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CORDIS - Résultats de la recherche de l’UE
CORDIS

ERA-NET for establishing synergies between the Joint Programming on Neurodegenerative Diseases Research and Horizon 2020

Livrables

Organization of a symposium for the dissemination of the results of JPco-fuND-funded research

Organization of a symposium for the dissemination of the results of JPcofuNDfunded research by ZonMw and ITMOH Month 30 60

Publications

Tdp-25 Routing to Autophagy and Proteasome Ameliorates its Aggregation in Amyotrophic Lateral Sclerosis Target Cells

Auteurs: Cicardi, Maria Elena; Cristofani, Riccardo; Rusmini, Paola; Meroni, Marco; Ferrari, Veronica; Vezzoli, Giulia; Tedesco, Barbara; Piccolella, Margherita; Messi, Elio; Galbiati, Mariarita; Boncoraglio, Alessandra; Carra, Serena; Crippa, Valeria; Poletti, Angelo
Publié dans: Scientific Reports, Numéro 2, 2018, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/s41598-018-29658-2

Modeling Parkinson’s disease in midbrain-like organoids

Auteurs: Smits, L.M., Reinhardt, L., Reinhardt, P. et al.
Publié dans: npj Parkinsons Dis., 2019, ISSN 2373-8057
Éditeur: Springer Nature
DOI: 10.1038/s41531-019-0078-4

The blood-brain barrier is disrupted in Machado-Joseph disease/spinocerebellar ataxia type 3: evidence from transgenic mice and human post-mortem samples

Auteurs: Duarte Lobo D, Nobre RJ, Oliveira Miranda C, Pereira D, Castelhano J, Sereno J, Koeppen A, Castelo-Branco M, Pereira de Almeida L.
Publié dans: Acta neuropathologica communications, 2020, ISSN 2051-5960
Éditeur: BioMed Central
DOI: 10.1186/s40478-020-00955-0

Bri2 BRICHOS client specificity and chaperone activity are governed by assembly state

Auteurs: Chen G, Abelein A, Nilsson H, Leppert A, Andrade-Talavera Y, Tambaro S, Hemmingsson L, Roshan F, Landreh M, Biverstål H, Koeck P, Presto J, Hebert H, Fisahn A, Johansson J,
Publié dans: Nature communications, 2017, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/s41467-017-02056-4

Repeated Mesenchymal Stromal Cell Treatment Sustainably Alleviates Machado-Joseph Disease

Auteurs: Oliveira Miranda C, Marcelo A, Silva TP, Barata J, Vasconcelos-Ferreira A, Pereira D, Nóbrega C, Duarte S, Barros I, Alves J, Sereno J, Petrella LI, Castelhano J, Paiva VH, Rodrigues-Santos P, Alves V, Nunes-Correia I, Nobre RJ, Gomes C, Castelo-Branco M, Pereira de Almeida L.
Publié dans: Molecular Therapy, 2018, ISSN 1525-0016
Éditeur: Nature Publishing Group
DOI: 10.1016/j.ymthe.2018.07.007

The ability of liposomes, tailored for blood-brain barrier targeting, to reach the brain is dramatically affected by the disease state

Auteurs: Magro RD, Cox A, Zambelli V, Mancini S, Masserini M, Re F.
Publié dans: Nanomedicine (Lond), 2018, ISSN 1743-5889
Éditeur: Future Medicine Ltd.
DOI: 10.2217/nnm-2017-0317

A variant near DHCR24 associates with microstructural properties of white matter and peripheral lipid metabolism in adolescents

Auteurs: Sliz E., Shin J., Syme C., Patel Y., Parker N., Richer L., Gaudet D., Bennett S., Paus T., Pausova Z.
Publié dans: Molecular psychiatry, 2021, ISSN 1359-4184
Éditeur: Nature Publishing Group
DOI: 10.1038/s41380-019-0640-9

Neuronal DNA Methyltransferases: Epigenetic Mediators between Synaptic Activity and Gene Expression?

Auteurs: Gonca Bayraktar, Michael R. Kreutz
Publié dans: The Neuroscientist, 2017, ISSN 1073-8584
Éditeur: Sage Science Press
DOI: 10.1177/1073858417707457

The Role of the Heat Shock Protein B8 (HSPB8) in Motoneuron Diseases

Auteurs: Paola Rusmini; Riccardo Cristofani; Mariarita Galbiati; Maria E. Cicardi; Marco Meroni; Veronica Ferrari; Giulia Vezzoli; Barbara Tedesco; Elio Messi; Margherita Piccolella; Serena Carra; Valeria Crippa; Valeria Crippa; Angelo Poletti; Angelo Poletti
Publié dans: Frontiers in Molecular Neuroscience, Vol 10 (2017), Numéro 2, 2017, ISSN 1662-5099
Éditeur: Frontiers Research Foundation
DOI: 10.3389/fnmol.2017.00176

Survival Associations Using Perfusion and Diffusion Magnetic Resonance Imaging in Patients With Histologic and Genetic Defined Diffuse Glioma World Health Organization Grades II and III

Auteurs: Latysheva A, Emblem KE, Server A, Brandal P, Meling TR, Pahnke J, Hald JK.
Publié dans: Journal of computer assisted tomography, 2018, ISSN 0363-8715
Éditeur: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/rct.0000000000000742

High-yield Production of Amyloid-β Peptide Enabled by a Customized Spider Silk Domain.

Auteurs: Axel Abelein; Gefei Chen; Kristīne Kitoka; Rihards Aleksis; Filips Oleskovs; Médoune Sarr; Michael Landreh; Jens Pahnke; Kerstin Nordling; Nina Kronqvist; Kristaps Jaudzems; Anna Rising; Anna Rising; Jan Johansson; Henrik Biverstål
Publié dans: Scientific Reports, Numéro Vol 10, Iss 1,, 2020, Page(s) Pp 1-10, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/s41598-019-57143-x

Validation of behavioral phenotypes in the BACHD rat model

Auteurs: Novati A, Manfré G, Flunkert S, Van der Harst JE, Homberg JR, Wronski R, Nguyen HP.
Publié dans: Behavioural Brain Research, 2020, ISSN 0166-4328
Éditeur: Elsevier BV
DOI: 10.1016/j.bbr.2020.112783

In vivo Phenotyping of Human Parkinson’s Disease-Specific Stem Cells Carrying the LRRK2-G2019S Mutation Reveals Increased a-Synuclein Levels but Absence of Spreading

Auteurs: Kathrin Hemmer, Lisa M. Smits, Silvia Bolognin, Jens Schwamborn
Publié dans: Opera Medica et Physiologica, 2018, ISSN 2500-2295
Éditeur: Opera Medica et Physiologica
DOI: 10.1101/140178

Golgi-Cox impregnation combined with fluorescence staining of amyloid plaques reveals local spine loss in an Alzheimer mouse model

Auteurs: Kartalou GI, Endres T, Lessmann V, Gottmann K.
Publié dans: Journal of Neuroscience Methods, 2020, ISSN 0165-0270
Éditeur: Elsevier BV
DOI: 10.1016/j.jneumeth.2020.108797

Environment-dependent striatal gene expression in the BACHD rat model for Huntington disease

Auteurs: Novati, Arianna; Hentrich, Thomas; Wassouf, Zinah; Weber, Jonasz J.; Yu-Taeger, Libo; Déglon, Nicole; Nguyen, Huu Phuc; Schulze-Hentrich, Julia M.
Publié dans: Scientific reports,, Numéro vol. 8, no. 1, 2018, Page(s) 5803, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/s41598-018-24243-z

Glymphatic distribution of CSF-derived apoE into brain is isoform specific and suppressed during sleep deprivation.

Auteurs: Achariyar TM, Li B, Peng W, Verghese PB, Shi Y, McConnell E, Benraiss A, Kasper T, Song W, Takano T, Holtzman DM, Nedergaard M, Deane R.
Publié dans: Molecular Neurodegeneration, 2017, ISSN 1750-1326
Éditeur: BioMed Central
DOI: 10.1186/s13024-016-0147-7

Defective ribosomal products challenge nuclear function by impairing nuclear condensate dynamics and immobilizing ubiquitin

Auteurs: Mediani, Laura; Guillén‐Boixet, Jordina; Vinet, Jonathan; Franzmann, Titus M; Bigi, Ilaria; Mateju, Daniel; Carrà, Arianna D; Morelli, Federica F; Tiago, Tatiana; Poser, Ina; Alberti, Simon; Carra, Serena
Publié dans: The EMBO Journal, Numéro 1, 2019, ISSN 0261-4189
Éditeur: Nature Publishing Group
DOI: 10.15252/embj.2018101341

The Regulation of the Small Heat Shock Protein B8 in Misfolding Protein Diseases Causing Motoneuronal and Muscle Cell Death

Auteurs: Riccardo Cristofani; Paola Rusmini; Mariarita Galbiati; Maria Elena Cicardi; Veronica Ferrari; Barbara Tedesco; Elena Casarotto; Marta Chierichetti; Elio Messi; Margherita Piccolella; Serena Carra; Valeria Crippa; Angelo Poletti; Angelo Poletti
Publié dans: Frontiers in Neuroscience, Vol 13 (2019), 2019, ISSN 1662-4548
Éditeur: Frontiers Research Foundation
DOI: 10.3389/fnins.2019.00796

Generation of a human induced pluripotent stem cell line (LL008 1.4) from a familial Alzheimer's disease patient carrying a double KM670/671NL (Swedish) mutation in APP gene.

Auteurs: Oksanen, Minna; Hyötyläinen, Ida; Voutilainen, Jenni; Puttonen, Katja A.; Hämäläinen, Riikka H.; Graff, Caroline; Lehtonen, Šárka; Koistinaho, Jari
Publié dans: Stem Cell Research, Vol 31, Iss , Pp 181-185 (2018), 2018, ISSN 1873-5061
Éditeur: Elsevier
DOI: 10.1016/j.scr.2018.07.024

Directing neuronal cell fate in vitro: Achievements and challenges

Auteurs: R.J.M.Riemensabc, D.L.A.van den Hovecd, M.Estelleraef, R.Delgado-Moralesac
Publié dans: Progress in Neurobiology, 2018, ISSN 0301-0082
Éditeur: Pergamon Press Ltd.
DOI: 10.1016/j.pneurobio.2018.04.003

Global and regional development of the human cerebral cortex: Molecular acrchitecture and occupational aptitudes.

Auteurs: Shin, J., Ma, S., Hofer, E., Patel, Y., Vosberg, D. E., Tilley, S., Roshchupkin, G. V., Sousa, A. M. M., Jian, X., Gottesman, R., Mosley, T. H., Fornage, M., Saba, Y., Pirpamer, L., Schmidt, R., Schmidt, H., Carrion Castillo, A., Crivello, F., Mazoyer, B., Bis, J. C., Li, S., Yang, Q., Luciano, M., Karama, S., Lewis, L., Bastin, M. E., Harris, M. A., Wardlaw, J. M., Deary, I. E., Scholz, M., Loeff
Publié dans: Cerebral Cortex, 2020, ISSN 1047-3211
Éditeur: Oxford University Press
DOI: 10.1093/cercor/bhaa035

Long-term depression at hippocampal mossy fiber-CA3 synapses involves BDNF but is not mediated by p75NTR signaling

Auteurs: Garad M, Edelmann E, Lessmann V.
Publié dans: Scientific Reports, 2021, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/s41598-021-87769-9

Loss of zebrafish Ataxin-7, a SAGA subunit responsible for SCA7 retinopathy, causes ocular coloboma and malformation of photoreceptors

Auteurs: Samantha Carrillo-Rosas, Chantal Weber, Lorraine Fievet, Nadia Messaddeq, Alice Karam, Yvon Trottier;
Publié dans: Human molecular genetics, 2019, ISSN 0964-6906
Éditeur: Oxford University Press
DOI: 10.1093/hmg/ddy401

A Molecular Grammar Governing the Driving Forces for Phase Separation of Prion-like RNA Binding Proteins

Auteurs: Wang, Jie; Choi, Jeong-Mo; Holehouse, Alex S.; Lee, Hyun O.; Zhang, Xiaojie; Jahnel, Marcus; Maharana, Shovamayee; Lemaitre, Régis; Pozniakovsky, Andrei; Drechsel, David; Poser, Ina; Pappu, Rohit V.; Alberti, Simon; Hyman, Anthony A.
Publié dans: Cells, 2018, ISSN 0092-8674
Éditeur: Cell Press
DOI: 10.1016/j.cell.2018.06.006

A kinetic model for Brain-Derived Neurotrophic Factor mediated spike timing-dependent LTP

Auteurs: Solinas SMG, Edelmann E, Leßmann V, Migliore M.
Publié dans: Plos Computational Biology, 2019, ISSN 1553-734X
Éditeur: Public Library of Science
DOI: 10.1371/journal.pcbi.1006975

Mitochondria in the signaling pathways that control longevity and health span.

Auteurs: Akbari M, Kirkwood TBL, Bohr VA.
Publié dans: Ageing Research Reviews, 2019, ISSN 1568-1637
Éditeur: Elsevier BV
DOI: 10.1016/j.arr.2019.100940

Can markers of biological age predict dependency in old age?

Auteurs: Jylhävä J, Jiang M, Foebel AD, Pedersen NL, Hägg S.
Publié dans: Biogerontology, 2019, ISSN 1389-5729
Éditeur: Kluwer Academic Publishers
DOI: 10.1007/s10522-019-09795-5

Impairment of macroautophagy in dopamine neurons has opposing effects on Parkinsonian pathology and behavior.

Auteurs: Hunn BHM, Vingill S, Threlfell S, Alegre-Abarrategui J, Magdelyns M, Deltheil T, Bengoa-Vergniory N, Oliver PL, Cioroch M, Doig NM, Bannerman DM, Cragg SJ and Wade-Martins R.
Publié dans: Cell reports, 2019, ISSN 2211-1247
Éditeur: Cell Press
DOI: 10.1016/j.celrep.2019.09.029

Gene Deregulation and Underlying Mechanisms in Spinocerebellar Ataxias With Polyglutamine Expansion

Auteurs: Niewiadomska-Cimicka A, Hache A, Trottier Y.
Publié dans: Frontiers in neuroscience, 2020, ISSN 1662-4548
Éditeur: Frontiers Research Foundation
DOI: 10.3389/fnins.2020.00571

ST Pipeline: an automated pipeline for spatial mapping of unique transcripts.

