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CORDIS

ERA-NET for establishing synergies between the Joint Programming on Neurodegenerative Diseases Research and Horizon 2020

Resultado final

Organization of a symposium for the dissemination of the results of JPco-fuND-funded research

Organization of a symposium for the dissemination of the results of JPcofuNDfunded research by ZonMw and ITMOH Month 30 60

Publicaciones

Tdp-25 Routing to Autophagy and Proteasome Ameliorates its Aggregation in Amyotrophic Lateral Sclerosis Target Cells

Autores: Cicardi, Maria Elena; Cristofani, Riccardo; Rusmini, Paola; Meroni, Marco; Ferrari, Veronica; Vezzoli, Giulia; Tedesco, Barbara; Piccolella, Margherita; Messi, Elio; Galbiati, Mariarita; Boncoraglio, Alessandra; Carra, Serena; Crippa, Valeria; Poletti, Angelo
Publicado en: Scientific Reports, Edición 2, 2018, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-018-29658-2

Modeling Parkinson’s disease in midbrain-like organoids

Autores: Smits, L.M., Reinhardt, L., Reinhardt, P. et al.
Publicado en: npj Parkinsons Dis., 2019, ISSN 2373-8057
Editor: Springer Nature
DOI: 10.1038/s41531-019-0078-4

The blood-brain barrier is disrupted in Machado-Joseph disease/spinocerebellar ataxia type 3: evidence from transgenic mice and human post-mortem samples

Autores: Duarte Lobo D, Nobre RJ, Oliveira Miranda C, Pereira D, Castelhano J, Sereno J, Koeppen A, Castelo-Branco M, Pereira de Almeida L.
Publicado en: Acta neuropathologica communications, 2020, ISSN 2051-5960
Editor: BioMed Central
DOI: 10.1186/s40478-020-00955-0

Bri2 BRICHOS client specificity and chaperone activity are governed by assembly state

Autores: Chen G, Abelein A, Nilsson H, Leppert A, Andrade-Talavera Y, Tambaro S, Hemmingsson L, Roshan F, Landreh M, Biverstål H, Koeck P, Presto J, Hebert H, Fisahn A, Johansson J,
Publicado en: Nature communications, 2017, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-017-02056-4

Repeated Mesenchymal Stromal Cell Treatment Sustainably Alleviates Machado-Joseph Disease

Autores: Oliveira Miranda C, Marcelo A, Silva TP, Barata J, Vasconcelos-Ferreira A, Pereira D, Nóbrega C, Duarte S, Barros I, Alves J, Sereno J, Petrella LI, Castelhano J, Paiva VH, Rodrigues-Santos P, Alves V, Nunes-Correia I, Nobre RJ, Gomes C, Castelo-Branco M, Pereira de Almeida L.
Publicado en: Molecular Therapy, 2018, ISSN 1525-0016
Editor: Nature Publishing Group
DOI: 10.1016/j.ymthe.2018.07.007

The ability of liposomes, tailored for blood-brain barrier targeting, to reach the brain is dramatically affected by the disease state

Autores: Magro RD, Cox A, Zambelli V, Mancini S, Masserini M, Re F.
Publicado en: Nanomedicine (Lond), 2018, ISSN 1743-5889
Editor: Future Medicine Ltd.
DOI: 10.2217/nnm-2017-0317

A variant near DHCR24 associates with microstructural properties of white matter and peripheral lipid metabolism in adolescents

Autores: Sliz E., Shin J., Syme C., Patel Y., Parker N., Richer L., Gaudet D., Bennett S., Paus T., Pausova Z.
Publicado en: Molecular psychiatry, 2021, ISSN 1359-4184
Editor: Nature Publishing Group
DOI: 10.1038/s41380-019-0640-9

Neuronal DNA Methyltransferases: Epigenetic Mediators between Synaptic Activity and Gene Expression?

Autores: Gonca Bayraktar, Michael R. Kreutz
Publicado en: The Neuroscientist, 2017, ISSN 1073-8584
Editor: Sage Science Press
DOI: 10.1177/1073858417707457

The Role of the Heat Shock Protein B8 (HSPB8) in Motoneuron Diseases

Autores: Paola Rusmini; Riccardo Cristofani; Mariarita Galbiati; Maria E. Cicardi; Marco Meroni; Veronica Ferrari; Giulia Vezzoli; Barbara Tedesco; Elio Messi; Margherita Piccolella; Serena Carra; Valeria Crippa; Valeria Crippa; Angelo Poletti; Angelo Poletti
Publicado en: Frontiers in Molecular Neuroscience, Vol 10 (2017), Edición 2, 2017, ISSN 1662-5099
Editor: Frontiers Research Foundation
DOI: 10.3389/fnmol.2017.00176

Survival Associations Using Perfusion and Diffusion Magnetic Resonance Imaging in Patients With Histologic and Genetic Defined Diffuse Glioma World Health Organization Grades II and III

Autores: Latysheva A, Emblem KE, Server A, Brandal P, Meling TR, Pahnke J, Hald JK.
Publicado en: Journal of computer assisted tomography, 2018, ISSN 0363-8715
Editor: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/rct.0000000000000742

High-yield Production of Amyloid-β Peptide Enabled by a Customized Spider Silk Domain.

Autores: Axel Abelein; Gefei Chen; Kristīne Kitoka; Rihards Aleksis; Filips Oleskovs; Médoune Sarr; Michael Landreh; Jens Pahnke; Kerstin Nordling; Nina Kronqvist; Kristaps Jaudzems; Anna Rising; Anna Rising; Jan Johansson; Henrik Biverstål
Publicado en: Scientific Reports, Edición Vol 10, Iss 1,, 2020, Página(s) Pp 1-10, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-019-57143-x

Validation of behavioral phenotypes in the BACHD rat model

Autores: Novati A, Manfré G, Flunkert S, Van der Harst JE, Homberg JR, Wronski R, Nguyen HP.
Publicado en: Behavioural Brain Research, 2020, ISSN 0166-4328
Editor: Elsevier BV
DOI: 10.1016/j.bbr.2020.112783

In vivo Phenotyping of Human Parkinson’s Disease-Specific Stem Cells Carrying the LRRK2-G2019S Mutation Reveals Increased a-Synuclein Levels but Absence of Spreading

Autores: Kathrin Hemmer, Lisa M. Smits, Silvia Bolognin, Jens Schwamborn
Publicado en: Opera Medica et Physiologica, 2018, ISSN 2500-2295
Editor: Opera Medica et Physiologica
DOI: 10.1101/140178

Golgi-Cox impregnation combined with fluorescence staining of amyloid plaques reveals local spine loss in an Alzheimer mouse model

Autores: Kartalou GI, Endres T, Lessmann V, Gottmann K.
Publicado en: Journal of Neuroscience Methods, 2020, ISSN 0165-0270
Editor: Elsevier BV
DOI: 10.1016/j.jneumeth.2020.108797

Environment-dependent striatal gene expression in the BACHD rat model for Huntington disease

Autores: Novati, Arianna; Hentrich, Thomas; Wassouf, Zinah; Weber, Jonasz J.; Yu-Taeger, Libo; Déglon, Nicole; Nguyen, Huu Phuc; Schulze-Hentrich, Julia M.
Publicado en: Scientific reports,, Edición vol. 8, no. 1, 2018, Página(s) 5803, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-018-24243-z

Glymphatic distribution of CSF-derived apoE into brain is isoform specific and suppressed during sleep deprivation.

Autores: Achariyar TM, Li B, Peng W, Verghese PB, Shi Y, McConnell E, Benraiss A, Kasper T, Song W, Takano T, Holtzman DM, Nedergaard M, Deane R.
Publicado en: Molecular Neurodegeneration, 2017, ISSN 1750-1326
Editor: BioMed Central
DOI: 10.1186/s13024-016-0147-7

Defective ribosomal products challenge nuclear function by impairing nuclear condensate dynamics and immobilizing ubiquitin

Autores: Mediani, Laura; Guillén‐Boixet, Jordina; Vinet, Jonathan; Franzmann, Titus M; Bigi, Ilaria; Mateju, Daniel; Carrà, Arianna D; Morelli, Federica F; Tiago, Tatiana; Poser, Ina; Alberti, Simon; Carra, Serena
Publicado en: The EMBO Journal, Edición 1, 2019, ISSN 0261-4189
Editor: Nature Publishing Group
DOI: 10.15252/embj.2018101341

The Regulation of the Small Heat Shock Protein B8 in Misfolding Protein Diseases Causing Motoneuronal and Muscle Cell Death

Autores: Riccardo Cristofani; Paola Rusmini; Mariarita Galbiati; Maria Elena Cicardi; Veronica Ferrari; Barbara Tedesco; Elena Casarotto; Marta Chierichetti; Elio Messi; Margherita Piccolella; Serena Carra; Valeria Crippa; Angelo Poletti; Angelo Poletti
Publicado en: Frontiers in Neuroscience, Vol 13 (2019), 2019, ISSN 1662-4548
Editor: Frontiers Research Foundation
DOI: 10.3389/fnins.2019.00796

Generation of a human induced pluripotent stem cell line (LL008 1.4) from a familial Alzheimer's disease patient carrying a double KM670/671NL (Swedish) mutation in APP gene.

Autores: Oksanen, Minna; Hyötyläinen, Ida; Voutilainen, Jenni; Puttonen, Katja A.; Hämäläinen, Riikka H.; Graff, Caroline; Lehtonen, Šárka; Koistinaho, Jari
Publicado en: Stem Cell Research, Vol 31, Iss , Pp 181-185 (2018), 2018, ISSN 1873-5061
Editor: Elsevier
DOI: 10.1016/j.scr.2018.07.024

Directing neuronal cell fate in vitro: Achievements and challenges

Autores: R.J.M.Riemensabc, D.L.A.van den Hovecd, M.Estelleraef, R.Delgado-Moralesac
Publicado en: Progress in Neurobiology, 2018, ISSN 0301-0082
Editor: Pergamon Press Ltd.
DOI: 10.1016/j.pneurobio.2018.04.003

Global and regional development of the human cerebral cortex: Molecular acrchitecture and occupational aptitudes.

Autores: Shin, J., Ma, S., Hofer, E., Patel, Y., Vosberg, D. E., Tilley, S., Roshchupkin, G. V., Sousa, A. M. M., Jian, X., Gottesman, R., Mosley, T. H., Fornage, M., Saba, Y., Pirpamer, L., Schmidt, R., Schmidt, H., Carrion Castillo, A., Crivello, F., Mazoyer, B., Bis, J. C., Li, S., Yang, Q., Luciano, M., Karama, S., Lewis, L., Bastin, M. E., Harris, M. A., Wardlaw, J. M., Deary, I. E., Scholz, M., Loeff
Publicado en: Cerebral Cortex, 2020, ISSN 1047-3211
Editor: Oxford University Press
DOI: 10.1093/cercor/bhaa035

Long-term depression at hippocampal mossy fiber-CA3 synapses involves BDNF but is not mediated by p75NTR signaling

Autores: Garad M, Edelmann E, Lessmann V.
Publicado en: Scientific Reports, 2021, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-021-87769-9

Loss of zebrafish Ataxin-7, a SAGA subunit responsible for SCA7 retinopathy, causes ocular coloboma and malformation of photoreceptors

Autores: Samantha Carrillo-Rosas, Chantal Weber, Lorraine Fievet, Nadia Messaddeq, Alice Karam, Yvon Trottier;
Publicado en: Human molecular genetics, 2019, ISSN 0964-6906
Editor: Oxford University Press
DOI: 10.1093/hmg/ddy401

A Molecular Grammar Governing the Driving Forces for Phase Separation of Prion-like RNA Binding Proteins

Autores: Wang, Jie; Choi, Jeong-Mo; Holehouse, Alex S.; Lee, Hyun O.; Zhang, Xiaojie; Jahnel, Marcus; Maharana, Shovamayee; Lemaitre, Régis; Pozniakovsky, Andrei; Drechsel, David; Poser, Ina; Pappu, Rohit V.; Alberti, Simon; Hyman, Anthony A.
Publicado en: Cells, 2018, ISSN 0092-8674
Editor: Cell Press
DOI: 10.1016/j.cell.2018.06.006

A kinetic model for Brain-Derived Neurotrophic Factor mediated spike timing-dependent LTP

Autores: Solinas SMG, Edelmann E, Leßmann V, Migliore M.
Publicado en: Plos Computational Biology, 2019, ISSN 1553-734X
Editor: Public Library of Science
DOI: 10.1371/journal.pcbi.1006975

Mitochondria in the signaling pathways that control longevity and health span.

Autores: Akbari M, Kirkwood TBL, Bohr VA.
Publicado en: Ageing Research Reviews, 2019, ISSN 1568-1637
Editor: Elsevier BV
DOI: 10.1016/j.arr.2019.100940

Can markers of biological age predict dependency in old age?

Autores: Jylhävä J, Jiang M, Foebel AD, Pedersen NL, Hägg S.
Publicado en: Biogerontology, 2019, ISSN 1389-5729
Editor: Kluwer Academic Publishers
DOI: 10.1007/s10522-019-09795-5

Impairment of macroautophagy in dopamine neurons has opposing effects on Parkinsonian pathology and behavior.

Autores: Hunn BHM, Vingill S, Threlfell S, Alegre-Abarrategui J, Magdelyns M, Deltheil T, Bengoa-Vergniory N, Oliver PL, Cioroch M, Doig NM, Bannerman DM, Cragg SJ and Wade-Martins R.
Publicado en: Cell reports, 2019, ISSN 2211-1247
Editor: Cell Press
DOI: 10.1016/j.celrep.2019.09.029

Gene Deregulation and Underlying Mechanisms in Spinocerebellar Ataxias With Polyglutamine Expansion

Autores: Niewiadomska-Cimicka A, Hache A, Trottier Y.
Publicado en: Frontiers in neuroscience, 2020, ISSN 1662-4548
Editor: Frontiers Research Foundation
DOI: 10.3389/fnins.2020.00571

ST Pipeline: an automated pipeline for spatial mapping of unique transcripts.

Autores: Navarro JF, Sjöstrand J, Salmén F, Lundeberg J, Ståhl PL.
Publicado en: Bioinformatics, 2017, ISSN 1367-4811
Editor: Oxford Academic
DOI: 10.1093/bioinformatics/btx211

Expression of endogenous mouse APP modulates β-amyloid deposition in hAPP-transgenic mice

Autores: Steffen, J., Krohn, M., Schwitlick, C. et al.
Publicado en: acta neuropathol commun, Edición 5, 2017, Página(s) 49, ISSN 2051-5960
Editor: BioMed Central
DOI: 10.1186/s40478-017-0448-2

The Emerging Role of Mechanics in Synapse Formation and Plasticity

Autores: Kilinc D
Publicado en: Front. Cell. Neurosci, Edición 12, 2018, Página(s) 483, ISSN 1662-5102
Editor: Frontiers Research Foundation
DOI: 10.3389/fncel.2018.00483

Differential Membrane Binding and Seeding of Distinct α-Synuclein Fibrillar Polymorphs

Autores: Shrivastava AN, Bousset L, Renner M, Redeker V, Savistchenko J, Triller A, Melki R
Publicado en: Biophysical journal, 2020, ISSN 0006-3495
Editor: Biophysical Society
DOI: 10.1016/j.bpj.2020.01.022

Genetic and lifestyle risk factors for MRI-defined brain infarcts in a population-based setting

Autores: Ganesh Chauhan, Hieab H H Adams, Claudia L Satizabal, Joshua C Bis, Alexander Teumer, Muralidharan Sargurupremraj, Edith Hofer, Stella Trompet, Saima Hilal, Albert Vernon Smith, Xueqiu Jian, Rainer Malik, Matthew Traylor, Sara L Pulit, Philippe Amouyel, Bernard Mazoyer, Yi-Cheng Zhu, Sara Kaffashian, Sabrina Schilling, Gary W Beecham, Thomas J Montine, Gerard D Schellenberg, Olafur Kjartansson, Vi
Publicado en: Neurology, 2019, ISSN 0028-3878
Editor: Lippincott Williams & Wilkins Ltd.
DOI: 10.1212/wnl.0000000000006851

Selection of Reference Genes for Normalization of Gene Expression Data in Blood of Machado-Joseph Disease/Spinocerebellar Ataxia Type 3 (MJD/SCA3) Subjects

Autores: Ferreira, A.F., Raposo, M., Vasconcelos, J. et al.
Publicado en: Journal of Molecular Neuroscience, Edición 69, 2019, Página(s) 450–455, ISSN 0895-8696
Editor: Humana Press, Inc.
DOI: 10.1007/s12031-019-01374-0

FACS-Assisted CRISPR-Cas9 Genome Editing Facilitates Parkinson's Disease Modeling

Autores: Jonathan Arias-Fuenzalida, JavierJarazo, Xiaobing Qing, Jonas Walter, Gemma Gomez-Giro, Sarah Louise Nickels, HolmZaehres45Hans Robert Schöler, Jens Christian Schwamborn
Publicado en: Stem Cell Reports, 2017, ISSN 2213-6711
Editor: Cell Press
DOI: 10.1016/j.stemcr.2017.08.026

Dual Inhibition of GSK3β and CDK5 Protects the Cytoskeleton of Neurons from Neuroinflammatory-Mediated Degeneration In Vitro and In Vivo

Autores: Reinhardt L, Kordes S, Reinhardt P, Glatza M, Baumann M, Drexler HCA, Menninger S, Zischinsky G, Eickhoff J, Fröb C, Bhattarai P, Arulmozhivarman G, Marrone L, Janosch A, Adachi K, Stehling M, Anderson EN, Abo-Rady M, Bickle M, Pandey UB, Reimer MM, Kizil C, Schöler HR, Nussbaumer P, Klebl B, and Sterneckert JL.
Publicado en: Stem Cell Reports, 2019, ISSN 2213-6711
Editor: Cell Press
DOI: 10.1016/j.stemcr.2019.01.015

The L444P Gba1 mutation enhances alpha-synuclein induced loss of nigral dopaminergic neurons in mice

Autores: Migdalska-Richards A, Wegrzynowicz M, Rusconi R, Deangeli G, Di Monte DA, Spillantini MG, Schapira AHV.
Publicado en: Brain, 2017, ISSN 0006-8950
Editor: Oxford University Press
DOI: 10.1093/brain/awx221

Glycation in Huntington's Disease: A Possible Modifier and Target for Intervention

Autores: Brás IC, König A, Outeiro TF.
Publicado en: Journal of Huntington's Disease, 2019, ISSN 1879-6397
Editor: IOS Press
DOI: 10.3233/jhd-190366

Lactate-Induced Glucose Output Is Unchanged by Metformin at a Therapeutic Concentration - A Mass Spectrometry Imaging Study of the Perfused Rat Liver.

Autores: Giulio Calza; Elisabeth Nyberg; Elisabeth Nyberg; Matias Mäkinen; Rabah Soliymani; Annunziata Cascone; Dan Lindholm; Dan Lindholm; Emanuele Barborini; Marc Baumann; Maciej Lalowski; Ove Eriksson
Publicado en: Frontiers in Pharmacology, Vol 9 (2018), 2018, ISSN 1663-9812
Editor: Frontiers Media S.A.
DOI: 10.3389/fphar.2018.00141

Using a qPCR device to screen for modulators of ABC transporter activity: A step-by-step protocol

Autores: Luisa Möhle; Luisa Möhle; Barbora Schwarzová; Markus Krohn; Sven Marcel Stefan; Jens Pahnke
Publicado en: Journal of Pharmacological and Toxicological Methods, Edición 1, 2020, ISSN 1056-8719
Editor: Elsevier BV
DOI: 10.1016/j.vascn.2020.106882

A comparative study on pathological features of transgenic rat lines expressing either three or four repeat misfolded tau

Autores: Valachova B, Brezovakova V, Bugos O, Jadhav S, Smolek T, Novak P, Zilka N.
Publicado en: Journal of Comparative Neurology, 2018, ISSN 0021-9967
Editor: John Wiley & Sons Inc.
DOI: 10.1002/cne.24447

Key Aging-Associated Alterations in Primary Microglia Response to Beta-Amyloid Stimulation

Autores: Caldeira C, Cunha C, Vaz AR, Falcão AS, Barateiro A, Seixas E, Fernandes A, Brites D.
Publicado en: Frontiers in ageing neuroscience, 2017, ISSN 1663-4365
Editor: Frontiers Research Foundation
DOI: 10.3389/fnagi.2017.00277

Evaluation of Lymphocyte Response to the Induced Oxidative Stress in a Cohort of Ageing Subjects, including Semisupercentenarians and Their Offspring

Autores: Sizzano, F., Collino, S., Cominetti, O., Monti, D., Garagnani, P., Ostan, R., Pirazzini, C., Bacalini, M.G., Mari, D., Passarino, G.,…Franceschi C., et al.
Publicado en: Mediators of Inflammation, 2018, ISSN 0962-9351
Editor: Hindawi Publishing Corporation
DOI: 10.1155/2018/7109312

Ibuprofen enhances synaptic function and neural progenitors proliferation markers and improves neuropathology and motor coordination in Machado-Joseph disease models

Autores: Mendonça LS, Nóbrega C, Tavino S, Brinkhaus M, Matos C, Tomé S, Moreira R, Henriques D, Kaspar BK, Pereira de Almeida L.
Publicado en: Human Molecular Genetics, 2019, ISSN 0964-6906
Editor: Oxford University Press
DOI: 10.1093/hmg/ddz097

Revisiting rodent models: Octodon degus as Alzheimer's disease model?

