Laser-induced vapour nanobubbles for intracellular delivery of nanomaterials and treatment of biofilm infections

Pubblicazioni

Bypassing Border Control: Nuclear Envelope Rupture in Disease

Autori: Gaëlle Houthaeve, Joke Robijns, Kevin Braeckmans, Winnok H. De Vos
Pubblicato in: Physiology, Numero 33/1, 2018, Pagina/e 39-49, ISSN 1548-9213
Editore: American Physiological Society
DOI: 10.1152/physiol.00029.2017

Cytosolic delivery of gadolinium via photoporation enables improved in vivo magnetic resonance imaging of cancer cells

Autori: Aranit Harizaj, Benedicte Descamps, Christophe Mangodt, Stephan Stremersch, Arianna Stoppa, Lieve Balcaen, Toon Brans, Hilde De Rooster, Nausikaa Devriendt, Juan C. Fraire, Eduardo Bolea-Fernandez, Olivier De Wever, Wouter Willaert, Frank Vanhaecke, Christian V. Stevens, Stefaan C. De Smedt, Bart Roman, Christian Vanhove, Ine Lentacker, Kevin Braeckmans
Pubblicato in: Biomaterials Science, Numero 9/11, 2021, Pagina/e 4005-4018, ISSN 2047-4830
Editore: Royal Society of Chemistry
DOI: 10.1039/d1bm00479d

Surface Functionalization with Polyethylene Glycol and Polyethyleneimine Improves the Performance of Graphene-Based Materials for Safe and Efficient Intracellular Delivery by Laser-Induced Photoporation

Autori: Jing Liu, Chengnan Li, Toon Brans, Aranit Harizaj, Shana Van de Steene, Thomas De Beer, Stefaan De Smedt, Sabine Szunerits, Rabah Boukherroub, Ranhua Xiong, Kevin Braeckmans
Pubblicato in: International Journal of Molecular Sciences, Numero 21/4, 2020, Pagina/e 1540, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21041540

Exploring Light-Sensitive Nanocarriers for Simultaneous Triggered Antibiotic Release and Disruption of Biofilms Upon Generation of Laser-Induced Vapor Nanobubbles

Autori: Eline Teirlinck, Alexandre Barras, Jing Liu, Juan C. Fraire, Tatu Lajunen, Ranhua Xiong, Katrien Forier, Chengnan Li, Arto Urtti, Rabah Boukherroub, Sabine Szunerits, Stefaan C. De Smedt, Tom Coenye, Kevin Braeckmans
Pubblicato in: Pharmaceutics, Numero 11/5, 2019, Pagina/e 201, ISSN 1999-4923
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics11050201

Laser-induced vapor nanobubbles improve diffusion in biofilms of antimicrobial agents for wound care

Autori: E. Teirlinck, J.C. Fraire, H. Van Acker, J. Wille, R. Swimberghe, T. Brans, R. Xiong, M. Meire, R.J.G. De Moor, S.C. De Smedt, T. Coenye, K. Braeckmans
Pubblicato in: Biofilm, Numero 1, 2019, Pagina/e 100004, ISSN 2590-2075
Editore: Elsevier
DOI: 10.1016/j.bioflm.2019.100004

Intracellular Labeling with Extrinsic Probes: Delivery Strategies and Applications

Autori: Jing Liu, Juan C. Fraire, Stefaan C. De Smedt, Ranhua Xiong, Kevin Braeckmans
Pubblicato in: Small, Numero 16/22, 2020, Pagina/e 2000146, ISSN 1613-6810
Editore: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/smll.202000146

Gold Nanoparticle-Mediated Photoporation Enables Delivery of Macromolecules over a Wide Range of Molecular Weights in Human CD4+ T Cells

Autori: Laurens Raes, Clarissa Van Hecke, Julie Michiels, Stephan Stremersch, Juan C. Fraire, Toon Brans, Ranhua Xiong, Stefaan De Smedt, Linos Vandekerckhove, Koen Raemdonck, Kevin Braeckmans
Pubblicato in: Crystals, Numero 9/8, 2019, Pagina/e 411, ISSN 2073-4352
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cryst9080411

Nanoparticle-sensitized photoporation enables inflammasome activation studies in targeted single cells

Autori: Aranit Harizaj, Filip Van Hauwermeiren, Stephan Stremersch, Riet De Rycke, Herlinde De Keersmaecker, Toon Brans, Juan C. Fraire, Karolien Grauwen, Stefaan C. De Smedt, Ine Lentacker, Mohamed Lamkanfi, Kevin Braeckmans
Pubblicato in: Nanoscale, Numero 13/13, 2021, Pagina/e 6592-6604, ISSN 2040-3364
Editore: Royal Society of Chemistry
DOI: 10.1039/d0nr05067a