Auteurs: Navarro JF, Sjöstrand J, Salmén F, Lundeberg J, Ståhl PL.
Publié dans: Bioinformatics, 2017, ISSN 1367-4811
Éditeur: Oxford Academic
DOI: 10.1093/bioinformatics/btx211

Expression of endogenous mouse APP modulates β-amyloid deposition in hAPP-transgenic mice

Auteurs: Steffen, J., Krohn, M., Schwitlick, C. et al.
Publié dans: acta neuropathol commun, Numéro 5, 2017, Page(s) 49, ISSN 2051-5960
Éditeur: BioMed Central
DOI: 10.1186/s40478-017-0448-2

The Emerging Role of Mechanics in Synapse Formation and Plasticity

Auteurs: Kilinc D
Publié dans: Front. Cell. Neurosci, Numéro 12, 2018, Page(s) 483, ISSN 1662-5102
Éditeur: Frontiers Research Foundation
DOI: 10.3389/fncel.2018.00483

Differential Membrane Binding and Seeding of Distinct α-Synuclein Fibrillar Polymorphs

Auteurs: Shrivastava AN, Bousset L, Renner M, Redeker V, Savistchenko J, Triller A, Melki R
Publié dans: Biophysical journal, 2020, ISSN 0006-3495
Éditeur: Biophysical Society
DOI: 10.1016/j.bpj.2020.01.022

Genetic and lifestyle risk factors for MRI-defined brain infarcts in a population-based setting

Auteurs: Ganesh Chauhan, Hieab H H Adams, Claudia L Satizabal, Joshua C Bis, Alexander Teumer, Muralidharan Sargurupremraj, Edith Hofer, Stella Trompet, Saima Hilal, Albert Vernon Smith, Xueqiu Jian, Rainer Malik, Matthew Traylor, Sara L Pulit, Philippe Amouyel, Bernard Mazoyer, Yi-Cheng Zhu, Sara Kaffashian, Sabrina Schilling, Gary W Beecham, Thomas J Montine, Gerard D Schellenberg, Olafur Kjartansson, Vi
Publié dans: Neurology, 2019, ISSN 0028-3878
Éditeur: Lippincott Williams & Wilkins Ltd.
DOI: 10.1212/wnl.0000000000006851

Selection of Reference Genes for Normalization of Gene Expression Data in Blood of Machado-Joseph Disease/Spinocerebellar Ataxia Type 3 (MJD/SCA3) Subjects

Auteurs: Ferreira, A.F., Raposo, M., Vasconcelos, J. et al.
Publié dans: Journal of Molecular Neuroscience, Numéro 69, 2019, Page(s) 450–455, ISSN 0895-8696
Éditeur: Humana Press, Inc.
DOI: 10.1007/s12031-019-01374-0

FACS-Assisted CRISPR-Cas9 Genome Editing Facilitates Parkinson's Disease Modeling

Auteurs: Jonathan Arias-Fuenzalida, JavierJarazo, Xiaobing Qing, Jonas Walter, Gemma Gomez-Giro, Sarah Louise Nickels, HolmZaehres45Hans Robert Schöler, Jens Christian Schwamborn
Publié dans: Stem Cell Reports, 2017, ISSN 2213-6711
Éditeur: Cell Press
DOI: 10.1016/j.stemcr.2017.08.026

Dual Inhibition of GSK3β and CDK5 Protects the Cytoskeleton of Neurons from Neuroinflammatory-Mediated Degeneration In Vitro and In Vivo

Auteurs: Reinhardt L, Kordes S, Reinhardt P, Glatza M, Baumann M, Drexler HCA, Menninger S, Zischinsky G, Eickhoff J, Fröb C, Bhattarai P, Arulmozhivarman G, Marrone L, Janosch A, Adachi K, Stehling M, Anderson EN, Abo-Rady M, Bickle M, Pandey UB, Reimer MM, Kizil C, Schöler HR, Nussbaumer P, Klebl B, and Sterneckert JL.
Publié dans: Stem Cell Reports, 2019, ISSN 2213-6711
Éditeur: Cell Press
DOI: 10.1016/j.stemcr.2019.01.015

The L444P Gba1 mutation enhances alpha-synuclein induced loss of nigral dopaminergic neurons in mice

Auteurs: Migdalska-Richards A, Wegrzynowicz M, Rusconi R, Deangeli G, Di Monte DA, Spillantini MG, Schapira AHV.
Publié dans: Brain, 2017, ISSN 0006-8950
Éditeur: Oxford University Press
DOI: 10.1093/brain/awx221

Glycation in Huntington's Disease: A Possible Modifier and Target for Intervention

Auteurs: Brás IC, König A, Outeiro TF.
Publié dans: Journal of Huntington's Disease, 2019, ISSN 1879-6397
Éditeur: IOS Press
DOI: 10.3233/jhd-190366

Lactate-Induced Glucose Output Is Unchanged by Metformin at a Therapeutic Concentration - A Mass Spectrometry Imaging Study of the Perfused Rat Liver.

Auteurs: Giulio Calza; Elisabeth Nyberg; Elisabeth Nyberg; Matias Mäkinen; Rabah Soliymani; Annunziata Cascone; Dan Lindholm; Dan Lindholm; Emanuele Barborini; Marc Baumann; Maciej Lalowski; Ove Eriksson
Publié dans: Frontiers in Pharmacology, Vol 9 (2018), 2018, ISSN 1663-9812
Éditeur: Frontiers Media S.A.
DOI: 10.3389/fphar.2018.00141

Using a qPCR device to screen for modulators of ABC transporter activity: A step-by-step protocol

Auteurs: Luisa Möhle; Luisa Möhle; Barbora Schwarzová; Markus Krohn; Sven Marcel Stefan; Jens Pahnke
Publié dans: Journal of Pharmacological and Toxicological Methods, Numéro 1, 2020, ISSN 1056-8719
Éditeur: Elsevier BV
DOI: 10.1016/j.vascn.2020.106882

A comparative study on pathological features of transgenic rat lines expressing either three or four repeat misfolded tau

Auteurs: Valachova B, Brezovakova V, Bugos O, Jadhav S, Smolek T, Novak P, Zilka N.
Publié dans: Journal of Comparative Neurology, 2018, ISSN 0021-9967
Éditeur: John Wiley & Sons Inc.
DOI: 10.1002/cne.24447

Key Aging-Associated Alterations in Primary Microglia Response to Beta-Amyloid Stimulation

Auteurs: Caldeira C, Cunha C, Vaz AR, Falcão AS, Barateiro A, Seixas E, Fernandes A, Brites D.
Publié dans: Frontiers in ageing neuroscience, 2017, ISSN 1663-4365
Éditeur: Frontiers Research Foundation
DOI: 10.3389/fnagi.2017.00277

Evaluation of Lymphocyte Response to the Induced Oxidative Stress in a Cohort of Ageing Subjects, including Semisupercentenarians and Their Offspring

Auteurs: Sizzano, F., Collino, S., Cominetti, O., Monti, D., Garagnani, P., Ostan, R., Pirazzini, C., Bacalini, M.G., Mari, D., Passarino, G.,…Franceschi C., et al.
Publié dans: Mediators of Inflammation, 2018, ISSN 0962-9351
Éditeur: Hindawi Publishing Corporation
DOI: 10.1155/2018/7109312

Ibuprofen enhances synaptic function and neural progenitors proliferation markers and improves neuropathology and motor coordination in Machado-Joseph disease models

Auteurs: Mendonça LS, Nóbrega C, Tavino S, Brinkhaus M, Matos C, Tomé S, Moreira R, Henriques D, Kaspar BK, Pereira de Almeida L.
Publié dans: Human Molecular Genetics, 2019, ISSN 0964-6906
Éditeur: Oxford University Press
DOI: 10.1093/hmg/ddz097

Revisiting rodent models: Octodon degus as Alzheimer's disease model?

Auteurs: Steffen J, Krohn M, Paarmann K, Schwitlick C, Bruning T, Marreiros R, Muller- Schiffmann A, Korth C, Braun K, Pahnke J
Publié dans: Acta neuropathologica communications, 2016, ISSN 2051-5960
Éditeur: BioMed Central
DOI: 10.1186/s40478-016-0363-y

Inhibition of copper transporter 1 prevents α-synuclein pathology and alleviates nigrostriatal degeneration in AAV-based mouse model of Parkinson's disease

Auteurs: Gou DH, Huang TT, Li W, Gao XD, Haikal C, Wang XH, Song DY, Liang X, Zhu L, Tang Y, Ding C, Li JY.
Publié dans: Redox Biology, 2021, ISSN 2213-2317
Éditeur: Elsevier BV
DOI: 10.1016/j.redox.2020.101795

Inhibiting pathologically active ADAM10 rescues synaptic and cognitive decline in Huntington's disease

Auteurs: Vezzoli E, Caron I, Talpo F, Besusso D, Conforti P, Battaglia E, Sogne E, Falqui A, Petricca L, Verani M, Martufi P, Caricasole A, Bresciani A, Cecchetti O, Rivetti di Val Cervo P, Sancini G, Riess O, Nguyen H, Seipold L, Saftig P, Biella G, Cattaneo E, Zuccato C.
Publié dans: Journal of Clinical Investigation, 2019, ISSN 0021-9738
Éditeur: American Society for Clinical Investigation
DOI: 10.1172/jci120616

CRISPR/Cas9 and piggyBac-mediated footprint-free LRRK2-G2019S knock-in reveals neuronal complexity phenotypes and α-Synuclein modulation in dopaminergic neurons

Auteurs: Xiaobing Qing 1, Jonas Walter 1, Javier Jarazo 1, Jonathan Arias-Fuenzalida 1, Anna-Lena Hillje 1, Jens C Schwamborn 2
Publié dans: Stem Cell Res, 2018, ISSN 1873-5061
Éditeur: Elsevier
DOI: 10.1016/j.scr.2017.08.013

The Continuum of Aging and Age-Related Diseases: Common Mechanisms but Different Rates

Auteurs: Claudio Franceschi 1, Paolo Garagnani 2 3 4 5, Cristina Morsiani 2, Maria Conte 2, Aurelia Santoro 2 6, Andrea Grignolio 7, Daniela Monti 8, Miriam Capri 2 6, Stefano Salvioli
Publié dans: Front Med (Lausanne), 2018, ISSN 2296-858X
Éditeur: Frontiers Media SA
DOI: 10.3389/fmed.2018.00061

Alpha-synuclein and the prion hypothesis in Parkinson's disease

Auteurs: Melki R.
Publié dans: Revue neurologique (Paris), 2018, ISSN 0035-3787
Éditeur: Elsevier Masson
DOI: 10.1016/j.neurol.2018.08.002

Neural Correlates of the Dual-Pathway Model for ADHD in Adolescents

Auteurs: Chun Shen, M.Sc., Qiang Luo, Ph.D., Tianye Jia, Ph.D., Qi Zhao, M.Sc., Sylvane Desrivières, Ph.D., Erin Burke Quinlan, Ph.D., Tobias Banaschewski, M.D., Ph.D., Sabina Millenet, D.Psych., Arun L.W. Bokde, Ph.D., Christian Büchel, M.D., Herta Flor, Ph.D., Vincent Frouin, Ph.D., Hugh Garavan, Ph.D., Penny Gowland, Ph.D., Andreas Heinz, M.D., Ph.D., Bernd Ittermann, Ph.D., Jean-Luc Martinot, M.D., P
Publié dans: American journal of psychiatry, 2020, ISSN 0002-953X
Éditeur: American Psychiatric Publishing, Inc.
DOI: 10.1176/appi.ajp.2020.19020183

3D Cultures of Parkinson's Disease-Specific Dopaminergic Neurons for High Content Phenotyping and Drug Testing

Auteurs: Silvia Bolognin 1 2, Marie Fossépré 1 2, Xiaobing Qing 1, Javier Jarazo 1, Janez Ščančar 3, Edinson Lucumi Moreno 1, Sarah L Nickels 1, Kobi Wasner 1, Nassima Ouzren 1, Jonas Walter 1 2, Anne Grünewald 1 4, Enrico Glaab 1, Luis Salamanca 1, Ronan M T Fleming 1, Paul M A Antony 1, Jens C Schwamborn
Publié dans: Adv Sci, 2019, ISSN 2198-3844
Éditeur: Wiley-VCH GmbH, Weinheim
DOI: 10.1002/advs.201800927

Secretome from SH-SY5Y APP Swe cells trigger time-dependent CHME3 microglia activation phenotypes, ultimately leading to miR-21 exosome shuttling

Auteurs: Fernandes A, Ribeiro AR, Monteiro M, Garcia G, Vaz AR, Brites D
Publié dans: Biochimie, 2018, ISSN 0300-9084
Éditeur: Elsevier BV
DOI: 10.1016/j.biochi.2018.05.015

Increased Immune Activation by Pathologic α-Synuclein in Parkinson's Disease

Auteurs: Grozdanov V, Bousset L, Hoffmeister M, Bliederhaeuser C, Meier C, Madiona K, Pieri L, Kiechle M, McLean PJ, Kassubek J, Behrends C, Ludolph AC, Weishaupt JH, Melki R, Danzer KM
Publié dans: Annals of neurology, 2019, ISSN 0364-5134
Éditeur: John Wiley & Sons Inc.
DOI: 10.1002/ana.25557

FTY720 treatment starting after onset of symptoms reverses synaptic and memory deficits in an AD mouse model.

Auteurs: Kartalou G-I, Salgueiro Pereira SP, Endres T, Lesnikova A, Casarotto P, Pousinha P, Delanoe K, Edelmann E, Castrén E, Gottmann K, Marie H, Lessmann V.
Publié dans: BioRxiv, 2019, ISSN 2692-8205
Éditeur: BioRxiv
DOI: 10.1101/2019.12.15.868026

Human iPSC-Derived Hippocampal Spheroids: An Innovative Tool for Stratifying Alzheimer Disease Patient-Specific Cellular Phenotypes and Developing Therapies

Auteurs: Pomeshchik Y, Klementieva O, Gil J, Martinsson I, Hansen MG, de Vries T, Sancho-Balsells A, Russ K, Savchenko E, Collin A, Vaz AR, Bagnoli S, Nacmias B, Rampon C, Sorbi S, Brites D, Marko-Varga G, Kokaia Z, Rezeli M, Gouras GK, Roybon L.
Publié dans: Stem Cell Reports, 2020, ISSN 2213-6711
Éditeur: Cell Press
DOI: 10.1016/j.stemcr.2020.06.001

Quality Control of Membraneless Organelles.

Auteurs: Simon Alberti; Serena Carra
Publié dans: Journal of Molecular Biology, 2018, ISSN 0022-2836
Éditeur: Academic Press
DOI: 10.1016/j.jmb.2018.05.013

"Brain-Derived Neurotrophic Factor and Vascular Endothelial Growth Factor: ""Siamese Twins"" in Antidepressant Action"

Auteurs: Lima-Ojeda JM, Castrén E.
Publié dans: Biological psychiatry, 2019, ISSN 0006-3223
Éditeur: Elsevier BV
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Transcranial optical imaging reveals a pathway for optimizing the delivery of immunotherapeutics to the brain.

Auteurs: Plog BA, Mestre H, Olveda GE, Sweeney AM, Kenney HM, Cove A, Dholakia KY, Tithof J, Nevins TD, Lundgaard I, Du T, Kelley DH, Nedergaard M.
Publié dans: JCI insight, 2018, ISSN 2379-3708
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The prion protein is an agonistic ligand of the G protein-coupled receptor Adgrg6

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Cell biology and dynamics of Neuronal Na +/K +-ATPase in health and diseases

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The Amyloid Precursor Protein C-Terminal Domain Alters CA1 Neuron Firing, Modifying Hippocampus Oscillations and Impairing Spatial Memory Encoding.

Auteurs: Pousinha, Paula A.; Mouska, Xavier; Bianchi, Daniela; Temido-Ferreira, Mariana; Rajão-Saraiva, Joana; Gomes, Rui; Fernandez, Sebastian P.; Salgueiro-Pereira, Ana Rita; Gandin, Carine; Raymond, Elisabeth F.; Barik, Jacques; Goutagny, Romain; Bethus, Ingrid; Lopes, Luisa V.; Migliore, Michele; Marie, Hélène
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Genetics of Human Longevity Within an Eco-Evolutionary Nature-Nurture Framework.

Auteurs: Giuliani C, Garagnani P, Franceschi C.
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Derivation of Human Midbrain-Specific Organoids from Neuroepithelial Stem Cells

Auteurs: Anna S Monzel 1, Lisa M Smits 1, Kathrin Hemmer 1, Siham Hachi 2, Edinson Lucumi Moreno 2, Thea van Wuellen 1, Javier Jarazo 1, Jonas Walter 1, Inga Brüggemann 1, Ibrahim Boussaad 3, Emanuel Berger 1, Ronan M T Fleming 2, Silvia Bolognin 1, Jens C Schwamborn 4
Publié dans: Stem Cell Reports, 2017, ISSN 2213-6711
Éditeur: Cell Press
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ɑ-Synuclein strains and seeding in Parkinson's disease, incidental Lewy body disease, dementia with Lewy bodies and multiple system atrophy: similarities and differences

Auteurs: Peelaerts W, Bousset L, Baekelandt V, Melki R.
Publié dans: Cell and Tissue Research, 2018, ISSN 0302-766X
Éditeur: Springer Verlag
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Protein Phase Separation as a Stress Survival Strategy

Auteurs: Franzmann TM, Alberti S
Publié dans: Cold Spring Harbor Perspectives in Biology, 2019, ISSN 1943-0264
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Inhibition of Stat3-mediated astrogliosis ameliorates pathology in an Alzheimer's disease model.

Auteurs: Reichenbach, Nicole; Delekate, Andrea; Plescher, Monika; Schmitt, Franziska; Krauss, Sybille; Blank, Nelli; Halle, Annett; Petzold, Gabor C
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Glucocerebrosidase activity, cathepsin D and monomeric α-synuclein interactions in a stem cell derived neuronal model of a PD associated GBA1 mutation

Auteurs: Shi-Yu Yang, Matthew Gegg , David Chau, Anthony Schapira
Publié dans: Neurobiology of Disease, 2019, ISSN 0969-9961
Éditeur: Academic Press
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Molecular subtypes of Alzheimer's disease

Auteurs: Di Fede G, Catania M, Maderna E, Ghidoni R, Benussi L, Tonoli E, Giaccone G, Moda F, Paterlini A, Campagnani I, Sorrentino S, Colombo L, Kubis A, Bistaffa E, Ghetti B, Tagliavini F.
Publié dans: Scientific reports, 2018, ISSN 2045-2322
Éditeur: Nature Publishing Group
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Endocytic vesicle rupture is a conserved mechanism of cellular invasion by amyloid proteins

Auteurs: Flavin WP, Bousset L, Green ZC, Chu Y, Skarpathiotis S, Chaney MJ, Kordower JH, Melki R, Campbell EM.
Publié dans: Acta neuropathologica, 2017, ISSN 0001-6322
Éditeur: Springer Verlag
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Brain Distribution of Dual ABCB1/ABCG2 Substrates Is Unaltered in a Beta-Amyloidosis Mouse Model.