Autores: Steffen J, Krohn M, Paarmann K, Schwitlick C, Bruning T, Marreiros R, Muller- Schiffmann A, Korth C, Braun K, Pahnke J
Publicado en: Acta neuropathologica communications, 2016, ISSN 2051-5960
Editor: BioMed Central
DOI: 10.1186/s40478-016-0363-y

Inhibition of copper transporter 1 prevents α-synuclein pathology and alleviates nigrostriatal degeneration in AAV-based mouse model of Parkinson's disease

Autores: Gou DH, Huang TT, Li W, Gao XD, Haikal C, Wang XH, Song DY, Liang X, Zhu L, Tang Y, Ding C, Li JY.
Publicado en: Redox Biology, 2021, ISSN 2213-2317
Editor: Elsevier BV
DOI: 10.1016/j.redox.2020.101795

Inhibiting pathologically active ADAM10 rescues synaptic and cognitive decline in Huntington's disease

Autores: Vezzoli E, Caron I, Talpo F, Besusso D, Conforti P, Battaglia E, Sogne E, Falqui A, Petricca L, Verani M, Martufi P, Caricasole A, Bresciani A, Cecchetti O, Rivetti di Val Cervo P, Sancini G, Riess O, Nguyen H, Seipold L, Saftig P, Biella G, Cattaneo E, Zuccato C.
Publicado en: Journal of Clinical Investigation, 2019, ISSN 0021-9738
Editor: American Society for Clinical Investigation
DOI: 10.1172/jci120616

CRISPR/Cas9 and piggyBac-mediated footprint-free LRRK2-G2019S knock-in reveals neuronal complexity phenotypes and α-Synuclein modulation in dopaminergic neurons

Autores: Xiaobing Qing 1, Jonas Walter 1, Javier Jarazo 1, Jonathan Arias-Fuenzalida 1, Anna-Lena Hillje 1, Jens C Schwamborn 2
Publicado en: Stem Cell Res, 2018, ISSN 1873-5061
Editor: Elsevier
DOI: 10.1016/j.scr.2017.08.013

The Continuum of Aging and Age-Related Diseases: Common Mechanisms but Different Rates

Autores: Claudio Franceschi 1, Paolo Garagnani 2 3 4 5, Cristina Morsiani 2, Maria Conte 2, Aurelia Santoro 2 6, Andrea Grignolio 7, Daniela Monti 8, Miriam Capri 2 6, Stefano Salvioli
Publicado en: Front Med (Lausanne), 2018, ISSN 2296-858X
Editor: Frontiers Media SA
DOI: 10.3389/fmed.2018.00061

Alpha-synuclein and the prion hypothesis in Parkinson's disease

Autores: Melki R.
Publicado en: Revue neurologique (Paris), 2018, ISSN 0035-3787
Editor: Elsevier Masson
DOI: 10.1016/j.neurol.2018.08.002

Neural Correlates of the Dual-Pathway Model for ADHD in Adolescents

Autores: Chun Shen, M.Sc., Qiang Luo, Ph.D., Tianye Jia, Ph.D., Qi Zhao, M.Sc., Sylvane Desrivières, Ph.D., Erin Burke Quinlan, Ph.D., Tobias Banaschewski, M.D., Ph.D., Sabina Millenet, D.Psych., Arun L.W. Bokde, Ph.D., Christian Büchel, M.D., Herta Flor, Ph.D., Vincent Frouin, Ph.D., Hugh Garavan, Ph.D., Penny Gowland, Ph.D., Andreas Heinz, M.D., Ph.D., Bernd Ittermann, Ph.D., Jean-Luc Martinot, M.D., P
Publicado en: American journal of psychiatry, 2020, ISSN 0002-953X
Editor: American Psychiatric Publishing, Inc.
DOI: 10.1176/appi.ajp.2020.19020183

3D Cultures of Parkinson's Disease-Specific Dopaminergic Neurons for High Content Phenotyping and Drug Testing

Autores: Silvia Bolognin 1 2, Marie Fossépré 1 2, Xiaobing Qing 1, Javier Jarazo 1, Janez Ščančar 3, Edinson Lucumi Moreno 1, Sarah L Nickels 1, Kobi Wasner 1, Nassima Ouzren 1, Jonas Walter 1 2, Anne Grünewald 1 4, Enrico Glaab 1, Luis Salamanca 1, Ronan M T Fleming 1, Paul M A Antony 1, Jens C Schwamborn
Publicado en: Adv Sci, 2019, ISSN 2198-3844
Editor: Wiley-VCH GmbH, Weinheim
DOI: 10.1002/advs.201800927

Secretome from SH-SY5Y APP Swe cells trigger time-dependent CHME3 microglia activation phenotypes, ultimately leading to miR-21 exosome shuttling

Autores: Fernandes A, Ribeiro AR, Monteiro M, Garcia G, Vaz AR, Brites D
Publicado en: Biochimie, 2018, ISSN 0300-9084
Editor: Elsevier BV
DOI: 10.1016/j.biochi.2018.05.015

Increased Immune Activation by Pathologic α-Synuclein in Parkinson's Disease

Autores: Grozdanov V, Bousset L, Hoffmeister M, Bliederhaeuser C, Meier C, Madiona K, Pieri L, Kiechle M, McLean PJ, Kassubek J, Behrends C, Ludolph AC, Weishaupt JH, Melki R, Danzer KM
Publicado en: Annals of neurology, 2019, ISSN 0364-5134
Editor: John Wiley & Sons Inc.
DOI: 10.1002/ana.25557

FTY720 treatment starting after onset of symptoms reverses synaptic and memory deficits in an AD mouse model.

Autores: Kartalou G-I, Salgueiro Pereira SP, Endres T, Lesnikova A, Casarotto P, Pousinha P, Delanoe K, Edelmann E, Castrén E, Gottmann K, Marie H, Lessmann V.
Publicado en: BioRxiv, 2019, ISSN 2692-8205
Editor: BioRxiv
DOI: 10.1101/2019.12.15.868026

Human iPSC-Derived Hippocampal Spheroids: An Innovative Tool for Stratifying Alzheimer Disease Patient-Specific Cellular Phenotypes and Developing Therapies

Autores: Pomeshchik Y, Klementieva O, Gil J, Martinsson I, Hansen MG, de Vries T, Sancho-Balsells A, Russ K, Savchenko E, Collin A, Vaz AR, Bagnoli S, Nacmias B, Rampon C, Sorbi S, Brites D, Marko-Varga G, Kokaia Z, Rezeli M, Gouras GK, Roybon L.
Publicado en: Stem Cell Reports, 2020, ISSN 2213-6711
Editor: Cell Press
DOI: 10.1016/j.stemcr.2020.06.001

Quality Control of Membraneless Organelles.

Autores: Simon Alberti; Serena Carra
Publicado en: Journal of Molecular Biology, 2018, ISSN 0022-2836
Editor: Academic Press
DOI: 10.1016/j.jmb.2018.05.013

"Brain-Derived Neurotrophic Factor and Vascular Endothelial Growth Factor: ""Siamese Twins"" in Antidepressant Action"

Autores: Lima-Ojeda JM, Castrén E.
Publicado en: Biological psychiatry, 2019, ISSN 0006-3223
Editor: Elsevier BV
DOI: 10.1016/j.biopsych.2019.05.003

Transcranial optical imaging reveals a pathway for optimizing the delivery of immunotherapeutics to the brain.

Autores: Plog BA, Mestre H, Olveda GE, Sweeney AM, Kenney HM, Cove A, Dholakia KY, Tithof J, Nevins TD, Lundgaard I, Du T, Kelley DH, Nedergaard M.
Publicado en: JCI insight, 2018, ISSN 2379-3708
Editor: The American Society for Clinical Investigation
DOI: 10.1172/jci.insight.120922

The prion protein is an agonistic ligand of the G protein-coupled receptor Adgrg6

Autores: Küffer, A., Lakkaraju, A., Mogha, A. et al.
Publicado en: Nature, Edición 536, 2016, Página(s) 464–468, ISSN 0028-0836
Editor: Nature Publishing Group
DOI: 10.1038/nature19312

Cell biology and dynamics of Neuronal Na +/K +-ATPase in health and diseases

Autores: Shrivastava AN, Triller A, Melki R.
Publicado en: Neuropharmacology, 2020, ISSN 0028-3908
Editor: Pergamon Press Ltd.
DOI: 10.1016/j.neuropharm.2018.12.008

The Amyloid Precursor Protein C-Terminal Domain Alters CA1 Neuron Firing, Modifying Hippocampus Oscillations and Impairing Spatial Memory Encoding.

Autores: Pousinha, Paula A.; Mouska, Xavier; Bianchi, Daniela; Temido-Ferreira, Mariana; Rajão-Saraiva, Joana; Gomes, Rui; Fernandez, Sebastian P.; Salgueiro-Pereira, Ana Rita; Gandin, Carine; Raymond, Elisabeth F.; Barik, Jacques; Goutagny, Romain; Bethus, Ingrid; Lopes, Luisa V.; Migliore, Michele; Marie, Hélène
Publicado en: Cell reports, Edición 1, 2019, ISSN 2211-1247
Editor: Cell Press
DOI: 10.1016/j.celrep.2019.08.103

Genetics of Human Longevity Within an Eco-Evolutionary Nature-Nurture Framework.

Autores: Giuliani C, Garagnani P, Franceschi C.
Publicado en: Circulation Research, 2018, ISSN 0009-7330
Editor: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/circresaha.118.312562

Derivation of Human Midbrain-Specific Organoids from Neuroepithelial Stem Cells

Autores: Anna S Monzel 1, Lisa M Smits 1, Kathrin Hemmer 1, Siham Hachi 2, Edinson Lucumi Moreno 2, Thea van Wuellen 1, Javier Jarazo 1, Jonas Walter 1, Inga Brüggemann 1, Ibrahim Boussaad 3, Emanuel Berger 1, Ronan M T Fleming 2, Silvia Bolognin 1, Jens C Schwamborn 4
Publicado en: Stem Cell Reports, 2017, ISSN 2213-6711
Editor: Cell Press
DOI: 10.1016/j.stemcr.2017.03.010

ɑ-Synuclein strains and seeding in Parkinson's disease, incidental Lewy body disease, dementia with Lewy bodies and multiple system atrophy: similarities and differences

Autores: Peelaerts W, Bousset L, Baekelandt V, Melki R.
Publicado en: Cell and Tissue Research, 2018, ISSN 0302-766X
Editor: Springer Verlag
DOI: 10.1007/s00441-018-2839-5

Protein Phase Separation as a Stress Survival Strategy

Autores: Franzmann TM, Alberti S
Publicado en: Cold Spring Harbor Perspectives in Biology, 2019, ISSN 1943-0264
Editor: Cold Spring Harbor Laboratory Press
DOI: 10.1101/cshperspect.a034058

Inhibition of Stat3-mediated astrogliosis ameliorates pathology in an Alzheimer's disease model.

Autores: Reichenbach, Nicole; Delekate, Andrea; Plescher, Monika; Schmitt, Franziska; Krauss, Sybille; Blank, Nelli; Halle, Annett; Petzold, Gabor C
Publicado en: EMBO Molecular Medicine, Vol 11, Iss 2, Pp n/a-n/a (2019), Edición 2, 2019, ISSN 1757-4676
Editor: John Wiley & Sons Ltd.
DOI: 10.15252/emmm.201809665

Glucocerebrosidase activity, cathepsin D and monomeric α-synuclein interactions in a stem cell derived neuronal model of a PD associated GBA1 mutation

Autores: Shi-Yu Yang, Matthew Gegg , David Chau, Anthony Schapira
Publicado en: Neurobiology of Disease, 2019, ISSN 0969-9961
Editor: Academic Press
DOI: 10.1016/j.nbd.2019.104620

Molecular subtypes of Alzheimer's disease

Autores: Di Fede G, Catania M, Maderna E, Ghidoni R, Benussi L, Tonoli E, Giaccone G, Moda F, Paterlini A, Campagnani I, Sorrentino S, Colombo L, Kubis A, Bistaffa E, Ghetti B, Tagliavini F.
Publicado en: Scientific reports, 2018, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-018-21641-1

Endocytic vesicle rupture is a conserved mechanism of cellular invasion by amyloid proteins

Autores: Flavin WP, Bousset L, Green ZC, Chu Y, Skarpathiotis S, Chaney MJ, Kordower JH, Melki R, Campbell EM.
Publicado en: Acta neuropathologica, 2017, ISSN 0001-6322
Editor: Springer Verlag
DOI: 10.1007/s00401-017-1722-x

Brain Distribution of Dual ABCB1/ABCG2 Substrates Is Unaltered in a Beta-Amyloidosis Mouse Model.

Autores: Thomas Wanek; Viktoria Zoufal; Mirjam Brackhan; Markus Krohn; Severin Mairinger; Thomas Filip; Michael Sauberer; Johann Stanek; Thomas Pekar; Jens Pahnke; Jens Pahnke; Jens Pahnke; Oliver Langer; Oliver Langer
Publicado en: International Journal of Molecular Sciences, 2020, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21218245

Evaluation of the Performance of AmpliSeq and SureSelect Exome Sequencing Libraries for Ion Proton

Autores: Gampawar P, Saba Y, Werner U, Schmidt R, Müller-Myhsok B, Schmidt H.
Publicado en: Frontiers in Genetics, 2019, ISSN 1664-8021
Editor: Frontiers Media
DOI: 10.3389/fgene.2019.00856

High-quality draft genome sequence of Sphaerisporangium cinnabarinum

Autores: Christensen LFB, Otzen DE, Dueholm MS
Publicado en: Genome announcements, 2018, ISSN 2169-8287
Editor: American Society for Microbiology
DOI: 10.1128/genomea.00456-18

Trehalose induces autophagy via lysosomal-mediated TFEB activation in models of motoneuron degeneration

Autores: "Rusmini, P.; Cortese, K.; Crippa, V.; Cristofani, R.; Cicardi, M.E.; Ferrari, V.; Vezzoli, G.; Tedesco, B.; Meroni, M.; Messi, E.; Piccolella, M.; Galbiati, M.; Garrè , M.; Morelli, E.; Vaccari, T.; Poletti, A."
Publicado en: Autophagy, Edición 1, 2018, ISSN 1554-8627
Editor: Landes Bioscience
DOI: 10.1080/15548627.2018.1535292

Age-Related Changes of Peak Width Skeletonized Mean Diffusivity (PSMD) Across the Adult Lifespan: A Multi-Cohort Study

Autores: Beaudet G, Tsuchida A, Petit L, Tzourio C, Caspers S, Schreiber J, Pausova Z, Patel Y, Paus T, Schmidt R, Pirpamer L, Sachdev P, Wen W, Armstrong N, Deary IJ, Bastin ME, Wardlaw JM, Munõz Maniega S, Witte V, Villringer A, Duering M, Debette S, Mazoyer B.
Publicado en: Frontiers in psychiatry, 2020, ISSN 1664-0640
Editor: Frontiers Research Foundation
DOI: 10.3389/fpsyt.2020.00342

Diminished OPA1 expression and impaired mitochondrial morphology and homeostasis in Aprataxin-deficient cells.

Autores: Zheng J, Croteau DL, Bohr VA, Akbari M.
Publicado en: Nucleic acids research, 2019, ISSN 1362-4962
Editor: Oxford Academic
DOI: 10.1093/nar/gkz083

Longitudinal changes in the genetic and environmental influences on the epigenetic clocks across old age: Evidence from two twin cohorts.

Autores: Jylhävä J, Hjelmborg J, Soerensen M, Munoz E, Tan Q, Kuja-Halkola R, Mengel-From J, Christensen K, Christiansen L, Hägg S, Pedersen NL, Reynolds CA.
Publicado en: EBioMedicine, 2019, ISSN 2352-3964
Editor: Elsevier BV
DOI: 10.1016/j.ebiom.2019.01.040

Voluntary running enhances glymphatic influx in awake behaving, young mice.

Autores: Holstein-Rathlou S, Petersen NC, Nedergaard M.
Publicado en: Neuroscience Letters, 2018, ISSN 0304-3940
Editor: Elsevier BV
DOI: 10.1016/j.neulet.2017.10.035

Improved method for cannula fixation for long-term intracerebral brain infusion

Autores: Ádám Sike, Jonas Wengenroth, Jolanta Upīte, Thomas Brüning, Iván Eiriz, Petra Sántha, Henrik Biverstål, Baiba Jansone, Håvard Jostein Haugen, Markus Krohn, Jens Pahnke
Publicado en: Journal of Neuroscience Methods, Edición 290, 2017, Página(s) 145-150, ISSN 0165-0270
Editor: Elsevier BV
DOI: 10.1016/j.jneumeth.2017.07.026

Diabetes Mellitus as a Risk Factor for Parkinson’s Disease: a Molecular Point of View.

Autores: Biosa, A., Outeiro, T.F., Bubacco, L. et al.
Publicado en: Molecular Neurobiology, Edición 55, 2018, Página(s) 8754–8763, ISSN 0893-7648
Editor: Humana Press, Inc.
DOI: 10.1007/s12035-018-1025-9

Age-Dependent Alpha-Synuclein Accumulation and Phosphorylation in the Enteric Nervous System in a Transgenic Mouse Model of Parkinson’s Disease

Autores: Zhong, CB., Chen, QQ., Haikal, C. et al.
Publicado en: Translational Neurodegeneration, 2018, ISSN 2047-9158
Editor: BioMed Central Ltd
DOI: 10.1007/s12264-017-0179-1

Clinical Significance of Magnetic Resonance Imaging Markers of Vascular Brain Injury: A Systematic Review and Meta-analysis

Autores: Debette S, Schilling S, Duperron MG, Larsson SC, Markus HS.
Publicado en: JAMA Neurology, 2019, ISSN 2168-6149
Editor: American Medical Association
DOI: 10.1001/jamaneurol.2018.3122

Age dependency of cerebral P-glycoprotein function in wild-type and APPPS1 mice measured with PET

Autores: Zoufal V, Wanek T, Krohn M, Mairinger S, Filip T, Sauberer M, Stanek J, Pekar T, Bauer M, Pahnke J, Langer O,
Publicado en: Journal of Cerebral Blood Flow & Metabolism, 2020, ISSN 0271-678X
Editor: Lippincott Williams & Wilkins Ltd.
DOI: 10.1177/0271678x18806640

Prion-like seeding and nucleation of intracellular amyloid-β

Autores: Olsson TT, Klementieva O, Gouras GK.
Publicado en: Neurobiology of disease, 2018, ISSN 0969-9961
Editor: Academic Press
DOI: 10.1016/j.nbd.2018.01.015

Stress granules sense metabolic stress at the plasma membrane and potentiate recovery by storing active Pkc1

Autores: Triana Amen and Daniel Kaganovich
Publicado en: Science Signaling, 2020, ISSN 1945-0877
Editor: American Association for the Advancement of Science
DOI: 10.1126/scisignal.aaz6339

Genetic Burden for Late-Life Neurodegenerative Disease and Its Association With Early-Life Lipids, Brain, Behavior, and Cognition

Autores: Sander Lamballais; Ryan L. Muetzel; Ryan L. Muetzel; Mohammad Arfan Ikram; Henning Tiemeier; Henning Tiemeier; Meike W. Vernooij; Meike W. Vernooij; Tonya White; Tonya White; Hieab H. H. Adams; Hieab H. H. Adams; Hieab H. H. Adams
Publicado en: Frontiers in Psychiatry, 11, 2020, ISSN 1664-0640
Editor: Frontiers Research Foundation
DOI: 10.3389/fpsyt.2020.00033

The synergistic effect of chlorotoxin-mApoE in boosting drug-loaded liposomes across the BBB

Autores: Formicola B, Dal Magro R, Montefusco-Pereira CV, Lehr CM, Koch M, Russo L, Grasso G, Deriu MA, Danani A, Bourdoulous S, Re F.
Publicado en: Journal of nanobiotechnology, 2019, ISSN 1477-3155
Editor: BioMed Central
DOI: 10.1186/s12951-019-0546-3

Short-Term Effects of Microglia-Specific Mitochondrial Dysfunction on Amyloidosis in Transgenic Models of Alzheimer's Disease

Autores: Steffen J, Stenzel J, Ibrahim S, Pahnke J,
Publicado en: Journal of Alzheimer's Disease, 2018, ISSN 1387-2877
Editor: IOS Press
DOI: 10.3233/jad-180395

Stratifying the presymptomatic phase of genetic frontotemporal dementia by serum NfL and pNfH: a longitudinal multicentre study

Autores: Wilke, Carlo; Reich, Selina; Swieten, John C.; Borroni, Barbara; Sanchez‐Valle, Raquel; Moreno, Fermin; Laforce, Robert; Graff, Caroline; Galimberti, Daniela; Rowe, James B.; Masellis, Mario; Tartaglia, Maria C.; Finger, Elizabeth; Vandenberghe, Rik; De Mendonça, Alexandre; Tagliavini, Fabrizio; Santana, Isabel; Ducharme, Simon; Butler, Chris R.; Gerhard, Alexander; Levin, Johannes; Danek, Adri
Publicado en: Annals of Neurology, 2021, ISSN 0364-5134
Editor: John Wiley & Sons Inc.
DOI: 10.1002/ana.26265

Novel tau filament fold in chronic traumatic encephalopathy encloses hydrophobic molecules

Autores: Falcon B, Zivanov J, Zhang W,Murzin A, Garringer H, Vidal R, Crowther A, Newell K, Ghetti B, Goedert M and Scheres S.
Publicado en: Nature, 2019, ISSN 0028-0836
Editor: Nature Publishing Group
DOI: 10.1038/s41586-019-1026-5

Neuroinflammatory responses in Alzheimer's disease.

Autores: Dansokho C, Heneka MT.
Publicado en: Journal of Neural Transmission, 2018, ISSN 0300-9564
Editor: Springer Verlag
DOI: 10.1007/s00702-017-1831-7

Leukocyte Derived Microvesicles as Disease Progression Biomarkers in Slow Progressing Amyotrophic Lateral Sclerosis Patients.