Delivery of Mixed-Lineage Kinase Domain-Like Protein by Vapor Nanobubble Photoporation Induces Necroptotic-Like Cell Death in Tumor Cells

Autori: Lien Van Hoecke, Laurens Raes, Stephan Stremersch, Toon Brans, Juan C. Fraire, Ria Roelandt, Wim Declercq, Peter Vandenabeele, Koen Raemdonck, Kevin Braeckmans, Xavier Saelens
Pubblicato in: International Journal of Molecular Sciences, Numero 20/17, 2019, Pagina/e 4254, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms20174254

Comparing photoporation and nucleofection for delivery of small interfering RNA to cytotoxic T cells

Autori: Laura Wayteck, Ranhua Xiong, Kevin Braeckmans, Stefaan C. De Smedt, Koen Raemdonck
Pubblicato in: Journal of Controlled Release, Numero 267, 2017, Pagina/e 154-162, ISSN 0168-3659
Editore: Elsevier BV
DOI: 10.1016/j.jconrel.2017.08.002

Fast spatial-selective delivery into live cells

Autori: Ranhua Xiong, Claire Drullion, Peter Verstraelen, Jo Demeester, Andre G. Skirtach, Corinne Abbadie, Winnok H. De Vos, Stefaan C. De Smedt, Kevin Braeckmans
Pubblicato in: Journal of Controlled Release, Numero 266, 2017, Pagina/e 198-204, ISSN 0168-3659
Editore: Elsevier BV
DOI: 10.1016/J.JCONREL.2017.09.033

Selective Labeling of Individual Neurons in Dense Cultured Networks With Nanoparticle-Enhanced Photoporation

Autori: Ranhua Xiong, Peter Verstraelen, Jo Demeester, Andre G. Skirtach, Jean-Pierre Timmermans, Stefaan C. De Smedt, Winnok H. De Vos, Kevin Braeckmans
Pubblicato in: Frontiers in Cellular Neuroscience, Numero 12, 2018, Pagina/e Article 80, ISSN 1662-5102
Editore: Frontiers Research Foundation
DOI: 10.3389/fncel.2018.00080

Photothermally Triggered Endosomal Escape and Its Influence on Transfection Efficiency of Gold-Functionalized JetPEI/pDNA Nanoparticles

Autori: Lotte Vermeulen, Juan Fraire, Laurens Raes, Ellen De Meester, Sarah De Keulenaer, Filip Van Nieuwerburgh, Stefaan De Smedt, Katrien Remaut, Kevin Braeckmans
Pubblicato in: International Journal of Molecular Sciences, Numero 19/8, 2018, Pagina/e 2400, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms19082400

Cytosolic Delivery of Nanolabels Prevents Their Asymmetric Inheritance and Enables Extended Quantitative in Vivo Cell Imaging

Autori: Ranhua Xiong, Freya Joris, Sayuan Liang, Riet De Rycke, Saskia Lippens, Jo Demeester, Andre Skirtach, Koen Raemdonck, Uwe Himmelreich, Stefaan C. De Smedt, Kevin Braeckmans
Pubblicato in: Nano Letters, Numero 16/10, 2016, Pagina/e 5975-5986, ISSN 1530-6984
Editore: American Chemical Society
DOI: 10.1021/acs.nanolett.6b01411

Laser-assisted photoporation: fundamentals, technological advances and applications

Autori: Ranhua Xiong, Sangram Keshari Samal, Jo Demeester, Andre G. Skirtach, Stefaan C. De Smedt, Kevin Braeckmans
Pubblicato in: Advances in Physics: X, Numero 1/4, 2016, Pagina/e 596-620, ISSN 2374-6149
Editore: Taylor & Francis Online
DOI: 10.1080/23746149.2016.1228476

Sizing nanomaterials in bio-fluids by cFRAP enables protein aggregation measurements and diagnosis of bio-barrier permeability

Autori: Ranhua Xiong, Roosmarijn E. Vandenbroucke, Katleen Broos, Toon Brans, Elien Van Wonterghem, Claude Libert, Jo Demeester, Stefaan C. De Smedt, Kevin Braeckmans
Pubblicato in: Nature Communications, Numero 7, 2016, Pagina/e 12982, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/ncomms12982

Targeted Perturbation of Nuclear Envelope Integrity with Vapor Nanobubble-Mediated Photoporation