Auteurs: Thomas Wanek; Viktoria Zoufal; Mirjam Brackhan; Markus Krohn; Severin Mairinger; Thomas Filip; Michael Sauberer; Johann Stanek; Thomas Pekar; Jens Pahnke; Jens Pahnke; Jens Pahnke; Oliver Langer; Oliver Langer
Publié dans: International Journal of Molecular Sciences, 2020, ISSN 1422-0067
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
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Evaluation of the Performance of AmpliSeq and SureSelect Exome Sequencing Libraries for Ion Proton

Auteurs: Gampawar P, Saba Y, Werner U, Schmidt R, Müller-Myhsok B, Schmidt H.
Publié dans: Frontiers in Genetics, 2019, ISSN 1664-8021
Éditeur: Frontiers Media
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High-quality draft genome sequence of Sphaerisporangium cinnabarinum

Auteurs: Christensen LFB, Otzen DE, Dueholm MS
Publié dans: Genome announcements, 2018, ISSN 2169-8287
Éditeur: American Society for Microbiology
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Trehalose induces autophagy via lysosomal-mediated TFEB activation in models of motoneuron degeneration

Auteurs: "Rusmini, P.; Cortese, K.; Crippa, V.; Cristofani, R.; Cicardi, M.E.; Ferrari, V.; Vezzoli, G.; Tedesco, B.; Meroni, M.; Messi, E.; Piccolella, M.; Galbiati, M.; Garrè , M.; Morelli, E.; Vaccari, T.; Poletti, A."
Publié dans: Autophagy, Numéro 1, 2018, ISSN 1554-8627
Éditeur: Landes Bioscience
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Age-Related Changes of Peak Width Skeletonized Mean Diffusivity (PSMD) Across the Adult Lifespan: A Multi-Cohort Study

Auteurs: Beaudet G, Tsuchida A, Petit L, Tzourio C, Caspers S, Schreiber J, Pausova Z, Patel Y, Paus T, Schmidt R, Pirpamer L, Sachdev P, Wen W, Armstrong N, Deary IJ, Bastin ME, Wardlaw JM, Munõz Maniega S, Witte V, Villringer A, Duering M, Debette S, Mazoyer B.
Publié dans: Frontiers in psychiatry, 2020, ISSN 1664-0640
Éditeur: Frontiers Research Foundation
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Diminished OPA1 expression and impaired mitochondrial morphology and homeostasis in Aprataxin-deficient cells.

Auteurs: Zheng J, Croteau DL, Bohr VA, Akbari M.
Publié dans: Nucleic acids research, 2019, ISSN 1362-4962
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Longitudinal changes in the genetic and environmental influences on the epigenetic clocks across old age: Evidence from two twin cohorts.

Auteurs: Jylhävä J, Hjelmborg J, Soerensen M, Munoz E, Tan Q, Kuja-Halkola R, Mengel-From J, Christensen K, Christiansen L, Hägg S, Pedersen NL, Reynolds CA.
Publié dans: EBioMedicine, 2019, ISSN 2352-3964
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Voluntary running enhances glymphatic influx in awake behaving, young mice.

Auteurs: Holstein-Rathlou S, Petersen NC, Nedergaard M.
Publié dans: Neuroscience Letters, 2018, ISSN 0304-3940
Éditeur: Elsevier BV
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Improved method for cannula fixation for long-term intracerebral brain infusion

Auteurs: Ádám Sike, Jonas Wengenroth, Jolanta Upīte, Thomas Brüning, Iván Eiriz, Petra Sántha, Henrik Biverstål, Baiba Jansone, Håvard Jostein Haugen, Markus Krohn, Jens Pahnke
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Diabetes Mellitus as a Risk Factor for Parkinson’s Disease: a Molecular Point of View.

Auteurs: Biosa, A., Outeiro, T.F., Bubacco, L. et al.
Publié dans: Molecular Neurobiology, Numéro 55, 2018, Page(s) 8754–8763, ISSN 0893-7648
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Age-Dependent Alpha-Synuclein Accumulation and Phosphorylation in the Enteric Nervous System in a Transgenic Mouse Model of Parkinson’s Disease

Auteurs: Zhong, CB., Chen, QQ., Haikal, C. et al.
Publié dans: Translational Neurodegeneration, 2018, ISSN 2047-9158
Éditeur: BioMed Central Ltd
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Clinical Significance of Magnetic Resonance Imaging Markers of Vascular Brain Injury: A Systematic Review and Meta-analysis

Auteurs: Debette S, Schilling S, Duperron MG, Larsson SC, Markus HS.
Publié dans: JAMA Neurology, 2019, ISSN 2168-6149
Éditeur: American Medical Association
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Age dependency of cerebral P-glycoprotein function in wild-type and APPPS1 mice measured with PET

Auteurs: Zoufal V, Wanek T, Krohn M, Mairinger S, Filip T, Sauberer M, Stanek J, Pekar T, Bauer M, Pahnke J, Langer O,
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Prion-like seeding and nucleation of intracellular amyloid-β

Auteurs: Olsson TT, Klementieva O, Gouras GK.
Publié dans: Neurobiology of disease, 2018, ISSN 0969-9961
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Stress granules sense metabolic stress at the plasma membrane and potentiate recovery by storing active Pkc1

Auteurs: Triana Amen and Daniel Kaganovich
Publié dans: Science Signaling, 2020, ISSN 1945-0877
Éditeur: American Association for the Advancement of Science
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Genetic Burden for Late-Life Neurodegenerative Disease and Its Association With Early-Life Lipids, Brain, Behavior, and Cognition

Auteurs: Sander Lamballais; Ryan L. Muetzel; Ryan L. Muetzel; Mohammad Arfan Ikram; Henning Tiemeier; Henning Tiemeier; Meike W. Vernooij; Meike W. Vernooij; Tonya White; Tonya White; Hieab H. H. Adams; Hieab H. H. Adams; Hieab H. H. Adams
Publié dans: Frontiers in Psychiatry, 11, 2020, ISSN 1664-0640
Éditeur: Frontiers Research Foundation
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The synergistic effect of chlorotoxin-mApoE in boosting drug-loaded liposomes across the BBB

Auteurs: Formicola B, Dal Magro R, Montefusco-Pereira CV, Lehr CM, Koch M, Russo L, Grasso G, Deriu MA, Danani A, Bourdoulous S, Re F.
Publié dans: Journal of nanobiotechnology, 2019, ISSN 1477-3155
Éditeur: BioMed Central
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Short-Term Effects of Microglia-Specific Mitochondrial Dysfunction on Amyloidosis in Transgenic Models of Alzheimer's Disease

Auteurs: Steffen J, Stenzel J, Ibrahim S, Pahnke J,
Publié dans: Journal of Alzheimer's Disease, 2018, ISSN 1387-2877
Éditeur: IOS Press
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Stratifying the presymptomatic phase of genetic frontotemporal dementia by serum NfL and pNfH: a longitudinal multicentre study

Auteurs: Wilke, Carlo; Reich, Selina; Swieten, John C.; Borroni, Barbara; Sanchez‐Valle, Raquel; Moreno, Fermin; Laforce, Robert; Graff, Caroline; Galimberti, Daniela; Rowe, James B.; Masellis, Mario; Tartaglia, Maria C.; Finger, Elizabeth; Vandenberghe, Rik; De Mendonça, Alexandre; Tagliavini, Fabrizio; Santana, Isabel; Ducharme, Simon; Butler, Chris R.; Gerhard, Alexander; Levin, Johannes; Danek, Adri
Publié dans: Annals of Neurology, 2021, ISSN 0364-5134
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Novel tau filament fold in chronic traumatic encephalopathy encloses hydrophobic molecules

Auteurs: Falcon B, Zivanov J, Zhang W,Murzin A, Garringer H, Vidal R, Crowther A, Newell K, Ghetti B, Goedert M and Scheres S.
Publié dans: Nature, 2019, ISSN 0028-0836
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Neuroinflammatory responses in Alzheimer's disease.

Auteurs: Dansokho C, Heneka MT.
Publié dans: Journal of Neural Transmission, 2018, ISSN 0300-9564
Éditeur: Springer Verlag
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Leukocyte Derived Microvesicles as Disease Progression Biomarkers in Slow Progressing Amyotrophic Lateral Sclerosis Patients.

Auteurs: Daisy Sproviero; Sabrina La Salvia; Federico Colombo; Susanna Zucca; Orietta Pansarasa; Luca Diamanti; Luca Diamanti; Alfredo Costa; Alfredo Costa; Luca Lova; Luca Lova; Marta Giannini; Marta Giannini; Stella Gagliardi; Eliana Lauranzano; Michela Matteoli; Michela Matteoli; Mauro Ceroni; Mauro Ceroni; Andrea Malaspina; Cristina Cereda
Publié dans: Frontiers in Neuroscience, Vol 13 (2019), 2019, ISSN 1662-4548
Éditeur: Frontiers Research Foundation
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LRP1 Has a Predominant Role in Production over Clearance of Aβ in a Mouse Model of Alzheimer's Disease

Auteurs: Van Gool B, Storck SE, Reekmans SM, Lechat B, Gordts PLSM, Pradier L, Pietrzik CU, Roebroek AJM,
Publié dans: Molecular neurobiology, 2019, ISSN 0893-7648
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A Surveillance Function of the HSPB8-BAG3-HSP70 Chaperone Complex Ensures Stress Granule Integrity and Dynamism

Auteurs: Massimo Ganassi, Daniel Mateju, Ilaria Bigi, Laura Mediani, Ina Poser, Hyun O.Lee, Samuel J.Seguin, Federica, F. Morelli, Jonathan Vinet, Giuseppina Leo, Orietta Pansarasa, Cristina Cereda, Angelo Poletti, SimonAlberti, SerenaCarra16
Publié dans: Molecular Cell, Numéro 63, 2016, Page(s) 796–810, ISSN 1097-2765
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Small-molecule induction of Aβ-42 peptide production in human cerebral organoids to model Alzheimer's disease associated phenotypes

Auteurs: Pavoni S, Jarray R, Nassor F, Guyot AC, Cottin S, Rontard J, Mikol J, Mabondzo A, Deslys JP, Yates F.
Publié dans: PLoS One, 2018, ISSN 1932-6203
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A High Output Method to Isolate Cerebral Pericytes from Mouse

Auteurs: Mehra A., Dehouck L., Vandenhaute E., Fatar M., Fenart L., Gosselet F.
Publié dans: Journal of visualized experiments, 2020, ISSN 1940-087X
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Pathological Proteins Are Transported by Extracellular Vesicles of Sporadic Amyotrophic Lateral Sclerosis Patients.

Auteurs: Daisy Sproviero; Sabrina La Salvia; Marta Giannini; Marta Giannini; Valeria Crippa; Stella Gagliardi; Stefano Bernuzzi; Luca Diamanti; Luca Diamanti; Mauro Ceroni; Mauro Ceroni; Orietta Pansarasa; Angelo Poletti; Cristina Cereda
Publié dans: Frontiers in Neuroscience,, Numéro Vol 12, 2018, ISSN 1662-4548
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Effects of ambroxol on the autophagy-lysosome pathway and mitochondria in primary cortical neurons.

Auteurs: Magalhaes, J; Gegg, ME; Migdalska-Richards, A; Schapira, AH;
Publié dans: Scientific Reports, 2018, ISSN 2045-2322
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The Genetic Variability of APOE in Different Human Populations and Its Implications for Longevity

Auteurs: Paolo Abondio 1, Marco Sazzini 2, Paolo Garagnani 3, Alessio Boattini 4, Daniela Monti 5, Claudio Franceschi 6, Donata Luiselli 7, Cristina Giuliani
Publié dans: Genes (Basel), 2019, ISSN 2073-4425
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
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Generation and characterization of an ABCC1 humanized mouse model (HABCC1<sup>FLX/FLX</sup>) with knockout capability

Auteurs: Krohn, Markus; Zoufal, Viktoria; Mairinger, Severin; Wanek, Thomas; Paarmann, Kristin; Brüning, Thomas; Eiriz Delgado, Iván; Brackhan, Mirjam; Langer, Oliver; Pahnke, Jens
Publié dans: Molecular Pharmacology, 2019, ISSN 1422-0067
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Evolution of prodromal parkinsonian features in a cohort of GBA mutation-positive individuals: a 6-year longitudinal study

Auteurs: Avenali M, Toffoli M, Mullin S, McNeil A, Hughes DA, Mehta A, Blandini F, Schapira AHV.
Publié dans: Journal of Neurology Neurosurgery and Psychiatry, 2019, ISSN 0022-3050
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Overdominant Effect of a CHRNA4 Polymorphism on Cingulo-Opercular Network Activity and Cognitive Control

Auteurs: Sadaghiani S, Ng B, [...], Paus T, Poustka L, Millenet , Fröhner JH, Smolka MN, Walter H, Whelan R, Schumann G, Napolioni V, Greicius M
Publié dans: Journal of Neuroscience, 2017, ISSN 0270-6474
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DJ-1 (Park7) affects the gut microbiome, metabolites and the development of innate lymphoid cells (ILCs).

Auteurs: Yogesh Singh, Christoph Trautwein, Achal Dhariwal, Madhuri S. Salker, Md Alauddin, Laimdota Zizmare, Lisann Pelzl, Martina Feger, Jakob Admard, Nicolas Casadei, Michael Föller, Vivek Pachauri, David S. Park, Tak W. Mak, Julia-Stefanie Frick, Diethelm Wallwiener, Sara Y. Brucker, Florian Lang and Olaf Riess
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NLRP3 Is Involved in the Maintenance of Cerebral Pericytes

Auteurs: Quan W, Luo Q, Tang Q, Furihata T, Li D, Fassbender K, and Liu Y
Publié dans: Frontiers in cellular neuroscience, 2020, ISSN 1662-5102
Éditeur: Frontiers Research Foundation
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Epigenetic mechanisms during ageing and neurogenesis as novel therapeutic avenues in human brain disorders

Auteurs: Raul Delgado-Morales; Roberto Carlos Agis-Balboa; Manel Esteller; Manel Esteller; María Berdasco
Publié dans: Clinical Epigenics, 2017, ISSN 1868-7075
Éditeur: Springer Verlag
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The Exosomal/Total α-Synuclein Ratio in Plasma Is Associated With Glucocerebrosidase Activity and Correlates With Measures of Disease Severity in PD Patients

Auteurs: Silvia Cerri1*, Cristina Ghezzi1, Maria Sampieri1, Francesca Siani1, Micol Avenali2,3, Gianluca Dornini4, Roberta Zangaglia5, Brigida Minafra5 and Fabio Blandini1
Publié dans: Frontiers in Cellular Neuroscience, 2018, ISSN 1662-5102
Éditeur: Frontiers Research Foundation
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Clinical and neuropathological phenotype associated with the novel V189I mutation in the prion protein gene

Auteurs: Di Fede G, Catania M, Atzori C, Moda F, Pasquali C, Indaco A, Grisoli M, Zuffi M, Guaita MC, Testi R, Taraglio S, Sessa M, Gusmaroli G, Spinelli M, Salzano G, Legname G, Tarletti R, Godi L, Pocchiari M, Tagliavini F, Imperiale D, Giaccone G.
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Éditeur: BioMed Central
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Granulostasis: Protein Quality Control of RNP Granules

Auteurs: Alberti, Simon; Mateju, Daniel; Mediani, Laura; Carra, Serena
Publié dans: Frontiers in molecular Neuroscience, Numéro 2, 2017, ISSN 1662-5099
Éditeur: Frontiers Research Foundation
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Inhibition of retrograde transport modulates misfolded protein accumulation and clearance in motoneuron diseases.

