the Advancement of Science
DOI: 10.1126/sciadv.aat6994

Dynamic susceptibility contrast and diffusion MR imaging identify oligodendroglioma as defined by the 2016 WHO classification for brain tumors: histogram analysis approach (opens in new window)

Author(s): Latysheva, Anna; Emblem, Kyrre Eeg; Brandal, Petter; Vik-Mo, Einar Osland; Pahnke, Jens; Røysland, Kjetil; Hald, John K.; Server, Andrés
Published in: Diagnostic Neuroradiology, Issue 1, 2019, ISSN 0028-3940
Publisher: Springer Verlag
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Impact of demography and population dynamics on the genetic architecture of human longevity. (opens in new window)

Author(s): Giuliani C, Sazzini M, Pirazzini C, Bacalini MG, Marasco E, Ruscone GAG, Fang F, Sarno S, Gentilini D, Di Blasio AM, Crocco P, Passarino G, Mari D, Monti D, Nacmias B, Sorbi S, Salvarani C, Catanoso M, Pettener D, Luiselli D, Ukraintseva S, Yashin A, Franceschi C, Garagnani P.
Published in: Aging, 2018, ISSN 1945-4589
Publisher: Impact Journals
DOI: 10.18632/aging.101515

Reverse NCX Attenuates Cellular Sodium Loading in Metabolically Compromised Cortex. (opens in new window)

Author(s): Niklas J. Gerkau; Cordula Rakers; Simone Durry; Gabor C. Petzold; Gabor C. Petzold; Christine R. Rose
Published in: Cerebral Cortex, 2018, ISSN 1047-3211
Publisher: Oxford University Press
DOI: 10.1093/cercor/bhx280

Impairment of Glycolysis-Derived l-Serine Production in Astrocytes Contributes to Cognitive Deficits in Alzheimer's Disease. (opens in new window)

Author(s): Juliette Le Douce; Marianne Maugard; Julien Veran; Julien Veran; Marco Matos; Marco Matos; Pierrick Jego; Pierre Antoine Vigneron; Emilie Faivre; Xavier Toussay; Michel E. Vandenberghe; Yaël Balbastre; Juliette Piquet; Elvire Guiot; Nguyet Thuy Tran; Myriam Taverna; Myriam Taverna; Stéphane Marinesco; Ayumi Koyanagi; Shigeki Furuya; Mylène Gaudin-Guérif; Sébastien Goutal; Aurélie Ghettas; Al
Published in: Cell Metabolism, 2020, ISSN 1550-4131
Publisher: Cell Press
DOI: 10.1016/j.cmet.2020.02.004

Generation of a human induced pluripotent stem cell line from a patient with a rare A673T variant in amyloid precursor protein gene that reduces the risk for Alzheimer's disease (opens in new window)

Author(s): Lehtonen Š, Höytyläinen I, Voutilainen J, Sonninen TM, Kuusisto J, Laakso M, Hämäläinen RH, Oksanen M, Koistinaho J.
Published in: Stem cell research, 2018, ISSN 1873-5061
Publisher: Elsevier
DOI: 10.1016/j.scr.2018.05.014

Quantification of Total and Mutant Huntingtin Protein Levels in Biospecimens Using a Novel alphaLISA Assay (opens in new window)

Author(s): Barbara Baldo , Muhammad Umar Sajjad, Rachel Y Cheong, Julie Bigarreau, Ravi Vijayvargia, Catriona McLean, Anselme L Perrier, Ihn Sik Seong, Glenda Halliday, Åsa Petersén, Deniz Kirik
Published in: eNeuro, 2018, ISSN 2373-2822
Publisher: eNeuro
DOI: 10.1523/eneuro.0234-18.2018

A customizable microfluidic platform for medium-throughput modeling of neuromuscular circuits (opens in new window)

Author(s): Jessica Bellmann; Ruchi Goswami; Salvatore Girardo; Nelly Rein; Zohreh Hosseinzadeh; Michael R. Hicks; Volker Busskamp; April D. Pyle; Carsten Werner; Jared Sterneckert
Published in: Biomaterials, 2019, ISSN 0142-9612
Publisher: Pergamon Press Ltd.
DOI: 10.34657/5812

Novel Players in the Aging Synapse: Impact on Cognition (opens in new window)

Author(s): Mariana Temido-Ferreira; Joana E. Coelho; Paula A. Pousinha; Luísa V. Lopes
Published in: JOURNAL OF CAFFEINE AND ADENOSINE RESEARCH, Issue Volume 9, Number 3, 2019, ISSN 2573-3397
Publisher: Mary Ann Liebert
DOI: 10.1089/caff.2019.0013