Autori: Gaëlle Houthaeve, Ranhua Xiong, Joke Robijns, Bert Luyckx, Yasmine Beulque, Toon Brans, Coen Campsteijn, Sangram K. Samal, Stephan Stremersch, Stefaan C. De Smedt, Kevin Braeckmans, Winnok H. De Vos
Pubblicato in: ACS Nano, Numero 12/8, 2018, Pagina/e 7791-7802, ISSN 1936-0851
Editore: American Chemical Society
DOI: 10.1021/acsnano.8b01860

Long-term live-cell microscopy with labeled nanobodies delivered by laser-induced photoporation

Autori: Jing Liu, Tim Hebbrecht, Toon Brans, Eef Parthoens, Saskia Lippens, Chengnan Li, Herlinde De Keersmaecker, Winnok H. De Vos, Stefaan C. De Smedt, Rabah Boukherroub, Jan Gettemans, Ranhua Xiong, Kevin Braeckmans
Pubblicato in: Nano Research, Numero 13/2, 2020, Pagina/e 485-495, ISSN 1998-0124
Editore: Tsinghua Univ Press
DOI: 10.1007/s12274-020-2633-z

Repeated photoporation with graphene quantum dots enables homogeneous labeling of live cells with extrinsic markers for fluorescence microscopy

Autori: Jing Liu, Ranhua Xiong, Toon Brans, Saskia Lippens, Eef Parthoens, Francesca Cella Zanacchi, Raffaella Magrassi, Santosh K. Singh, Sreekumar Kurungot, Sabine Szunerits, Hannelore Bové, Marcel Ameloot, Juan C. Fraire, Eline Teirlinck, Sangram Keshari Samal, Riet De Rycke, Gaëlle Houthaeve, Stefaan C. De Smedt, Rabah Boukherroub, Kevin Braeckmans
Pubblicato in: Light: Science & Applications, Numero 7/1, 2018, ISSN 2047-7538
Editore: Springer Nature
DOI: 10.1038/s41377-018-0048-3

Non-viral transfection technologies for next-generation therapeutic T cell engineering

Autori: Laurens Raes, Stefaan C. De Smedt, Koen Raemdonck, Kevin Braeckmans
Pubblicato in: Biotechnology Advances, Numero 49, 2021, Pagina/e 107760, ISSN 0734-9750
Editore: Elsevier BV
DOI: 10.1016/j.biotechadv.2021.107760

Physical transfection technologies for macrophages and dendritic cells in immunotherapy

Autori: Aranit Harizaj, Stefaan C. De Smedt, Ine Lentacker, Kevin Braeckmans
Pubblicato in: Expert Opinion on Drug Delivery, Numero 18/2, 2021, Pagina/e 229-247, ISSN 1742-5247
Editore: Ashley Publications Ltd.
DOI: 10.1080/17425247.2021.1828340

Laser-induced vapour nanobubbles improve drug diffusion and efficiency in bacterial biofilms

Autori: Eline Teirlinck, Ranhua Xiong, Toon Brans, Katrien Forier, Juan Fraire, Heleen Van Acker, Nele Matthijs, Riet De Rycke, Stefaan C. De Smedt, Tom Coenye, Kevin Braeckmans
Pubblicato in: Nature Communications, Numero 9/1, 2018, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-018-06884-w

Stimuli-responsive nanobubbles for biomedical applications

Autori: Ranhua Xiong, Ronald X. Xu, Chaobo Huang, Stefaan De Smedt, Kevin Braeckmans
Pubblicato in: Chemical Society Reviews, Numero 50/9, 2021, Pagina/e 5746-5776, ISSN 0306-0012
Editore: Royal Society of Chemistry
DOI: 10.1039/c9cs00839j

Diritti di proprietà intellettuale

Carbon-based particles for vapour bubble generation

Numero candidatura/pubblicazione: PCT/EP2016/ 065075
Data: 2016-06-29

Carbon-based particles for vapour bubble generation

Numero candidatura/pubblicazione: PCT/EP2016/ 065075
Data: 2016-06-29

Carbon-based particles for vapour bubble generation

Numero candidatura/pubblicazione: PCT/EP2016/ 065075
Data: 2016-06-29

Disruption or alteration of microbiological films

Numero candidatura/pubblicazione: PCT/EP2016/ 065073
Data: 2016-06-29

Disruption or alteration of microbiological films

Numero candidatura/pubblicazione: PCT/EP2016/ 065073
Data: 2016-06-29

Disruption or alteration of microbiological films

Numero candidatura/pubblicazione: PCT/EP2016/ 065073
Data: 2016-06-29

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