Auteurs: Cristofani R., Crippa V., Rusmini P., Cicardi M.E., Meroni M., Licata N.V., Sala G., Giorgetti E., Grunseich C., Galbiati M., Piccolella M., Messi E., Ferrarese C., Carra S, Poletti A.
Publié dans: Autophagy, 2017, ISSN 1554-8627
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Understanding Dopaminergic Cell Death Pathways in Parkinson Disease

Auteurs: Patrick P. Michel, Etienne C. Hirsch, Stephane Hunot
Publié dans: Neuron, Numéro Volume 90, Numéro 4, 2016, Page(s) Pages 675-691, ISSN 0896-6273
Éditeur: Cell Press
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Soluble Aβ oligomers and protofibrils induce NLRP3 inflammasome activation in microglia

Auteurs: Lučiūnaitė A, McManus RM, Jankunec M, Rácz I, Dansokho C, Dalgėdienė I, Schwartz S, Brosseron F, Heneka MT.
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Impairment of Glycolysis-Derived l-Serine Production in Astrocytes Contributes to Cognitive Deficits in Alzheimer’s Disease

Auteurs: Le Douce, Juliette; Maugard, Marianne; Veran, Julien; Matos, Marco; Jégo, Pierrick; Vigneron, Pierre-Antoine; Faivre, Emilie; Toussay, Xavier; Vandenberghe, Michel; Balbastre, Yaël; Piquet, Juliette; Guiot, Elvire; Tran, Nguyet Thuy; Taverna, Myriam; Marinesco, Stéphane; Koyanagi, Ayumi; Furuya, Shigeki; Gaudin-Guérif, Mylène; Goutal, Sébastien; Ghettas, Aurélie; Pruvost, Alain; Bemelmans,
Publié dans: Cell Metabolism, 2020, Page(s) pp.503-517, ISSN 0893-7648
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Intravenous treatment with human recombinant ApoA-I Milano reduces beta amyloid cerebral deposition in the APP23-transgenic mouse model of Alzheimer's disease

Auteurs: Fernández-de Retana S, Montañola A, Marazuela P, De La Cuesta M, Batlle A, Fatar M, Grudzenski S, Montaner J, Hernández-Guillamon M.
Publié dans: Neurobiology of aging, 2017, ISSN 0197-4580
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Genome-wide pleiotropy between depression and body mass index

Auteurs: Garvert, L., Roshchupkin, G.V., Völzke, H., Nauck, M., Milaneschi, Y., Grabe, J., Van der Auwera, S.
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A User's Guide for Phase Separation Assays with Purified Proteins.

Auteurs: Simon Alberti; Shambaditya Saha; Jeffrey B. Woodruff; Titus M. Franzmann; Jie Wang; Anthony A. Hyman
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Neurological effects of glucocerebrosidase gene mutations

Auteurs: Mullin S, Hughes D, Mehta A, Schapira AHV.
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Brain Peak Width of Skeletonized Mean Diffusivity (PSMD) and Cognitive Function in Later Life

Auteurs: Deary IJ, Ritchie SJ, Muñoz Maniega S, Cox SR, Valdés Hernández MC, Luciano M, Starr JM, Wardlaw JM, Bastin ME.
Publié dans: Frontiers in Psychiatry, 2019, ISSN 1664-0640
Éditeur: Frontiers Research Foundation
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Faulty neuronal determination and cell polarization are reverted by modulating HD early phenotypes

Auteurs: Conforti P, Besusso D, Bocchi VD, Faedo A, Cesana E, Rossetti G, Ranzani V, Svendsen CN, Thompson LM, Toselli M, Biella G, Pagani M, Cattaneo E.
Publié dans: PNAS, 2018, ISSN 0027-8424
Éditeur: National Academy of Sciences
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Considerations and Challenges in Studying Liquid-Liquid Phase Separation and Biomolecular Condensates

Auteurs: Alberti S, Gladfelter A, Mittag T
Publié dans: Cell, 2019, ISSN 0092-8674
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Tau/DDX6 interaction increases microRNA activity

Auteurs: Alban Chauderlier; Melissa Gilles; Andrea Spolcova; Raphaëlle Caillierez; Maggy Chwastyniak; Michel Kress; Hervé Drobecq; Eliette Bonnefoy; Florence Pinet; Dominique Weil; Luc Buée; Marie-Christine Galas; Bruno Lefebvre
Publié dans: Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, Numéro Volume 1861, Numéro 8, August 2018,, 2018, Page(s) 762-772, ISSN 1874-9399
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Measurement of cerebral ABCC1 transport activity in wild-type and APP/PS1-21 mice with positron emission tomography

Auteurs: Zoufal V, Mairinger S, Krohn M, Wanek T, Filip T, Sauberer M, Stanek J, Kuntner C, Pahnke J, Langer O,
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Preclinical Evaluation of a Lentiviral Vector for Huntingtin Silencing

Auteurs: Karine Cambon, Virginie Zimmer, Sylvain Martineau, Marie-Claude Gaillard, Margot Jarrige, Aurore Bugi, Jana Miniarikova, Maria Rey, Raymonde Hassig, Noelle Dufour, Gwenaelle Auregan, Philippe Hantraye, Anselme L. Perrier, Nicole Déglon
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How the shapes of seeds can influence pathology

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Expression of the Parkinson’s Disease-Associated Gene Alpha-Synuclein is Regulated by the Neuronal Cell Fate Determinant TRIM32

Auteurs: Maria Angeliki S. Pavlou, Nicoló Colombo, Sandra Fuertes-Alvarez, Sarah Nicklas, Laura Gonzalez Cano, Maria C. Marín, Jorge Goncalves, Jens C. Schwamborn
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Antidepressants act by binding to the cholesterolinteraction site at TrkB neurotrophin receptor

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The Role of Sex and Sex Hormones in Neurodegenerative Diseases

Auteurs: Vegeto E., Villa A., Della Torre S., Crippa V. Rusmini P., Cristofani R., Galbiati M., Maggi A., Poletti A.
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Knocking out C9ORF72 Exacerbates Axonal Trafficking Defects Associated with Hexanucleotide Repeat Expansion and Reduces Levels of Heat Shock Proteins

Auteurs: Abo-Rady, Masin; Kalmbach, Norman; Pal, Arun; Schludi, Carina; Janosch, Antje; Richter, Tanja; Freitag, Petra; Bickle, Marc; Kahlert, Anne-Karin; Petri, Susanne; Stefanov, Stefan; Glass, Hannes; Staege, Selma; Just, Walter; Bhatnagar, Rajat; Edbauer, Dieter; Hermann, Andreas; Wegner, Florian; Sterneckert, Jared L.
Publié dans: Stem Cell Reports, Vol 14, Iss 3, Pp 390-405 (2020), 2020, ISSN 2213-6711
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Associations between sleep apnea and advanced brain aging in a large-scale population study

Auteurs: Antoine Weihs, Stefan Frenzel, Katharina Wittfeld, Anne Obst, Beate Stubbe, Mohamad Habes, András Szentkirályi, Klaus Berger, Ingo Fietze, Thomas Penzel, Norbert Hosten, Ralf Ewert, Henry Völzke, Helena U Zacharias, Hans J Grabe
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Spatial Transcriptomics Reveals Genes Associated with Dysregulated Mitochondrial Functions and Stress Signaling in Alzheimer Disease.

Auteurs: José Fernández Navarro; Deborah L. Croteau; Aleksandra Jurek; Zaneta Andrusivova; Beimeng Yang; Yue Wang; Benjamin Ogedegbe; Tahira Riaz; Mari Støen; Claus Desler; Lene Juel Rasmussen; Tone Tønjum; Marie-Christine Galas; Joakim Lundeberg; Vilhelm A. Bohr; Vilhelm A. Bohr
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PDGF-B Is Required for Development of the Glymphatic System.

Auteurs: Munk, Anne Sofie; Wang, Wei; Bechet, Nicholas Burdon; Eltanahy, Ahmed M.; Cheng, Anne Xiaoan; Sigurdsson, Bjorn; Benraiss, Abdellatif; Mäe, Maarja Andaloussi; Kress, Benjamin Travis; Kelley, Douglas H.; Betsholtz, Christer; Mollgard, Kjeld; Meissner, Anja; Nedergaard, Maiken; Lundgaard, Iben
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Neural circuitry underlying sustained attention in healthy adolescents and in ADHD symptomatology

Auteurs: Laura O'Halloran, Zhipeng Cao, Kathy Ruddy, Lee Jollans, Matthew D Albaugh, Andrea Aleni, Alexandra S Potter, Nigel Vahey, Tobias Banaschewski, Sarah Hohmann, Arun L W Bokde, Uli Bromberg, Christian Büchel, Erin Burke Quinlan, Sylvane Desrivières, Herta Flor, Vincent Frouin, Penny Gowland, Andreas Heinz, Bernd Ittermann, Frauke Nees, Dimitri Papadopoulos Orfanos, Tomáš Paus, Michael N Smolka,
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Transcriptional induction of the heat shock protein B8 mediates the clearance of misfolded proteins responsible for motor neuron diseases.

Auteurs: Crippa V., D'Agostino V.G., Cristofani R., Rusmini P., Cicardi M.E., Messi E., Loffredo R., Pancher M., Piccolella M., Galbiati M., Meroni M., Cereda C., Carra S., Provenzani A., Poletti A.
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Genome-wide identification of genic and intergenic neuronal DNA regions bound by Tau protein under physiological and stress conditions.

Auteurs: Benhelli-Mokrani, Houda; Mansuroglu, Zeyni; Chauderlier, Alban; Albaud, Benoit; Gentien, David; Sommer, Sabrina; Schirmer, Claire; Laqueuvre, Lucie; Josse, Thibaut; Buée, Luc; Lefebvre, Bruno; Galas, Marie-Christine; Souès, Sylvie; Bonnefoy, Eliette
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The IMAGEN study: a decade of imaging genetics in adolescents

Auteurs: Lea Mascarell Maričić, Henrik Walter, Annika Rosenthal, Stephan Ripke, Erin Burke Quinlan, Tobias Banaschewski, Gareth J. Barker, Arun L. W. Bokde, Uli Bromberg, Christian Büchel, Sylvane Desrivières, Herta Flor, Vincent Frouin, Hugh Garavan, Bernd Itterman, Jean-Luc Martinot, Marie-Laure Paillère Martinot, Frauke Nees, Dimitri Papadopoulos Orfanos, Tomáš Paus, Luise Poustka, Sarah Hohmann,
Publié dans: Molecular psychiatry, 2020, ISSN 1359-4184
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Linking Neuroinflammation and Neurodegeneration in Parkinson's Disease.

Auteurs: Gelders G, Baekelandt V, Van der Perren A.
Publié dans: Journal of immunology research, 2018, ISSN 2314-8861
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Cell-Type-Specific Gene Expression Profiling in Adult Mouse Brain Reveals Normal and Disease-State Signatures

Auteurs: Nicolas Merienne, Cécile Meunier, Anne Schneider, Jonathan Seguin, Satish S Nair, Anne B Rocher, Stéphanie Le Gras, Céline Keime, Richard Faull, Luc Pellerin, Jean-Yves Chatton, Christian Neri, Karine Merienne, Nicole Déglon;
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Sexual behavior and testis morphology in the BACHD rat model.

Auteurs: Novati, Arianna; Yu-Taeger, Libo; Gonzalez Menendez, Irene; Quintanilla Martinez, Leticia; Nguyen, Huu Phuc
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Psychosisassociated DNA methylomic variation in Alzheimer's disease cortex.

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Publié dans: Neurobiology of Aging, 2020, ISSN 0197-4580
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Whole exome sequencing study identifies novel rare and common Alzheimer's-Associated variants involved in immune response and transcriptional regulation.

Auteurs: Bis JC, Jian X, Kunkle BW, Chen Y, Hamilton-Nelson KL, Bush WS, Salerno WJ, Lancour D, Ma Y, Renton AE, Marcora E, Farrell JJ, Zhao Y, Qu L, Ahmad S, Amin N, Amouyel P, Beecham GW, Below JE, Campion D, Cantwell L, Charbonnier C, Chung J, Crane PK, Cruchaga C, Cupples LA, Dartigues JF, Debette S, Deleuze JF, Fulton L, Gabriel SB, Genin E, Gibbs RA, Goate A, Grenier-Boley B, Gupta N, Haines JL, Havu
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The Self-Inactivating KamiCas9 System for the Editing of CNS Disease Genes

Auteurs: Nicolas Merienne , Gabriel Vachey , Lucie de Longprez , Cécile Meunier , Virginie Zimmer , Guillaume Perriard , Mathieu Canales , Amandine Mathias , Lucas Herrgott , Tim Beltraminelli , Axelle Maulet , Thomas Dequesne , Catherine Pythoud , Maria Rey , Luc Pellerin , Emmanuel Brouillet , Anselme L Perrier, Renaud du Pasquier , Nicole Déglon;
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In Vivo Transient and Partial Cell Reprogramming to Pluripotency as a Therapeutic Tool for Neurodegenerative Diseases

Auteurs: Tamanini, S., Comi, G.P. & Corti, S.
Publié dans: Molecular Neurobiology, Numéro 55, 2018, Page(s) 6850–6862, ISSN 0893-7648
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Reconstituting Corticostriatal Network on-a-Chip Reveals the Contribution of the Presynaptic Compartment to Huntington's Disease

Auteurs: Virlogeux A, Moutaux E, Christaller W, Genoux A, Bruyère J, Fino E, Charlot B, Cazorla M, Saudou F.
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Chondroitinase and antidepressants promote plasticity by releasing TRKB from dephosphorylating control of PTPσ in parvalbumin neurons

Auteurs: Lesnikova, A., Casarotto, P. C., Fred, S. M., Voipio, M., WInkel, F., Steinzeig, A., Antila, H., Umemori, J., Biojone, C., Castrén, E.
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The small heat shock protein B8 (HSPB8) efficiently removes aggregating species of dipeptides produced in C9ORF72-related neurodegenerative diseases

Auteurs: Cristofani, Riccardo; Crippa, Valeria; Vezzoli, Giulia; Rusmini, Paola; Galbiati, Mariarita; Cicardi, Maria Elena; Meroni, Marco; Ferrari, Veronica; Tedesco, Barbara; Piccolella, Margherita; Messi, Elio; Carra, Serena; Poletti, Angelo
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Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes

Auteurs: Malik R, Chauhan G, Traylor M, Sargurupremraj M, Okada Y, Mishra A, Rutten-Jacobs L, Giese AK, van der Laan SW, Gretarsdottir S, Anderson CD, Chong M, Adams HHH, Ago T, Almgren P, Amouyel P, […], Ikram MA, [...], Schmidt R [...], Tzourio C, [...], Stefansson K, Worrall BB, Kittner J, Seshadri S, Fornage M, Markus HS, Howson JMM, Kamatani Y, Debette S*, Dichgans M*.
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Dihydromyricetin and Salvianolic acid B inhibit alpha-synuclein aggregation and enhance chaperone-mediated autophagy.

Auteurs: Wu JZ, Ardah M, Haikal C, Svanbergsson A, Diepenbroek M, Vaikath NN, Li W, Wang ZY, Outeiro TF, El-Agnaf OM, Li JY.
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Inflammaging 2018: An update and a model

Auteurs: Claudio Franceschi 1, Alexey Zaikin 2, Susanna Gordleeva 3, Mikhail Ivanchenko 3, Francesca Bonifazi 4, Gianluca Storci 5, Massimiliano Bonafè
Publié dans: Semin Immunol, 2018, ISSN 1044-5323
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Chronic inflammation in the etiology of disease across the life span

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Molecular Mechanisms and Therapeutic Strategies in Spinocerebellar Ataxia Type 7

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RNA Interference Therapy for Machado-Joseph Disease: Long-Term Safety Profile of Lentiviral Vectors Encoding Short Hairpin RNAs Targeting Mutant Ataxin-3

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Altered Brain Endothelial Cell Phenotype from a Familial Alzheimer Mutation and Its Potential Implications for Amyloid Clearance and Drug Delivery

Auteurs: Lotta E. Oikari; Rucha Pandit; Romal Stewart; Carla Cuni-Lopez; Hazel Quek; Ratneswary Sutharsan; Ratneswary Sutharsan; Laura M. Rantanen; Minna Oksanen; Šárka Lehtonen; Šárka Lehtonen; Carmela Maria de Boer; Carmela Maria de Boer; Jose M. Polo; Jose M. Polo; Jose M. Polo; Jürgen Götz; Jari Koistinaho; Jari Koistinaho; Anthony R. White
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Stroke target identification guided by astrocyte transcriptome analysis

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Antisense oligonucleotide therapeutics in neurodegenerative diseases: the case of polyglutamine disorders

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The Extent of Human Apolipoprotein A-I Lipidation Strongly Affects the β-Amyloid Efflux Across the Blood-Brain Barrier in vitro

Auteurs: Dal Magro R, Simonelli S, Cox A, Formicola B, Corti R, Cassina V, Nardo L, Mantegazza F, Salerno D, Grasso G, Deriu MA, Danani A, Calabresi L, Re F.
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First-in-Rat Study of Human Alzheimer's Disease Tau Propagation

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In vivo imaging of early signs of dopaminergic neuronal death in an animal model of Parkinson's disease

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PPARβ/δ-agonist GW0742 ameliorates dysfunction in fatty acid oxidation in PSEN1ΔE9 astrocytes

Auteurs: Konttinen H, Gureviciene I, Oksanen M, Grubman A, Loppi S, Huuskonen MT, Korhonen P, Lampinen R, Keuters M, Belaya I, Tanila H, Kanninen KM, Goldsteins G, Landreth G, Koistinaho J, Malm T.
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Comprehensive longitudinal study of epigenetic mutations in aging.