Autores: Daisy Sproviero; Sabrina La Salvia; Federico Colombo; Susanna Zucca; Orietta Pansarasa; Luca Diamanti; Luca Diamanti; Alfredo Costa; Alfredo Costa; Luca Lova; Luca Lova; Marta Giannini; Marta Giannini; Stella Gagliardi; Eliana Lauranzano; Michela Matteoli; Michela Matteoli; Mauro Ceroni; Mauro Ceroni; Andrea Malaspina; Cristina Cereda
Publicado en: Frontiers in Neuroscience, Vol 13 (2019), 2019, ISSN 1662-4548
Editor: Frontiers Research Foundation
DOI: 10.3389/fnins.2019.00344

LRP1 Has a Predominant Role in Production over Clearance of Aβ in a Mouse Model of Alzheimer's Disease

Autores: Van Gool B, Storck SE, Reekmans SM, Lechat B, Gordts PLSM, Pradier L, Pietrzik CU, Roebroek AJM,
Publicado en: Molecular neurobiology, 2019, ISSN 0893-7648
Editor: Humana Press, Inc.
DOI: 10.1007/s12035-019-1594-2

A Surveillance Function of the HSPB8-BAG3-HSP70 Chaperone Complex Ensures Stress Granule Integrity and Dynamism

Autores: Massimo Ganassi, Daniel Mateju, Ilaria Bigi, Laura Mediani, Ina Poser, Hyun O.Lee, Samuel J.Seguin, Federica, F. Morelli, Jonathan Vinet, Giuseppina Leo, Orietta Pansarasa, Cristina Cereda, Angelo Poletti, SimonAlberti, SerenaCarra16
Publicado en: Molecular Cell, Edición 63, 2016, Página(s) 796–810, ISSN 1097-2765
Editor: Cell Press
DOI: 10.1016/j.molcel.2016.07.021

Small-molecule induction of Aβ-42 peptide production in human cerebral organoids to model Alzheimer's disease associated phenotypes

Autores: Pavoni S, Jarray R, Nassor F, Guyot AC, Cottin S, Rontard J, Mikol J, Mabondzo A, Deslys JP, Yates F.
Publicado en: PLoS One, 2018, ISSN 1932-6203
Editor: Public Library of Science
DOI: 10.1371/journal.pone.0209150

A High Output Method to Isolate Cerebral Pericytes from Mouse

Autores: Mehra A., Dehouck L., Vandenhaute E., Fatar M., Fenart L., Gosselet F.
Publicado en: Journal of visualized experiments, 2020, ISSN 1940-087X
Editor: MYJoVE Corporation
DOI: 10.3791/60588

Pathological Proteins Are Transported by Extracellular Vesicles of Sporadic Amyotrophic Lateral Sclerosis Patients.

Autores: Daisy Sproviero; Sabrina La Salvia; Marta Giannini; Marta Giannini; Valeria Crippa; Stella Gagliardi; Stefano Bernuzzi; Luca Diamanti; Luca Diamanti; Mauro Ceroni; Mauro Ceroni; Orietta Pansarasa; Angelo Poletti; Cristina Cereda
Publicado en: Frontiers in Neuroscience,, Edición Vol 12, 2018, ISSN 1662-4548
Editor: Frontiers Research Foundation
DOI: 10.3389/fnins.2018.00487

Effects of ambroxol on the autophagy-lysosome pathway and mitochondria in primary cortical neurons.

Autores: Magalhaes, J; Gegg, ME; Migdalska-Richards, A; Schapira, AH;
Publicado en: Scientific Reports, 2018, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-018-19479-8

The Genetic Variability of APOE in Different Human Populations and Its Implications for Longevity

Autores: Paolo Abondio 1, Marco Sazzini 2, Paolo Garagnani 3, Alessio Boattini 4, Daniela Monti 5, Claudio Franceschi 6, Donata Luiselli 7, Cristina Giuliani
Publicado en: Genes (Basel), 2019, ISSN 2073-4425
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/genes10030222

Generation and characterization of an ABCC1 humanized mouse model (HABCC1<sup>FLX/FLX</sup>) with knockout capability

Autores: Krohn, Markus; Zoufal, Viktoria; Mairinger, Severin; Wanek, Thomas; Paarmann, Kristin; Brüning, Thomas; Eiriz Delgado, Iván; Brackhan, Mirjam; Langer, Oliver; Pahnke, Jens
Publicado en: Molecular Pharmacology, 2019, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.1124/mol.119.115824

Evolution of prodromal parkinsonian features in a cohort of GBA mutation-positive individuals: a 6-year longitudinal study

Autores: Avenali M, Toffoli M, Mullin S, McNeil A, Hughes DA, Mehta A, Blandini F, Schapira AHV.
Publicado en: Journal of Neurology Neurosurgery and Psychiatry, 2019, ISSN 0022-3050
Editor: BMJ Publishing Group
DOI: 10.1136/jnnp-2019-320394

Overdominant Effect of a CHRNA4 Polymorphism on Cingulo-Opercular Network Activity and Cognitive Control

Autores: Sadaghiani S, Ng B, [...], Paus T, Poustka L, Millenet , Fröhner JH, Smolka MN, Walter H, Whelan R, Schumann G, Napolioni V, Greicius M
Publicado en: Journal of Neuroscience, 2017, ISSN 0270-6474
Editor: Society for Neuroscience
DOI: 10.1523/jneurosci.0991-17.2017

DJ-1 (Park7) affects the gut microbiome, metabolites and the development of innate lymphoid cells (ILCs).

Autores: Yogesh Singh, Christoph Trautwein, Achal Dhariwal, Madhuri S. Salker, Md Alauddin, Laimdota Zizmare, Lisann Pelzl, Martina Feger, Jakob Admard, Nicolas Casadei, Michael Föller, Vivek Pachauri, David S. Park, Tak W. Mak, Julia-Stefanie Frick, Diethelm Wallwiener, Sara Y. Brucker, Florian Lang and Olaf Riess
Publicado en: Scientific Reports, 2020, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-020-72903-w

NLRP3 Is Involved in the Maintenance of Cerebral Pericytes

Autores: Quan W, Luo Q, Tang Q, Furihata T, Li D, Fassbender K, and Liu Y
Publicado en: Frontiers in cellular neuroscience, 2020, ISSN 1662-5102
Editor: Frontiers Research Foundation
DOI: 10.3389/fncel.2020.00276

Epigenetic mechanisms during ageing and neurogenesis as novel therapeutic avenues in human brain disorders

Autores: Raul Delgado-Morales; Roberto Carlos Agis-Balboa; Manel Esteller; Manel Esteller; María Berdasco
Publicado en: Clinical Epigenics, 2017, ISSN 1868-7075
Editor: Springer Verlag
DOI: 10.1186/s13148-017-0365-z

The Exosomal/Total α-Synuclein Ratio in Plasma Is Associated With Glucocerebrosidase Activity and Correlates With Measures of Disease Severity in PD Patients

Autores: Silvia Cerri1*, Cristina Ghezzi1, Maria Sampieri1, Francesca Siani1, Micol Avenali2,3, Gianluca Dornini4, Roberta Zangaglia5, Brigida Minafra5 and Fabio Blandini1
Publicado en: Frontiers in Cellular Neuroscience, 2018, ISSN 1662-5102
Editor: Frontiers Research Foundation
DOI: 10.3389/fncel.2018.00125

Clinical and neuropathological phenotype associated with the novel V189I mutation in the prion protein gene

Autores: Di Fede G, Catania M, Atzori C, Moda F, Pasquali C, Indaco A, Grisoli M, Zuffi M, Guaita MC, Testi R, Taraglio S, Sessa M, Gusmaroli G, Spinelli M, Salzano G, Legname G, Tarletti R, Godi L, Pocchiari M, Tagliavini F, Imperiale D, Giaccone G.
Publicado en: acta neuropathologica communications, 2019, ISSN 2051-5960
Editor: BioMed Central
DOI: 10.1186/s40478-018-0656-4

Granulostasis: Protein Quality Control of RNP Granules

Autores: Alberti, Simon; Mateju, Daniel; Mediani, Laura; Carra, Serena
Publicado en: Frontiers in molecular Neuroscience, Edición 2, 2017, ISSN 1662-5099
Editor: Frontiers Research Foundation
DOI: 10.3389/fnmol.2017.00084

Inhibition of retrograde transport modulates misfolded protein accumulation and clearance in motoneuron diseases.

Autores: Cristofani R., Crippa V., Rusmini P., Cicardi M.E., Meroni M., Licata N.V., Sala G., Giorgetti E., Grunseich C., Galbiati M., Piccolella M., Messi E., Ferrarese C., Carra S, Poletti A.
Publicado en: Autophagy, 2017, ISSN 1554-8627
Editor: Landes Bioscience
DOI: 10.1080/15548627.2017.1308985

Understanding Dopaminergic Cell Death Pathways in Parkinson Disease

Autores: Patrick P. Michel, Etienne C. Hirsch, Stephane Hunot
Publicado en: Neuron, Edición Volume 90, Edición 4, 2016, Página(s) Pages 675-691, ISSN 0896-6273
Editor: Cell Press
DOI: 10.1016/j.neuron.2016.03.038

Soluble Aβ oligomers and protofibrils induce NLRP3 inflammasome activation in microglia

Autores: Lučiūnaitė A, McManus RM, Jankunec M, Rácz I, Dansokho C, Dalgėdienė I, Schwartz S, Brosseron F, Heneka MT.
Publicado en: Journal of neurochemistry, 2020, ISSN 0022-3042
Editor: Blackwell Publishing Inc.
DOI: 10.1111/jnc.14945

Impairment of Glycolysis-Derived l-Serine Production in Astrocytes Contributes to Cognitive Deficits in Alzheimer’s Disease

Autores: Le Douce, Juliette; Maugard, Marianne; Veran, Julien; Matos, Marco; Jégo, Pierrick; Vigneron, Pierre-Antoine; Faivre, Emilie; Toussay, Xavier; Vandenberghe, Michel; Balbastre, Yaël; Piquet, Juliette; Guiot, Elvire; Tran, Nguyet Thuy; Taverna, Myriam; Marinesco, Stéphane; Koyanagi, Ayumi; Furuya, Shigeki; Gaudin-Guérif, Mylène; Goutal, Sébastien; Ghettas, Aurélie; Pruvost, Alain; Bemelmans,
Publicado en: Cell Metabolism, 2020, Página(s) pp.503-517, ISSN 0893-7648
Editor: Humana Press, Inc.

Intravenous treatment with human recombinant ApoA-I Milano reduces beta amyloid cerebral deposition in the APP23-transgenic mouse model of Alzheimer's disease

Autores: Fernández-de Retana S, Montañola A, Marazuela P, De La Cuesta M, Batlle A, Fatar M, Grudzenski S, Montaner J, Hernández-Guillamon M.
Publicado en: Neurobiology of aging, 2017, ISSN 0197-4580
Editor: Elsevier BV
DOI: 10.1016/j.neurobiolaging.2017.08.028

Genome-wide pleiotropy between depression and body mass index

Autores: Garvert, L., Roshchupkin, G.V., Völzke, H., Nauck, M., Milaneschi, Y., Grabe, J., Van der Auwera, S.
Publicado en: Pharmacopsychiatry, 2020, ISSN 0176-3679
Editor: Georg Thieme Verlag
DOI: 10.1055/s-0039-3403015

A User's Guide for Phase Separation Assays with Purified Proteins.

Autores: Simon Alberti; Shambaditya Saha; Jeffrey B. Woodruff; Titus M. Franzmann; Jie Wang; Anthony A. Hyman
Publicado en: Journal of Molecular Biology, 2018, ISSN 0022-2836
Editor: Academic Press
DOI: 10.1016/j.jmb.2018.06.038

Neurological effects of glucocerebrosidase gene mutations

Autores: Mullin S, Hughes D, Mehta A, Schapira AHV.
Publicado en: European Journal of Neurology, 2019, ISSN 1351-5101
Editor: Blackwell Publishing Inc.
DOI: 10.1111/ene.13837

Brain Peak Width of Skeletonized Mean Diffusivity (PSMD) and Cognitive Function in Later Life

Autores: Deary IJ, Ritchie SJ, Muñoz Maniega S, Cox SR, Valdés Hernández MC, Luciano M, Starr JM, Wardlaw JM, Bastin ME.
Publicado en: Frontiers in Psychiatry, 2019, ISSN 1664-0640
Editor: Frontiers Research Foundation
DOI: 10.3389/fpsyt.2019.00524

Faulty neuronal determination and cell polarization are reverted by modulating HD early phenotypes

Autores: Conforti P, Besusso D, Bocchi VD, Faedo A, Cesana E, Rossetti G, Ranzani V, Svendsen CN, Thompson LM, Toselli M, Biella G, Pagani M, Cattaneo E.
Publicado en: PNAS, 2018, ISSN 0027-8424
Editor: National Academy of Sciences
DOI: 10.1073/pnas.1715865115

Considerations and Challenges in Studying Liquid-Liquid Phase Separation and Biomolecular Condensates

Autores: Alberti S, Gladfelter A, Mittag T
Publicado en: Cell, 2019, ISSN 0092-8674
Editor: Cell Press
DOI: 10.1016/j.cell.2018.12.035

Tau/DDX6 interaction increases microRNA activity

Autores: Alban Chauderlier; Melissa Gilles; Andrea Spolcova; Raphaëlle Caillierez; Maggy Chwastyniak; Michel Kress; Hervé Drobecq; Eliette Bonnefoy; Florence Pinet; Dominique Weil; Luc Buée; Marie-Christine Galas; Bruno Lefebvre
Publicado en: Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, Edición Volume 1861, Edición 8, August 2018,, 2018, Página(s) 762-772, ISSN 1874-9399
Editor: Elsevier BV
DOI: 10.1016/j.bbagrm.2018.06.006

Measurement of cerebral ABCC1 transport activity in wild-type and APP/PS1-21 mice with positron emission tomography

Autores: Zoufal V, Mairinger S, Krohn M, Wanek T, Filip T, Sauberer M, Stanek J, Kuntner C, Pahnke J, Langer O,
Publicado en: Journal of Cerebral Blood Flow & Metabolism, 2020, ISSN 0271-678X
Editor: Lippincott Williams & Wilkins Ltd.
DOI: 10.1177/0271678x19854541

Preclinical Evaluation of a Lentiviral Vector for Huntingtin Silencing

Autores: Karine Cambon, Virginie Zimmer, Sylvain Martineau, Marie-Claude Gaillard, Margot Jarrige, Aurore Bugi, Jana Miniarikova, Maria Rey, Raymonde Hassig, Noelle Dufour, Gwenaelle Auregan, Philippe Hantraye, Anselme L. Perrier, Nicole Déglon
Publicado en: Molecular Therapy - Methods & Clinical Development, Edición Volume 5, 2017, Página(s) 259-276, ISSN 2329-0501
Editor: The American Society of Gene and Cell Therapy. Elsevier
DOI: 10.1016/j.omtm.2017.05.001

How the shapes of seeds can influence pathology

Autores: Melki R.
Publicado en: Neurobiology of Disease, 2018, ISSN 0969-9961
Editor: Academic Press
DOI: 10.1016/j.nbd.2017.03.011

Expression of the Parkinson’s Disease-Associated Gene Alpha-Synuclein is Regulated by the Neuronal Cell Fate Determinant TRIM32

Autores: Maria Angeliki S. Pavlou, Nicoló Colombo, Sandra Fuertes-Alvarez, Sarah Nicklas, Laura Gonzalez Cano, Maria C. Marín, Jorge Goncalves, Jens C. Schwamborn
Publicado en: Mol Neurobiol, 2017, ISSN 0893-7648
Editor: Humana Press, Inc.
DOI: 10.1007/s12035-016-9989-9

Antidepressants act by binding to the cholesterolinteraction site at TrkB neurotrophin receptor

Autores: Casarotto PC, M.Girych, S.M. Fred, R. Moliner, G. Enkavi, C. Biojone, C.Cannarozzo, C.A.Brunello, A.Steinzeig, F.Winkel, S.Patil, S.Vestring, T.Serchov, V.Kovaleva, C.Diniz, L.Laukkanen, I.Cardon, H.Antila, T.Rog, M.Saarma, C.R.Bramham, C.Normann, S.E.Lauri, I.Vattulainen, Eero Castrén.
Publicado en: BioRxiv, 2019, ISSN 2692-8205
Editor: BioRxiv
DOI: 10.1101/757989

The Role of Sex and Sex Hormones in Neurodegenerative Diseases

Autores: Vegeto E., Villa A., Della Torre S., Crippa V. Rusmini P., Cristofani R., Galbiati M., Maggi A., Poletti A.
Publicado en: Endocrine Reviews, 2020, ISSN 0163-769X
Editor: The Endocrine Society
DOI: 10.1210/endrev/bnz005

Knocking out C9ORF72 Exacerbates Axonal Trafficking Defects Associated with Hexanucleotide Repeat Expansion and Reduces Levels of Heat Shock Proteins

Autores: Abo-Rady, Masin; Kalmbach, Norman; Pal, Arun; Schludi, Carina; Janosch, Antje; Richter, Tanja; Freitag, Petra; Bickle, Marc; Kahlert, Anne-Karin; Petri, Susanne; Stefanov, Stefan; Glass, Hannes; Staege, Selma; Just, Walter; Bhatnagar, Rajat; Edbauer, Dieter; Hermann, Andreas; Wegner, Florian; Sterneckert, Jared L.
Publicado en: Stem Cell Reports, Vol 14, Iss 3, Pp 390-405 (2020), 2020, ISSN 2213-6711
Editor: Cell Press
DOI: 10.1016/j.stemcr.2020.01.010

Associations between sleep apnea and advanced brain aging in a large-scale population study

Autores: Antoine Weihs, Stefan Frenzel, Katharina Wittfeld, Anne Obst, Beate Stubbe, Mohamad Habes, András Szentkirályi, Klaus Berger, Ingo Fietze, Thomas Penzel, Norbert Hosten, Ralf Ewert, Henry Völzke, Helena U Zacharias, Hans J Grabe
Publicado en: Sleep, 2021, ISSN 0161-8105
Editor: The American Academy of Sleep Medicine
DOI: 10.1093/sleep/zsaa204

Spatial Transcriptomics Reveals Genes Associated with Dysregulated Mitochondrial Functions and Stress Signaling in Alzheimer Disease.

Autores: José Fernández Navarro; Deborah L. Croteau; Aleksandra Jurek; Zaneta Andrusivova; Beimeng Yang; Yue Wang; Benjamin Ogedegbe; Tahira Riaz; Mari Støen; Claus Desler; Lene Juel Rasmussen; Tone Tønjum; Marie-Christine Galas; Joakim Lundeberg; Vilhelm A. Bohr; Vilhelm A. Bohr
Publicado en: iScience, Edición 1, 2020, ISSN 2589-0042
Editor: Elsevier Inc.
DOI: 10.1016/j.isci.2020.101556

PDGF-B Is Required for Development of the Glymphatic System.

Autores: Munk, Anne Sofie; Wang, Wei; Bechet, Nicholas Burdon; Eltanahy, Ahmed M.; Cheng, Anne Xiaoan; Sigurdsson, Bjorn; Benraiss, Abdellatif; Mäe, Maarja Andaloussi; Kress, Benjamin Travis; Kelley, Douglas H.; Betsholtz, Christer; Mollgard, Kjeld; Meissner, Anja; Nedergaard, Maiken; Lundgaard, Iben
Publicado en: Cell Reports, Edición vol. 26, 2019, Página(s) 11, ISSN 2211-1247
Editor: Cell Press
DOI: 10.1016/j.celrep.2019.02.050

Neural circuitry underlying sustained attention in healthy adolescents and in ADHD symptomatology

Autores: Laura O'Halloran, Zhipeng Cao, Kathy Ruddy, Lee Jollans, Matthew D Albaugh, Andrea Aleni, Alexandra S Potter, Nigel Vahey, Tobias Banaschewski, Sarah Hohmann, Arun L W Bokde, Uli Bromberg, Christian Büchel, Erin Burke Quinlan, Sylvane Desrivières, Herta Flor, Vincent Frouin, Penny Gowland, Andreas Heinz, Bernd Ittermann, Frauke Nees, Dimitri Papadopoulos Orfanos, Tomáš Paus, Michael N Smolka,
Publicado en: Neuroimage, 2018, ISSN 2666-9560
Editor: New York Elsevier Inc
DOI: 10.1016/j.neuroimage.2017.12.030

Transcriptional induction of the heat shock protein B8 mediates the clearance of misfolded proteins responsible for motor neuron diseases.

Autores: Crippa V., D'Agostino V.G., Cristofani R., Rusmini P., Cicardi M.E., Messi E., Loffredo R., Pancher M., Piccolella M., Galbiati M., Meroni M., Cereda C., Carra S., Provenzani A., Poletti A.
Publicado en: Scientific Reports, 2016, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/srep22827

Genome-wide identification of genic and intergenic neuronal DNA regions bound by Tau protein under physiological and stress conditions.

Autores: Benhelli-Mokrani, Houda; Mansuroglu, Zeyni; Chauderlier, Alban; Albaud, Benoit; Gentien, David; Sommer, Sabrina; Schirmer, Claire; Laqueuvre, Lucie; Josse, Thibaut; Buée, Luc; Lefebvre, Bruno; Galas, Marie-Christine; Souès, Sylvie; Bonnefoy, Eliette
Publicado en: Nucleic Acids Research, 2018, ISSN 0305-1048
Editor: Oxford University Press
DOI: 10.1093/nar/gky929

The IMAGEN study: a decade of imaging genetics in adolescents

Autores: Lea Mascarell Maričić, Henrik Walter, Annika Rosenthal, Stephan Ripke, Erin Burke Quinlan, Tobias Banaschewski, Gareth J. Barker, Arun L. W. Bokde, Uli Bromberg, Christian Büchel, Sylvane Desrivières, Herta Flor, Vincent Frouin, Hugh Garavan, Bernd Itterman, Jean-Luc Martinot, Marie-Laure Paillère Martinot, Frauke Nees, Dimitri Papadopoulos Orfanos, Tomáš Paus, Luise Poustka, Sarah Hohmann,
Publicado en: Molecular psychiatry, 2020, ISSN 1359-4184
Editor: Nature Publishing Group
DOI: 10.1038/s41380-020-0822-5

Linking Neuroinflammation and Neurodegeneration in Parkinson's Disease.

