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CORDIS - Risultati della ricerca dell’UE
CORDIS

ERA-NET for establishing synergies between the Joint Programming on Neurodegenerative Diseases Research and Horizon 2020

Risultati finali

Organization of a symposium for the dissemination of the results of JPco-fuND-funded research

Organization of a symposium for the dissemination of the results of JPcofuNDfunded research by ZonMw and ITMOH Month 30 60

Pubblicazioni

Tdp-25 Routing to Autophagy and Proteasome Ameliorates its Aggregation in Amyotrophic Lateral Sclerosis Target Cells

Autori: Cicardi, Maria Elena; Cristofani, Riccardo; Rusmini, Paola; Meroni, Marco; Ferrari, Veronica; Vezzoli, Giulia; Tedesco, Barbara; Piccolella, Margherita; Messi, Elio; Galbiati, Mariarita; Boncoraglio, Alessandra; Carra, Serena; Crippa, Valeria; Poletti, Angelo
Pubblicato in: Scientific Reports, Numero 2, 2018, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-018-29658-2

Modeling Parkinson’s disease in midbrain-like organoids

Autori: Smits, L.M., Reinhardt, L., Reinhardt, P. et al.
Pubblicato in: npj Parkinsons Dis., 2019, ISSN 2373-8057
Editore: Springer Nature
DOI: 10.1038/s41531-019-0078-4

The blood-brain barrier is disrupted in Machado-Joseph disease/spinocerebellar ataxia type 3: evidence from transgenic mice and human post-mortem samples

Autori: Duarte Lobo D, Nobre RJ, Oliveira Miranda C, Pereira D, Castelhano J, Sereno J, Koeppen A, Castelo-Branco M, Pereira de Almeida L.
Pubblicato in: Acta neuropathologica communications, 2020, ISSN 2051-5960
Editore: BioMed Central
DOI: 10.1186/s40478-020-00955-0

Bri2 BRICHOS client specificity and chaperone activity are governed by assembly state

Autori: Chen G, Abelein A, Nilsson H, Leppert A, Andrade-Talavera Y, Tambaro S, Hemmingsson L, Roshan F, Landreh M, Biverstål H, Koeck P, Presto J, Hebert H, Fisahn A, Johansson J,
Pubblicato in: Nature communications, 2017, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-017-02056-4

Repeated Mesenchymal Stromal Cell Treatment Sustainably Alleviates Machado-Joseph Disease

Autori: Oliveira Miranda C, Marcelo A, Silva TP, Barata J, Vasconcelos-Ferreira A, Pereira D, Nóbrega C, Duarte S, Barros I, Alves J, Sereno J, Petrella LI, Castelhano J, Paiva VH, Rodrigues-Santos P, Alves V, Nunes-Correia I, Nobre RJ, Gomes C, Castelo-Branco M, Pereira de Almeida L.
Pubblicato in: Molecular Therapy, 2018, ISSN 1525-0016
Editore: Nature Publishing Group
DOI: 10.1016/j.ymthe.2018.07.007

The ability of liposomes, tailored for blood-brain barrier targeting, to reach the brain is dramatically affected by the disease state

Autori: Magro RD, Cox A, Zambelli V, Mancini S, Masserini M, Re F.
Pubblicato in: Nanomedicine (Lond), 2018, ISSN 1743-5889
Editore: Future Medicine Ltd.
DOI: 10.2217/nnm-2017-0317

A variant near DHCR24 associates with microstructural properties of white matter and peripheral lipid metabolism in adolescents

Autori: Sliz E., Shin J., Syme C., Patel Y., Parker N., Richer L., Gaudet D., Bennett S., Paus T., Pausova Z.
Pubblicato in: Molecular psychiatry, 2021, ISSN 1359-4184
Editore: Nature Publishing Group
DOI: 10.1038/s41380-019-0640-9

Neuronal DNA Methyltransferases: Epigenetic Mediators between Synaptic Activity and Gene Expression?

Autori: Gonca Bayraktar, Michael R. Kreutz
Pubblicato in: The Neuroscientist, 2017, ISSN 1073-8584
Editore: Sage Science Press
DOI: 10.1177/1073858417707457

The Role of the Heat Shock Protein B8 (HSPB8) in Motoneuron Diseases

Autori: Paola Rusmini; Riccardo Cristofani; Mariarita Galbiati; Maria E. Cicardi; Marco Meroni; Veronica Ferrari; Giulia Vezzoli; Barbara Tedesco; Elio Messi; Margherita Piccolella; Serena Carra; Valeria Crippa; Valeria Crippa; Angelo Poletti; Angelo Poletti
Pubblicato in: Frontiers in Molecular Neuroscience, Vol 10 (2017), Numero 2, 2017, ISSN 1662-5099
Editore: Frontiers Research Foundation
DOI: 10.3389/fnmol.2017.00176

Survival Associations Using Perfusion and Diffusion Magnetic Resonance Imaging in Patients With Histologic and Genetic Defined Diffuse Glioma World Health Organization Grades II and III

Autori: Latysheva A, Emblem KE, Server A, Brandal P, Meling TR, Pahnke J, Hald JK.
Pubblicato in: Journal of computer assisted tomography, 2018, ISSN 0363-8715
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/rct.0000000000000742

High-yield Production of Amyloid-β Peptide Enabled by a Customized Spider Silk Domain.