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Age-related epigenetic changes in hippocampal subregions of four animal models of Alzheimer's disease

Auteurs: Roy Lardenoije, Daniël L.A. van den Hove, Monique Havermans, Anne van Casteren, Kevin X. Le, Roberta Palmour, Cynthia A. Lemere, Bart P.F. Rutten
Publié dans: Molecular and Cellular Neuroscience, Numéro Volume 86, 2018, Page(s) Pages 1-15, ISSN 1044-7431
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Accelerated bio-cognitive aging in Down syndrome: State of the art and possible deceleration strategies

Auteurs: Claudio Franceschi , Paolo Garagnani, Noémie Gensous, Maria Giulia Bacalini, Maria Conte , Stefano Salvioli
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Genetic correlations and genome-wide associations of cortical structure in general population samples of 22,824 adults.

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Tau Stabilizes Chromatin Compaction.

Auteurs: Thomas Rico; Melissa Gilles; Alban Chauderlier; Thomas Comptdaer; Romain Magnez; Maggy Chwastyniak; Hervé Drobecq; Florence Pinet; Xavier Thuru; Luc Buée; Marie-Christine Galas; Bruno Lefebvre
Publié dans: "Frontiers in Cell and Developmental Biology, Frontiers media, 2021, 9, pp.740550. ⟨10.3389/fcell.2021.740550⟩", Numéro 1, 2021, ISSN 2296-634X
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The genetic architecture of the human cerebral cortex

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Efficient protein production inspired by how spiders make silk

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Synapse-to-nucleus communication: from developmental disorders to Alzheimer's disease

Auteurs: Marcello E, Di Luca M, Gardoni F
Publié dans: Current opinion in neurobiology, 2018, ISSN 0959-4388
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HSC70 expression is reduced in lymphomonocytes of sporadic ALS patients and contributes to TDP-43 accumulation.

Auteurs: Arosio A., Cristofani R., Pansarasa O., Crippa V., Riva C., Sirtori R., Menendez V., Riva N., Gerardi F., Lunetta C., Cereda C., Poletti A., Ferrarese C., Tremolizzo L., Sala G.
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PSEN1 Mutant iPSC-Derived Model Reveals Severe Astrocyte Pathology in Alzheimer's Disease.

Auteurs: Oksanen, M; Petersen, AJ; Naumenko, N; Puttonen, K; Lehtonen, S; Olive, MG; Shakirzyanova, A; Leskela, S; Sarajarvi, T; Viitanen, M; Rinne, JO; Hiltunen, M; Haapasalo, A; Giniatullin, R; Tavi, P; Zhang, SC; Kanninen, KM; Hamalainen, RH; Koistinaho, J; Koistinaho, J
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Simple and Fast SEC-Based Protocol to Isolate Human Plasma-Derived Extracellular Vesicles for Transcriptional Research

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Sideritis spp. Extracts Enhance Memory and Learning in Alzheimer's β-Amyloidosis Mouse Models and Aged C57Bl/6 Mice

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Genetic architecture of subcortical brain structures in 38,851 individuals

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Developmental Expression of 4-Repeat-Tau Induces Neuronal Aneuploidy in Drosophila Tauopathy Models

Auteurs: Nicolas Malmanche; Nicolas Malmanche; Nicolas Malmanche; Pierre Dourlen; Pierre Dourlen; Pierre Dourlen; Marc Gistelinck; Florie Demiautte; Florie Demiautte; Florie Demiautte; Nichole Link; Cloé Dupont; Cloé Dupont; Cloé Dupont; Lies Vanden Broeck; Elisabeth Werkmeister; Philippe Amouyel; Philippe Amouyel; Philippe Amouyel; Antonino Bongiovanni; Hélène Bauderlique; Dieder Moechars; Anne Royou
Publié dans: SCIENTIFIC REPORTS, Numéro 1, 2017, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/srep40764

Reporter-Based Screens for the Ubiquitin/Proteasome System

Auteurs: Gierisch, M.1, T.A. Giovannucci1, Nico P. Dantuma
Publié dans: Journal of Neurochemistry, 2020, ISSN 0022-3042
Éditeur: Blackwell Publishing Inc.
DOI: 10.3389/fchem.2020.00064

Protocol for the Characterization of the Cytosine-Adenine-Guanine Tract and Flanking Polymorphisms in Machado-Joseph Disease: Impact on Diagnosis and Development of Gene-Based Therapies

Auteurs: opes SM, Faro R, Lopes MM, Onofre I, Mendonça N, Ribeiro J, Januário C, Nobre RJ, Pereira de Almeida L.
Publié dans: Journal of Molecular Diagnostics, 2020, ISSN 1525-1578
Éditeur: American Society for Investigative Pathology
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PSEN1ΔE9, APPswe, and APOE4 Confer Disparate Phenotypes in Human iPSC-Derived Microglia

Auteurs: Konttinen H, Cabral-da-Silva MEC, Ohtonen S, Wojciechowski S, Shakirzyanova A, Caligola S, Giugno R, Ishchenko Y, Hernández D, Fazaludeen MF, Eamen S, Budia MG,Fagerlund I, Scoyni F, Korhonen P, Huber N, Haapasalo A, Hewitt AW, Vickers J, Smith GC, Oksanen M, Graff C, Kanninen KM, Lehtonen S, Propson N, Schwartz MP, Pébay A, Koistinaho J, Ooi L, Malm T.
Publié dans: Stem cell reports, 2019, ISSN 2213-6711
Éditeur: Cell Press
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The BACHD rat model of Huntington disease shows slowed learning in a Go/No-Go-like test of visual discrimination

Auteurs: Clemensson EKH, Novati A, Clemensson LE, Riess O, Nguyen HP.
Publié dans: Behavioural Brain Research, 2019, ISSN 0166-4328
Éditeur: Elsevier BV
DOI: 10.1016/j.bbr.2018.10.036

An aberrant phase transition of stress granules triggered by misfolded protein and prevented by chaperone function

Auteurs: Mateju, Daniel; Franzmann, Titus M; Patel, Avinash; Kopach, Andrii; Boczek, Edgar E; Maharana, Shovamayee; Lee, Hyun O; Carra, Serena; Hyman, Anthony A; Alberti, Simon
Publié dans: The EMBO Journal, 2017, ISSN 0261-4189
Éditeur: Nature Publishing Group
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A Biomarker for Alzheimer's Disease Based on Patterns of Regional Brain Atrophy

Auteurs: Frenzel S., Wittfeld K., Habes M., Klinger-König J., Bülow R., Völzke H., Grabe HJ.
Publié dans: Frontiers in Psychiatry, 2020, ISSN 1664-0640
Éditeur: Frontiers Research Foundation
DOI: 10.3389/fpsyt.2019.00953

Inflammaging: a new immune–metabolic viewpoint for age-related diseases

Auteurs: Franceschi, C., Garagnani, P., Parini, P. et al.
Publié dans: Nat Rev Endocrinol, 2018, ISSN 1759-5029
Éditeur: Nature Publishing Group
DOI: 10.1038/s41574-018-0059-4

C@PA: Computer-Aided Pattern Analysis to Predict Multitarget ABC Transporter Inhibitors.

Auteurs: Vigneshwaran Namasivayam; Katja Silbermann; Michael Wiese; Jens Pahnke; Sven Marcel Stefan; Sven Marcel Stefan; Sven Marcel Stefan
Publié dans: Journal of Medicinal Chemistry, 2021, ISSN 0022-2623
Éditeur: American Chemical Society
DOI: 10.1021/acs.jmedchem.0c02199

Burden of Dilated Perivascular Spaces, an Emerging Marker of Cerebral Small Vessel Disease, Is Highly Heritable

Auteurs: Duperron MG, Tzourio C, Sargurupremraj M, Mazoyer B, Soumaré A, Schilling S, Amouyel P, Chauhan G, Zhu YC, Debette S.
Publié dans: Stroke, 2018, ISSN 0039-2499
Éditeur: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/strokeaha.117.019309

iPlasticity: Induced juvenile-like plasticity in the adult brain as a mechanism of antidepressants

Auteurs: Umemori, J., Winkel, F., Didio, G., Llach Pou, M., Castren, E.
Publié dans: Psychiatry and Clinical Neurosciences, 2018, ISSN 1323-1316
Éditeur: Blackwell Publishing Inc.
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Extracellular vesicles: Novel promising delivery systems for therapy of brain diseases

Auteurs: David Rufino-Ramos Patrícia R Albuquerque Vitor Carmona, Rita Perfeito, Rui Jorge Nobre, Luis Pereira de Almeida
Publié dans: Journal of Controlled Release, Numéro Volume 262, 2017, Page(s) Pages 247-258, ISSN 0168-3659
Éditeur: Elsevier BV
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Quantitating denaturation by formic acid: imperfect repeats are essential to the stability of the functional amyloid protein FapC

Auteurs: Christensen LFB, Nowak JS, Sønderby T, Frank SA, Otzen DE
Publié dans: The journal of Biological Chemistry, 2020, ISSN 0021-9258
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Glucocerebrosidase mutations and synucleinopathies: Toward a model of precision medicine.

Auteurs: Fabio Blandini MD, Roberto Cilia MD, Silvia Cerri PhD, Gianni Pezzoli MD, Anthony H.V. Schapira MD, Stephen Mullin PhD, José L. Lanciego MD, PhD
Publié dans: Movement Disorders, 2019, ISSN 0885-3185
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Protein Phase Separation: A New Phase in Cell Biology

Auteurs: Boeynaems S, Alberti S, Fawzi NL, Mittag T, Polymenidou M, Rousseau F, Schymkowitz J, Shorter J, Wolozin B, Van Den Bosch L, Tompa P, Fuxreiter M
Publié dans: Trends in Cell Biology, 2018, ISSN 0962-8924
Éditeur: Elsevier BV
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Impact of Chronic BDNF Depletion on GABAergic Synaptic Transmission in the Lateral Amygdala

Auteurs: Meis S, Endres T, Munsch T, Lessmann V.
Publié dans: International Journal of Molecular Sciences, 2019, ISSN 1422-0067
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
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Peripheral Inflammation Regulates CNS Immune Surveillance Through the Recruitment of Inflammatory Monocytes Upon Systemic α-Synuclein Administration

Auteurs: Peralta Ramos J, Iribarren P, Bousset L, Melki R, Baekelandt V, Van der Perren A.
Publié dans: Frontiers in immunology, 2019, ISSN 1664-3224
Éditeur: Lausanne Frontiers Media S.A.
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Allele-Specific Methylation of SPDEF: A Novel Moderator of Psychosocial Stress and Substance Abuse

Auteurs: Nicole Tay, M.Sc., Christine Macare, Ph.D., Yun Liu, Ph.D., Barbara Ruggeri, Ph.D., Tianye Jia, Ph.D., Congying Chu, Ph.D., Francesca Biondo, Ph.D., Alex Ing, Ph.D., Qiang Luo, Ph.D., Daniil Sarkysian, Ph.D., Tobias Banaschewski, M.D., Ph.D., Gareth J. Barker, Ph.D., Arun L.W. Bokde, Ph.D., Uli Bromberg, Ph.D., Christian Büchel, M.D., Erin Burke Quinlan, Ph.D., Sylvane Desrivières, Ph.D., Herta
Publié dans: The American Journal of Psychiatry, 2019, ISSN 0002-953X
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FUS pathology in ALS is linked to alterations in multiple ALS-associated proteins and rescued by drugs stimulating autophagy

Auteurs: Marrone L, Drexler HCA, Wang J, Tripathi P, Distler T, Heisterkamp P, Anderson EN, Kour S, Moraiti A, Maharana S, Bhatnagar R, Belgard TG, Tripathy V, Kalmbach N, Hosseinzadeh Z, Crippa V, Abo-Rady M, Wegner F, Poletti A, Troost D, Aronica E, Busskamp V, Weis J, Pandey UB, Hyman AA, Alberti S, Goswami A, Sterneckert J
Publié dans: Acta Neuropathologica, 2019, ISSN 1432-0533
Éditeur: Springer
DOI: 10.1007/s00401-019-01998-x

Structural studies of amyloid-β peptides: Unlocking the mechanism of aggregation and the associated toxicity

Auteurs: Aleksis R, Oleskovs F, Jaudzems K, Pahnke J, Biverstal H,
Publié dans: Biochimie, 2017, ISSN 0300-9084
Éditeur: Elsevier BV
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Genetically Elevated LDL Associates with Lower Risk of Intracerebral Hemorrhage

Auteurs: Guido J. Falcone MD, ScD, MPH,Elayna Kirsch BA,Julian N. Acosta MD,Rommell B. Noche MS,Audrey Leasure BS,Sandro Marini MD,Jaeyoon Chung PhD,Magdy Selim MD, PhD,James F. Meschia MD,Devin L. Brown MD, MS,Bradford B. Worrall MD, MSc,David L. Tirschwell MD, MSc,Jeremiasz M. Jagiella MD, PhD,Helena Schmidt MD,Jordi Jimenez-Conde MD, PhD,Israel Fernandez-Cadenas PhD,Arne Lindgren MD,Agnieszka Slowik MD,
Publié dans: Annals of Neurology, 2020, ISSN 0364-5134
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Impairment of the glymphatic system after diabetes.

Auteurs: Jiang Q, Zhang L, Ding G, Davoodi-Bojd E, Li Q, Li L, Sandry N, Nedergaard M, Chopp M, Zhang Z.
Publié dans: Journal of Cerebral Blood Flow and Metabolism, 2016, ISSN 0271-678X
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TrkB-ICD Fragment, Originating From BDNF Receptor Cleavage, Is Translocated to Cell Nucleus and Phosphorylates Nuclear and Axonal Proteins

Auteurs: Fonseca-Gomes, J., Jerónimo-Santos, A., Lesnikova, A., Casarotto, P., Castrén, E., Sebastião, A. M., and Diógenes, M. J.
Publié dans: Frontiers in Molecular Neuroscience, 2019, ISSN 1662-5099
Éditeur: Frontiers Research Foundation
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A tool for analysis and visualization of spatial transcriptomics datasets.

Auteurs: Fernández Navarro J, Lundeberg J, Ståhl PL.
Publié dans: Bioinformatics, 2019, ISSN 1367-4811
Éditeur: Oxford Academic
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Transforming growth factor beta 1 signaling is altered in the spinal cord and muscle of amyotrophic lateral sclerosis mice and patients.