Autores: Gelders G, Baekelandt V, Van der Perren A.
Publicado en: Journal of immunology research, 2018, ISSN 2314-8861
Editor: Hindawi Publishing Corporation
DOI: 10.1155/2018/4784268

Cell-Type-Specific Gene Expression Profiling in Adult Mouse Brain Reveals Normal and Disease-State Signatures

Autores: Nicolas Merienne, Cécile Meunier, Anne Schneider, Jonathan Seguin, Satish S Nair, Anne B Rocher, Stéphanie Le Gras, Céline Keime, Richard Faull, Luc Pellerin, Jean-Yves Chatton, Christian Neri, Karine Merienne, Nicole Déglon;
Publicado en: Cell reports, 2019, ISSN 2211-1247
Editor: Cell Press
DOI: 10.1016/j.celrep.2019.02.003

Sexual behavior and testis morphology in the BACHD rat model.

Autores: Novati, Arianna; Yu-Taeger, Libo; Gonzalez Menendez, Irene; Quintanilla Martinez, Leticia; Nguyen, Huu Phuc
Publicado en: PLoS ONE, 2018, ISSN 1932-6203
Editor: Public Library of Science
DOI: 10.1371/journal.pone.0198338

Psychosisassociated DNA methylomic variation in Alzheimer's disease cortex.

Autores: Pishva E, Creese B, Smith AR, Viechtbauer W, Proitsi P, van den Hove DLA, Ballard C, Mill J, Lunnon K.
Publicado en: Neurobiology of Aging, 2020, ISSN 0197-4580
Editor: Elsevier BV
DOI: 10.1016/j.neurobiolaging.2020.01.001

Whole exome sequencing study identifies novel rare and common Alzheimer's-Associated variants involved in immune response and transcriptional regulation.

Autores: Bis JC, Jian X, Kunkle BW, Chen Y, Hamilton-Nelson KL, Bush WS, Salerno WJ, Lancour D, Ma Y, Renton AE, Marcora E, Farrell JJ, Zhao Y, Qu L, Ahmad S, Amin N, Amouyel P, Beecham GW, Below JE, Campion D, Cantwell L, Charbonnier C, Chung J, Crane PK, Cruchaga C, Cupples LA, Dartigues JF, Debette S, Deleuze JF, Fulton L, Gabriel SB, Genin E, Gibbs RA, Goate A, Grenier-Boley B, Gupta N, Haines JL, Havu
Publicado en: Molecular psychiatry, 2020, ISSN 1359-4184
Editor: Nature Publishing Group
DOI: 10.1038/s41380-018-0112-7

The Self-Inactivating KamiCas9 System for the Editing of CNS Disease Genes

Autores: Nicolas Merienne , Gabriel Vachey , Lucie de Longprez , Cécile Meunier , Virginie Zimmer , Guillaume Perriard , Mathieu Canales , Amandine Mathias , Lucas Herrgott , Tim Beltraminelli , Axelle Maulet , Thomas Dequesne , Catherine Pythoud , Maria Rey , Luc Pellerin , Emmanuel Brouillet , Anselme L Perrier, Renaud du Pasquier , Nicole Déglon;
Publicado en: Cell reports, 2017, ISSN 2211-1247
Editor: Cell Press
DOI: 10.1016/j.celrep.2017.08.075

In Vivo Transient and Partial Cell Reprogramming to Pluripotency as a Therapeutic Tool for Neurodegenerative Diseases

Autores: Tamanini, S., Comi, G.P. & Corti, S.
Publicado en: Molecular Neurobiology, Edición 55, 2018, Página(s) 6850–6862, ISSN 0893-7648
Editor: Humana Press, Inc.
DOI: 10.1007/s12035-018-0888-0

Reconstituting Corticostriatal Network on-a-Chip Reveals the Contribution of the Presynaptic Compartment to Huntington's Disease

Autores: Virlogeux A, Moutaux E, Christaller W, Genoux A, Bruyère J, Fino E, Charlot B, Cazorla M, Saudou F.
Publicado en: Cell Reports, 2018, ISSN 2211-1247
Editor: Cell Press
DOI: 10.1016/j.celrep.2017.12.013

Chondroitinase and antidepressants promote plasticity by releasing TRKB from dephosphorylating control of PTPσ in parvalbumin neurons

Autores: Lesnikova, A., Casarotto, P. C., Fred, S. M., Voipio, M., WInkel, F., Steinzeig, A., Antila, H., Umemori, J., Biojone, C., Castrén, E.
Publicado en: BioRxiv, 2020, ISSN 2692-8205
Editor: BioRxiv
DOI: 10.1101/2020.08.13.249615

The small heat shock protein B8 (HSPB8) efficiently removes aggregating species of dipeptides produced in C9ORF72-related neurodegenerative diseases

Autores: Cristofani, Riccardo; Crippa, Valeria; Vezzoli, Giulia; Rusmini, Paola; Galbiati, Mariarita; Cicardi, Maria Elena; Meroni, Marco; Ferrari, Veronica; Tedesco, Barbara; Piccolella, Margherita; Messi, Elio; Carra, Serena; Poletti, Angelo
Publicado en: Cell Stress & Chaperones, Edición 2, 2018, ISSN 1355-8145
Editor: Cell Stress Society International
DOI: 10.1007/s12192-017-0806-9

Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes

Autores: Malik R, Chauhan G, Traylor M, Sargurupremraj M, Okada Y, Mishra A, Rutten-Jacobs L, Giese AK, van der Laan SW, Gretarsdottir S, Anderson CD, Chong M, Adams HHH, Ago T, Almgren P, Amouyel P, […], Ikram MA, [...], Schmidt R [...], Tzourio C, [...], Stefansson K, Worrall BB, Kittner J, Seshadri S, Fornage M, Markus HS, Howson JMM, Kamatani Y, Debette S*, Dichgans M*.
Publicado en: Nature Genetics, 2018, ISSN 1061-4036
Editor: Nature Publishing Group
DOI: 10.1038/s41588-018-0058-3

Dihydromyricetin and Salvianolic acid B inhibit alpha-synuclein aggregation and enhance chaperone-mediated autophagy.

Autores: Wu JZ, Ardah M, Haikal C, Svanbergsson A, Diepenbroek M, Vaikath NN, Li W, Wang ZY, Outeiro TF, El-Agnaf OM, Li JY.
Publicado en: Translational Neurodegeneration, 2019, ISSN 2047-9158
Editor: BioMed Central Ltd.
DOI: 10.1186/s40035-019-0159-7

Inflammaging 2018: An update and a model

Autores: Claudio Franceschi 1, Alexey Zaikin 2, Susanna Gordleeva 3, Mikhail Ivanchenko 3, Francesca Bonifazi 4, Gianluca Storci 5, Massimiliano Bonafè
Publicado en: Semin Immunol, 2018, ISSN 1044-5323
Editor: Academic Press
DOI: 10.1016/j.smim.2018.10.008

Chronic inflammation in the etiology of disease across the life span

Autores: Furman D, Campisi J, Verdin E, Carrera-Bastos P, Targ S, Franceschi C, Ferrucci L, Gilroy DW, Fasano A, Miller GW, Miller AH, Mantovani A, Weyand CM, Barzilai N, Goronzy JJ, Rando TA, Effros RB, Lucia A, Kleinstreuer N, Slavich GM.
Publicado en: Nature Medicine., 2019, ISSN 1078-8956
Editor: Nature Publishing Group
DOI: 10.1038/s41591-019-0675-0

Molecular Mechanisms and Therapeutic Strategies in Spinocerebellar Ataxia Type 7

Autores: Karam A, Trottier Y.
Publicado en: Advances in Experimental Medicine and Biology, 2018, ISSN 0065-2598
Editor: Kluwer Academic/Plenum Publishers
DOI: 10.1007/978-3-319-71779-1_9

RNA Interference Therapy for Machado-Joseph Disease: Long-Term Safety Profile of Lentiviral Vectors Encoding Short Hairpin RNAs Targeting Mutant Ataxin-3

Autores: Nóbrega C, Codêsso JM, Mendonça L, Pereira de Almeida L.
Publicado en: Human Gene Therapy, 2019, ISSN 1043-0342
Editor: Mary Ann Liebert Inc.
DOI: 10.1089/hum.2018.157

Altered Brain Endothelial Cell Phenotype from a Familial Alzheimer Mutation and Its Potential Implications for Amyloid Clearance and Drug Delivery

Autores: Lotta E. Oikari; Rucha Pandit; Romal Stewart; Carla Cuni-Lopez; Hazel Quek; Ratneswary Sutharsan; Ratneswary Sutharsan; Laura M. Rantanen; Minna Oksanen; Šárka Lehtonen; Šárka Lehtonen; Carmela Maria de Boer; Carmela Maria de Boer; Jose M. Polo; Jose M. Polo; Jose M. Polo; Jürgen Götz; Jari Koistinaho; Jari Koistinaho; Anthony R. White
Publicado en: Stem Cell reports, Edición 1, 2020, ISSN 2213-6711
Editor: Cell Press
DOI: 10.1016/j.stemcr.2020.03.011

Stroke target identification guided by astrocyte transcriptome analysis

Autores: Rakers C, Schleif M, Blank N, Matušková H, Ulas T, Händler K, Torres SV, Schumacher T, Tai K, Schultze JL, Jackson WS, Petzold GC.
Publicado en: Glia, 2019, ISSN 0894-1491
Editor: John Wiley & Sons Inc.
DOI: 10.1002/glia.23544

Antisense oligonucleotide therapeutics in neurodegenerative diseases: the case of polyglutamine disorders

Autores: Silva AC, Lobo DD, Martins IM, Lopes SM, Henriques C, Duarte SP, Dodart JC, Nobre RJ, Pereira de Almeida L.
Publicado en: Brain, 2020, ISSN 2632-1297
Editor: Oxford Academy
DOI: 10.1093/brain/awz328

The Extent of Human Apolipoprotein A-I Lipidation Strongly Affects the β-Amyloid Efflux Across the Blood-Brain Barrier in vitro

Autores: Dal Magro R, Simonelli S, Cox A, Formicola B, Corti R, Cassina V, Nardo L, Mantegazza F, Salerno D, Grasso G, Deriu MA, Danani A, Calabresi L, Re F.
Publicado en: Frontiers in neuroscience, 2019, ISSN 1662-4548
Editor: Frontiers Research Foundation
DOI: 10.3389/fnins.2019.00419

First-in-Rat Study of Human Alzheimer's Disease Tau Propagation

Autores: Smolek T, Jadhav S, Brezovakova V, Cubinkova V, Valachova B, Novak P, Zilka N.
Publicado en: Molecular Neurobiology, 2019, ISSN 0893-7648
Editor: Humana Press, Inc.
DOI: 10.1007/s12035-018-1102-0

In vivo imaging of early signs of dopaminergic neuronal death in an animal model of Parkinson's disease

Autores: Rizzi N, Brunialti E, Cerri S, Cermisoni G, Levandis G, Cesari N, Maggi A, Blandini F, Ciana P.
Publicado en: Neurobiology of Disease, 2018, ISSN 0969-9961
Editor: Academic Press
DOI: 10.1016/j.nbd.2018.02.005

PPARβ/δ-agonist GW0742 ameliorates dysfunction in fatty acid oxidation in PSEN1ΔE9 astrocytes

Autores: Konttinen H, Gureviciene I, Oksanen M, Grubman A, Loppi S, Huuskonen MT, Korhonen P, Lampinen R, Keuters M, Belaya I, Tanila H, Kanninen KM, Goldsteins G, Landreth G, Koistinaho J, Malm T.
Publicado en: Glia, 2019, ISSN 0894-1491
Editor: John Wiley & Sons Inc.
DOI: 10.1002/glia.23534

Comprehensive longitudinal study of epigenetic mutations in aging.

Autores: Wang Y, Karlsson R, Jylhävä J, Hedman ÅK, Almqvist C, Karlsson IK, Pedersen NL, Almgren M, Hägg S.
Publicado en: Clinical Epigenetics, 2019, ISSN 1868-7075
Editor: Springer Verlag
DOI: 10.1186/s13148-019-0788-9

Age-related epigenetic changes in hippocampal subregions of four animal models of Alzheimer's disease

Autores: Roy Lardenoije, Daniël L.A. van den Hove, Monique Havermans, Anne van Casteren, Kevin X. Le, Roberta Palmour, Cynthia A. Lemere, Bart P.F. Rutten
Publicado en: Molecular and Cellular Neuroscience, Edición Volume 86, 2018, Página(s) Pages 1-15, ISSN 1044-7431
Editor: Academic Press
DOI: 10.1016/j.mcn.2017.11.002

Accelerated bio-cognitive aging in Down syndrome: State of the art and possible deceleration strategies

Autores: Claudio Franceschi , Paolo Garagnani, Noémie Gensous, Maria Giulia Bacalini, Maria Conte , Stefano Salvioli
Publicado en: Ageing Cell, 2019, ISSN 1474-9718
Editor: Blackwell Publishing Inc.
DOI: 10.1111/acel.12903

Genetic correlations and genome-wide associations of cortical structure in general population samples of 22,824 adults.

Autores: Hofer E , Roshchupkin G , Adams HHH , Knol M , Lin H, Li S, Zare H , Ahmad S, Armstrong N , Satizabal C , Bernard M , Bis J , Gillespie N, Luciano M, Mishra A, Scholz M, Teumer A, Xia R, Jian X, Mosley T, Saba Y, Pirpamer L , Seiler S, Becker J, Carmichael O, Rotter J, Psaty B, Lopez O, Amin N , van der Lee S, Yang Q, Himali J, Maillard P, Beiser A, DeCarli C, Karama S, Lewis L, Bastin M, Deary I,
Publicado en: Nature communications, 2020, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-020-18367-y

Tau Stabilizes Chromatin Compaction.

Autores: Thomas Rico; Melissa Gilles; Alban Chauderlier; Thomas Comptdaer; Romain Magnez; Maggy Chwastyniak; Hervé Drobecq; Florence Pinet; Xavier Thuru; Luc Buée; Marie-Christine Galas; Bruno Lefebvre
Publicado en: "Frontiers in Cell and Developmental Biology, Frontiers media, 2021, 9, pp.740550. ⟨10.3389/fcell.2021.740550⟩", Edición 1, 2021, ISSN 2296-634X
Editor: Frontiers media
DOI: 10.3389/fcell.2021.740550

The genetic architecture of the human cerebral cortex

Autores: Grasby KL, Jahanshad N, Painter JN, Colodro-Conde L, Bralten J, Hibar DP, Lind PA, Pizzagalli F, Ching CRK, McMahon MAB, Shatokhina N, Zsembik LCP, Thomopoulos SI, Zhu AH, Strike LT, Agartz I, Alhusaini S, Almeida MAA, Alnæs D, Amlien IK, Andersson M, Ard T, Armstrong NJ, Ashley-Koch A, Atkins JR, Bernard M, Brouwer RM, Buimer EEL, Bülow R, Bürger C, Cannon DM, Chakravarty M, Chen Q, Cheung JW,
Publicado en: Science, 2020, ISSN 0036-8075
Editor: American Association for the Advancement of Science
DOI: 10.1126/science.aay6690

Efficient protein production inspired by how spiders make silk

Autores: Kronqvist N, Sarr M, Lindqvist A, Nordling K, Otikovs M, Venturi L, Pioselli B, Purhonen P, Landreh M, Biverstål H, Toleikis Z, Sjöberg L, Robinson CV, Pelizzi N, Jörnvall H, Hebert H, Jaudzems K, Curstedt T, Rising A, Johansson J.
Publicado en: Nature communications, 2017, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/ncomms15504

Synapse-to-nucleus communication: from developmental disorders to Alzheimer's disease

Autores: Marcello E, Di Luca M, Gardoni F
Publicado en: Current opinion in neurobiology, 2018, ISSN 0959-4388
Editor: Elsevier BV
DOI: 10.1016/j.conb.2017.12.017

HSC70 expression is reduced in lymphomonocytes of sporadic ALS patients and contributes to TDP-43 accumulation.

Autores: Arosio A., Cristofani R., Pansarasa O., Crippa V., Riva C., Sirtori R., Menendez V., Riva N., Gerardi F., Lunetta C., Cereda C., Poletti A., Ferrarese C., Tremolizzo L., Sala G.
Publicado en: Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, 2020, ISSN 2167-8421
Editor: Informa Healthcare
DOI: 10.1080/21678421.2019.1672749

PSEN1 Mutant iPSC-Derived Model Reveals Severe Astrocyte Pathology in Alzheimer's Disease.

Autores: Oksanen, M; Petersen, AJ; Naumenko, N; Puttonen, K; Lehtonen, S; Olive, MG; Shakirzyanova, A; Leskela, S; Sarajarvi, T; Viitanen, M; Rinne, JO; Hiltunen, M; Haapasalo, A; Giniatullin, R; Tavi, P; Zhang, SC; Kanninen, KM; Hamalainen, RH; Koistinaho, J; Koistinaho, J
Publicado en: Stem Cell Reports, Edición Vol 9, Iss 6,, 2017, Página(s) 1885-1897, ISSN 2213-6711
Editor: Cell Press
DOI: 10.1016/j.stemcr.2017.10.016

Simple and Fast SEC-Based Protocol to Isolate Human Plasma-Derived Extracellular Vesicles for Transcriptional Research

Autores: Gaspar L, Santana MM, Henriques C, Ribeiro-Rodrigues T, Girão H, Nobre RJ, Pereira de Almeida L.
Publicado en: Molecular Therapy - Methods and Clinical Development, 2020, ISSN 2329-0501
Editor: CellPress
DOI: 10.1016/j.omtm.2020.07.012

Sideritis spp. Extracts Enhance Memory and Learning in Alzheimer's β-Amyloidosis Mouse Models and Aged C57Bl/6 Mice

Autores: Hofrichter J, Krohn M, Schumacher T, Lange C, Feistel B, Walbroel B, Pahnke J
Publicado en: Journal of Alzheimer's Disease, 2016, ISSN 1387-2877
Editor: IOS Press
DOI: 10.3233/jad-160301

Genetic architecture of subcortical brain structures in 38,851 individuals

Autores: Claudia L. Satizabal, Hieab H. H. Adams, Derrek P. Hibar, Charles C. White, Maria J. Knol, Jason L. Stein, Markus Scholz, Muralidharan Sargurupremraj, Neda Jahanshad, Gennady V. Roshchupkin, Albert V. Smith, Joshua C. Bis, Xueqiu Jian, Michelle Luciano, Edith Hofer, Alexander Teumer, Sven J. van der Lee, Jingyun Yang, Lisa R. Yanek, Tom V. Lee, Shuo Li, Yanhui Hu, Jia Yu Koh, John D. Eicher, Sylva
Publicado en: Nature Genetics, 2019, ISSN 1061-4036
Editor: Nature Publishing Group
DOI: 10.1038/s41588-019-0511-y

Developmental Expression of 4-Repeat-Tau Induces Neuronal Aneuploidy in Drosophila Tauopathy Models

Autores: Nicolas Malmanche; Nicolas Malmanche; Nicolas Malmanche; Pierre Dourlen; Pierre Dourlen; Pierre Dourlen; Marc Gistelinck; Florie Demiautte; Florie Demiautte; Florie Demiautte; Nichole Link; Cloé Dupont; Cloé Dupont; Cloé Dupont; Lies Vanden Broeck; Elisabeth Werkmeister; Philippe Amouyel; Philippe Amouyel; Philippe Amouyel; Antonino Bongiovanni; Hélène Bauderlique; Dieder Moechars; Anne Royou
Publicado en: SCIENTIFIC REPORTS, Edición 1, 2017, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/srep40764

Reporter-Based Screens for the Ubiquitin/Proteasome System

Autores: Gierisch, M.1, T.A. Giovannucci1, Nico P. Dantuma
Publicado en: Journal of Neurochemistry, 2020, ISSN 0022-3042
Editor: Blackwell Publishing Inc.
DOI: 10.3389/fchem.2020.00064

Protocol for the Characterization of the Cytosine-Adenine-Guanine Tract and Flanking Polymorphisms in Machado-Joseph Disease: Impact on Diagnosis and Development of Gene-Based Therapies

Autores: opes SM, Faro R, Lopes MM, Onofre I, Mendonça N, Ribeiro J, Januário C, Nobre RJ, Pereira de Almeida L.
Publicado en: Journal of Molecular Diagnostics, 2020, ISSN 1525-1578
Editor: American Society for Investigative Pathology
DOI: 10.1016/j.jmoldx.2020.03.003

PSEN1ΔE9, APPswe, and APOE4 Confer Disparate Phenotypes in Human iPSC-Derived Microglia

Autores: Konttinen H, Cabral-da-Silva MEC, Ohtonen S, Wojciechowski S, Shakirzyanova A, Caligola S, Giugno R, Ishchenko Y, Hernández D, Fazaludeen MF, Eamen S, Budia MG,Fagerlund I, Scoyni F, Korhonen P, Huber N, Haapasalo A, Hewitt AW, Vickers J, Smith GC, Oksanen M, Graff C, Kanninen KM, Lehtonen S, Propson N, Schwartz MP, Pébay A, Koistinaho J, Ooi L, Malm T.
Publicado en: Stem cell reports, 2019, ISSN 2213-6711
Editor: Cell Press
DOI: 10.1016/j.stemcr.2019.08.004

The BACHD rat model of Huntington disease shows slowed learning in a Go/No-Go-like test of visual discrimination

Autores: Clemensson EKH, Novati A, Clemensson LE, Riess O, Nguyen HP.
Publicado en: Behavioural Brain Research, 2019, ISSN 0166-4328
Editor: Elsevier BV
DOI: 10.1016/j.bbr.2018.10.036

An aberrant phase transition of stress granules triggered by misfolded protein and prevented by chaperone function

Autores: Mateju, Daniel; Franzmann, Titus M; Patel, Avinash; Kopach, Andrii; Boczek, Edgar E; Maharana, Shovamayee; Lee, Hyun O; Carra, Serena; Hyman, Anthony A; Alberti, Simon
Publicado en: The EMBO Journal, 2017, ISSN 0261-4189
Editor: Nature Publishing Group
DOI: 10.15252/embj.201695957

A Biomarker for Alzheimer's Disease Based on Patterns of Regional Brain Atrophy

Autores: Frenzel S., Wittfeld K., Habes M., Klinger-König J., Bülow R., Völzke H., Grabe HJ.
Publicado en: Frontiers in Psychiatry, 2020, ISSN 1664-0640
Editor: Frontiers Research Foundation
DOI: 10.3389/fpsyt.2019.00953

Inflammaging: a new immune–metabolic viewpoint for age-related diseases

Autores: Franceschi, C., Garagnani, P., Parini, P. et al.
Publicado en: Nat Rev Endocrinol, 2018, ISSN 1759-5029
Editor: Nature Publishing Group
DOI: 10.1038/s41574-018-0059-4

C@PA: Computer-Aided Pattern Analysis to Predict Multitarget ABC Transporter Inhibitors.