Autori: Axel Abelein; Gefei Chen; Kristīne Kitoka; Rihards Aleksis; Filips Oleskovs; Médoune Sarr; Michael Landreh; Jens Pahnke; Kerstin Nordling; Nina Kronqvist; Kristaps Jaudzems; Anna Rising; Anna Rising; Jan Johansson; Henrik Biverstål
Pubblicato in: Scientific Reports, Numero Vol 10, Iss 1,, 2020, Pagina/e Pp 1-10, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-019-57143-x

Validation of behavioral phenotypes in the BACHD rat model

Autori: Novati A, Manfré G, Flunkert S, Van der Harst JE, Homberg JR, Wronski R, Nguyen HP.
Pubblicato in: Behavioural Brain Research, 2020, ISSN 0166-4328
Editore: Elsevier BV
DOI: 10.1016/j.bbr.2020.112783

In vivo Phenotyping of Human Parkinson’s Disease-Specific Stem Cells Carrying the LRRK2-G2019S Mutation Reveals Increased a-Synuclein Levels but Absence of Spreading

Autori: Kathrin Hemmer, Lisa M. Smits, Silvia Bolognin, Jens Schwamborn
Pubblicato in: Opera Medica et Physiologica, 2018, ISSN 2500-2295
Editore: Opera Medica et Physiologica
DOI: 10.1101/140178

Golgi-Cox impregnation combined with fluorescence staining of amyloid plaques reveals local spine loss in an Alzheimer mouse model

Autori: Kartalou GI, Endres T, Lessmann V, Gottmann K.
Pubblicato in: Journal of Neuroscience Methods, 2020, ISSN 0165-0270
Editore: Elsevier BV
DOI: 10.1016/j.jneumeth.2020.108797

Environment-dependent striatal gene expression in the BACHD rat model for Huntington disease

Autori: Novati, Arianna; Hentrich, Thomas; Wassouf, Zinah; Weber, Jonasz J.; Yu-Taeger, Libo; Déglon, Nicole; Nguyen, Huu Phuc; Schulze-Hentrich, Julia M.
Pubblicato in: Scientific reports,, Numero vol. 8, no. 1, 2018, Pagina/e 5803, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-018-24243-z

Glymphatic distribution of CSF-derived apoE into brain is isoform specific and suppressed during sleep deprivation.

Autori: Achariyar TM, Li B, Peng W, Verghese PB, Shi Y, McConnell E, Benraiss A, Kasper T, Song W, Takano T, Holtzman DM, Nedergaard M, Deane R.
Pubblicato in: Molecular Neurodegeneration, 2017, ISSN 1750-1326
Editore: BioMed Central
DOI: 10.1186/s13024-016-0147-7

Defective ribosomal products challenge nuclear function by impairing nuclear condensate dynamics and immobilizing ubiquitin

Autori: Mediani, Laura; Guillén‐Boixet, Jordina; Vinet, Jonathan; Franzmann, Titus M; Bigi, Ilaria; Mateju, Daniel; Carrà, Arianna D; Morelli, Federica F; Tiago, Tatiana; Poser, Ina; Alberti, Simon; Carra, Serena
Pubblicato in: The EMBO Journal, Numero 1, 2019, ISSN 0261-4189
Editore: Nature Publishing Group
DOI: 10.15252/embj.2018101341

The Regulation of the Small Heat Shock Protein B8 in Misfolding Protein Diseases Causing Motoneuronal and Muscle Cell Death

Autori: Riccardo Cristofani; Paola Rusmini; Mariarita Galbiati; Maria Elena Cicardi; Veronica Ferrari; Barbara Tedesco; Elena Casarotto; Marta Chierichetti; Elio Messi; Margherita Piccolella; Serena Carra; Valeria Crippa; Angelo Poletti; Angelo Poletti
Pubblicato in: Frontiers in Neuroscience, Vol 13 (2019), 2019, ISSN 1662-4548
Editore: Frontiers Research Foundation
DOI: 10.3389/fnins.2019.00796

Generation of a human induced pluripotent stem cell line (LL008 1.4) from a familial Alzheimer's disease patient carrying a double KM670/671NL (Swedish) mutation in APP gene.