Auteurs: Meroni M., Crippa V., Cristofani R., Rusmini P., Cicardi M.E., Messi E., Piccolella M., Tedesco B., Ferrari V., Sorarù G., M., Pennuto M, Poletti A., Galbiati M.
Publié dans: Neurobiology of Disease, 2019, ISSN 0969-9961
Éditeur: Academic Press
DOI: 10.1016/j.neurobiolaging.2019.07.001

Vesicular ATP-binding cassette transporters in human disease: relevant aspects of their organization for future drug development

Auteurs: Katja Stefan; Lionel Yi Wen Leck; Lionel Yi Wen Leck; Vigneshwaran Namasivayam; Pablo Bascuñana; Michael L.-H. Huang; Patrick J. Riss; Jens Pahnke; Patric J. Jansson; Patric J. Jansson; Sven Marcel Stefan
Publié dans: Future Science, 2020, ISSN 1756-8919
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Protease resistance of infectious prions is suppressed by removal of a single atom in the cellular prion protein

Auteurs: Henning Leske, Simone Hornemann, Uli Simon Herrmann, Caihong Zhu, Paolo Dametto, Bei Li, Florent Laferriere, Magdalini Polymenidou, Pawel Pelczar, Regina Rose Reimann, Petra Schwarz, Elisabeth Jane Rushing, Kurt Wüthrich , Adriano Aguzzi
Publié dans: PLOS ONE, 2017, ISSN 1932-6203
Éditeur: Public Library of Science
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Inflammatory markers and imaging patterns of advanced brain aging in the general population

Auteurs: Janowitz, D, Habes M, Toledo J, Hannemann A, Frenzel S. ,Terock J., Davatzikos C, Hoffmann W, Grabe HJ.
Publié dans: Brain Imaging and Behavior, 2020, ISSN 1931-7557
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Parallel profiling of DNA methylation and hydroxymethylation highlights neuropathology-associated epigenetic variation in Alzheimer's disease

Auteurs: Smith, Adam R.; Smith, Rebecca G.; Pishva, Ehsan; Hannon, Eilis; Roubroeks, Janou A. Y.; Burrage, Joe; Troakes, Claire; Al-Sarraj, Safa; Sloan, Carolyn; Mill, Jonathan; van den Hove, Daniel L.; Lunnon, Katie
Publié dans: Clinical epigenetics, Numéro vol. 11, 2019, ISSN 1868-7075
Éditeur: Springer Verlag
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The structural differences between patient-derived α-synuclein strains dictate characteristics of Parkinson's disease, multiple system atrophy and dementia with Lewy bodies

Auteurs: Van der Perren A, Gelders G, Fenyi A, Bousset L, Brito F, Peelaerts W, Van den Haute C, Gentleman S, Melki R, Baekelandt V
Publié dans: Acta neuropathologica, 2020, ISSN 0001-6322
Éditeur: Springer Verlag
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The SAC1 domain in synaptojanin is required for autophagosome maturation at presynaptic terminals

Auteurs: Roeland Vanhauwaert 1 2, Sabine Kuenen 1 2, Roy Masius 3, Adekunle Bademosi 4, Julia Manetsberger 1 2, Nils Schoovaerts 1 2, Laura Bounti 1 2, Serguei Gontcharenko 1 2, Jef Swerts 1 2, Sven Vilain 1 2, Marina Picillo 5, Paolo Barone 5, Shashini T Munshi 6, Femke Ms de Vrij 6, Steven A Kushner 6, Natalia V Gounko 1 2 7, Wim Mandemakers 3, Vincenzo Bonifati 3, Frederic A Meunier 4, Sandra-Fausia Sou
Publié dans: EMBO J, 2017, ISSN 0261-4189
Éditeur: Nature Publishing Group
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Long Term Gene Expression in Human Induced Pluripotent Stem Cells and Cerebral Organoids to Model a Neurodegenerative Disease.

Auteurs: Nassor F, Jarray R, Biard DSF, Maïza A, Papy-Garcia D, Pavoni S, Deslys J-P and Yates F
Publié dans: Front. Cell. Neurosci, 2020, ISSN 1662-5102
Éditeur: Frontiers Research Foundation
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Richness and ecosystem development across faecal snapshots of the gut microbiota

Auteurs: Falony G, Vieira-Silva S, Raes J.
Publié dans: Nature microbiology, 2018, ISSN 2058-5276
Éditeur: Nature microbiology
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Identification of neurobehavioural symptom groups based on shared brain mechanisms

Auteurs: Alex Ing, Philipp G Sämann, Congying Chu, Nicole Tay, Francesca Biondo, Gabriel Robert, Tianye Jia, Thomas Wolfers, Sylvane Desrivières, Tobias Banaschewski, Arun L W Bokde, Uli Bromberg, Christian Büchel, Patricia Conrod, Tahmine Fadai, Herta Flor, Vincent Froui, Hugh Garavan, Philip A Spechler, Penny Gowland, Yvonne Grimmer, Andreas Heinz, Bernd Ittermann, Viola Kappel, Jean-Luc Martinot, And
Publié dans: Nature human behaviour, 2019, ISSN 2397-3374
Éditeur: Nature human behaviour
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Psychosocial Stress and Brain Function in Adolescent Psychopathology

Auteurs: Erin Burke Quinlan, Ph.D., Anna Cattrell, Ph.D., Tianye Jia, Ph.D., Eric Artiges, M.D., Ph.D., Tobias Banaschewski, M.D., Ph.D, Gareth Barker, Ph.D., Arun L.W. Bokde, Ph.D., Uli Bromberg, Dipl.-Psych., Christian Büchel, M.D., Rüdiger Brühl, Ph.D., Patricia J. Conrod, Ph.D., Sylvane Desrivieres, Ph.D., Herta Flor, Ph.D., Vincent Frouin, Ph.D., Jürgen Gallinat, M.D., Hugh Garavan, Ph.D., Penny G
Publié dans: The american journal of psychiatry, 2017, ISSN 0002-953X
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The autophagy-enhancing drug carbamazepine improves neuropathology and motor impairment in mouse models of Machado–Joseph disease

Auteurs: Ana Vasconcelos-Ferreira; Sara Carmo-Silva; José Miguel Codêsso; Patrick Silva; Alberto R. M. Martinez; Marcondes C. França; Clévio Nóbrega; Luís Pereira de Almeida
Publié dans: Neuropathology and Applied Neurobiology, Numéro 2, 2022, ISSN 0305-1846
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Cultivation and characterization of human midbrain organoids in sensor integrated microfluidic chips

Auteurs: Spitz S., Zanetti C., Bolognin S., Muwanigwa M.N., Smits L., Berger E., Jäger C., Harasek M., Schwamborn J.C., Peter Ertl
Publié dans: bioRxiv, 2019, ISSN 2692-8205
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Reducing pericyte-derived scarring promotes recovery after spinal cord injury.

Auteurs: Oliveira Dias D, Kim H, Holl D, Werne Solnestam B, Lundeberg J, Carlén M, Göritz C* and Frisén J*.
Publié dans: Cell, 2018, ISSN 0092-8674
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Alzheimer’s disease-associated (hydroxy)methylomic changes in the brain and blood

Auteurs: Lardenoije, Roy; Roubroeks, Janou A. Y.; Pishva, Ehsan; Leber, Markus; Wagner, Holger; Iatrou, Artemis; Smith, Adam R.; Smith, Rebecca G.; Eijssen, Lars M. T.; Kleineidam, Luca; Kawalia, Amit; Hoffmann, Per; Luck, Tobias; Riedel-Heller, Steffi; Jessen, Frank; Maier, Wolfgang; Wagner, Michael; Hurlemann, René; Kenis, Gunter; Ali, Muhammad; del Sol, Antonio; Mastroeni, Diego; Delvaux, Elaine; Colem
Publié dans: Clinical epigenetics, 2019, ISSN 1868-7075
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Biological Age Predictors

Auteurs: Jylhävä J, Pedersen NL, Hägg S
Publié dans: EBioMedicine, 2017, ISSN 2352-3964
Éditeur: Elsevier BV
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Epigenome-wide meta-analysis of blood DNA methylation and its association with subcortical volumes: findings from the ENIGMA Epigenetics Working Group

Auteurs: Tianye Jia, Congying Chu, Yun Liu, Jenny van Dongen, Evangelos Papastergios, Nicola J. Armstrong, Mark E. Bastin, Tania Carrillo-Roa, Anouk den Braber, Mathew Harris, Rick Jansen, Jingyu Liu, Michelle Luciano, Anil P. S. Ori, Roberto Roiz Santiañez, Barbara Ruggeri, Daniil Sarkisyan, Jean Shin, Kim Sungeun, Diana Tordesillas Gutiérrez, Dennis van’t Ent, David Ames, Eric Artiges, Georgy Bakalki
Publié dans: Molecular psychiatry, 2021, ISSN 1359-4184
Éditeur: Nature Publishing Group
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Physico-Pathologic Mechanisms Involved in Neurodegeneration: Misfolded Protein-Plasma Membrane Interactions

Auteurs: Shrivastava AN, Aperia A, Melki R, Triller A.
Publié dans: Neuron, 2017, ISSN 0896-6273
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Neurobehavioural characterisation and stratification of reinforcement-related behaviour

Auteurs: Tianye Jia, Alex Ing, Erin Burke Quinlan, Nicole Tay, Qiang Luo, Biondo Francesca, Tobias Banaschewski, Gareth J. Barker, Arun L. W. Bokde, Uli Bromberg, Christian Büchel, Sylvane Desrivières, Jianfeng Feng, Herta Flor, Antoine Grigis, Hugh Garavan, Penny Gowland, Andreas Heinz, Bernd Ittermann, Jean-Luc Martinot, Marie-Laure Paillère Martinot, Frauke Nees, Dimitri Papadopoulos Orfanos, Tomáš
Publié dans: Nature Human Behaviour, 2020, ISSN 2397-3374
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"Corrigendum to ""Morphometric analysis of the cerebral expression of ATP-binding cassette transporter protein ABCB1 in chronic schizophrenia: Circumscribed deficits in the habenula"" [Schizophr. Res. 2016 Nov;177(1-3):52-58]"

Auteurs: Bernstein HG, Hildebrandt J, Dobrowolny H, Steiner J, Bogerts B, Pahnke J,
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Fibroblasts of Machado Joseph Disease patients reveal autophagy impairmen

Auteurs: Isabel Onofre1,2,*, Nuno Mendonça1,3,4,*, Sara Lopes1,5, Rui Nobre1,5, Joana Barbosa de Melo1,4,6, Isabel Marques Carreira1,4,6, Cristina Januário3,4, António Freire Gonçalves3,4 & Luis Pereira de Almeida1,2
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Machine Learning-Supported Analyses Improve Quantitative Histological Assessments of Amyloid-β Deposits and Activated Microglia

Auteurs: Bascunana P, Brackhan M, Pahnke J,
Publié dans: Journal of Alzheimer's Disease, 2021, ISSN 1387-2877
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Differential overexpression of SERPINA3 in human prion diseases

Auteurs: Vanni, S., Moda, F., Zattoni, M. et al.
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Leukocyte Telomere Length Is Related to Brain Parenchymal Fraction and Attention/Speed in the Elderly: Results of the Austrian Stroke Prevention Study.

Auteurs: Piyush Gampawar; Reinhold Schmidt; Helena Schmidt
Publié dans: Frontiers in Psychiatry, Vol 11 (2020), 2020, ISSN 1664-0640
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Targeting Neuroinflammation to Treat Alzheimer's Disease

Auteurs: Ardura-Fabregat A, Boddeke EWGM, Boza-Serrano A, Brioschi S, Castro-Gomez S, Ceyzériat K, Dansokho C, Dierkes T, Gelders G, Heneka MT, Hoeijmakers L, Hoffmann A, Iaccarino L, Jahnert S, Kuhbandner K, Landreth G, Lonnemann N, Löschmann PA, McManus RM, Paulus A, Reemst K, Sanchez-Caro JM, Tiberi A, Van der Perren A, Vautheny A, Venegas C, Webers A, Weydt P, Wijasa TS, Xiang X, Yang Y
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Millifluidic culture improves human midbrain organoid vitality and differentiation

Auteurs: Emanuel Berger,aChiara Magliaro,bNicole Paczia,cAnna S. Monzel,aPaul Antony,dCarole L. Linster,cSilvia Bolognin,aArti Ahluwaliaband Jens C. Schwamborn
Publié dans: Lab Chip, 2018, ISSN 1473-0197
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Are rodent models of Parkinson's disease behaving as they should ?

Auteurs: Vingill S, Cohhor-Robson N and Wade-Martins R
Publié dans: Behavioural Brain Research, 2018, ISSN 0166-4328
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Dynamic Arc SUMOylation and Selective Interaction with F-Actin-Binding Protein Drebrin A in LTP Consolidation In Vivo

Auteurs: Nair RR, Patil S, Tiron A, Kanhema T, Panja D, Schiro L, Parobzak K, Wilczynski G, Bramham CR.
Publié dans: Frontiers in Synaptic Neuroscience, 2017, ISSN 1663-3563
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Fingolimod as a Treatment in Neurologic Disorders Beyond Multiple Sclerosis

Auteurs: Pablo Bascuñana; Luisa Möhle; Mirjam Brackhan; Jens Pahnke
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Gut microbiota changes in the extreme decades of human life: a focus on centenarians

Auteurs: Santoro, A., Ostan, R., Candela, M. et al.
Publié dans: Cellular and Molecular Life Sciences, Numéro 75, 2018, Page(s) 129–148, ISSN 1420-682X
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Unravelling Endogenous MicroRNA System Dysfunction as a New Pathophysiological Mechanism in Machado-Joseph Disease

Auteurs: Vitor Carmona,Janete Cunha-Santos, Isabel Onofre,Ana Teresa Simões,Udaya Vijayakumar,Beverly L. Davidson, and Luís Pereira de Almeida
Publié dans: Molecular therapy, 2017, ISSN 1525-0016
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RNA buffers the phase separation behavior of prion-like RNA binding proteins

Auteurs: Maharana, Shovamayee; Wang, Jie; Papadopoulos, Dimitrios K.; Richter, Doris; Pozniakovsky, Andrey; Poser, Ina; Bickle, Marc; Rizk, Sandra; Guillén-Boixet, Jordina; Franzmann, Titus M.; Jahnel, Marcus; Marrone, Lara; Chang, Young-Tae; Sterneckert, Jared; Tomancak, Pavel; Hyman, Anthony A.; Alberti, Simon
Publié dans: Science, Numéro 1, 2018, ISSN 0036-8075
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Amplifying mitochondrial function rescues adult neurogenesis in a mouse model of Alzheimer's disease

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Nanomedicine for the Treatment of Alzheimer's Disease

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Intrinsic Xenobiotic Resistance of the Intestinal Stem Cell Niche

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CNS-Specific Synthesis of Interleukin 23 Induces a Progressive Cerebellar Ataxia and the Accumulation of Both T and B Cells in the Brain: Characterization of a Novel Transgenic Mouse Model.

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Prion-like low-complexity sequences: Key regulators of protein solubility and phase behavior

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There Is an Inclusion for That: Material Properties of Protein Granules Provide a Platform for Building Diverse Cellular Functions

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Early Cognitive Training Rescues Remote Spatial Memory but Reduces Cognitive Flexibility in Alzheimer's Disease Mice.

Auteurs: Surya Prakash Rai; Markus Krohn; Markus Krohn; Jens Pahnke
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Restoring brain cholesterol turnover improves autophagy and has therapeutic potential in mouse models of spinocerebellar ataxia.

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Genetic variation underlying cognition and its relation with neurological outcomes and brain imaging.

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The choroid plexus in health and in disease: dialogues into and out of the brain

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Age-related ultrastructural changes of the basement membrane in the mouse blood-brain barrier

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The small heat shock protein B8 (HSPB8) modulates proliferation and migration of breast cancer cells

Auteurs: Piccolella M., Crippa V., Cristofani R., Rusmini P., Galbiati M., Cicardi M.E., Meroni M., Ferri N., Morelli F.F., Carra S., Messi E., Poletti A.
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Detection and Prediction of Mild Cognitive Impairment in Alzheimer's Disease Mice.