Autores: Vigneshwaran Namasivayam; Katja Silbermann; Michael Wiese; Jens Pahnke; Sven Marcel Stefan; Sven Marcel Stefan; Sven Marcel Stefan
Publicado en: Journal of Medicinal Chemistry, 2021, ISSN 0022-2623
Editor: American Chemical Society
DOI: 10.1021/acs.jmedchem.0c02199

Burden of Dilated Perivascular Spaces, an Emerging Marker of Cerebral Small Vessel Disease, Is Highly Heritable

Autores: Duperron MG, Tzourio C, Sargurupremraj M, Mazoyer B, Soumaré A, Schilling S, Amouyel P, Chauhan G, Zhu YC, Debette S.
Publicado en: Stroke, 2018, ISSN 0039-2499
Editor: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/strokeaha.117.019309

iPlasticity: Induced juvenile-like plasticity in the adult brain as a mechanism of antidepressants

Autores: Umemori, J., Winkel, F., Didio, G., Llach Pou, M., Castren, E.
Publicado en: Psychiatry and Clinical Neurosciences, 2018, ISSN 1323-1316
Editor: Blackwell Publishing Inc.
DOI: 10.1111/pcn.12683

Extracellular vesicles: Novel promising delivery systems for therapy of brain diseases

Autores: David Rufino-Ramos Patrícia R Albuquerque Vitor Carmona, Rita Perfeito, Rui Jorge Nobre, Luis Pereira de Almeida
Publicado en: Journal of Controlled Release, Edición Volume 262, 2017, Página(s) Pages 247-258, ISSN 0168-3659
Editor: Elsevier BV
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Quantitating denaturation by formic acid: imperfect repeats are essential to the stability of the functional amyloid protein FapC

Autores: Christensen LFB, Nowak JS, Sønderby T, Frank SA, Otzen DE
Publicado en: The journal of Biological Chemistry, 2020, ISSN 0021-9258
Editor: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1074/jbc.ra120.013396

Glucocerebrosidase mutations and synucleinopathies: Toward a model of precision medicine.

Autores: Fabio Blandini MD, Roberto Cilia MD, Silvia Cerri PhD, Gianni Pezzoli MD, Anthony H.V. Schapira MD, Stephen Mullin PhD, José L. Lanciego MD, PhD
Publicado en: Movement Disorders, 2019, ISSN 0885-3185
Editor: John Wiley & Sons Inc.
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Protein Phase Separation: A New Phase in Cell Biology

Autores: Boeynaems S, Alberti S, Fawzi NL, Mittag T, Polymenidou M, Rousseau F, Schymkowitz J, Shorter J, Wolozin B, Van Den Bosch L, Tompa P, Fuxreiter M
Publicado en: Trends in Cell Biology, 2018, ISSN 0962-8924
Editor: Elsevier BV
DOI: 10.1016/j.tcb.2018.02.004

Impact of Chronic BDNF Depletion on GABAergic Synaptic Transmission in the Lateral Amygdala

Autores: Meis S, Endres T, Munsch T, Lessmann V.
Publicado en: International Journal of Molecular Sciences, 2019, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms20174310

Peripheral Inflammation Regulates CNS Immune Surveillance Through the Recruitment of Inflammatory Monocytes Upon Systemic α-Synuclein Administration

Autores: Peralta Ramos J, Iribarren P, Bousset L, Melki R, Baekelandt V, Van der Perren A.
Publicado en: Frontiers in immunology, 2019, ISSN 1664-3224
Editor: Lausanne Frontiers Media S.A.
DOI: 10.3389/fimmu.2019.00080

Allele-Specific Methylation of SPDEF: A Novel Moderator of Psychosocial Stress and Substance Abuse

Autores: Nicole Tay, M.Sc., Christine Macare, Ph.D., Yun Liu, Ph.D., Barbara Ruggeri, Ph.D., Tianye Jia, Ph.D., Congying Chu, Ph.D., Francesca Biondo, Ph.D., Alex Ing, Ph.D., Qiang Luo, Ph.D., Daniil Sarkysian, Ph.D., Tobias Banaschewski, M.D., Ph.D., Gareth J. Barker, Ph.D., Arun L.W. Bokde, Ph.D., Uli Bromberg, Ph.D., Christian Büchel, M.D., Erin Burke Quinlan, Ph.D., Sylvane Desrivières, Ph.D., Herta
Publicado en: The American Journal of Psychiatry, 2019, ISSN 0002-953X
Editor: American Psychiatric Publishing, Inc.
DOI: 10.1176/appi.ajp.2018.17121360

FUS pathology in ALS is linked to alterations in multiple ALS-associated proteins and rescued by drugs stimulating autophagy

Autores: Marrone L, Drexler HCA, Wang J, Tripathi P, Distler T, Heisterkamp P, Anderson EN, Kour S, Moraiti A, Maharana S, Bhatnagar R, Belgard TG, Tripathy V, Kalmbach N, Hosseinzadeh Z, Crippa V, Abo-Rady M, Wegner F, Poletti A, Troost D, Aronica E, Busskamp V, Weis J, Pandey UB, Hyman AA, Alberti S, Goswami A, Sterneckert J
Publicado en: Acta Neuropathologica, 2019, ISSN 1432-0533
Editor: Springer
DOI: 10.1007/s00401-019-01998-x

Structural studies of amyloid-β peptides: Unlocking the mechanism of aggregation and the associated toxicity

Autores: Aleksis R, Oleskovs F, Jaudzems K, Pahnke J, Biverstal H,
Publicado en: Biochimie, 2017, ISSN 0300-9084
Editor: Elsevier BV
DOI: 10.1016/j.biochi.2017.07.011

Genetically Elevated LDL Associates with Lower Risk of Intracerebral Hemorrhage

Autores: Guido J. Falcone MD, ScD, MPH,Elayna Kirsch BA,Julian N. Acosta MD,Rommell B. Noche MS,Audrey Leasure BS,Sandro Marini MD,Jaeyoon Chung PhD,Magdy Selim MD, PhD,James F. Meschia MD,Devin L. Brown MD, MS,Bradford B. Worrall MD, MSc,David L. Tirschwell MD, MSc,Jeremiasz M. Jagiella MD, PhD,Helena Schmidt MD,Jordi Jimenez-Conde MD, PhD,Israel Fernandez-Cadenas PhD,Arne Lindgren MD,Agnieszka Slowik MD,
Publicado en: Annals of Neurology, 2020, ISSN 0364-5134
Editor: John Wiley & Sons Inc.
DOI: 10.1002/ana.25740

Impairment of the glymphatic system after diabetes.

Autores: Jiang Q, Zhang L, Ding G, Davoodi-Bojd E, Li Q, Li L, Sandry N, Nedergaard M, Chopp M, Zhang Z.
Publicado en: Journal of Cerebral Blood Flow and Metabolism, 2016, ISSN 0271-678X
Editor: Lippincott Williams & Wilkins Ltd.
DOI: 10.1177/0271678x16654702

TrkB-ICD Fragment, Originating From BDNF Receptor Cleavage, Is Translocated to Cell Nucleus and Phosphorylates Nuclear and Axonal Proteins

Autores: Fonseca-Gomes, J., Jerónimo-Santos, A., Lesnikova, A., Casarotto, P., Castrén, E., Sebastião, A. M., and Diógenes, M. J.
Publicado en: Frontiers in Molecular Neuroscience, 2019, ISSN 1662-5099
Editor: Frontiers Research Foundation
DOI: 10.3389/fnmol.2019.00004

A tool for analysis and visualization of spatial transcriptomics datasets.

Autores: Fernández Navarro J, Lundeberg J, Ståhl PL.
Publicado en: Bioinformatics, 2019, ISSN 1367-4811
Editor: Oxford Academic
DOI: 10.1093/bioinformatics/bty714

Transforming growth factor beta 1 signaling is altered in the spinal cord and muscle of amyotrophic lateral sclerosis mice and patients.

Autores: Meroni M., Crippa V., Cristofani R., Rusmini P., Cicardi M.E., Messi E., Piccolella M., Tedesco B., Ferrari V., Sorarù G., M., Pennuto M, Poletti A., Galbiati M.
Publicado en: Neurobiology of Disease, 2019, ISSN 0969-9961
Editor: Academic Press
DOI: 10.1016/j.neurobiolaging.2019.07.001

Vesicular ATP-binding cassette transporters in human disease: relevant aspects of their organization for future drug development

Autores: Katja Stefan; Lionel Yi Wen Leck; Lionel Yi Wen Leck; Vigneshwaran Namasivayam; Pablo Bascuñana; Michael L.-H. Huang; Patrick J. Riss; Jens Pahnke; Patric J. Jansson; Patric J. Jansson; Sven Marcel Stefan
Publicado en: Future Science, 2020, ISSN 1756-8919
Editor: Future Science Ltd.
DOI: 10.4155/fdd-2020-0025

Protease resistance of infectious prions is suppressed by removal of a single atom in the cellular prion protein

Autores: Henning Leske, Simone Hornemann, Uli Simon Herrmann, Caihong Zhu, Paolo Dametto, Bei Li, Florent Laferriere, Magdalini Polymenidou, Pawel Pelczar, Regina Rose Reimann, Petra Schwarz, Elisabeth Jane Rushing, Kurt Wüthrich , Adriano Aguzzi
Publicado en: PLOS ONE, 2017, ISSN 1932-6203
Editor: Public Library of Science
DOI: 10.1371/journal.pone.0170503

Inflammatory markers and imaging patterns of advanced brain aging in the general population

Autores: Janowitz, D, Habes M, Toledo J, Hannemann A, Frenzel S. ,Terock J., Davatzikos C, Hoffmann W, Grabe HJ.
Publicado en: Brain Imaging and Behavior, 2020, ISSN 1931-7557
Editor: Springer Pub. Co.,
DOI: 10.1007/s11682-019-00058-y

Parallel profiling of DNA methylation and hydroxymethylation highlights neuropathology-associated epigenetic variation in Alzheimer's disease

Autores: Smith, Adam R.; Smith, Rebecca G.; Pishva, Ehsan; Hannon, Eilis; Roubroeks, Janou A. Y.; Burrage, Joe; Troakes, Claire; Al-Sarraj, Safa; Sloan, Carolyn; Mill, Jonathan; van den Hove, Daniel L.; Lunnon, Katie
Publicado en: Clinical epigenetics, Edición vol. 11, 2019, ISSN 1868-7075
Editor: Springer Verlag
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The structural differences between patient-derived α-synuclein strains dictate characteristics of Parkinson's disease, multiple system atrophy and dementia with Lewy bodies

Autores: Van der Perren A, Gelders G, Fenyi A, Bousset L, Brito F, Peelaerts W, Van den Haute C, Gentleman S, Melki R, Baekelandt V
Publicado en: Acta neuropathologica, 2020, ISSN 0001-6322
Editor: Springer Verlag
DOI: 10.1007/s00401-020-02157-3

The SAC1 domain in synaptojanin is required for autophagosome maturation at presynaptic terminals

Autores: Roeland Vanhauwaert 1 2, Sabine Kuenen 1 2, Roy Masius 3, Adekunle Bademosi 4, Julia Manetsberger 1 2, Nils Schoovaerts 1 2, Laura Bounti 1 2, Serguei Gontcharenko 1 2, Jef Swerts 1 2, Sven Vilain 1 2, Marina Picillo 5, Paolo Barone 5, Shashini T Munshi 6, Femke Ms de Vrij 6, Steven A Kushner 6, Natalia V Gounko 1 2 7, Wim Mandemakers 3, Vincenzo Bonifati 3, Frederic A Meunier 4, Sandra-Fausia Sou
Publicado en: EMBO J, 2017, ISSN 0261-4189
Editor: Nature Publishing Group
DOI: 10.15252/embj.201695773

Long Term Gene Expression in Human Induced Pluripotent Stem Cells and Cerebral Organoids to Model a Neurodegenerative Disease.

Autores: Nassor F, Jarray R, Biard DSF, Maïza A, Papy-Garcia D, Pavoni S, Deslys J-P and Yates F
Publicado en: Front. Cell. Neurosci, 2020, ISSN 1662-5102
Editor: Frontiers Research Foundation
DOI: 10.3389/fncel.2020.00014

Richness and ecosystem development across faecal snapshots of the gut microbiota

Autores: Falony G, Vieira-Silva S, Raes J.
Publicado en: Nature microbiology, 2018, ISSN 2058-5276
Editor: Nature microbiology
DOI: 10.1038/s41564-018-0143-5

Identification of neurobehavioural symptom groups based on shared brain mechanisms

Autores: Alex Ing, Philipp G Sämann, Congying Chu, Nicole Tay, Francesca Biondo, Gabriel Robert, Tianye Jia, Thomas Wolfers, Sylvane Desrivières, Tobias Banaschewski, Arun L W Bokde, Uli Bromberg, Christian Büchel, Patricia Conrod, Tahmine Fadai, Herta Flor, Vincent Froui, Hugh Garavan, Philip A Spechler, Penny Gowland, Yvonne Grimmer, Andreas Heinz, Bernd Ittermann, Viola Kappel, Jean-Luc Martinot, And
Publicado en: Nature human behaviour, 2019, ISSN 2397-3374
Editor: Nature human behaviour
DOI: 10.1038/s41562-019-0738-8

Psychosocial Stress and Brain Function in Adolescent Psychopathology

Autores: Erin Burke Quinlan, Ph.D., Anna Cattrell, Ph.D., Tianye Jia, Ph.D., Eric Artiges, M.D., Ph.D., Tobias Banaschewski, M.D., Ph.D, Gareth Barker, Ph.D., Arun L.W. Bokde, Ph.D., Uli Bromberg, Dipl.-Psych., Christian Büchel, M.D., Rüdiger Brühl, Ph.D., Patricia J. Conrod, Ph.D., Sylvane Desrivieres, Ph.D., Herta Flor, Ph.D., Vincent Frouin, Ph.D., Jürgen Gallinat, M.D., Hugh Garavan, Ph.D., Penny G
Publicado en: The american journal of psychiatry, 2017, ISSN 0002-953X
Editor: American Psychiatric Publishing, Inc.
DOI: 10.1176/appi.ajp.2017.16040464

The autophagy-enhancing drug carbamazepine improves neuropathology and motor impairment in mouse models of Machado–Joseph disease

Autores: Ana Vasconcelos-Ferreira; Sara Carmo-Silva; José Miguel Codêsso; Patrick Silva; Alberto R. M. Martinez; Marcondes C. França; Clévio Nóbrega; Luís Pereira de Almeida
Publicado en: Neuropathology and Applied Neurobiology, Edición 2, 2022, ISSN 0305-1846
Editor: Blackwell Publishing Inc.
DOI: 10.1111/nan.12763

Cultivation and characterization of human midbrain organoids in sensor integrated microfluidic chips

Autores: Spitz S., Zanetti C., Bolognin S., Muwanigwa M.N., Smits L., Berger E., Jäger C., Harasek M., Schwamborn J.C., Peter Ertl
Publicado en: bioRxiv, 2019, ISSN 2692-8205
Editor: bioRxiv
DOI: 10.1101/869701

Reducing pericyte-derived scarring promotes recovery after spinal cord injury.

Autores: Oliveira Dias D, Kim H, Holl D, Werne Solnestam B, Lundeberg J, Carlén M, Göritz C* and Frisén J*.
Publicado en: Cell, 2018, ISSN 0092-8674
Editor: Cell Press
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Alzheimer’s disease-associated (hydroxy)methylomic changes in the brain and blood

Autores: Lardenoije, Roy; Roubroeks, Janou A. Y.; Pishva, Ehsan; Leber, Markus; Wagner, Holger; Iatrou, Artemis; Smith, Adam R.; Smith, Rebecca G.; Eijssen, Lars M. T.; Kleineidam, Luca; Kawalia, Amit; Hoffmann, Per; Luck, Tobias; Riedel-Heller, Steffi; Jessen, Frank; Maier, Wolfgang; Wagner, Michael; Hurlemann, René; Kenis, Gunter; Ali, Muhammad; del Sol, Antonio; Mastroeni, Diego; Delvaux, Elaine; Colem
Publicado en: Clinical epigenetics, 2019, ISSN 1868-7075
Editor: Springer Verlag
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Biological Age Predictors

Autores: Jylhävä J, Pedersen NL, Hägg S
Publicado en: EBioMedicine, 2017, ISSN 2352-3964
Editor: Elsevier BV
DOI: 10.1016/j.ebiom.2017.03.046

Epigenome-wide meta-analysis of blood DNA methylation and its association with subcortical volumes: findings from the ENIGMA Epigenetics Working Group

Autores: Tianye Jia, Congying Chu, Yun Liu, Jenny van Dongen, Evangelos Papastergios, Nicola J. Armstrong, Mark E. Bastin, Tania Carrillo-Roa, Anouk den Braber, Mathew Harris, Rick Jansen, Jingyu Liu, Michelle Luciano, Anil P. S. Ori, Roberto Roiz Santiañez, Barbara Ruggeri, Daniil Sarkisyan, Jean Shin, Kim Sungeun, Diana Tordesillas Gutiérrez, Dennis van’t Ent, David Ames, Eric Artiges, Georgy Bakalki
Publicado en: Molecular psychiatry, 2021, ISSN 1359-4184
Editor: Nature Publishing Group
DOI: 10.1038/s41380-019-0605-z

Physico-Pathologic Mechanisms Involved in Neurodegeneration: Misfolded Protein-Plasma Membrane Interactions

Autores: Shrivastava AN, Aperia A, Melki R, Triller A.
Publicado en: Neuron, 2017, ISSN 0896-6273
Editor: Cell Press
DOI: 10.1016/j.neuron.2017.05.026

Neurobehavioural characterisation and stratification of reinforcement-related behaviour

Autores: Tianye Jia, Alex Ing, Erin Burke Quinlan, Nicole Tay, Qiang Luo, Biondo Francesca, Tobias Banaschewski, Gareth J. Barker, Arun L. W. Bokde, Uli Bromberg, Christian Büchel, Sylvane Desrivières, Jianfeng Feng, Herta Flor, Antoine Grigis, Hugh Garavan, Penny Gowland, Andreas Heinz, Bernd Ittermann, Jean-Luc Martinot, Marie-Laure Paillère Martinot, Frauke Nees, Dimitri Papadopoulos Orfanos, Tomáš
Publicado en: Nature Human Behaviour, 2020, ISSN 2397-3374
Editor: Nature Human Behaviour
DOI: 10.1038/s41562-020-0846-5

"Corrigendum to ""Morphometric analysis of the cerebral expression of ATP-binding cassette transporter protein ABCB1 in chronic schizophrenia: Circumscribed deficits in the habenula"" [Schizophr. Res. 2016 Nov;177(1-3):52-58]"

Autores: Bernstein HG, Hildebrandt J, Dobrowolny H, Steiner J, Bogerts B, Pahnke J,
Publicado en: Schizophrenia Research, 2018, ISSN 0920-9964
Editor: Elsevier BV
DOI: 10.1016/j.schres.2018.03.036

Fibroblasts of Machado Joseph Disease patients reveal autophagy impairmen

Autores: Isabel Onofre1,2,*, Nuno Mendonça1,3,4,*, Sara Lopes1,5, Rui Nobre1,5, Joana Barbosa de Melo1,4,6, Isabel Marques Carreira1,4,6, Cristina Januário3,4, António Freire Gonçalves3,4 & Luis Pereira de Almeida1,2
Publicado en: Scientifc Reports, 2016, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/srep28220

Machine Learning-Supported Analyses Improve Quantitative Histological Assessments of Amyloid-β Deposits and Activated Microglia

Autores: Bascunana P, Brackhan M, Pahnke J,
Publicado en: Journal of Alzheimer's Disease, 2021, ISSN 1387-2877
Editor: IOS Press
DOI: 10.3233/jad-201120

Differential overexpression of SERPINA3 in human prion diseases

Autores: Vanni, S., Moda, F., Zattoni, M. et al.
Publicado en: Scientific Reports, Edición 7, 2017, Página(s) 15637, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-017-15778-8

Leukocyte Telomere Length Is Related to Brain Parenchymal Fraction and Attention/Speed in the Elderly: Results of the Austrian Stroke Prevention Study.

Autores: Piyush Gampawar; Reinhold Schmidt; Helena Schmidt
Publicado en: Frontiers in Psychiatry, Vol 11 (2020), 2020, ISSN 1664-0640
Editor: Frontiers Research Foundation
DOI: 10.3389/fpsyt.2020.00100

Targeting Neuroinflammation to Treat Alzheimer's Disease

Autores: Ardura-Fabregat A, Boddeke EWGM, Boza-Serrano A, Brioschi S, Castro-Gomez S, Ceyzériat K, Dansokho C, Dierkes T, Gelders G, Heneka MT, Hoeijmakers L, Hoffmann A, Iaccarino L, Jahnert S, Kuhbandner K, Landreth G, Lonnemann N, Löschmann PA, McManus RM, Paulus A, Reemst K, Sanchez-Caro JM, Tiberi A, Van der Perren A, Vautheny A, Venegas C, Webers A, Weydt P, Wijasa TS, Xiang X, Yang Y
Publicado en: CNS Drugs, 2017, ISSN 1172-7047
Editor: Adis International Ltd.
DOI: 10.1007/s40263-017-0483-3

Millifluidic culture improves human midbrain organoid vitality and differentiation

Autores: Emanuel Berger,aChiara Magliaro,bNicole Paczia,cAnna S. Monzel,aPaul Antony,dCarole L. Linster,cSilvia Bolognin,aArti Ahluwaliaband Jens C. Schwamborn
Publicado en: Lab Chip, 2018, ISSN 1473-0197
Editor: Royal Society of Chemistry
DOI: 10.1039/c8lc00206a

Are rodent models of Parkinson's disease behaving as they should ?