Autori: Oksanen, Minna; Hyötyläinen, Ida; Voutilainen, Jenni; Puttonen, Katja A.; Hämäläinen, Riikka H.; Graff, Caroline; Lehtonen, Šárka; Koistinaho, Jari
Pubblicato in: Stem Cell Research, Vol 31, Iss , Pp 181-185 (2018), 2018, ISSN 1873-5061
Editore: Elsevier
DOI: 10.1016/j.scr.2018.07.024

Directing neuronal cell fate in vitro: Achievements and challenges

Autori: R.J.M.Riemensabc, D.L.A.van den Hovecd, M.Estelleraef, R.Delgado-Moralesac
Pubblicato in: Progress in Neurobiology, 2018, ISSN 0301-0082
Editore: Pergamon Press Ltd.
DOI: 10.1016/j.pneurobio.2018.04.003

Global and regional development of the human cerebral cortex: Molecular acrchitecture and occupational aptitudes.

Autori: Shin, J., Ma, S., Hofer, E., Patel, Y., Vosberg, D. E., Tilley, S., Roshchupkin, G. V., Sousa, A. M. M., Jian, X., Gottesman, R., Mosley, T. H., Fornage, M., Saba, Y., Pirpamer, L., Schmidt, R., Schmidt, H., Carrion Castillo, A., Crivello, F., Mazoyer, B., Bis, J. C., Li, S., Yang, Q., Luciano, M., Karama, S., Lewis, L., Bastin, M. E., Harris, M. A., Wardlaw, J. M., Deary, I. E., Scholz, M., Loeff
Pubblicato in: Cerebral Cortex, 2020, ISSN 1047-3211
Editore: Oxford University Press
DOI: 10.1093/cercor/bhaa035

Long-term depression at hippocampal mossy fiber-CA3 synapses involves BDNF but is not mediated by p75NTR signaling

Autori: Garad M, Edelmann E, Lessmann V.
Pubblicato in: Scientific Reports, 2021, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-021-87769-9

Loss of zebrafish Ataxin-7, a SAGA subunit responsible for SCA7 retinopathy, causes ocular coloboma and malformation of photoreceptors

Autori: Samantha Carrillo-Rosas, Chantal Weber, Lorraine Fievet, Nadia Messaddeq, Alice Karam, Yvon Trottier;
Pubblicato in: Human molecular genetics, 2019, ISSN 0964-6906
Editore: Oxford University Press
DOI: 10.1093/hmg/ddy401

A Molecular Grammar Governing the Driving Forces for Phase Separation of Prion-like RNA Binding Proteins

Autori: Wang, Jie; Choi, Jeong-Mo; Holehouse, Alex S.; Lee, Hyun O.; Zhang, Xiaojie; Jahnel, Marcus; Maharana, Shovamayee; Lemaitre, Régis; Pozniakovsky, Andrei; Drechsel, David; Poser, Ina; Pappu, Rohit V.; Alberti, Simon; Hyman, Anthony A.
Pubblicato in: Cells, 2018, ISSN 0092-8674
Editore: Cell Press
DOI: 10.1016/j.cell.2018.06.006

A kinetic model for Brain-Derived Neurotrophic Factor mediated spike timing-dependent LTP

Autori: Solinas SMG, Edelmann E, Leßmann V, Migliore M.
Pubblicato in: Plos Computational Biology, 2019, ISSN 1553-734X
Editore: Public Library of Science
DOI: 10.1371/journal.pcbi.1006975

Mitochondria in the signaling pathways that control longevity and health span.

Autori: Akbari M, Kirkwood TBL, Bohr VA.
Pubblicato in: Ageing Research Reviews, 2019, ISSN 1568-1637
Editore: Elsevier BV
DOI: 10.1016/j.arr.2019.100940

Can markers of biological age predict dependency in old age?

Autori: Jylhävä J, Jiang M, Foebel AD, Pedersen NL, Hägg S.
Pubblicato in: Biogerontology, 2019, ISSN 1389-5729
Editore: Kluwer Academic Publishers
DOI: 10.1007/s10522-019-09795-5

Impairment of macroautophagy in dopamine neurons has opposing effects on Parkinsonian pathology and behavior.

Autori: Hunn BHM, Vingill S, Threlfell S, Alegre-Abarrategui J, Magdelyns M, Deltheil T, Bengoa-Vergniory N, Oliver PL, Cioroch M, Doig NM, Bannerman DM, Cragg SJ and Wade-Martins R.
Pubblicato in: Cell reports, 2019, ISSN 2211-1247
Editore: Cell Press
DOI: 10.1016/j.celrep.2019.09.029

Gene Deregulation and Underlying Mechanisms in Spinocerebellar Ataxias With Polyglutamine Expansion

Autori: Niewiadomska-Cimicka A, Hache A, Trottier Y.
Pubblicato in: Frontiers in neuroscience, 2020, ISSN 1662-4548
Editore: Frontiers Research Foundation
DOI: 10.3389/fnins.2020.00571

ST Pipeline: an automated pipeline for spatial mapping of unique transcripts.