Auteurs: Surya Prakash Rai; Pablo Bascuñana; Mirjam Brackhan; Markus Krohn; Luisa Möhle; Kristin Paarmann; Jens Pahnke
Publié dans: J Alzheimers Dis, Numéro 2, 2020, ISSN 1387-2877
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Evaluating β-amyloidosis progression in Alzheimer's disease with Mueller polarimetry

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From Stroke to Dementia: a Comprehensive Review Exposing Tight Interactions Between Stroke and Amyloid-β Formation

Auteurs: Goulay R, Mena Romo L, Hol EM, Dijkhuizen RM.
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The concerted amyloid-beta clearance of LRP1 and ABCB1/P-gp across the blood-brain barrier is linked by PICALM

Auteurs: Storck SE, Hartz AMS, Bernard J, Wolf A, Kachlmeier A, Mahringer A, Weggen S, Pahnke J, Pietrzik CU
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Differential Exchange of Multifunctional Liposomes Between Glioblastoma Cells and Healthy Astrocytes via Tunneling Nanotubes

Auteurs: Formicola B, D'Aloia A, Dal Magro R, Stucchi S, Rigolio R, Ceriani M, Re F.
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SCA7 Mouse Cerebellar Pathology Reveals Preferential Downregulation of Key Purkinje Cell-Identity Genes and Shared Disease Signature with SCA1 and SCA2

Auteurs: Niewiadomska-Cimicka A, Doussau F, Perot JB, Roux MJ, Keime C, Hache A, Piguet F, Novati A, Weber C, Yalcin B, Meziane H, Champy MF, Grandgirard E, Karam A, Messaddeq N, Eisenmann A, Brouillet E, Nguyen HHP, Flament J, Isope P and Trottier Y.
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Prying into the Prion Hypothesis for Parkinson's Disease

Auteurs: Brundin P, Melki R
Publié dans: The Journal of Neuroscience, 2017, ISSN 0270-6474
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Endothelial LRP1 - A Potential Target for the Treatment of Alzheimer's Disease : Theme: Drug Discovery, Development and Delivery in Alzheimer's Disease Guest Editor: Davide Brambilla

Auteurs: Storck SE, Pietrzik CU
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The physiology of regulated BDNF release

Auteurs: Brigadski T, Leßmann V.
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Evolution of Nanoparticle Protein Corona across the Blood-Brain Barrier

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Publié dans: ACS nano, 2018, ISSN 1936-0851
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3D human brain cell models: New frontiers in disease understanding and drug discovery for neurodegenerative diseases

Auteurs: Korhonen P, Malm T and White A R. White AR.
Publié dans: Neurochemistry international, 2018, ISSN 0197-0186
Éditeur: Elsevier BV
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Humanization of the Blood-Brain Barrier Transporter ABCB1 in Mice Disrupts Genomic Locus - Lessons from Three Unsuccessful Approaches

Auteurs: Krohn M, Wanek T, Menet MC, Noack A, Decleves X, Langer O, Loscher W, Pahnke J,
Publié dans: European journal of microbiology and immunology, 2018, ISSN 2062-509X
Éditeur: European journal of microbiology & immunology
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Neuroticism as a predictor of frailty in old age: a genetically informative approach

Auteurs: Hilda Bjork Danielsdottir, Juulia Jylhävä, Sara Hägg, Yi Lu, Lucía Colodro-Conde, Nicholas G. Martin, Nancy L. Pedersen, Miriam A. Mosing, Kelli Lehto
Publié dans: Psychosomatic Medicine, 2019, ISSN 0033-3174
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Spatial Transcriptomics and In Situ Sequencing to Study Alzheimer's Disease.

Auteurs: Chen WT, Lu A, Craessaerts K, Pavie B, Sala Frigerio C, Corthout N, Qian X, Laláková J, Kühnemund M, Voytyuk I, Wolfs L, Mancuso R, Salta E, Balusu S, Snellinx A, Munck S, Jurek A, Fernandez Navarro J, Saido TC, Huitinga I, Lundeberg J, Fiers M, De Strooper B.
Publié dans: Cell, 2020, ISSN 0092-8674
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Hippocampal tau oligomerization early in tau pathology coincides with a transient alteration of mitochondrial homeostasis and DNA repair in a mouse model of tauopathy

Auteurs: Zheng, Jin; Akbari, Mansour; Schirmer, Claire; Reynaert, Marie-Line; Loyens, Anne; Lefebvre, Bruno; Buée, Luc; Croteau, Deborah L.; Galas, Marie-Christine; Bohr, Vilhelm A.
Publié dans: Acta Neuropathologica Communications, Numéro Vol 8, Iss 1, 2020, Page(s) Pp 1-23, ISSN 2051-5960
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Teaming up to tackle neurodegenerative diseases

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Cerebral small vessel disease genomics and its implications across the lifespan

Auteurs: Sargurupremraj M, Suzuki H, Jian X, Sarnowski C, Evans TE, Bis JC, Eiriksdottir G, Sakaue S, Terzikhan N, Habes M, Zhao W, Armstrong NJ, Hofer E, Yanek LR, Hagenaars SP, Kumar RB, van den Akker EB, McWhirter RE, Trompet S, Mishra A, Saba Y, Satizabal CL, Beaudet G, Petit L, Tsuchida A, Zago L, Schilling S, Sigurdsson S, Gottesman RF, Lewis CE, Aggarwal NT, Lopez OL, Smith JA, Valdés Hernández MC
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Activation of Mitochondrial Complex II-Dependent Respiration Is Beneficial for α-Synucleinopathies

Auteurs: Frohlich C, Zschiebsch K, Groger V, Paarmann K, Steffen J, Thurm C, Schropp EM, Bruning T, Gellerich F, Radloff M, Schwabe R, Lachmann I, Krohn M, Ibrahim S, Pahnke J,
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LRRK2 modifies α-syn pathology and spread in mouse models and human neurons

Auteurs: Bieri G, Brahic M, Bousset L, Couthouis J, Kramer NJ, Ma R, Nakayama L, Monbureau M, Defensor E, Schüle B, Shamloo M, Melki R, Gitler AD.
Publié dans: Acta neuropathologica, 2019, ISSN 0001-6322
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Recent advances in applying mass spectrometry and systems biology to determine brain dynamics

Auteurs: Scifo E*, Calza G*, Fuhrmann M, Soliymani R, Baumann M, Lalowski M,
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Corticosteroids and Regional Variations in Thickness of the Human Cerebral Cortex across the Lifespan

Auteurs: Parker N, Vidal-Pineiro D, French L, Shin J, Adams HHH, Cox SR, Deary IJ, Fjell AM, Frenzel S, Grabe, HJ, Hosten N, Ikram MA, Jiang J, Knol MJ, Mazoyer B, Mishra A, Sachdev PS, Salum G, Schmidt H, Schmidt R, Seshadri S, Schumann G, Völzke H, Walhovd KB, Wei W, Wittfeld K, Yang Q, Debette S, Pausova Z, Paus T.
Publié dans: Cerebral cortex, 2020, ISSN 1047-3211
Éditeur: Oxford University Press
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CSF clearance in Alzheimer Disease measured with dynamic PET.

Auteurs: de Leon MJ, Li Y, Okamura N, Tsui WH, Saint Louis LA, Glodzik L, Osorio RS, Fortea J, Butler T, Pirraglia E, Fossati S, Kim HJ, Carare RO, Nedergaard M, Benveniste H, Rusinek H.
Publié dans: Journal of Nuclear Medicine, 2017, ISSN 0161-5505
Éditeur: Kexue Chubaneshe/Science Press
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Development of Disordered Eating Behaviors and Comorbid Depressive Symptoms in Adolescence: Neural and Psychopathological Predictors

Auteurs: Zuo Zhang, Lauren Robinson, Tianye Jia, Erin Burke Quinlan, Nicole Tay, Congying Chu, Edward D Barker, Tobias Banaschewski, Gareth J Barker, Arun L W Bokde, Herta Flor, Antoine Grigis, Hugh Garavan, Penny Gowland, Andreas Heinz, Bernd Ittermann, Jean-Luc Martinot, Argyris Stringaris, Jani Penttilä, Betteke van Noort, Yvonne Grimmer, Marie-Laure Paillère Martinot, Corinna Isensee, Andreas Becker,
Publié dans: Biological psychiatry, 2021, ISSN 0006-3223
Éditeur: Elsevier BV
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Common Genetic Variation Indicates Separate Causes for Periventricular and Deep White Matter Hyperintensities

Auteurs: Nicola J. Armstrong, Karen A. Mather, Muralidharan Sargurupremraj, Maria J. Knol, Rainer Malik, Claudia L. Satizabal, Lisa R. Yanek, Wei Wen, Vilmundur G. Gudnason, Nicole D. Dueker, Lloyd T. Elliott, Edith Hofer, Joshua Bis, Neda Jahanshad, Shuo Li, Mark A. Logue, Michelle Luciano, Markus Scholz, Albert V. Smith, Stella Trompet, Dina Vojinovic, Rui Xia, Fidel Alfaro-Almagro, David Ames, Najaf Ami
Publié dans: Stroke, 2020, ISSN 0039-2499
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Thickness of the cerebral cortex shows positive association with blood levels of triacylglycerols carrying 18-carbon fatty acids

Auteurs: Sliz E., Shin E., Syme C., Black S., Seshadri S., Paus T., Pausova Z.
Publié dans: Communications biology, 2020, ISSN 2399-3642
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Measurement of Rapid Protein Diffusion in the Cytoplasm by Photo-Converted Intensity Profile Expansion

Auteurs: Rotem Gura Sadovsky, Shlomi Brielle, Daniel Kaganovich, Jeremy L. England
Publié dans: Molecular Cell, 2016, ISSN 2211-1247
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Posttranslational modification impact on the mechanism by which amyloid-β induces synaptic dysfunction

Auteurs: Katarzyna M Grochowska PingAn Yuanxiang Julia Bär Rajeev Raman Gemma Brugal Giriraj Sahu Michaela Schweizer Arthur Bikbaev Stephan Schilling Hans-Ulrich Demuth Michael R Kreutz
Publié dans: EMBO reports, 2017, ISSN 1469-221X
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BACHD rats expressing full-length mutant huntingtin exhibit differences in social behavior compared to wild-type littermates

Auteurs: Giuseppe Manfré, Arianna Novati, Ilaria Faccini, Andrea C Rossetti, Kari Bosch, Raffaella Molteni, Marco A Riva, Johanneke E Van der Harst, Huu Phuc Nguyen, Judith R Homberg;
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Cellular correlates of cortical thinning throughout the lifespan

Auteurs: Didac Vidal-Pineiro, Nadine Parker, Jean Shin, Leon French, Håkon Grydeland, Andrea P. Jackowski, Athanasia M. Mowinckel, Yash Patel, Zdenka Pausova, Giovanni Salum, Øystein Sørensen, Kristine B. Walhovd, Tomas Paus, Anders M. Fjell, and the Alzheimer’s Disease Neuroimaging Initiative and the Australian Imaging Biomarkers and Lifestyle flagship study of ageing
Publié dans: Scientific reports, 2020, ISSN 2045-2322
Éditeur: Nature Publishing Group
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Reducing the amyloidogenicity of functional amyloid FapC increases its ability to inhibit a-synuclein fibrillation

Auteurs: Christensen LFB, Jensen KF, Nielsen J, Vad BS, Christiansen G, Otzen DE,
Publié dans: ACS Omega, 2019, ISSN 2470-1343
Éditeur: American Chemical Society omega
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A genome-wide association study identifies genetic loci associated with specific lobar brain volumes

Auteurs: Lee, S.J. van der; Knol, M.J.; Chauhan, G.; Satizabal, C.L.; Smith, A.V.; Hofer, E.; Bis, J.C.; Hibar, D.P.; Hilal, S.; Akker, E.B. van den; Arfanakis, K.; Bernard, M.; Yanek, L.R.; Amin, N.; Crivello, F.; Cheung, J.W.; Harris, T.B.; Saba, Y.; Lopez, O.L.; Li, S.; Grond, J. van der; Yu, L.; Paus, T.; Roshchupkin, G.V.; Amouyel, P.; Jahanshad, N.; Taylor, K.D.; Yang, Q.; Mathias, R.A.; Boehringer,
Publié dans: Communications Biology, 2019, ISSN 2399-3642
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P2Y1 receptor blockade normalizes network dysfunction and cognition in an Alzheimer's disease model.

Auteurs: Reichenbach N, Delekate A, Breithausen B, Keppler K, Poll S, Schulte T, Peter J, Plescher M, Hansen JN, Blank N, Keller A, Fuhrmann M, Henneberger C, Halle A, Petzold GC.
Publié dans: Journal of Experimental Medicine, 2018, ISSN 0022-1007
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The new genetic landscape of Alzheimer's disease: from amyloid cascade to genetically driven synaptic failure hypothesis?

Auteurs: Dourlen P, Kilinc D, Malmanche N, Chapuis J, Lambert JC.
Publié dans: Acta Neuropathol, 2019, ISSN 0001-6322
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The Role of Activity-Dependent DNA Demethylation in the Adult Brain and in Neurological Disorders

Auteurs: Bayraktar G, Kreutz MR
Publié dans: Frontiers in molecular neuroscience, 2018, ISSN 1662-5099
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Virtual histology of multi-modal magnetic resonance imaging of cerebral cortex in young men

Auteurs: Yash Patel, Jean Shin, Mark Drakesmith, John Evans, Zdenka Pausova, Tomas Paus
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Alexithymia Is Associated with Altered Cortical Thickness Networks in the General Population

Auteurs: Terock J. · Frenzel S. · Wittfeld K. · Klinger-König J. · Janowitz D. · Bülow R. · Hosten N. · Völzke H. · Grabe H.J.
Publié dans: Neuropsychobiology, 2020, ISSN 0302-282X
Éditeur: S. Karger AG
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Lack of association between proton pump inhibitor use and brain aging: a cross-sectional study

Auteurs: Nayeon Ahn, Stefan Frenzel, Katharina Wittfeld, Robin Bülow, Henry Völzke, Markus M Lerch, Jean-Francois Chenot, Ulf Schminke, Michael Nolde, Ute Amann, Christa Meisinger, Jakob Linseisen, Sebastian E Baumeister, Hans Jörgen Grabe, Ina-Maria Rückert-Eheberg
Publié dans: European Journal of Clinical Pharmacology, 2021, ISSN 0031-6970
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The neuroactive potential of the human gut microbiota in quality of life and depression

Auteurs: Mireia Valles-Colomer, Gwen Falony, Youssef Darzi, Ettje F. Tigchelaar, Jun Wang, Raul Y. Tito, Carmen Schiweck, Alexander Kurilshikov, Marie Joossens, Cisca Wijmenga, Stephan Claes, Lukas Van Oudenhove, Alexandra Zhernakova, Sara Vieira-Silva & Jeroen Raes
Publié dans: Nature microbiology, 2019, ISSN 2058-5276
Éditeur: Nature microbiology
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Anti-Inflammatory Treatment with FTY720 Starting after Onset of Symptoms Reverses Synaptic Deficits in an AD Mouse Model.

Auteurs: Georgia-Ioanna Kartalou; Georgia-Ioanna Kartalou; Ana Rita Salgueiro-Pereira; Thomas Endres; Angelina Lesnikova; Plinio C. Casarotto; Paula A. Pousinha; Kevin Delanoe; Elke Edelmann; Eero Castrén; Kurt Gottmann; Hélène Marie; Volkmar Lessmann
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Creation of a library of induced pluripotent stem cells from Parkinsonian patients

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BIN1 recovers tauopathy-induced long-term memory deficits in mice and interacts with Tau through Thr348 phosphorylation

Auteurs: Sartori, M., Mendes, T., Desai, S. et al.
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French maritime pine bark treatment decelerates plaque development and improves spatial memory in Alzheimer's disease mice

Auteurs: Paarmann K, Prakash SR, Krohn M, Mohle L, Brackhan M, Bruning T, Eiriz I, Pahnke J,
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Immunobiography and the Heterogeneity of Immune Responses in the Elderly: A Focus on Inflammaging and Trained Immunity

Auteurs: Claudio Franceschi, Stefano Salvioli, Paolo Garagnani, Magda de Eguileor, Daniela Monti and Miriam Capri
Publié dans: Frontiers in Immunology, 2017, ISSN 1664-3224
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Gut Inflammation in Association With Pathogenesis of Parkinson's Disease.

Auteurs: Chen QQ, Haikal C, Li W, Li JY.
Publié dans: Frontiers in Molecular Neuroscience, 2019, ISSN 1662-5099
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Pharmacologically diverse antidepressant drugs disrupt the interaction of BDNF receptor TRKB and the endocytic adaptor AP-2

Auteurs: SM Fred, L Laukkanen, L Vesa, H Goos, I Cardon, R Moliner, T Maritzen, M Varjosalo, PC Casarotto, E Castren
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Iatrogenic early onset cerebral amyloid angiopathy 30 years after cerebral trauma with neurosurgery: vascular amyloid deposits are made up of both Aβ40 and Aβ42

Auteurs: Giaccone G, Maderna E, Marucci G, Catania M, Erbetta A, Chiapparini L, Indaco A, Caroppo P, Bersano A, Parati E, Di Fede G, Caputi L
Publié dans: Acta Neuropathologica Communications, 2019, ISSN 2051-5960
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Phenotypic Screening Using Mouse and Human Stem Cell-Based Models of Neuroinflammation and Gene Expression Analysis to Study Drug Responses: Methods and Protocols

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Neurofilaments as blood biomarkers at the preataxic and ataxic stage of spinocerebellar ataxia type 3: a cross-species analysis in humans and mice.