Autores: Vingill S, Cohhor-Robson N and Wade-Martins R
Publicado en: Behavioural Brain Research, 2018, ISSN 0166-4328
Editor: Elsevier BV
DOI: 10.1016/j.bbr.2017.10.021

Dynamic Arc SUMOylation and Selective Interaction with F-Actin-Binding Protein Drebrin A in LTP Consolidation In Vivo

Autores: Nair RR, Patil S, Tiron A, Kanhema T, Panja D, Schiro L, Parobzak K, Wilczynski G, Bramham CR.
Publicado en: Frontiers in Synaptic Neuroscience, 2017, ISSN 1663-3563
Editor: Frontiers Research Foundation
DOI: 10.3389/fnsyn.2017.00008

Fingolimod as a Treatment in Neurologic Disorders Beyond Multiple Sclerosis

Autores: Pablo Bascuñana; Luisa Möhle; Mirjam Brackhan; Jens Pahnke
Publicado en: Drugs in R&D, 2020, ISSN 1174-5886
Editor: Adis International Ltd.
DOI: 10.1007/s40268-020-00316-1

Gut microbiota changes in the extreme decades of human life: a focus on centenarians

Autores: Santoro, A., Ostan, R., Candela, M. et al.
Publicado en: Cellular and Molecular Life Sciences, Edición 75, 2018, Página(s) 129–148, ISSN 1420-682X
Editor: Birkhauser Verlag
DOI: 10.1007/s00018-017-2674-y

Unravelling Endogenous MicroRNA System Dysfunction as a New Pathophysiological Mechanism in Machado-Joseph Disease

Autores: Vitor Carmona,Janete Cunha-Santos, Isabel Onofre,Ana Teresa Simões,Udaya Vijayakumar,Beverly L. Davidson, and Luís Pereira de Almeida
Publicado en: Molecular therapy, 2017, ISSN 1525-0016
Editor: Nature Publishing Group
DOI: 10.1016/j.ymthe.2017.01.021

RNA buffers the phase separation behavior of prion-like RNA binding proteins

Autores: Maharana, Shovamayee; Wang, Jie; Papadopoulos, Dimitrios K.; Richter, Doris; Pozniakovsky, Andrey; Poser, Ina; Bickle, Marc; Rizk, Sandra; Guillén-Boixet, Jordina; Franzmann, Titus M.; Jahnel, Marcus; Marrone, Lara; Chang, Young-Tae; Sterneckert, Jared; Tomancak, Pavel; Hyman, Anthony A.; Alberti, Simon
Publicado en: Science, Edición 1, 2018, ISSN 0036-8075
Editor: American Association for the Advancement of Science
DOI: 10.1126/science.aar7366

Amplifying mitochondrial function rescues adult neurogenesis in a mouse model of Alzheimer's disease

Autores: Richetin K, Moulis M, Millet A, Arràzola MS, Andraini T, Hua J, Davezac N, Roybon L, Belenguer P, Miquel MC, Rampon C.
Publicado en: Neurobiology of Disease, Edición Volume 102, 2017, Página(s) 113-124, ISSN 0969-9961
Editor: Academic Press
DOI: 10.1016/j.nbd.2017.03.002

Nanomedicine for the Treatment of Alzheimer's Disease

Autores: Formicola B, Cox A, Dal Magro R, Masserini M, Re F.
Publicado en: Journal of biomedical nanotechnology, 2019, ISSN 1550-7033
Editor: American Scientific Publishers
DOI: 10.1166/jbn.2019.2837

Intrinsic Xenobiotic Resistance of the Intestinal Stem Cell Niche

Autores: Yuemin Celina Chee; Jens Pahnke; Jens Pahnke; Jens Pahnke; Ralph M. Bunte; Vikrant A. Adsool; Babita Madan; David M. Virshup; David M. Virshup
Publicado en: Developmental Cell, 2018, ISSN 1534-5807
Editor: Cell Press
DOI: 10.1016/j.devcel.2018.07.023

CNS-Specific Synthesis of Interleukin 23 Induces a Progressive Cerebellar Ataxia and the Accumulation of Both T and B Cells in the Brain: Characterization of a Novel Transgenic Mouse Model.

Autores: Nitsch L, Zimmermann J, Krauthausen M, Hofer MJ, Saggu R, Petzold GC, Heneka MT, Getts DR, Becker A, Campbell IL, Müller M.
Publicado en: MOL NEUROBIOL, 2019, ISSN 0893-7648
Editor: Humana Press, Inc.
DOI: 10.1007/s12035-019-1640-0

Prion-like low-complexity sequences: Key regulators of protein solubility and phase behavior

Autores: Franzmann T, Alberti S
Publicado en: Journal of Biological Chemistry, 2018, ISSN 0021-9258
Editor: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1074/jbc.tm118.001190

There Is an Inclusion for That: Material Properties of Protein Granules Provide a Platform for Building Diverse Cellular Functions

Autores: Daniel Kaganovich
Publicado en: Trends in Biochemical Sciences, 2017, ISSN 0968-0004
Editor: Elsevier BV
DOI: 10.1016/j.tibs.2017.08.002

Early Cognitive Training Rescues Remote Spatial Memory but Reduces Cognitive Flexibility in Alzheimer's Disease Mice.

Autores: Surya Prakash Rai; Markus Krohn; Markus Krohn; Jens Pahnke
Publicado en: Journal of Alzheimers Disease & Parkinsonism., Edición 1, 2020, ISSN 1387-2877
Editor: IOS Press
DOI: 10.3233/jad-200161

Restoring brain cholesterol turnover improves autophagy and has therapeutic potential in mouse models of spinocerebellar ataxia.

Autores: Nóbrega, Clévio; Mendonça, Liliana; Marcelo, Adriana; Lamazière, Antonin; Tomé, Sandra; Despres, Gaetan; Matos, Carlos A.; Mechmet, Fatich; Langui, Dominique; den Dunnen, Wilfred; de Almeida, Luis Pereira; Cartier, Nathalie; Alves, Sandro
Publicado en: Acta neuropothologica, 2019, ISSN 0001-6322
Editor: Springer Verlag
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Genetic variation underlying cognition and its relation with neurological outcomes and brain imaging.

Autores: Maria J. Knol; Alis Heshmatollah; Lotte G.M. Cremers; M. Kamran Ikram; André G. Uitterlinden; Cornelia M. van Duijn; Wiro J. Niessen; Wiro J. Niessen; Meike W. Vernooij; M. Arfan Ikram; Hieab H.H. Adams
Publicado en: Aging, 2019, ISSN 2589-9589
Editor: Impact Journals LLC
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The choroid plexus in health and in disease: dialogues into and out of the brain

Autores: Marques F, Sousa JC, Brito MA, Pahnke J, Santos C, Correia-Neves M, Palha JA,
Publicado en: Neurobiology of disease, 2017, ISSN 0969-9961
Editor: Academic Press
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Age-related ultrastructural changes of the basement membrane in the mouse blood-brain barrier

Autores: Ceafalan, Laura Cristina; Fertig, Tudor Emanuel; Gheorghe, Teodora Cristina; Hinescu, Mihail Eugen; Popescu, Bogdan Ovidiu; Pahnke, Jens; Gherghiceanu, Mihaela
Publicado en: Journal of Cellular and Molecular Medicine, 2018, ISSN 1582-1838
Editor: Wiley-Blackwell
DOI: 10.1111/jcmm.13980

The small heat shock protein B8 (HSPB8) modulates proliferation and migration of breast cancer cells

Autores: Piccolella M., Crippa V., Cristofani R., Rusmini P., Galbiati M., Cicardi M.E., Meroni M., Ferri N., Morelli F.F., Carra S., Messi E., Poletti A.
Publicado en: Oncotarget, 2017, ISSN 1949-2553
Editor: Impact Journals
DOI: 10.18632/oncotarget.14422

Detection and Prediction of Mild Cognitive Impairment in Alzheimer's Disease Mice.

Autores: Surya Prakash Rai; Pablo Bascuñana; Mirjam Brackhan; Markus Krohn; Luisa Möhle; Kristin Paarmann; Jens Pahnke
Publicado en: J Alzheimers Dis, Edición 2, 2020, ISSN 1387-2877
Editor: IOS Press
DOI: 10.3233/jad-200675

Evaluating β-amyloidosis progression in Alzheimer's disease with Mueller polarimetry

Autores: Borovkova M, Bykov A, Popov A, Pierangelo A, Novikova T, Pahnke J, Meglinski I
Publicado en: Biomedical Optics Express, 2020, ISSN 2156-7085
Editor: The Optical Society
DOI: 10.1364/boe.396294

From Stroke to Dementia: a Comprehensive Review Exposing Tight Interactions Between Stroke and Amyloid-β Formation

Autores: Goulay R, Mena Romo L, Hol EM, Dijkhuizen RM.
Publicado en: Translational stroke research, 2020, ISSN 1868-4483
Editor: Springer Pub. Co.,
DOI: 10.1007/s12975-019-00755-2

The concerted amyloid-beta clearance of LRP1 and ABCB1/P-gp across the blood-brain barrier is linked by PICALM

Autores: Storck SE, Hartz AMS, Bernard J, Wolf A, Kachlmeier A, Mahringer A, Weggen S, Pahnke J, Pietrzik CU
Publicado en: Brain, Behavior, and Immunity, 2018, ISSN 0889-1591
Editor: Academic Press
DOI: 10.1016/j.bbi.2018.07.017

Differential Exchange of Multifunctional Liposomes Between Glioblastoma Cells and Healthy Astrocytes via Tunneling Nanotubes

Autores: Formicola B, D'Aloia A, Dal Magro R, Stucchi S, Rigolio R, Ceriani M, Re F.
Publicado en: Frontiers in bioengineering and biotechnology, 2019, ISSN 2296-4185
Editor: Lausanne: Frontiers Media S.A.
DOI: 10.3389/fbioe.2019.00403

SCA7 Mouse Cerebellar Pathology Reveals Preferential Downregulation of Key Purkinje Cell-Identity Genes and Shared Disease Signature with SCA1 and SCA2

Autores: Niewiadomska-Cimicka A, Doussau F, Perot JB, Roux MJ, Keime C, Hache A, Piguet F, Novati A, Weber C, Yalcin B, Meziane H, Champy MF, Grandgirard E, Karam A, Messaddeq N, Eisenmann A, Brouillet E, Nguyen HHP, Flament J, Isope P and Trottier Y.
Publicado en: The journal of neuroscience, 2021, ISSN 0270-6474
Editor: Society for Neuroscience
DOI: 10.1523/jneurosci.1882-20.2021

Prying into the Prion Hypothesis for Parkinson's Disease

Autores: Brundin P, Melki R
Publicado en: The Journal of Neuroscience, 2017, ISSN 0270-6474
Editor: Society for Neuroscience
DOI: 10.1523/jneurosci.1788-16.2017

Endothelial LRP1 - A Potential Target for the Treatment of Alzheimer's Disease : Theme: Drug Discovery, Development and Delivery in Alzheimer's Disease Guest Editor: Davide Brambilla

Autores: Storck SE, Pietrzik CU
Publicado en: Pharmaceutical research, 2017, ISSN 0724-8741
Editor: Kluwer Academic/Plenum Publishers
DOI: 10.1007/s11095-017-2267-3

The physiology of regulated BDNF release

Autores: Brigadski T, Leßmann V.
Publicado en: Cell and Tissue Research | Home, 2020, ISSN 1432-0878
Editor: Springer
DOI: 10.1007/s00441-020-03253-2

Evolution of Nanoparticle Protein Corona across the Blood-Brain Barrier

Autores: Cox A, Andreozzi P, Dal Magro R, Fiordaliso F, Corbelli A, Talamini L, Chinello C, Raimondo F, Magni F, Tringali M, Krol S, Jacob Silva P, Stellacci F, Masserini M, Re F.
Publicado en: ACS nano, 2018, ISSN 1936-0851
Editor: American Chemical Society
DOI: 10.1021/acsnano.8b03500

3D human brain cell models: New frontiers in disease understanding and drug discovery for neurodegenerative diseases

Autores: Korhonen P, Malm T and White A R. White AR.
Publicado en: Neurochemistry international, 2018, ISSN 0197-0186
Editor: Elsevier BV
DOI: 10.1016/j.neuint.2018.08.012

Humanization of the Blood-Brain Barrier Transporter ABCB1 in Mice Disrupts Genomic Locus - Lessons from Three Unsuccessful Approaches

Autores: Krohn M, Wanek T, Menet MC, Noack A, Decleves X, Langer O, Loscher W, Pahnke J,
Publicado en: European journal of microbiology and immunology, 2018, ISSN 2062-509X
Editor: European journal of microbiology & immunology
DOI: 10.1556/1886.2018.00008

Neuroticism as a predictor of frailty in old age: a genetically informative approach

Autores: Hilda Bjork Danielsdottir, Juulia Jylhävä, Sara Hägg, Yi Lu, Lucía Colodro-Conde, Nicholas G. Martin, Nancy L. Pedersen, Miriam A. Mosing, Kelli Lehto
Publicado en: Psychosomatic Medicine, 2019, ISSN 0033-3174
Editor: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/psy.0000000000000742

Spatial Transcriptomics and In Situ Sequencing to Study Alzheimer's Disease.

Autores: Chen WT, Lu A, Craessaerts K, Pavie B, Sala Frigerio C, Corthout N, Qian X, Laláková J, Kühnemund M, Voytyuk I, Wolfs L, Mancuso R, Salta E, Balusu S, Snellinx A, Munck S, Jurek A, Fernandez Navarro J, Saido TC, Huitinga I, Lundeberg J, Fiers M, De Strooper B.
Publicado en: Cell, 2020, ISSN 0092-8674
Editor: Cell Press
DOI: 10.1016/j.cell.2020.06.038

Hippocampal tau oligomerization early in tau pathology coincides with a transient alteration of mitochondrial homeostasis and DNA repair in a mouse model of tauopathy

Autores: Zheng, Jin; Akbari, Mansour; Schirmer, Claire; Reynaert, Marie-Line; Loyens, Anne; Lefebvre, Bruno; Buée, Luc; Croteau, Deborah L.; Galas, Marie-Christine; Bohr, Vilhelm A.
Publicado en: Acta Neuropathologica Communications, Edición Vol 8, Iss 1, 2020, Página(s) Pp 1-23, ISSN 2051-5960
Editor: BioMed Central
DOI: 10.1186/s40478-020-00896-8

Teaming up to tackle neurodegenerative diseases

Autores: Editorial
Publicado en: The Lancet Neurology, 2015, ISSN 1474-4422
Editor: The Lancet Publishing Group
DOI: 10.1016/s1474-4422(15)70029-3

Cerebral small vessel disease genomics and its implications across the lifespan

Autores: Sargurupremraj M, Suzuki H, Jian X, Sarnowski C, Evans TE, Bis JC, Eiriksdottir G, Sakaue S, Terzikhan N, Habes M, Zhao W, Armstrong NJ, Hofer E, Yanek LR, Hagenaars SP, Kumar RB, van den Akker EB, McWhirter RE, Trompet S, Mishra A, Saba Y, Satizabal CL, Beaudet G, Petit L, Tsuchida A, Zago L, Schilling S, Sigurdsson S, Gottesman RF, Lewis CE, Aggarwal NT, Lopez OL, Smith JA, Valdés Hernández MC
Publicado en: Nature communication, 2020, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-020-19111-2

Activation of Mitochondrial Complex II-Dependent Respiration Is Beneficial for α-Synucleinopathies

Autores: Frohlich C, Zschiebsch K, Groger V, Paarmann K, Steffen J, Thurm C, Schropp EM, Bruning T, Gellerich F, Radloff M, Schwabe R, Lachmann I, Krohn M, Ibrahim S, Pahnke J,
Publicado en: Molecular neurobiology, 2016, ISSN 0893-7648
Editor: Humana Press, Inc.
DOI: 10.1007/s12035-015-9399-4

LRRK2 modifies α-syn pathology and spread in mouse models and human neurons

Autores: Bieri G, Brahic M, Bousset L, Couthouis J, Kramer NJ, Ma R, Nakayama L, Monbureau M, Defensor E, Schüle B, Shamloo M, Melki R, Gitler AD.
Publicado en: Acta neuropathologica, 2019, ISSN 0001-6322
Editor: Springer Verlag
DOI: 10.1007/s00401-019-01995-0

Recent advances in applying mass spectrometry and systems biology to determine brain dynamics

Autores: Scifo E*, Calza G*, Fuhrmann M, Soliymani R, Baumann M, Lalowski M,
Publicado en: Expert Review of Proteomics, 2017, ISSN 1478-9450
Editor: Future Drugs Ltd.
DOI: 10.1080/14789450.2017.1335200

Corticosteroids and Regional Variations in Thickness of the Human Cerebral Cortex across the Lifespan

Autores: Parker N, Vidal-Pineiro D, French L, Shin J, Adams HHH, Cox SR, Deary IJ, Fjell AM, Frenzel S, Grabe, HJ, Hosten N, Ikram MA, Jiang J, Knol MJ, Mazoyer B, Mishra A, Sachdev PS, Salum G, Schmidt H, Schmidt R, Seshadri S, Schumann G, Völzke H, Walhovd KB, Wei W, Wittfeld K, Yang Q, Debette S, Pausova Z, Paus T.
Publicado en: Cerebral cortex, 2020, ISSN 1047-3211
Editor: Oxford University Press
DOI: 10.1093/cercor/bhz108

CSF clearance in Alzheimer Disease measured with dynamic PET.

Autores: de Leon MJ, Li Y, Okamura N, Tsui WH, Saint Louis LA, Glodzik L, Osorio RS, Fortea J, Butler T, Pirraglia E, Fossati S, Kim HJ, Carare RO, Nedergaard M, Benveniste H, Rusinek H.
Publicado en: Journal of Nuclear Medicine, 2017, ISSN 0161-5505
Editor: Kexue Chubaneshe/Science Press
DOI: 10.2967/jnumed.116.187211

Development of Disordered Eating Behaviors and Comorbid Depressive Symptoms in Adolescence: Neural and Psychopathological Predictors

Autores: Zuo Zhang, Lauren Robinson, Tianye Jia, Erin Burke Quinlan, Nicole Tay, Congying Chu, Edward D Barker, Tobias Banaschewski, Gareth J Barker, Arun L W Bokde, Herta Flor, Antoine Grigis, Hugh Garavan, Penny Gowland, Andreas Heinz, Bernd Ittermann, Jean-Luc Martinot, Argyris Stringaris, Jani Penttilä, Betteke van Noort, Yvonne Grimmer, Marie-Laure Paillère Martinot, Corinna Isensee, Andreas Becker,
Publicado en: Biological psychiatry, 2021, ISSN 0006-3223
Editor: Elsevier BV
DOI: 10.1016/j.biopsych.2020.06.003

Common Genetic Variation Indicates Separate Causes for Periventricular and Deep White Matter Hyperintensities

Autores: Nicola J. Armstrong, Karen A. Mather, Muralidharan Sargurupremraj, Maria J. Knol, Rainer Malik, Claudia L. Satizabal, Lisa R. Yanek, Wei Wen, Vilmundur G. Gudnason, Nicole D. Dueker, Lloyd T. Elliott, Edith Hofer, Joshua Bis, Neda Jahanshad, Shuo Li, Mark A. Logue, Michelle Luciano, Markus Scholz, Albert V. Smith, Stella Trompet, Dina Vojinovic, Rui Xia, Fidel Alfaro-Almagro, David Ames, Najaf Ami
Publicado en: Stroke, 2020, ISSN 0039-2499
Editor: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/strokeaha.119.027544

Thickness of the cerebral cortex shows positive association with blood levels of triacylglycerols carrying 18-carbon fatty acids

Autores: Sliz E., Shin E., Syme C., Black S., Seshadri S., Paus T., Pausova Z.
Publicado en: Communications biology, 2020, ISSN 2399-3642
Editor: Springer Nature
DOI: 10.1038/s42003-020-01189-5

Measurement of Rapid Protein Diffusion in the Cytoplasm by Photo-Converted Intensity Profile Expansion

Autores: Rotem Gura Sadovsky, Shlomi Brielle, Daniel Kaganovich, Jeremy L. England
Publicado en: Molecular Cell, 2016, ISSN 2211-1247
Editor: Cell Press
DOI: 10.1016/j.celrep.2017.02.063

Posttranslational modification impact on the mechanism by which amyloid-β induces synaptic dysfunction

Autores: Katarzyna M Grochowska PingAn Yuanxiang Julia Bär Rajeev Raman Gemma Brugal Giriraj Sahu Michaela Schweizer Arthur Bikbaev Stephan Schilling Hans-Ulrich Demuth Michael R Kreutz
Publicado en: EMBO reports, 2017, ISSN 1469-221X
Editor: Nature Publishing Group
DOI: 10.15252/embr.201643519

BACHD rats expressing full-length mutant huntingtin exhibit differences in social behavior compared to wild-type littermates

Autores: Giuseppe Manfré, Arianna Novati, Ilaria Faccini, Andrea C Rossetti, Kari Bosch, Raffaella Molteni, Marco A Riva, Johanneke E Van der Harst, Huu Phuc Nguyen, Judith R Homberg;
Publicado en: Plos One, 2017, ISSN 1932-6203
Editor: Public Library of Science
DOI: 10.1371/journal.pone.0192289

Cellular correlates of cortical thinning throughout the lifespan

Autores: Didac Vidal-Pineiro, Nadine Parker, Jean Shin, Leon French, Håkon Grydeland, Andrea P. Jackowski, Athanasia M. Mowinckel, Yash Patel, Zdenka Pausova, Giovanni Salum, Øystein Sørensen, Kristine B. Walhovd, Tomas Paus, Anders M. Fjell, and the Alzheimer’s Disease Neuroimaging Initiative and the Australian Imaging Biomarkers and Lifestyle flagship study of ageing
Publicado en: Scientific reports, 2020, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-020-78471-3

Reducing the amyloidogenicity of functional amyloid FapC increases its ability to inhibit a-synuclein fibrillation

Autores: Christensen LFB, Jensen KF, Nielsen J, Vad BS, Christiansen G, Otzen DE,
Publicado en: ACS Omega, 2019, ISSN 2470-1343
Editor: American Chemical Society omega
DOI: 10.1021/acsomega.8b03590

A genome-wide association study identifies genetic loci associated with specific lobar brain volumes

Autores: Lee, S.J. van der; Knol, M.J.; Chauhan, G.; Satizabal, C.L.; Smith, A.V.; Hofer, E.; Bis, J.C.; Hibar, D.P.; Hilal, S.; Akker, E.B. van den; Arfanakis, K.; Bernard, M.; Yanek, L.R.; Amin, N.; Crivello, F.; Cheung, J.W.; Harris, T.B.; Saba, Y.; Lopez, O.L.; Li, S.; Grond, J. van der; Yu, L.; Paus, T.; Roshchupkin, G.V.; Amouyel, P.; Jahanshad, N.; Taylor, K.D.; Yang, Q.; Mathias, R.A.; Boehringer,
Publicado en: Communications Biology, 2019, ISSN 2399-3642
Editor: Springer Nature
DOI: 10.1038/s42003-019-0537-9

P2Y1 receptor blockade normalizes network dysfunction and cognition in an Alzheimer's disease model.