Autori: Navarro JF, Sjöstrand J, Salmén F, Lundeberg J, Ståhl PL.
Pubblicato in: Bioinformatics, 2017, ISSN 1367-4811
Editore: Oxford Academic
DOI: 10.1093/bioinformatics/btx211

Expression of endogenous mouse APP modulates β-amyloid deposition in hAPP-transgenic mice

Autori: Steffen, J., Krohn, M., Schwitlick, C. et al.
Pubblicato in: acta neuropathol commun, Numero 5, 2017, Pagina/e 49, ISSN 2051-5960
Editore: BioMed Central
DOI: 10.1186/s40478-017-0448-2

The Emerging Role of Mechanics in Synapse Formation and Plasticity

Autori: Kilinc D
Pubblicato in: Front. Cell. Neurosci, Numero 12, 2018, Pagina/e 483, ISSN 1662-5102
Editore: Frontiers Research Foundation
DOI: 10.3389/fncel.2018.00483

Differential Membrane Binding and Seeding of Distinct α-Synuclein Fibrillar Polymorphs

Autori: Shrivastava AN, Bousset L, Renner M, Redeker V, Savistchenko J, Triller A, Melki R
Pubblicato in: Biophysical journal, 2020, ISSN 0006-3495
Editore: Biophysical Society
DOI: 10.1016/j.bpj.2020.01.022

Genetic and lifestyle risk factors for MRI-defined brain infarcts in a population-based setting

Autori: Ganesh Chauhan, Hieab H H Adams, Claudia L Satizabal, Joshua C Bis, Alexander Teumer, Muralidharan Sargurupremraj, Edith Hofer, Stella Trompet, Saima Hilal, Albert Vernon Smith, Xueqiu Jian, Rainer Malik, Matthew Traylor, Sara L Pulit, Philippe Amouyel, Bernard Mazoyer, Yi-Cheng Zhu, Sara Kaffashian, Sabrina Schilling, Gary W Beecham, Thomas J Montine, Gerard D Schellenberg, Olafur Kjartansson, Vi
Pubblicato in: Neurology, 2019, ISSN 0028-3878
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1212/wnl.0000000000006851

Selection of Reference Genes for Normalization of Gene Expression Data in Blood of Machado-Joseph Disease/Spinocerebellar Ataxia Type 3 (MJD/SCA3) Subjects

Autori: Ferreira, A.F., Raposo, M., Vasconcelos, J. et al.
Pubblicato in: Journal of Molecular Neuroscience, Numero 69, 2019, Pagina/e 450–455, ISSN 0895-8696
Editore: Humana Press, Inc.
DOI: 10.1007/s12031-019-01374-0

FACS-Assisted CRISPR-Cas9 Genome Editing Facilitates Parkinson's Disease Modeling

Autori: Jonathan Arias-Fuenzalida, JavierJarazo, Xiaobing Qing, Jonas Walter, Gemma Gomez-Giro, Sarah Louise Nickels, HolmZaehres45Hans Robert Schöler, Jens Christian Schwamborn
Pubblicato in: Stem Cell Reports, 2017, ISSN 2213-6711
Editore: Cell Press
DOI: 10.1016/j.stemcr.2017.08.026

Dual Inhibition of GSK3β and CDK5 Protects the Cytoskeleton of Neurons from Neuroinflammatory-Mediated Degeneration In Vitro and In Vivo

Autori: Reinhardt L, Kordes S, Reinhardt P, Glatza M, Baumann M, Drexler HCA, Menninger S, Zischinsky G, Eickhoff J, Fröb C, Bhattarai P, Arulmozhivarman G, Marrone L, Janosch A, Adachi K, Stehling M, Anderson EN, Abo-Rady M, Bickle M, Pandey UB, Reimer MM, Kizil C, Schöler HR, Nussbaumer P, Klebl B, and Sterneckert JL.
Pubblicato in: Stem Cell Reports, 2019, ISSN 2213-6711
Editore: Cell Press
DOI: 10.1016/j.stemcr.2019.01.015

The L444P Gba1 mutation enhances alpha-synuclein induced loss of nigral dopaminergic neurons in mice

Autori: Migdalska-Richards A, Wegrzynowicz M, Rusconi R, Deangeli G, Di Monte DA, Spillantini MG, Schapira AHV.
Pubblicato in: Brain, 2017, ISSN 0006-8950
Editore: Oxford University Press
DOI: 10.1093/brain/awx221

Glycation in Huntington's Disease: A Possible Modifier and Target for Intervention

Autori: Brás IC, König A, Outeiro TF.
Pubblicato in: Journal of Huntington's Disease, 2019, ISSN 1879-6397
Editore: IOS Press
DOI: 10.3233/jhd-190366

Lactate-Induced Glucose Output Is Unchanged by Metformin at a Therapeutic Concentration - A Mass Spectrometry Imaging Study of the Perfused Rat Liver.