Auteurs: Wilke C, Haas E, Reetz K, Faber J, Garcia-Moreno H, Santana MM, van de Warrenburg B, Hengel H, Lima M, Filla A, Durr A, Melegh B, Masciullo M, Infante J, Giunti P, Neumann M, de Vries J, Pereira de Almeida L, Rakowicz M, Jacobi H, Schuele R, Kaeser SA, Kuhle J, Klockgether T, Schoels L, SCA3 neurofilament study group, Barro C*, Huebener-Schmid J*, Synofzik M*.
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Publié dans: Neurobiology of aging, 2020, ISSN 0197-4580
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Brain aging in major depressive disorder: results from the ENIGMA major depressive disorder working group

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Neuropathology and biochemistry of early onset familial Alzheimer's disease caused by presenilin-1 missense mutation Thr116Asn

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Nucleoli and Promyelocytic Leukemia Protein (PML) bodies are phase separated nuclear protein quality control compartments for misfolded proteins

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Combinatorial treatment for spinal muscular atrophy: An Editorial for 'Combined treatment with the histone deacetylase inhibitor LBH589 and a splice-switch antisense oligonucleotide enhances SMN2 splicing and SMN expression in Spinal Muscular Atrophy cells'

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Deficiency of TLR4 ameliorates hypoperfusion-induced brain pathology

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ST Spot: a web-based application for automatic spot and tissue detection for spatial Transcriptomics image datasets.

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The Blood brain-barrier and its role in Alzheimer’s disease

Auteurs: Steffen E. Storck and Claus U. Pietrzik
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TRPV4 channels contribute to calcium transients in astrocytes and neurons during peri-infarct depolarizations in a stroke model

Auteurs: Cordula Rakers, Matthias Schmid, Gabor C. Petzold
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Methylomic profiling in trisomy 21 identifies cognition- and Alzheimer’s disease-related dysregulation

Auteurs: Haertle, Larissa; Müller, Tobias; Lardenoije, Roy; Maierhofer, Anna; Dittrich, Marcus; Riemens, Renzo J. M.; Stora, Samantha; Roche, Mathilde; Leber, Markus; Riedel-Heller, Steffi; Wagner, Michael; Scherer, Martin; Ravel, Aimé; Mircher, Clotilde; Cieuta-Walti, Cecile; Durand, Sophie; van de Hove, Daniel L. A.; Hoffmann, Per; Ramirez, Alfredo; Haaf, Thomas; El Hajj, Nady; Mégarbané, André
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PLCG2 protective variant p.P522R modulates tau pathology and disease progression in patients with mild cognitive impairment

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Obesity in geroscience — is cellular senescence the culprit?

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Trehalose alleviates the phenotype of Machado–Joseph disease mouse models

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Huntingtin phosphorylation governs BDNF homeostasis and improves the phenotype of Mecp2 knockout mice

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Exome sequencing identifies novel AD-associated genes

Auteurs: Henne Holstege, Marc Hulsman, Camille Charbonnier, Benjamin Grenier-Boley, Olivier Quenez, Detelina Grozeva, Jeroen G.J. van Rooij, Rebecca Sims, Shahzad Ahmad, Najaf Amin, Penny J. Norsworthy, Oriol Dols-Icardo, Holger Hummerich, Amit Kawalia, Philippe Amouyel, Gary W. Beecham, Claudine Berr, Joshua C. Bis, Anne Boland, Paola Bossù, Femke Bouwman, Dominique Campion, Antonio Daniele, Jean-Franço
Publié dans: Alzheimer’s and Dementia, 2020, ISSN 1552-5260
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Endocrine influence on neuroinflammation: the use of reporter systems

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The biological function of the cellular prion protein: an update

Auteurs: Wulf, Marie-Angela; Senatore, Assunta; Aguzzi, Adriano
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Parkinson’s Disease-Associated Mutant LRRK2-Mediated Inhibition of miRNA Activity is Antagonized by TRIM32

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Functional Neuroimaging Predictors of Self-Reported Psychotic Symptoms in Adolescents

Auteurs: Josiane Bourque, M.Sc., Philip A. Spechler, B.A., Stéphane Potvin, Ph.D., Robert Whelan, Ph.D., Tobias Banaschewski, M.D., Ph.D., Arun L.W. Bokde, Ph.D., Uli Bromberg, Dipl.-Psych., Christian Büchel, M.D., Erin Burke Quinlan, Ph.D., Sylvane Desrivières, Ph.D., Herta Flor, Ph.D., Vincent Frouin, Ph.D., Penny Gowland, Ph.D., Andreas Heinz, M.D., Ph.D., Bernd Ittermann, Ph.D., Jean-Luc Martinot, M
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ABCA7 Downregulation Modifies Cellular Cholesterol Homeostasis and Decreases Amyloid-β Peptide Efflux in an in vitro Model of the Blood-Brain Barrier

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Analysis of the vasculature by immunohistochemistry in paraffin-embedded brains

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An epigenome-wide association study of Alzheimer's disease blood highlights robust DNA hypermethylation in the HOXB6 gene

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Viral Infections Exacerbate FUS-ALS Phenotypes in iPSC-Derived Spinal Neurons in a Virus Species-Specific Manner.

Auteurs: Jessica Bellmann; Anne Monette; Anne Monette; Vadreenath Tripathy; Anna Sójka; Masin Abo-Rady; Antje Janosh; Rajat Bhatnagar; Marc Bickle; Andrew J. Mouland; Andrew J. Mouland; Jared Sterneckert
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The Synaptonuclear Messenger RNF10 Acts as an Architect of Neuronal Morphology

Auteurs: Nicolò Carrano, Tanmoy Samaddar, Electra Brunialti, Luca Franchini, Elena Marcello, Paolo Ciana, Daniela Mauceri, Monica Di Luca and Fabrizio Gardoni
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Successes and Hurdles in Stem Cells Application and Production for Brain Transplantation

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Publié dans: Frontiers in Neuroscience, 2019, ISSN 1662-4548
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Cerebrospinal and Interstitial Fluid Transport via the Glymphatic Pathway Modeled by Optimal Transport.

Auteurs: Ratner V, Gao Y, Lee H, Elkin R, Nedergaard M, Benveniste H, Tannenbaum A.
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A nonsynonymous mutation in PLCG2 reduces the risk of Alzheimer's disease, dementia with Lewy bodies and frontotemporal dementia, and increases the likelihood of longevity.

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Loss of Tau protein affects the structure, transcription and repair of neuronal pericentromeric heterochromatin.

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Evolution and clustering of prodromal parkinsonian features in GBA1 carriers

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Publié dans: Movement Disorders, 2019, ISSN 0885-3185
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Striatal infusion of cholesterol promotes dose-dependent behavioral benefits and exerts disease-modifying effects in Huntington's disease mice

Auteurs: Birolini G, Valenza M, Di Paolo E, Vezzoli E, Talp F, Maniezz C, Caccia C, Leoni V, F Taroni F, Bocchi VD, Conforti P, Sogne E, Petricca L, Cariulo C, Verani M, A Caricasole A, Falqui A, Biella G, Cattaneo E.
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Propagation of α-Synuclein Strains within Human Reconstructed Neuronal Network

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NF-E2-related factor 2 activation boosts antioxidant defenses and ameliorates inflammatory and amyloid properties in human Presenilin-1 mutated Alzheimer's disease astrocytes

Auteurs: Oksanen, Minna; Hyötyläinen, Ida; Trontti, Kalevi; Rolova, Taisia; Wojciechowski, Sara; Koskuvi, Marja; Viitanen, Matti; Levonen, Anna‐Liisa; Hovatta, Iiris; Roybon, Laurent; Lehtonen, Šárka; Kanninen, Katja M.; Hämäläinen, Riikka H.; Koistinaho, Jari
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Longitudinal trajectories, correlations and mortality associations of nine biological ages across 20-years follow-up.

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Caldendrin Directly Couples Postsynaptic Calcium Signals to Actin Remodeling in Dendritic Spines

Auteurs: Mikhaylova M, Bär J, van Bommel B, Schätzle P, YuanXiang P, Raman R, Hradsky J, Konietzny A, Loktionov EY, Reddy PP, Lopez-Rojas J, Spilker C, Kobler O, Raza SA, Stork O, Hoogenraad CC, Kreutz MR
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Assessment of the efficacy of different procedures that remove and disassemble alpha-synuclein, tau and A-beta fibrils from laboratory material and surfaces

Auteurs: Fenyi A, Coens A, Bellande T, Melki R, Bousset L
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Machado-Joseph Disease: A Stress Combating Deubiquitylating Enzyme Changing Sides

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Association of variants in HTRA1 and NOTCH3 with MRI-defined extremes of cerebral small vessel disease in older subjects

Auteurs: Mishra A, Chauhan G, Violleau MH, Soumare A, Vojinovic D, Jian X, Bis J, Li S, Saba Y, Yang Q, Bartz T, Hofer E, Zhu Y, Mazoyer B, Lathrop M, Schmidt H, Van Duijn C, Ikram MA, Longstreth WT, Fornage M, Seshadri S, Joutel A, Tzourio C, Debette S.
Publié dans: Brain, 2019, ISSN 0006-8950
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Genetic Background Influences the Propagation of Tau Pathology in Transgenic Rodent Models of Tauopathy

Auteurs: Smolek T, Cubinkova V, Brezovakova V, Valachova B, Szalay P, Zilka N, Jadhav S.
Publié dans: Frontiers in aging neuroscience, 2019, ISSN 1663-4365
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Isogenic FUS-eGFP iPSC Reporter Lines Enable Quantification of FUS Stress Granule Pathology that Is Rescued by Drugs Inducing Autophagy

Auteurs: L. Marrone, I. Poser, I. Casci, J. Japtok, P. Reinhardt, A. Janosch, C. Andree, H. O. Lee, C. Moebius, E. Koerner, L. Reinhardt, M. E. Cicardi, K. Hackmann, B. Klink, A. Poletti, S. Alberti, M. Bickle, A. Hermann, U. Pandey, A. A. Hyman, and J. L. Sterneckert
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ALS and FTD: Where RNA metabolism meets protein quality control

Auteurs: Mandrioli J, Mediani L, Alberti S, Carra S
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Familial Alzheimer’s Disease Lymphocytes Respond Differently Than Sporadic Cells to Oxidative Stress: Upregulated p53-p21 Signaling Linked with Presenilin 1 Mutants

Auteurs: Joanna Wojsiat; Katarzyna Laskowska-Kaszub; Carolina Alquézar; Emilia Bialopiotrowicz; Noemí Esteras; Mykola Zdioruk; Ángeles Martín-Requero; Urszula Wojda
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Human α-synuclein overexpression in a mouse model of Parkinson's disease leads to vascular pathology, blood brain barrier leakage and pericyte activation

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Presynaptic Regulation of Tonic Inhibition by Neuromodulatory Transmitters in the Basal Amygdala.

Auteurs: Meis, S., Endres, T., Munsch, T. et al.
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Traditional Japanese Herbal Medicine Yokukansan Targets Distinct but Overlapping Mechanisms in Aged Mice and in the 5xFAD Mouse Model of Alzheimer's Disease

Auteurs: Kaushik R, Morkovin E, Schneeberg J, Confettura AD, Kreutz MR, Senkov O, Dityatev A.
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SIPA1L2 controls trafficking and local signaling of TrkB-containing amphisomes at presynaptic terminals

Auteurs: Maria Andres-Alonso, Mohamed Raafet Ammar, Ioana Butnaru, Guilherme M Gomes, Gustavo Acuña Sanhueza, Rajeev Raman, PingAn Yuanxiang, Maximilian Borgmeyer, Jeffrey Lopez-Rojas, Syed Ahsan Raza, Nicola Brice, Torben J Hausrat, Tamar Macharadze, Silvia Diaz-Gonzalez, Mark Carlton, Antonio Virgilio Failla, Oliver Stork, Michaela Schweizer, Eckart D Gundelfinger, Matthias Kneussel, Christina Spilker,
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Microbiome changes: an indicator of Parkinson's disease?

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Does Global Astrocytic Calcium Signaling Participate in Awake Brain State Transitions and Neuronal Circuit Function?

Auteurs: Celia Kjaerby, Rune Rasmussen, Mie Andersen & Maiken Nedergaard
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Enriched environmental conditions modify the gut microbiome composition and fecal markers of inflammation in Parkinson’s disease

Auteurs: Yogesh Singh, Mohamed El-Hadidi, Jakob Admard, Zinah Wassouf, Julia Schulze-Hentrich, Ursula Kohlhofer, Leticia Quintanilla-Martinez, Daniel Huson, Olaf Riess, Nicolas Casadei
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RUES2 hESCs exhibit MGE-biased neuronal differentiation and muHTT-dependent defective specification hinting at SP1

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Transmission of Tau Pathology from Human to Rodent Brain: How to Humanise Animal Models for Alzheimer’s Disease Research

Auteurs: Tomas Smolek, Santosh Jadhav, Bernadeta Valachova, Thomas Vogels, Jaroslav Legath, Petr Novak and Norbert Zilka
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Neuronal network maturation differently affects secretory vesicles and mitochondria transport in axons

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Simulation, Implementation and Measurement of Defined Sound Fields for Blood–Brain Barrier Opening in Rats

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The Clustering of mApoE Anti-Amyloidogenic Peptide on Nanoparticle Surface Does Not Alter Its Performance in Controlling Beta-Amyloid Aggregation

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Effects of pharmacological modulators of α-synuclein and tau aggregation and internalization.

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High dilated perivascular space burden: a new MRI marker for risk of intracerebral hemorrhage

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Memory enhancement by ferulic acid ester across species.

Auteurs: Michels, Birgit; Zwaka, Hanna; Bartels, Ruth; Lushchak, Oleh; Franke, Katrin; Endres, Thomas; Fendt, Markus; Song, Inseon; Bakr, May; Budragchaa, Tuvshinjargal; Westermann, Bernhard; Mishra, Dushyant; Eschbach, Claire; Schreyer, Stefanie; Lingnau, Annika; Vahl, Caroline; Hilker, Marike; Menzel, Randolf; Kähne, Thilo; Leßmann, Volkmar; Dityatev, Alexander; Wessjohann, Ludger; Gerber, Bertram
Publié dans: Science advances, 2018, ISSN 2375-2548
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Dynamic susceptibility contrast and diffusion MR imaging identify oligodendroglioma as defined by the 2016 WHO classification for brain tumors: histogram analysis approach

Auteurs: Latysheva, Anna; Emblem, Kyrre Eeg; Brandal, Petter; Vik-Mo, Einar Osland; Pahnke, Jens; Røysland, Kjetil; Hald, John K.; Server, Andrés
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Impact of demography and population dynamics on the genetic architecture of human longevity.

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Reverse NCX Attenuates Cellular Sodium Loading in Metabolically Compromised Cortex.

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Publié dans: Cerebral Cortex, 2018, ISSN 1047-3211
Éditeur: Oxford University Press
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Impairment of Glycolysis-Derived l-Serine Production in Astrocytes Contributes to Cognitive Deficits in Alzheimer's Disease.

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Generation of a human induced pluripotent stem cell line from a patient with a rare A673T variant in amyloid precursor protein gene that reduces the risk for Alzheimer's disease

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Quantification of Total and Mutant Huntingtin Protein Levels in Biospecimens Using a Novel alphaLISA Assay

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A customizable microfluidic platform for medium-throughput modeling of neuromuscular circuits

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Novel Players in the Aging Synapse: Impact on Cognition

Auteurs: Mariana Temido-Ferreira; Joana E. Coelho; Paula A. Pousinha; Luísa V. Lopes
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Molecular Targets and Therapeutic Strategies in Spinocerebellar Ataxia Type 7

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Muscleblind acts as a modifier of FUS toxicity by modulating stress granule dynamics and SMN localization

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Common variants in Alzheimer’s disease: Novel association of six genetic variants with AD and risk stratification by polygenic risk scores.

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Dipeptidyl Vinyl Sulfone as a Novel Chemical Tool to Inhibit HMGB1/NLRP3-Inflammasome and Inflamma-miRs in Aβ-Mediated Microglial Inflammation

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Astroglial NF-kB contributes to white matter damage and cognitive impairment in a mouse model of vascular dementia

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Bacterial amyloids: biogenesis and biomaterials

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Astrocytic calcium release mediates peri-infarct depolarizations in a rodent stroke model.

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Autophagic and Proteasomal Mediated Removal of Mutant Androgen Receptor in Muscle Models of Spinal and Bulbar Muscular Atrophy

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The sheaths of Methanospirillum are made of a new type of amyloid protein

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Focal solute trapping and global glymphatic pathway impairment in a murine model of microinfarcts.

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Towards the Identification of Molecular Biomarkers of Spinocerebellar Ataxia Type 3 (SCA3)/Machado-Joseph Disease (MJD)

Auteurs: Manuela Lima, Mafalda Raposo
Publié dans: Polyglutamine Disorders, 2018, ISSN 0065-2598
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