Autores: Reichenbach N, Delekate A, Breithausen B, Keppler K, Poll S, Schulte T, Peter J, Plescher M, Hansen JN, Blank N, Keller A, Fuhrmann M, Henneberger C, Halle A, Petzold GC.
Publicado en: Journal of Experimental Medicine, 2018, ISSN 0022-1007
Editor: Rockefeller University Press
DOI: 10.1084/jem.20171487

The new genetic landscape of Alzheimer's disease: from amyloid cascade to genetically driven synaptic failure hypothesis?

Autores: Dourlen P, Kilinc D, Malmanche N, Chapuis J, Lambert JC.
Publicado en: Acta Neuropathol, 2019, ISSN 0001-6322
Editor: Springer Verlag
DOI: 10.1007/s00401-019-02004-0

The Role of Activity-Dependent DNA Demethylation in the Adult Brain and in Neurological Disorders

Autores: Bayraktar G, Kreutz MR
Publicado en: Frontiers in molecular neuroscience, 2018, ISSN 1662-5099
Editor: Frontiers Research Foundation
DOI: 10.3389/fnmol.2018.00169

Virtual histology of multi-modal magnetic resonance imaging of cerebral cortex in young men

Autores: Yash Patel, Jean Shin, Mark Drakesmith, John Evans, Zdenka Pausova, Tomas Paus
Publicado en: Neuroimage, 2020, ISSN 2666-9560
Editor: New York Elsevier Inc.
DOI: 10.1016/j.neuroimage.2020.116968

Alexithymia Is Associated with Altered Cortical Thickness Networks in the General Population

Autores: Terock J. · Frenzel S. · Wittfeld K. · Klinger-König J. · Janowitz D. · Bülow R. · Hosten N. · Völzke H. · Grabe H.J.
Publicado en: Neuropsychobiology, 2020, ISSN 0302-282X
Editor: S. Karger AG
DOI: 10.1159/000504983

Lack of association between proton pump inhibitor use and brain aging: a cross-sectional study

Autores: Nayeon Ahn, Stefan Frenzel, Katharina Wittfeld, Robin Bülow, Henry Völzke, Markus M Lerch, Jean-Francois Chenot, Ulf Schminke, Michael Nolde, Ute Amann, Christa Meisinger, Jakob Linseisen, Sebastian E Baumeister, Hans Jörgen Grabe, Ina-Maria Rückert-Eheberg
Publicado en: European Journal of Clinical Pharmacology, 2021, ISSN 0031-6970
Editor: Springer Verlag
DOI: 10.1007/s00228-020-03068-8

The neuroactive potential of the human gut microbiota in quality of life and depression

Autores: Mireia Valles-Colomer, Gwen Falony, Youssef Darzi, Ettje F. Tigchelaar, Jun Wang, Raul Y. Tito, Carmen Schiweck, Alexander Kurilshikov, Marie Joossens, Cisca Wijmenga, Stephan Claes, Lukas Van Oudenhove, Alexandra Zhernakova, Sara Vieira-Silva & Jeroen Raes
Publicado en: Nature microbiology, 2019, ISSN 2058-5276
Editor: Nature microbiology
DOI: 10.1038/s41564-018-0337-x

Anti-Inflammatory Treatment with FTY720 Starting after Onset of Symptoms Reverses Synaptic Deficits in an AD Mouse Model.

Autores: Georgia-Ioanna Kartalou; Georgia-Ioanna Kartalou; Ana Rita Salgueiro-Pereira; Thomas Endres; Angelina Lesnikova; Plinio C. Casarotto; Paula A. Pousinha; Kevin Delanoe; Elke Edelmann; Eero Castrén; Kurt Gottmann; Hélène Marie; Volkmar Lessmann
Publicado en: International Journal of Molecular Sciences, Edición Edición 23, 2020, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21238957

Creation of a library of induced pluripotent stem cells from Parkinsonian patients

Autores: Holmqvist S, Lehtonen Š, Chumarina M, Puttonen KA, Azevedo C, Lebedeva O, Ruponen M, Oksanen M, Djelloul M, Collin A, Goldwurm S, Meyer M, Lagarkova M, Kiselev S, Koistinaho J, Roybon L.
Publicado en: NPJ Parkinson's Disease, 2016, ISSN 2373-8057
Editor: Springer Nature
DOI: 10.1038/npjparkd.2016.9

BIN1 recovers tauopathy-induced long-term memory deficits in mice and interacts with Tau through Thr348 phosphorylation

Autores: Sartori, M., Mendes, T., Desai, S. et al.
Publicado en: Acta Neuropathol, 2019, ISSN 0001-6322
Editor: Springer Verlag
DOI: 10.1007/s00401-019-02017-9

French maritime pine bark treatment decelerates plaque development and improves spatial memory in Alzheimer's disease mice

Autores: Paarmann K, Prakash SR, Krohn M, Mohle L, Brackhan M, Bruning T, Eiriz I, Pahnke J,
Publicado en: Phytomedicine, 2019, ISSN 0944-7113
Editor: Elsevier BV
DOI: 10.1016/j.phymed.2018.11.033

Immunobiography and the Heterogeneity of Immune Responses in the Elderly: A Focus on Inflammaging and Trained Immunity

Autores: Claudio Franceschi, Stefano Salvioli, Paolo Garagnani, Magda de Eguileor, Daniela Monti and Miriam Capri
Publicado en: Frontiers in Immunology, 2017, ISSN 1664-3224
Editor: Frontiers Media SA
DOI: 10.3389/fimmu.2017.00982

Gut Inflammation in Association With Pathogenesis of Parkinson's Disease.

Autores: Chen QQ, Haikal C, Li W, Li JY.
Publicado en: Frontiers in Molecular Neuroscience, 2019, ISSN 1662-5099
Editor: Frontiers Research Foundation
DOI: 10.3389/fnmol.2019.00218

Pharmacologically diverse antidepressant drugs disrupt the interaction of BDNF receptor TRKB and the endocytic adaptor AP-2

Autores: SM Fred, L Laukkanen, L Vesa, H Goos, I Cardon, R Moliner, T Maritzen, M Varjosalo, PC Casarotto, E Castren
Publicado en: Journal of Biological Chemistry, 2019, ISSN 0021-9258
Editor: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1074/jbc.ra119.008837

Iatrogenic early onset cerebral amyloid angiopathy 30 years after cerebral trauma with neurosurgery: vascular amyloid deposits are made up of both Aβ40 and Aβ42

Autores: Giaccone G, Maderna E, Marucci G, Catania M, Erbetta A, Chiapparini L, Indaco A, Caroppo P, Bersano A, Parati E, Di Fede G, Caputi L
Publicado en: Acta Neuropathologica Communications, 2019, ISSN 2051-5960
Editor: BioMed Central
DOI: 10.1186/s40478-019-0719-1

Phenotypic Screening Using Mouse and Human Stem Cell-Based Models of Neuroinflammation and Gene Expression Analysis to Study Drug Responses: Methods and Protocols

Autores: Abo-Rady M, Bellmann J, Glatza M, Marrone L, Reinhardt L, Tena S, Sterneckert J.
Publicado en: Methods in molecular biology, 2019, ISSN 1064-3745
Editor: Humana Press, Inc.
DOI: 10.1007/978-1-4939-8891-4_2

Neurofilaments as blood biomarkers at the preataxic and ataxic stage of spinocerebellar ataxia type 3: a cross-species analysis in humans and mice.

Autores: Wilke C, Haas E, Reetz K, Faber J, Garcia-Moreno H, Santana MM, van de Warrenburg B, Hengel H, Lima M, Filla A, Durr A, Melegh B, Masciullo M, Infante J, Giunti P, Neumann M, de Vries J, Pereira de Almeida L, Rakowicz M, Jacobi H, Schuele R, Kaeser SA, Kuhle J, Klockgether T, Schoels L, SCA3 neurofilament study group, Barro C*, Huebener-Schmid J*, Synofzik M*.
Publicado en: EMBO Molecular Medicine, 2019, ISSN 1757-4676
Editor: John Wiley & Sons Ltd.
DOI: 10.1101/19011882

Normal brain aging and Alzheimer's disease are associated with lower cerebral pH: an in vivo histidine 1 H-MR spectroscopy study

Autores: Lyros E, Ragoschke-Schumm A, Kostopoulos P, Sehr A, Backens M, Kalampokini S, Decker Y, Lesmeister M, Liu Y, Reith W, Fassbender K.
Publicado en: Neurobiology of aging, 2020, ISSN 0197-4580
Editor: Elsevier BV
DOI: 10.1016/j.neurobiolaging.2019.11.012

Brain aging in major depressive disorder: results from the ENIGMA major depressive disorder working group

Autores: Laura K M Han, Richard Dinga, Tim Hahn, Christopher R K Ching, Lisa T Eyler, Lyubomir Aftanas, Moji Aghajani, André Aleman, Bernhard T Baune, Klaus Berger, Ivan Brak, Geraldo Busatto Filho, Angela Carballedo, Colm G Connolly, Baptiste Couvy-Duchesne, Kathryn R Cullen, Udo Dannlowski, Christopher G Davey, Danai Dima, Fabio L S Duran, Verena Enneking, Elena Filimonova, Stefan Frenzel, Thomas Frodl,
Publicado en: Molecular psychiatry, 2020, ISSN 1359-4184
Editor: Nature Publishing Group
DOI: 10.1038/s41380-020-0754-0

Neuropathology and biochemistry of early onset familial Alzheimer's disease caused by presenilin-1 missense mutation Thr116Asn

Autores: Sutovsky S, Smolek T, Turcani P, Petrovic R, Brandoburova P, Jadhav S, Novak P, Attems J, Zilka N.
Publicado en: Journal of Neural Transmission, 2018, ISSN 0300-9564
Editor: Springer Verlag
DOI: 10.1007/s00702-018-1850-z

Nucleoli and Promyelocytic Leukemia Protein (PML) bodies are phase separated nuclear protein quality control compartments for misfolded proteins

Autores: Mediani L, Guillén-Boixet J, Alberti S, Carra S.
Publicado en: Molecular & Cellular Oncology, 2019, ISSN 2372-3556
Editor: Taylor and Francis Ltd
DOI: 10.1080/23723556.2019.1652519

Combinatorial treatment for spinal muscular atrophy: An Editorial for 'Combined treatment with the histone deacetylase inhibitor LBH589 and a splice-switch antisense oligonucleotide enhances SMN2 splicing and SMN expression in Spinal Muscular Atrophy cells'

Autores: Poletti A., Fischbeck K.H.
Publicado en: Journal of Neurochemistry, 2020, ISSN 0022-3042
Editor: Blackwell Publishing Inc.
DOI: 10.1111/jnc.14974

Deficiency of TLR4 ameliorates hypoperfusion-induced brain pathology

Autores: Liu Y, Fassbender K
Publicado en: Theranostics, 2018, ISSN 1838-7640
Editor: Ivyspring International Publisher
DOI: 10.7150/thno.30953

ST Spot: a web-based application for automatic spot and tissue detection for spatial Transcriptomics image datasets.

Autores: Wong K*, Navarro JF*, Bergenstråhle L, Ståhl PL, Lundeberg J.
Publicado en: Bioinformatics, 2018, ISSN 1367-4811
Editor: Oxford Academic
DOI: 10.1093/bioinformatics/bty030

The Blood brain-barrier and its role in Alzheimer’s disease

Autores: Steffen E. Storck and Claus U. Pietrzik
Publicado en: Neuroforum, 2018, ISSN 0947-0875
Editor: Spektrum Akademischer Verlag GmbH
DOI: 10.1515/nf-2018-a014

TRPV4 channels contribute to calcium transients in astrocytes and neurons during peri-infarct depolarizations in a stroke model

Autores: Cordula Rakers, Matthias Schmid, Gabor C. Petzold
Publicado en: Glia, 2017, ISSN 0894-1491
Editor: John Wiley & Sons Inc.
DOI: 10.1002/glia.23183

Methylomic profiling in trisomy 21 identifies cognition- and Alzheimer’s disease-related dysregulation

Autores: Haertle, Larissa; Müller, Tobias; Lardenoije, Roy; Maierhofer, Anna; Dittrich, Marcus; Riemens, Renzo J. M.; Stora, Samantha; Roche, Mathilde; Leber, Markus; Riedel-Heller, Steffi; Wagner, Michael; Scherer, Martin; Ravel, Aimé; Mircher, Clotilde; Cieuta-Walti, Cecile; Durand, Sophie; van de Hove, Daniel L. A.; Hoffmann, Per; Ramirez, Alfredo; Haaf, Thomas; El Hajj, Nady; Mégarbané, André
Publicado en: Clinical epigenetics, 11(1):195. BioMed Central Ltd, Edición 1, 2019, ISSN 1868-7075
Editor: Springer Verlag
DOI: 10.1186/s13148-019-0787-x

PLCG2 protective variant p.P522R modulates tau pathology and disease progression in patients with mild cognitive impairment

Autores: Kleineidam L, et al.
Publicado en: Acta Neuropathologica, 2020, ISSN 0001-6322
Editor: Springer Verlag
DOI: 10.1007/s00401-020-02138-6

Obesity in geroscience — is cellular senescence the culprit?

Autores: Franceschi, C
Publicado en: Nat Rev Endocrinol, Edición 13, 2017, Página(s) 76–78, ISSN 1759-5029
Editor: Nature Publishing Group
DOI: 10.1038/nrendo.2016.213

Trehalose alleviates the phenotype of Machado–Joseph disease mouse models

Autores: Santana, M.M., Paixão, S., Cunha-Santos, J. et al.
Publicado en: Journal of Translational Medicine, 2020, ISSN 1479-5876
Editor: BioMed Central
DOI: 10.1186/s12967-020-02302-2

Huntingtin phosphorylation governs BDNF homeostasis and improves the phenotype of Mecp2 knockout mice

Autores: Yann Ehinger Julie Bruyère Nicolas Panayotis Yah-Se Abada Emilie Borloz Valérie Matagne Chiara Scaramuzzino Hélène Vitet Benoit Delatour Lydia Saidi Laurent Villard Frédéric Saudou Jean-Christophe Roux
Publicado en: EMBO Molecular Medicine, 2020, ISSN 1757-4676
Editor: John Wiley & Sons Ltd.
DOI: 10.15252/emmm.201910889

Exome sequencing identifies novel AD-associated genes

Autores: Henne Holstege, Marc Hulsman, Camille Charbonnier, Benjamin Grenier-Boley, Olivier Quenez, Detelina Grozeva, Jeroen G.J. van Rooij, Rebecca Sims, Shahzad Ahmad, Najaf Amin, Penny J. Norsworthy, Oriol Dols-Icardo, Holger Hummerich, Amit Kawalia, Philippe Amouyel, Gary W. Beecham, Claudine Berr, Joshua C. Bis, Anne Boland, Paola Bossù, Femke Bouwman, Dominique Campion, Antonio Daniele, Jean-Franço
Publicado en: Alzheimer’s and Dementia, 2020, ISSN 1552-5260
Editor: Elsevier BV
DOI: 10.1002/alz.041592

Endocrine influence on neuroinflammation: the use of reporter systems

Autores: N. Rizzi, A. Villa, V. Benedusi, E. Brunialti, N. Cesari, P. Ciana, A. Maggi
Publicado en: Journal of Neuroendocrinology, 2017, ISSN 0953-8194
Editor: Blackwell Publishing Inc.
DOI: 10.1111/jne.12496

The biological function of the cellular prion protein: an update

Autores: Wulf, Marie-Angela; Senatore, Assunta; Aguzzi, Adriano
Publicado en: BMC Biology, 2017, ISSN 1741-7007
Editor: BioMed Central
DOI: 10.1186/s12915-017-0375-5

Parkinson’s Disease-Associated Mutant LRRK2-Mediated Inhibition of miRNA Activity is Antagonized by TRIM32

Autores: Gonzalez-Cano, L., Menzl, I., Tisserand, J. et al.
Publicado en: Mol Neurobiol, Edición 55, 2017, Página(s) 3490–3498, ISSN 0893-7648
Editor: Humana Press, Inc.
DOI: 10.1007/s12035-017-0570-y

Functional Neuroimaging Predictors of Self-Reported Psychotic Symptoms in Adolescents

Autores: Josiane Bourque, M.Sc., Philip A. Spechler, B.A., Stéphane Potvin, Ph.D., Robert Whelan, Ph.D., Tobias Banaschewski, M.D., Ph.D., Arun L.W. Bokde, Ph.D., Uli Bromberg, Dipl.-Psych., Christian Büchel, M.D., Erin Burke Quinlan, Ph.D., Sylvane Desrivières, Ph.D., Herta Flor, Ph.D., Vincent Frouin, Ph.D., Penny Gowland, Ph.D., Andreas Heinz, M.D., Ph.D., Bernd Ittermann, Ph.D., Jean-Luc Martinot, M
Publicado en: The american journal of psychiatry, 2017, ISSN 0002-953X
Editor: American Psychiatric Publishing, Inc.
DOI: 10.1176/appi.ajp.2017.16080897

ABCA7 Downregulation Modifies Cellular Cholesterol Homeostasis and Decreases Amyloid-β Peptide Efflux in an in vitro Model of the Blood-Brain Barrier

Autores: Lamartiniere Y, Boucau MC, Dehouck L, Krohn M, Pahnke J, Candela P, Gosselet F, Fenart L
Publicado en: Journal of Alzheimer's Disease, 2018, ISSN 1387-2877
Editor: IOS Press
DOI: 10.3233/jad-170883

Analysis of the vasculature by immunohistochemistry in paraffin-embedded brains

Autores: Decker Y, Müller A, Németh E, Schulz-Schaeffer WJ, Fatar M, Menger MD, Liu Y, Fassbender K.
Publicado en: Brain Structure and Function, 2018, ISSN 1863-2653
Editor: Springer Verlag
DOI: 10.1007/s00429-017-1595-8

An epigenome-wide association study of Alzheimer's disease blood highlights robust DNA hypermethylation in the HOXB6 gene

Autores: Roubroeks JAY, Smith AR, Smith RG, Pishva E, Ibrahim Z, Sattlecker M, Hannon EJ, Kłoszewska I, Mecocci P, Soininen H, Tsolaki M, Vellas B, Wahlund LO, Aarsland D, Proitsi P, Hodges A, Lovestone S, Newhouse SJ, Dobson RJB, Mill J, van den Hove DLA, Lunnon K.
Publicado en: NEUROBIOLOGY OF AGING, 2020, ISSN 0197-4580
Editor: Elsevier BV
DOI: 10.1016/j.neurobiolaging.2020.06.023

Viral Infections Exacerbate FUS-ALS Phenotypes in iPSC-Derived Spinal Neurons in a Virus Species-Specific Manner.

Autores: Jessica Bellmann; Anne Monette; Anne Monette; Vadreenath Tripathy; Anna Sójka; Masin Abo-Rady; Antje Janosh; Rajat Bhatnagar; Marc Bickle; Andrew J. Mouland; Andrew J. Mouland; Jared Sterneckert
Publicado en: Front. Cell. Neurosci, 2019, ISSN 1662-5102
Editor: Frontiers Research Foundation
DOI: 10.3389/fncel.2019.00480

The Synaptonuclear Messenger RNF10 Acts as an Architect of Neuronal Morphology

Autores: Nicolò Carrano, Tanmoy Samaddar, Electra Brunialti, Luca Franchini, Elena Marcello, Paolo Ciana, Daniela Mauceri, Monica Di Luca and Fabrizio Gardoni
Publicado en: Molecular Neurobiology, 2019, ISSN 0893-7648
Editor: Humana Press, Inc.
DOI: 10.1007/s12035-019-1631-1

Successes and Hurdles in Stem Cells Application and Production for Brain Transplantation

Autores: Henriques D, Moreira R, Schwamborn J, Pereira de Almeida L, Mendonça LS.
Publicado en: Frontiers in Neuroscience, 2019, ISSN 1662-4548
Editor: Frontiers Research Foundation
DOI: 10.3389/fnins.2019.01194

Cerebrospinal and Interstitial Fluid Transport via the Glymphatic Pathway Modeled by Optimal Transport.

Autores: Ratner V, Gao Y, Lee H, Elkin R, Nedergaard M, Benveniste H, Tannenbaum A.
Publicado en: NeuroImage, 2017, ISSN 1053-8119
Editor: Academic Press
DOI: 10.1016/j.neuroimage.2017.03.021

A nonsynonymous mutation in PLCG2 reduces the risk of Alzheimer's disease, dementia with Lewy bodies and frontotemporal dementia, and increases the likelihood of longevity.

Autores: Van der Lee SJ et al,
Publicado en: Acta Neuropathologica, 2019, ISSN 0001-6322
Editor: Springer Verlag
DOI: 10.1007/s00401-019-02026-8

Loss of Tau protein affects the structure, transcription and repair of neuronal pericentromeric heterochromatin.