Autori: Giulio Calza; Elisabeth Nyberg; Elisabeth Nyberg; Matias Mäkinen; Rabah Soliymani; Annunziata Cascone; Dan Lindholm; Dan Lindholm; Emanuele Barborini; Marc Baumann; Maciej Lalowski; Ove Eriksson
Pubblicato in: Frontiers in Pharmacology, Vol 9 (2018), 2018, ISSN 1663-9812
Editore: Frontiers Media S.A.
DOI: 10.3389/fphar.2018.00141

Using a qPCR device to screen for modulators of ABC transporter activity: A step-by-step protocol

Autori: Luisa Möhle; Luisa Möhle; Barbora Schwarzová; Markus Krohn; Sven Marcel Stefan; Jens Pahnke
Pubblicato in: Journal of Pharmacological and Toxicological Methods, Numero 1, 2020, ISSN 1056-8719
Editore: Elsevier BV
DOI: 10.1016/j.vascn.2020.106882

A comparative study on pathological features of transgenic rat lines expressing either three or four repeat misfolded tau

Autori: Valachova B, Brezovakova V, Bugos O, Jadhav S, Smolek T, Novak P, Zilka N.
Pubblicato in: Journal of Comparative Neurology, 2018, ISSN 0021-9967
Editore: John Wiley & Sons Inc.
DOI: 10.1002/cne.24447

Key Aging-Associated Alterations in Primary Microglia Response to Beta-Amyloid Stimulation

Autori: Caldeira C, Cunha C, Vaz AR, Falcão AS, Barateiro A, Seixas E, Fernandes A, Brites D.
Pubblicato in: Frontiers in ageing neuroscience, 2017, ISSN 1663-4365
Editore: Frontiers Research Foundation
DOI: 10.3389/fnagi.2017.00277

Evaluation of Lymphocyte Response to the Induced Oxidative Stress in a Cohort of Ageing Subjects, including Semisupercentenarians and Their Offspring

Autori: Sizzano, F., Collino, S., Cominetti, O., Monti, D., Garagnani, P., Ostan, R., Pirazzini, C., Bacalini, M.G., Mari, D., Passarino, G.,…Franceschi C., et al.
Pubblicato in: Mediators of Inflammation, 2018, ISSN 0962-9351
Editore: Hindawi Publishing Corporation
DOI: 10.1155/2018/7109312

Ibuprofen enhances synaptic function and neural progenitors proliferation markers and improves neuropathology and motor coordination in Machado-Joseph disease models

Autori: Mendonça LS, Nóbrega C, Tavino S, Brinkhaus M, Matos C, Tomé S, Moreira R, Henriques D, Kaspar BK, Pereira de Almeida L.
Pubblicato in: Human Molecular Genetics, 2019, ISSN 0964-6906
Editore: Oxford University Press
DOI: 10.1093/hmg/ddz097

Revisiting rodent models: Octodon degus as Alzheimer's disease model?

Autori: Steffen J, Krohn M, Paarmann K, Schwitlick C, Bruning T, Marreiros R, Muller- Schiffmann A, Korth C, Braun K, Pahnke J
Pubblicato in: Acta neuropathologica communications, 2016, ISSN 2051-5960
Editore: BioMed Central
DOI: 10.1186/s40478-016-0363-y

Inhibition of copper transporter 1 prevents α-synuclein pathology and alleviates nigrostriatal degeneration in AAV-based mouse model of Parkinson's disease

Autori: Gou DH, Huang TT, Li W, Gao XD, Haikal C, Wang XH, Song DY, Liang X, Zhu L, Tang Y, Ding C, Li JY.
Pubblicato in: Redox Biology, 2021, ISSN 2213-2317
Editore: Elsevier BV
DOI: 10.1016/j.redox.2020.101795

Inhibiting pathologically active ADAM10 rescues synaptic and cognitive decline in Huntington's disease

Autori: Vezzoli E, Caron I, Talpo F, Besusso D, Conforti P, Battaglia E, Sogne E, Falqui A, Petricca L, Verani M, Martufi P, Caricasole A, Bresciani A, Cecchetti O, Rivetti di Val Cervo P, Sancini G, Riess O, Nguyen H, Seipold L, Saftig P, Biella G, Cattaneo E, Zuccato C.
Pubblicato in: Journal of Clinical Investigation, 2019, ISSN 0021-9738
Editore: American Society for Clinical Investigation
DOI: 10.1172/jci120616

CRISPR/Cas9 and piggyBac-mediated footprint-free LRRK2-G2019S knock-in reveals neuronal complexity phenotypes and α-Synuclein modulation in dopaminergic neurons

Autori: Xiaobing Qing 1, Jonas Walter 1, Javier Jarazo 1, Jonathan Arias-Fuenzalida 1, Anna-Lena Hillje 1, Jens C Schwamborn 2
Pubblicato in: Stem Cell Res, 2018, ISSN 1873-5061
Editore: Elsevier
DOI: 10.1016/j.scr.2017.08.013