Molecular Targets and Therapeutic Strategies in Spinocerebellar Ataxia Type 7 (opens in new window)

Author(s): Niewiadomska-Cimicka A, Trottier Y.
Published in: Neurotherapeutics, 2019, ISSN 1933-7213
Publisher: Elsevier BV
DOI: 10.1007/s13311-019-00778-5

Muscleblind acts as a modifier of FUS toxicity by modulating stress granule dynamics and SMN localization (opens in new window)

Author(s): Casci I, Krishnamurthy K, Kour S, Tripathy V, Ramesh N, Anderson EN, Marrone L, Grant RA, Oliver S, Gochenaur L, Patel K, Sterneckert J, Gleixner AM, Donnelly CJ, Ruepp MD, Sini AM, Zuccaro E, Pennuto M, Pasinelli P, Bhan Pandey U.
Published in: Nature Communications, 2019, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-019-13383-z

Common variants in Alzheimer’s disease: Novel association of six genetic variants with AD and risk stratification by polygenic risk scores. (opens in new window)

Author(s): De Rojas I, et al.
Published in: Nature communications, 2020, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1101/19012021

Dipeptidyl Vinyl Sulfone as a Novel Chemical Tool to Inhibit HMGB1/NLRP3-Inflammasome and Inflamma-miRs in Aβ-Mediated Microglial Inflammation (opens in new window)

Author(s): Falcão AS, Carvalho LAR, Lidónio G, Vaz AR, Lucas SD, Moreira R, Brites D
Published in: ACS chemical neuroscience, 2017, ISSN 1948-7193
Publisher: American Chemical Society
DOI: 10.1021/acschemneuro.6b00250

Astroglial NF-kB contributes to white matter damage and cognitive impairment in a mouse model of vascular dementia (opens in new window)

Author(s): Saggu, Raman; Schumacher, Toni; Gerich, Florian; Rakers, Cordula; Tai, Khalid; Delekate, Andrea; Petzold, Gabor C.
Published in: Acta Neuropathologica Communications, 2016, ISSN 2051-5960
Publisher: BioMed Central
DOI: 10.1186/s40478-016-0350-3

Bacterial amyloids: biogenesis and biomaterials (opens in new window)

Author(s): Christensen LFB, Schafer N, Wolf-Perez A, Madsen DJ, Otzen DE
Published in: Advances in experimental medicine and biology, 2019, ISSN 0065-2598
Publisher: Kluwer Academic/Plenum Publishers
DOI: 10.1007/978-981-13-9791-2_4

Astrocytic calcium release mediates peri-infarct depolarizations in a rodent stroke model. (opens in new window)

Author(s): Rakers C, Petzold GC.
Published in: Journal of Clinical Investigation, 2019, ISSN 0021-9738
Publisher: American Society for Clinical Investigation
DOI: 10.1172/jci89354

Autophagic and Proteasomal Mediated Removal of Mutant Androgen Receptor in Muscle Models of Spinal and Bulbar Muscular Atrophy (opens in new window)

Author(s): Cicardi M.E, Cristofani R., Crippa V., Ferrari V., Tedesco B., Casarotto E., Chierichetti M., Galbiati M., Piccolella M., Messi E., Carra S., Pennuto M., Rusmini P., Poletti A .
Published in: Frontiers in endocrinology, 2019, ISSN 1664-2392
Publisher: Lausanne : Frontiers Research Foundation
DOI: 10.3389/fendo.2019.00569

The sheaths of Methanospirillum are made of a new type of amyloid protein (opens in new window)

Author(s): Christensen LFB, Hansen LM, Finster K, Christiansen G, Nielsen PH, Otzen DE, Dueholm MS
Published in: Frontiers in Microbiology, 2018, ISSN 1664-302X
Publisher: Frontiers Media
DOI: 10.3389/fmicb.2018.02729

Focal solute trapping and global glymphatic pathway impairment in a murine model of microinfarcts. (opens in new window)

Author(s): Wang M, Nedergaard M, Iliff J.
Published in: Journal of Neuroscience, 2017, ISSN 0270-6474
Publisher: Society for Neuroscience
DOI: 10.1523/jneurosci.2112-16.2017

Towards the Identification of Molecular Biomarkers of Spinocerebellar Ataxia Type 3 (SCA3)/Machado-Joseph Disease (MJD) (opens in new window)

Author(s): Manuela Lima, Mafalda Raposo
Published in: Polyglutamine Disorders, 2018, ISSN 0065-2598
Publisher: Kluwer Academic/Plenum Publishers
DOI: 10.1007/978-3-319-71779-1_16

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