Autores: Mansuroglu Z, Benhelli-Mokrani H, Marcato V, Sultan A, Violet M, Chauderlier A, Delattre L, Loyens A, Talahari S, Bégard S, Nesslany F, Colin M, Souès S, Lefebvre B, Buée L, Galas MC, Bonnefoy E.
Publicado en: Scientifc Reports, 2016, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/srep33047

Evolution and clustering of prodromal parkinsonian features in GBA1 carriers

Autores: Mullin S, Beavan M, Bestwick J, McNeill A, Proukakis C, Cox T, Hughes D, Mehta A, Zetterberg H, Schapira AHV.
Publicado en: Movement Disorders, 2019, ISSN 0885-3185
Editor: John Wiley & Sons Inc.
DOI: 10.1002/mds.27775

Striatal infusion of cholesterol promotes dose-dependent behavioral benefits and exerts disease-modifying effects in Huntington's disease mice

Autores: Birolini G, Valenza M, Di Paolo E, Vezzoli E, Talp F, Maniezz C, Caccia C, Leoni V, F Taroni F, Bocchi VD, Conforti P, Sogne E, Petricca L, Cariulo C, Verani M, A Caricasole A, Falqui A, Biella G, Cattaneo E.
Publicado en: EMBO Molecular Medicine, 2020, ISSN 1757-4676
Editor: John Wiley & Sons Ltd.
DOI: 10.15252/emmm.202012519

Propagation of α-Synuclein Strains within Human Reconstructed Neuronal Network

Autores: Gribaudo S, Tixador P, Bousset L, Fenyi A, Lino P, Melki R, Peyrin JM, Perrier AL.
Publicado en: Stem Cell Reports, 2019, ISSN 2213-6711
Editor: Cell Press
DOI: 10.1016/j.stemcr.2018.12.007

NF-E2-related factor 2 activation boosts antioxidant defenses and ameliorates inflammatory and amyloid properties in human Presenilin-1 mutated Alzheimer's disease astrocytes

Autores: Oksanen, Minna; Hyötyläinen, Ida; Trontti, Kalevi; Rolova, Taisia; Wojciechowski, Sara; Koskuvi, Marja; Viitanen, Matti; Levonen, Anna‐Liisa; Hovatta, Iiris; Roybon, Laurent; Lehtonen, Šárka; Kanninen, Katja M.; Hämäläinen, Riikka H.; Koistinaho, Jari
Publicado en: Glia, Edición 1, 2019, ISSN 0894-1491
Editor: John Wiley & Sons Inc.
DOI: 10.1002/glia.23741

Longitudinal trajectories, correlations and mortality associations of nine biological ages across 20-years follow-up.

Autores: Li X, Ploner A, Wang Y, Magnusson PK, Reynolds C, Finkel D, Pedersen NL, Jylhävä J, Hägg S.
Publicado en: Elife, 2020, ISSN 2050-084X
Editor: eLife Sciences Publications
DOI: 10.7554/elife.51507

Caldendrin Directly Couples Postsynaptic Calcium Signals to Actin Remodeling in Dendritic Spines

Autores: Mikhaylova M, Bär J, van Bommel B, Schätzle P, YuanXiang P, Raman R, Hradsky J, Konietzny A, Loktionov EY, Reddy PP, Lopez-Rojas J, Spilker C, Kobler O, Raza SA, Stork O, Hoogenraad CC, Kreutz MR
Publicado en: Neuron, 2018, ISSN 0896-6273
Editor: Cell Press
DOI: 10.1016/j.neuron.2018.01.046

Assessment of the efficacy of different procedures that remove and disassemble alpha-synuclein, tau and A-beta fibrils from laboratory material and surfaces

Autores: Fenyi A, Coens A, Bellande T, Melki R, Bousset L
Publicado en: Scientific Reports, 2018, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-018-28856-2

Machado-Joseph Disease: A Stress Combating Deubiquitylating Enzyme Changing Sides

Autores: Dantuma NP, and Herzog LK.
Publicado en: Advances in Experimental Medicine and Biology, 2020, ISSN 0065-2598
Editor: Kluwer Academic/Plenum Publishers
DOI: 10.1007/978-3-030-38266-7_10

Association of variants in HTRA1 and NOTCH3 with MRI-defined extremes of cerebral small vessel disease in older subjects

Autores: Mishra A, Chauhan G, Violleau MH, Soumare A, Vojinovic D, Jian X, Bis J, Li S, Saba Y, Yang Q, Bartz T, Hofer E, Zhu Y, Mazoyer B, Lathrop M, Schmidt H, Van Duijn C, Ikram MA, Longstreth WT, Fornage M, Seshadri S, Joutel A, Tzourio C, Debette S.
Publicado en: Brain, 2019, ISSN 0006-8950
Editor: Oxford University Press
DOI: 10.1093/brain/awz024

Genetic Background Influences the Propagation of Tau Pathology in Transgenic Rodent Models of Tauopathy

Autores: Smolek T, Cubinkova V, Brezovakova V, Valachova B, Szalay P, Zilka N, Jadhav S.
Publicado en: Frontiers in aging neuroscience, 2019, ISSN 1663-4365
Editor: Frontiers Research Foundation
DOI: 10.3389/fnagi.2019.00343

Isogenic FUS-eGFP iPSC Reporter Lines Enable Quantification of FUS Stress Granule Pathology that Is Rescued by Drugs Inducing Autophagy

Autores: L. Marrone, I. Poser, I. Casci, J. Japtok, P. Reinhardt, A. Janosch, C. Andree, H. O. Lee, C. Moebius, E. Koerner, L. Reinhardt, M. E. Cicardi, K. Hackmann, B. Klink, A. Poletti, S. Alberti, M. Bickle, A. Hermann, U. Pandey, A. A. Hyman, and J. L. Sterneckert
Publicado en: Stem Cell Reports, 2018, ISSN 2213-6711
Editor: Cell Press
DOI: 10.1016/j.stemcr.2017.12.018

ALS and FTD: Where RNA metabolism meets protein quality control

Autores: Mandrioli J, Mediani L, Alberti S, Carra S
Publicado en: Seminars in Cell & Developmental Biology, 2019, ISSN 1084-9521
Editor: Academic Press
DOI: 10.1016/j.semcdb.2019.06.003

Familial Alzheimer’s Disease Lymphocytes Respond Differently Than Sporadic Cells to Oxidative Stress: Upregulated p53-p21 Signaling Linked with Presenilin 1 Mutants

Autores: Joanna Wojsiat; Katarzyna Laskowska-Kaszub; Carolina Alquézar; Emilia Bialopiotrowicz; Noemí Esteras; Mykola Zdioruk; Ángeles Martín-Requero; Urszula Wojda
Publicado en: Molecular Neurobiology, 2017, ISSN 0893-7648
Editor: Humana Press, Inc.
DOI: 10.1007/s12035-016-0105-y

Human α-synuclein overexpression in a mouse model of Parkinson's disease leads to vascular pathology, blood brain barrier leakage and pericyte activation

Autores: Elabi O, Gaceb A, Carlsson R, Padel T, Soylu-Kucharz R, Cortijo I, Li W, Li JY, Paul G.
Publicado en: Scientific Reports, 2021, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-020-80889-8

Presynaptic Regulation of Tonic Inhibition by Neuromodulatory Transmitters in the Basal Amygdala.

Autores: Meis, S., Endres, T., Munsch, T. et al.
Publicado en: Molecular Neurobiology, Edición 55, 2018, Página(s) 8509–8521, ISSN 0893-7648
Editor: Humana Press, Inc.
DOI: 10.1007/s12035-018-0984-1

Traditional Japanese Herbal Medicine Yokukansan Targets Distinct but Overlapping Mechanisms in Aged Mice and in the 5xFAD Mouse Model of Alzheimer's Disease

Autores: Kaushik R, Morkovin E, Schneeberg J, Confettura AD, Kreutz MR, Senkov O, Dityatev A.
Publicado en: Frontiers in aging neuroscience, 2018, ISSN 1663-4365
Editor: Frontiers Research Foundation
DOI: 10.3389/fnagi.2018.00411

SIPA1L2 controls trafficking and local signaling of TrkB-containing amphisomes at presynaptic terminals

Autores: Maria Andres-Alonso, Mohamed Raafet Ammar, Ioana Butnaru, Guilherme M Gomes, Gustavo Acuña Sanhueza, Rajeev Raman, PingAn Yuanxiang, Maximilian Borgmeyer, Jeffrey Lopez-Rojas, Syed Ahsan Raza, Nicola Brice, Torben J Hausrat, Tamar Macharadze, Silvia Diaz-Gonzalez, Mark Carlton, Antonio Virgilio Failla, Oliver Stork, Michaela Schweizer, Eckart D Gundelfinger, Matthias Kneussel, Christina Spilker,
Publicado en: Nature Communications, 2019, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-019-13224-z

Microbiome changes: an indicator of Parkinson's disease?

Autores: Haikal C, Chen QQ, Li JY.
Publicado en: Translational Neurodegeneration, 2019, ISSN 2047-9158
Editor: BioMed Central
DOI: 10.1186/s40035-019-0175-7

Does Global Astrocytic Calcium Signaling Participate in Awake Brain State Transitions and Neuronal Circuit Function?

Autores: Celia Kjaerby, Rune Rasmussen, Mie Andersen & Maiken Nedergaard
Publicado en: Neurochemical Research, Edición 42, p, 2017, Página(s) ages 1810–1822, ISSN 0364-3190
Editor: Kluwer Academic/Plenum Publishers
DOI: 10.1007/s11064-017-2195-y

Enriched environmental conditions modify the gut microbiome composition and fecal markers of inflammation in Parkinson’s disease

Autores: Yogesh Singh, Mohamed El-Hadidi, Jakob Admard, Zinah Wassouf, Julia Schulze-Hentrich, Ursula Kohlhofer, Leticia Quintanilla-Martinez, Daniel Huson, Olaf Riess, Nicolas Casadei
Publicado en: Frontiers in neuroscience, 2019, ISSN 1662-4548
Editor: Frontiers Research Foundation
DOI: 10.3389/fnins.2019.01032

RUES2 hESCs exhibit MGE-biased neuronal differentiation and muHTT-dependent defective specification hinting at SP1

Autores: Conforti P, Besusso D, Brocchetti S, Campus I, Cappadona C, Galimberti M, Laporta A, Iennaco R, Rossi RL, Bocchi VD, Cattaneo E.
Publicado en: Neurobiology_of_Disease, 2020, ISSN 0969-9961
Editor: Academic Press
DOI: 10.1016/j.nbd.2020.105140

Transmission of Tau Pathology from Human to Rodent Brain: How to Humanise Animal Models for Alzheimer’s Disease Research

Autores: Tomas Smolek, Santosh Jadhav, Bernadeta Valachova, Thomas Vogels, Jaroslav Legath, Petr Novak and Norbert Zilka
Publicado en: Journal of Alzheimers Disease and Parkinsonism, 2017, ISSN 2161-0460
Editor: OMICS International Pvt Ltd
DOI: 10.4172/2161-0460.1000400

Neuronal network maturation differently affects secretory vesicles and mitochondria transport in axons

Autores: Moutaux E, Christaller W, Scaramuzzino C, Genoux A, Charlot B, Cazorla M, Saudou F.
Publicado en: Scientific Reports, 2018, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-018-31759-x

Simulation, Implementation and Measurement of Defined Sound Fields for Blood–Brain Barrier Opening in Rats

Autores: Saskia Grudzenski; Stefan Heger; Andreas de Jonge; Julia Schipp; Erik Dumont; Benoit Larrat; Lothar Schad; Michael Platten; Marc Fatar
Publicado en: Ultrasound in Medicine and Biology, 2021, ISSN 0301-5629
Editor: Elsevier BV
DOI: 10.1016/j.ultrasmedbio.2021.10.003

The Clustering of mApoE Anti-Amyloidogenic Peptide on Nanoparticle Surface Does Not Alter Its Performance in Controlling Beta-Amyloid Aggregation

Autores: Corti R, Cox A, Cassina V, Nardo L, Salerno D, Marrano CA, Missana N, Andreozzi P, Silva PJ, Stellacci F, Dal Magro R, Re F, Mantegazza F.
Publicado en: The International Journal of Molecular Sciences, 2020, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21031066

Effects of pharmacological modulators of α-synuclein and tau aggregation and internalization.

Autores: Dominguez-Meijide A, Vasili E, König A, Cima-Omori MS, Ibáñez de Opakua A, Leonov A, Ryazanov S, Zweckstetter M, Griesinger C, Outeiro TF.
Publicado en: Scientific Reports, 2020, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-020-69744-y

High dilated perivascular space burden: a new MRI marker for risk of intracerebral hemorrhage

Autores: Duperron MG, Tzourio C, Schilling S, Zhu YC, Soumaré A, Mazoyer B, Debette S.
Publicado en: Neurobiology of Ageing, 2019, ISSN 0197-4580
Editor: Elsevier BV
DOI: 10.1016/j.neurobiolaging.2019.08.031

Memory enhancement by ferulic acid ester across species.

Autores: Michels, Birgit; Zwaka, Hanna; Bartels, Ruth; Lushchak, Oleh; Franke, Katrin; Endres, Thomas; Fendt, Markus; Song, Inseon; Bakr, May; Budragchaa, Tuvshinjargal; Westermann, Bernhard; Mishra, Dushyant; Eschbach, Claire; Schreyer, Stefanie; Lingnau, Annika; Vahl, Caroline; Hilker, Marike; Menzel, Randolf; Kähne, Thilo; Leßmann, Volkmar; Dityatev, Alexander; Wessjohann, Ludger; Gerber, Bertram
Publicado en: Science advances, 2018, ISSN 2375-2548
Editor: American Association for the Advancement of Science
DOI: 10.1126/sciadv.aat6994

Dynamic susceptibility contrast and diffusion MR imaging identify oligodendroglioma as defined by the 2016 WHO classification for brain tumors: histogram analysis approach

Autores: Latysheva, Anna; Emblem, Kyrre Eeg; Brandal, Petter; Vik-Mo, Einar Osland; Pahnke, Jens; Røysland, Kjetil; Hald, John K.; Server, Andrés
Publicado en: Diagnostic Neuroradiology, Edición 1, 2019, ISSN 0028-3940
Editor: Springer Verlag
DOI: 10.1007/s00234-019-02173-5

Impact of demography and population dynamics on the genetic architecture of human longevity.

Autores: Giuliani C, Sazzini M, Pirazzini C, Bacalini MG, Marasco E, Ruscone GAG, Fang F, Sarno S, Gentilini D, Di Blasio AM, Crocco P, Passarino G, Mari D, Monti D, Nacmias B, Sorbi S, Salvarani C, Catanoso M, Pettener D, Luiselli D, Ukraintseva S, Yashin A, Franceschi C, Garagnani P.
Publicado en: Aging, 2018, ISSN 1945-4589
Editor: Impact Journals
DOI: 10.18632/aging.101515

Reverse NCX Attenuates Cellular Sodium Loading in Metabolically Compromised Cortex.

Autores: Niklas J. Gerkau; Cordula Rakers; Simone Durry; Gabor C. Petzold; Gabor C. Petzold; Christine R. Rose
Publicado en: Cerebral Cortex, 2018, ISSN 1047-3211
Editor: Oxford University Press
DOI: 10.1093/cercor/bhx280

Impairment of Glycolysis-Derived l-Serine Production in Astrocytes Contributes to Cognitive Deficits in Alzheimer's Disease.

Autores: Juliette Le Douce; Marianne Maugard; Julien Veran; Julien Veran; Marco Matos; Marco Matos; Pierrick Jego; Pierre Antoine Vigneron; Emilie Faivre; Xavier Toussay; Michel E. Vandenberghe; Yaël Balbastre; Juliette Piquet; Elvire Guiot; Nguyet Thuy Tran; Myriam Taverna; Myriam Taverna; Stéphane Marinesco; Ayumi Koyanagi; Shigeki Furuya; Mylène Gaudin-Guérif; Sébastien Goutal; Aurélie Ghettas; Al
Publicado en: Cell Metabolism, 2020, ISSN 1550-4131
Editor: Cell Press
DOI: 10.1016/j.cmet.2020.02.004

Generation of a human induced pluripotent stem cell line from a patient with a rare A673T variant in amyloid precursor protein gene that reduces the risk for Alzheimer's disease

Autores: Lehtonen Š, Höytyläinen I, Voutilainen J, Sonninen TM, Kuusisto J, Laakso M, Hämäläinen RH, Oksanen M, Koistinaho J.
Publicado en: Stem cell research, 2018, ISSN 1873-5061
Editor: Elsevier
DOI: 10.1016/j.scr.2018.05.014

Quantification of Total and Mutant Huntingtin Protein Levels in Biospecimens Using a Novel alphaLISA Assay

Autores: Barbara Baldo , Muhammad Umar Sajjad, Rachel Y Cheong, Julie Bigarreau, Ravi Vijayvargia, Catriona McLean, Anselme L Perrier, Ihn Sik Seong, Glenda Halliday, Åsa Petersén, Deniz Kirik
Publicado en: eNeuro, 2018, ISSN 2373-2822
Editor: eNeuro
DOI: 10.1523/eneuro.0234-18.2018

A customizable microfluidic platform for medium-throughput modeling of neuromuscular circuits

Autores: Jessica Bellmann; Ruchi Goswami; Salvatore Girardo; Nelly Rein; Zohreh Hosseinzadeh; Michael R. Hicks; Volker Busskamp; April D. Pyle; Carsten Werner; Jared Sterneckert
Publicado en: Biomaterials, 2019, ISSN 0142-9612
Editor: Pergamon Press Ltd.
DOI: 10.34657/5812

Novel Players in the Aging Synapse: Impact on Cognition

Autores: Mariana Temido-Ferreira; Joana E. Coelho; Paula A. Pousinha; Luísa V. Lopes
Publicado en: JOURNAL OF CAFFEINE AND ADENOSINE RESEARCH, Edición Volume 9, Number 3, 2019, ISSN 2573-3397
Editor: Mary Ann Liebert
DOI: 10.1089/caff.2019.0013

Molecular Targets and Therapeutic Strategies in Spinocerebellar Ataxia Type 7

Autores: Niewiadomska-Cimicka A, Trottier Y.
Publicado en: Neurotherapeutics, 2019, ISSN 1933-7213
Editor: Elsevier BV
DOI: 10.1007/s13311-019-00778-5

Muscleblind acts as a modifier of FUS toxicity by modulating stress granule dynamics and SMN localization

Autores: Casci I, Krishnamurthy K, Kour S, Tripathy V, Ramesh N, Anderson EN, Marrone L, Grant RA, Oliver S, Gochenaur L, Patel K, Sterneckert J, Gleixner AM, Donnelly CJ, Ruepp MD, Sini AM, Zuccaro E, Pennuto M, Pasinelli P, Bhan Pandey U.
Publicado en: Nature Communications, 2019, ISSN 2041-1723
Editor: Nature Publishing Group
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Common variants in Alzheimer’s disease: Novel association of six genetic variants with AD and risk stratification by polygenic risk scores.

Autores: De Rojas I, et al.
Publicado en: Nature communications, 2020, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1101/19012021

Dipeptidyl Vinyl Sulfone as a Novel Chemical Tool to Inhibit HMGB1/NLRP3-Inflammasome and Inflamma-miRs in Aβ-Mediated Microglial Inflammation

Autores: Falcão AS, Carvalho LAR, Lidónio G, Vaz AR, Lucas SD, Moreira R, Brites D
Publicado en: ACS chemical neuroscience, 2017, ISSN 1948-7193
Editor: American Chemical Society
DOI: 10.1021/acschemneuro.6b00250

Astroglial NF-kB contributes to white matter damage and cognitive impairment in a mouse model of vascular dementia

Autores: Saggu, Raman; Schumacher, Toni; Gerich, Florian; Rakers, Cordula; Tai, Khalid; Delekate, Andrea; Petzold, Gabor C.
Publicado en: Acta Neuropathologica Communications, 2016, ISSN 2051-5960
Editor: BioMed Central
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Bacterial amyloids: biogenesis and biomaterials

Autores: Christensen LFB, Schafer N, Wolf-Perez A, Madsen DJ, Otzen DE
Publicado en: Advances in experimental medicine and biology, 2019, ISSN 0065-2598
Editor: Kluwer Academic/Plenum Publishers
DOI: 10.1007/978-981-13-9791-2_4

Astrocytic calcium release mediates peri-infarct depolarizations in a rodent stroke model.

Autores: Rakers C, Petzold GC.
Publicado en: Journal of Clinical Investigation, 2019, ISSN 0021-9738
Editor: American Society for Clinical Investigation
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Autophagic and Proteasomal Mediated Removal of Mutant Androgen Receptor in Muscle Models of Spinal and Bulbar Muscular Atrophy

Autores: Cicardi M.E, Cristofani R., Crippa V., Ferrari V., Tedesco B., Casarotto E., Chierichetti M., Galbiati M., Piccolella M., Messi E., Carra S., Pennuto M., Rusmini P., Poletti A .
Publicado en: Frontiers in endocrinology, 2019, ISSN 1664-2392
Editor: Lausanne : Frontiers Research Foundation
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The sheaths of Methanospirillum are made of a new type of amyloid protein

Autores: Christensen LFB, Hansen LM, Finster K, Christiansen G, Nielsen PH, Otzen DE, Dueholm MS
Publicado en: Frontiers in Microbiology, 2018, ISSN 1664-302X
Editor: Frontiers Media
DOI: 10.3389/fmicb.2018.02729

Focal solute trapping and global glymphatic pathway impairment in a murine model of microinfarcts.

Autores: Wang M, Nedergaard M, Iliff J.
Publicado en: Journal of Neuroscience, 2017, ISSN 0270-6474
Editor: Society for Neuroscience
DOI: 10.1523/jneurosci.2112-16.2017

Towards the Identification of Molecular Biomarkers of Spinocerebellar Ataxia Type 3 (SCA3)/Machado-Joseph Disease (MJD)

Autores: Manuela Lima, Mafalda Raposo
Publicado en: Polyglutamine Disorders, 2018, ISSN 0065-2598
Editor: Kluwer Academic/Plenum Publishers
DOI: 10.1007/978-3-319-71779-1_16

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