The Continuum of Aging and Age-Related Diseases: Common Mechanisms but Different Rates

Autori: Claudio Franceschi 1, Paolo Garagnani 2 3 4 5, Cristina Morsiani 2, Maria Conte 2, Aurelia Santoro 2 6, Andrea Grignolio 7, Daniela Monti 8, Miriam Capri 2 6, Stefano Salvioli
Pubblicato in: Front Med (Lausanne), 2018, ISSN 2296-858X
Editore: Frontiers Media SA
DOI: 10.3389/fmed.2018.00061

Alpha-synuclein and the prion hypothesis in Parkinson's disease

Autori: Melki R.
Pubblicato in: Revue neurologique (Paris), 2018, ISSN 0035-3787
Editore: Elsevier Masson
DOI: 10.1016/j.neurol.2018.08.002

Neural Correlates of the Dual-Pathway Model for ADHD in Adolescents

Autori: Chun Shen, M.Sc., Qiang Luo, Ph.D., Tianye Jia, Ph.D., Qi Zhao, M.Sc., Sylvane Desrivières, Ph.D., Erin Burke Quinlan, Ph.D., Tobias Banaschewski, M.D., Ph.D., Sabina Millenet, D.Psych., Arun L.W. Bokde, Ph.D., Christian Büchel, M.D., Herta Flor, Ph.D., Vincent Frouin, Ph.D., Hugh Garavan, Ph.D., Penny Gowland, Ph.D., Andreas Heinz, M.D., Ph.D., Bernd Ittermann, Ph.D., Jean-Luc Martinot, M.D., P
Pubblicato in: American journal of psychiatry, 2020, ISSN 0002-953X
Editore: American Psychiatric Publishing, Inc.
DOI: 10.1176/appi.ajp.2020.19020183

3D Cultures of Parkinson's Disease-Specific Dopaminergic Neurons for High Content Phenotyping and Drug Testing

Autori: Silvia Bolognin 1 2, Marie Fossépré 1 2, Xiaobing Qing 1, Javier Jarazo 1, Janez Ščančar 3, Edinson Lucumi Moreno 1, Sarah L Nickels 1, Kobi Wasner 1, Nassima Ouzren 1, Jonas Walter 1 2, Anne Grünewald 1 4, Enrico Glaab 1, Luis Salamanca 1, Ronan M T Fleming 1, Paul M A Antony 1, Jens C Schwamborn
Pubblicato in: Adv Sci, 2019, ISSN 2198-3844
Editore: Wiley-VCH GmbH, Weinheim
DOI: 10.1002/advs.201800927

Secretome from SH-SY5Y APP Swe cells trigger time-dependent CHME3 microglia activation phenotypes, ultimately leading to miR-21 exosome shuttling

Autori: Fernandes A, Ribeiro AR, Monteiro M, Garcia G, Vaz AR, Brites D
Pubblicato in: Biochimie, 2018, ISSN 0300-9084
Editore: Elsevier BV
DOI: 10.1016/j.biochi.2018.05.015

Increased Immune Activation by Pathologic α-Synuclein in Parkinson's Disease

Autori: Grozdanov V, Bousset L, Hoffmeister M, Bliederhaeuser C, Meier C, Madiona K, Pieri L, Kiechle M, McLean PJ, Kassubek J, Behrends C, Ludolph AC, Weishaupt JH, Melki R, Danzer KM
Pubblicato in: Annals of neurology, 2019, ISSN 0364-5134
Editore: John Wiley & Sons Inc.
DOI: 10.1002/ana.25557

FTY720 treatment starting after onset of symptoms reverses synaptic and memory deficits in an AD mouse model.

Autori: Kartalou G-I, Salgueiro Pereira SP, Endres T, Lesnikova A, Casarotto P, Pousinha P, Delanoe K, Edelmann E, Castrén E, Gottmann K, Marie H, Lessmann V.
Pubblicato in: BioRxiv, 2019, ISSN 2692-8205
Editore: BioRxiv
DOI: 10.1101/2019.12.15.868026

Human iPSC-Derived Hippocampal Spheroids: An Innovative Tool for Stratifying Alzheimer Disease Patient-Specific Cellular Phenotypes and Developing Therapies

Autori: Pomeshchik Y, Klementieva O, Gil J, Martinsson I, Hansen MG, de Vries T, Sancho-Balsells A, Russ K, Savchenko E, Collin A, Vaz AR, Bagnoli S, Nacmias B, Rampon C, Sorbi S, Brites D, Marko-Varga G, Kokaia Z, Rezeli M, Gouras GK, Roybon L.
Pubblicato in: Stem Cell Reports, 2020, ISSN 2213-6711
Editore: Cell Press
DOI: 10.1016/j.stemcr.2020.06.001

Quality Control of Membraneless Organelles.

Autori: Simon Alberti; Serena Carra
Pubblicato in: Journal of Molecular Biology, 2018, ISSN 0022-2836
Editore: Academic Press
DOI: 10.1016/j.jmb.2018.05.013

"Brain-Derived Neurotrophic Factor and Vascular Endothelial Growth Factor: ""Siamese Twins"" in Antidepressant Action"

Autori: Lima-Ojeda JM, Castrén E.
Pubblicato in: Biological psychiatry, 2019, ISSN 0006-3223
Editore: Elsevier BV
DOI: 10.1016/j.biopsych.2019.05.003

Transcranial optical imaging reveals a pathway for optimizing the delivery of immunotherapeutics to the brain.

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NLRP3 Is Involved in the Maintenance of Cerebral Pericytes

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The Exosomal/Total α-Synuclein Ratio in Plasma Is Associated With Glucocerebrosidase Activity and Correlates With Measures of Disease Severity in PD Patients

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Granulostasis: Protein Quality Control of RNP Granules

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Understanding Dopaminergic Cell Death Pathways in Parkinson Disease

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Brain Peak Width of Skeletonized Mean Diffusivity (PSMD) and Cognitive Function in Later Life

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In Vivo Transient and Partial Cell Reprogramming to Pluripotency as a Therapeutic Tool for Neurodegenerative Diseases

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Accelerated bio-cognitive aging in Down syndrome: State of the art and possible deceleration strategies

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PSEN1 Mutant iPSC-Derived Model Reveals Severe Astrocyte Pathology in Alzheimer's Disease.

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Sideritis spp. Extracts Enhance Memory and Learning in Alzheimer's β-Amyloidosis Mouse Models and Aged C57Bl/6 Mice

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Developmental Expression of 4-Repeat-Tau Induces Neuronal Aneuploidy in Drosophila Tauopathy Models

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SCA7 Mouse Cerebellar Pathology Reveals Preferential Downregulation of Key Purkinje Cell-Identity Genes and Shared Disease Signature with SCA1 and SCA2

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Endothelial LRP1 - A Potential Target for the Treatment of Alzheimer's Disease : Theme: Drug Discovery, Development and Delivery in Alzheimer's Disease Guest Editor: Davide Brambilla

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Common Genetic Variation Indicates Separate Causes for Periventricular and Deep White Matter Hyperintensities

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Thickness of the cerebral cortex shows positive association with blood levels of triacylglycerols carrying 18-carbon fatty acids

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BACHD rats expressing full-length mutant huntingtin exhibit differences in social behavior compared to wild-type littermates

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A genome-wide association study identifies genetic loci associated with specific lobar brain volumes

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P2Y1 receptor blockade normalizes network dysfunction and cognition in an Alzheimer's disease model.

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The Role of Activity-Dependent DNA Demethylation in the Adult Brain and in Neurological Disorders

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Alexithymia Is Associated with Altered Cortical Thickness Networks in the General Population

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The neuroactive potential of the human gut microbiota in quality of life and depression

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Anti-Inflammatory Treatment with FTY720 Starting after Onset of Symptoms Reverses Synaptic Deficits in an AD Mouse Model.

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BIN1 recovers tauopathy-induced long-term memory deficits in mice and interacts with Tau through Thr348 phosphorylation

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Parkinson’s Disease-Associated Mutant LRRK2-Mediated Inhibition of miRNA Activity is Antagonized by TRIM32

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Machado-Joseph Disease: A Stress Combating Deubiquitylating Enzyme Changing Sides

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Familial Alzheimer’s Disease Lymphocytes Respond Differently Than Sporadic Cells to Oxidative Stress: Upregulated p53-p21 Signaling Linked with Presenilin 1 Mutants

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Traditional Japanese Herbal Medicine Yokukansan Targets Distinct but Overlapping Mechanisms in Aged Mice and in the 5xFAD Mouse Model of Alzheimer's Disease

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Does Global Astrocytic Calcium Signaling Participate in Awake Brain State Transitions and Neuronal Circuit Function?

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Enriched environmental conditions modify the gut microbiome composition and fecal markers of inflammation in Parkinson’s disease

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Transmission of Tau Pathology from Human to Rodent Brain: How to Humanise Animal Models for Alzheimer’s Disease Research

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Neuronal network maturation differently affects secretory vesicles and mitochondria transport in axons

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Simulation, Implementation and Measurement of Defined Sound Fields for Blood–Brain Barrier Opening in Rats

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The Clustering of mApoE Anti-Amyloidogenic Peptide on Nanoparticle Surface Does Not Alter Its Performance in Controlling Beta-Amyloid Aggregation

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High dilated perivascular space burden: a new MRI marker for risk of intracerebral hemorrhage

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Dynamic susceptibility contrast and diffusion MR imaging identify oligodendroglioma as defined by the 2016 WHO classification for brain tumors: histogram analysis approach

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Impact of demography and population dynamics on the genetic architecture of human longevity.

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Reverse NCX Attenuates Cellular Sodium Loading in Metabolically Compromised Cortex.

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Impairment of Glycolysis-Derived l-Serine Production in Astrocytes Contributes to Cognitive Deficits in Alzheimer's Disease.

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Novel Players in the Aging Synapse: Impact on Cognition

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Editore: Mary Ann Liebert
DOI: 10.1089/caff.2019.0013

Molecular Targets and Therapeutic Strategies in Spinocerebellar Ataxia Type 7

Autori: Niewiadomska-Cimicka A, Trottier Y.
Pubblicato in: Neurotherapeutics, 2019, ISSN 1933-7213
Editore: Elsevier BV
DOI: 10.1007/s13311-019-00778-5

Muscleblind acts as a modifier of FUS toxicity by modulating stress granule dynamics and SMN localization

Autori: Casci I, Krishnamurthy K, Kour S, Tripathy V, Ramesh N, Anderson EN, Marrone L, Grant RA, Oliver S, Gochenaur L, Patel K, Sterneckert J, Gleixner AM, Donnelly CJ, Ruepp MD, Sini AM, Zuccaro E, Pennuto M, Pasinelli P, Bhan Pandey U.
Pubblicato in: Nature Communications, 2019, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-019-13383-z

Common variants in Alzheimer’s disease: Novel association of six genetic variants with AD and risk stratification by polygenic risk scores.

Autori: De Rojas I, et al.
Pubblicato in: Nature communications, 2020, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1101/19012021

Dipeptidyl Vinyl Sulfone as a Novel Chemical Tool to Inhibit HMGB1/NLRP3-Inflammasome and Inflamma-miRs in Aβ-Mediated Microglial Inflammation

Autori: Falcão AS, Carvalho LAR, Lidónio G, Vaz AR, Lucas SD, Moreira R, Brites D
Pubblicato in: ACS chemical neuroscience, 2017, ISSN 1948-7193
Editore: American Chemical Society
DOI: 10.1021/acschemneuro.6b00250

Astroglial NF-kB contributes to white matter damage and cognitive impairment in a mouse model of vascular dementia

Autori: Saggu, Raman; Schumacher, Toni; Gerich, Florian; Rakers, Cordula; Tai, Khalid; Delekate, Andrea; Petzold, Gabor C.
Pubblicato in: Acta Neuropathologica Communications, 2016, ISSN 2051-5960
Editore: BioMed Central
DOI: 10.1186/s40478-016-0350-3

Bacterial amyloids: biogenesis and biomaterials

Autori: Christensen LFB, Schafer N, Wolf-Perez A, Madsen DJ, Otzen DE
Pubblicato in: Advances in experimental medicine and biology, 2019, ISSN 0065-2598
Editore: Kluwer Academic/Plenum Publishers
DOI: 10.1007/978-981-13-9791-2_4

Astrocytic calcium release mediates peri-infarct depolarizations in a rodent stroke model.

Autori: Rakers C, Petzold GC.
Pubblicato in: Journal of Clinical Investigation, 2019, ISSN 0021-9738
Editore: American Society for Clinical Investigation
DOI: 10.1172/jci89354

Autophagic and Proteasomal Mediated Removal of Mutant Androgen Receptor in Muscle Models of Spinal and Bulbar Muscular Atrophy

Autori: Cicardi M.E, Cristofani R., Crippa V., Ferrari V., Tedesco B., Casarotto E., Chierichetti M., Galbiati M., Piccolella M., Messi E., Carra S., Pennuto M., Rusmini P., Poletti A .
Pubblicato in: Frontiers in endocrinology, 2019, ISSN 1664-2392
Editore: Lausanne : Frontiers Research Foundation
DOI: 10.3389/fendo.2019.00569

The sheaths of Methanospirillum are made of a new type of amyloid protein

Autori: Christensen LFB, Hansen LM, Finster K, Christiansen G, Nielsen PH, Otzen DE, Dueholm MS
Pubblicato in: Frontiers in Microbiology, 2018, ISSN 1664-302X
Editore: Frontiers Media
DOI: 10.3389/fmicb.2018.02729

Focal solute trapping and global glymphatic pathway impairment in a murine model of microinfarcts.

Autori: Wang M, Nedergaard M, Iliff J.
Pubblicato in: Journal of Neuroscience, 2017, ISSN 0270-6474
Editore: Society for Neuroscience
DOI: 10.1523/jneurosci.2112-16.2017

Towards the Identification of Molecular Biomarkers of Spinocerebellar Ataxia Type 3 (SCA3)/Machado-Joseph Disease (MJD)

Autori: Manuela Lima, Mafalda Raposo
Pubblicato in: Polyglutamine Disorders, 2018, ISSN 0065-2598
Editore: Kluwer Academic/Plenum Publishers
DOI: 10.1007/978-3-319-71779-1_16

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