Regulating the immune regulators: targeting adaptive immune control

Informazioni relative al progetto

REGiREG

ID dell’accordo di sovvenzione: 648145

DOI 10.3030/648145

Progetto chiuso

Data della firma CE 9 Giugno 2015

Data di avvio 1 Luglio 2015

Data di completamento 30 Giugno 2021

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale € 1 955 000,00

Contributo UE € 1 955 000,00

Coordinato da

KLINIKUM DER UNIVERSITAET REGENSBURG
Germany

Pubblicazioni

Peer reviewed articles (8)

Quantitative Proteomics Identifies TCF1 as a Negative Regulator of Foxp3 Expression in Conventional T Cells

Autori: Michael Delacher, Melanie M. Barra, Yonatan Herzig, Katrin Eichelbaum, Mahmoud-Reza Rafiee, David M. Richards, Ulrike Träger, Ann-Cathrin Hofer, Alexander Kazakov, Kathrin L. Braband, Marina Gonzalez, Lukas Wöhrl, Kathrin Schambeck, Charles D. Imbusch, Jakub Abramson, Jeroen Krijgsveld, Markus Feuerer
Pubblicato in: iScience, Numero 23/5, 2020, Pagina/e 101127, ISSN 2589-0042
Editore: ELSEVIER
DOI: 10.1016/j.isci.2020.101127

Re-examining the Nature and Function of Self-Reactive T cells

Autori: David M. Richards, Bruno Kyewski, Markus Feuerer
Pubblicato in: Trends in Immunology, Numero 37/2, 2016, Pagina/e 114-125, ISSN 1471-4906
Editore: Elsevier BV
DOI: 10.1016/j.it.2015.12.005

Genome-wide DNA-methylation landscape defines specialization of regulatory T cells in tissues

Autori: Michael Delacher, Charles D Imbusch, Dieter Weichenhan, Achim Breiling, Agnes Hotz-Wagenblatt, Ulrike Träger, Ann-Cathrin Hofer, Danny Kägebein, Qi Wang, Felix Frauhammer, Jan-Philipp Mallm, Katharina Bauer, Carl Herrmann, Philipp A Lang, Benedikt Brors, Christoph Plass, Markus Feuerer
Pubblicato in: Nature Immunology, Numero 18/10, 2017, Pagina/e 1160-1172, ISSN 1529-2908
Editore: Nature Publishing Group
DOI: 10.1038/ni.3799

Rbpj expression in regulatory T cells is critical for restraining TH2 responses

Autori: Michael Delacher, Christian Schmidl, Yonatan Herzig, Minka Breloer, Wiebke Hartmann, Fabian Brunk, Danny Kägebein, Ulrike Träger, Ann-Cathrin Hofer, Sebastian Bittner, Dieter Weichenhan, Charles D. Imbusch, Agnes Hotz-Wagenblatt, Thomas Hielscher, Achim Breiling, Giuseppina Federico, Hermann-Josef Gröne, Roland M. Schmid, Michael Rehli, Jakub Abramson, Markus Feuerer
Pubblicato in: Nature Communications, Numero 10/1, 2019, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-019-09276-w

Epigenetic mechanisms regulating T-cell responses

Autori: Christian Schmidl, Michael Delacher, Jochen Huehn, Markus Feuerer
Pubblicato in: Journal of Allergy and Clinical Immunology, Numero 142/3, 2018, Pagina/e 728-743, ISSN 0091-6749
Editore: Mosby Inc.
DOI: 10.1016/j.jaci.2018.07.014

Precursors for Nonlymphoid-Tissue Treg Cells Reside in Secondary Lymphoid Organs and Are Programmed by the Transcription Factor BATF

Autori: Michael Delacher, Charles D. Imbusch, Agnes Hotz-Wagenblatt, Jan-Philipp Mallm, Katharina Bauer, Malte Simon, Dania Riegel, André F. Rendeiro, Sebastian Bittner, Lieke Sanderink, Asmita Pant, Lisa Schmidleithner, Kathrin L. Braband, Bernd Echtenachter, Alexander Fischer, Valentina Giunchiglia, Petra Hoffmann, Matthias Edinger, Christoph Bock, Michael Rehli, Benedikt Brors, Christian Schmidl, Mark
Pubblicato in: Immunity, 2020, ISSN 1074-7613
Editore: Cell Press
DOI: 10.1016/j.immuni.2019.12.002

Single-cell chromatin accessibility landscape identifies tissue repair program in human regulatory T cells

Autori: Michael Delacher, Malte Simon, Lieke Sanderink, Agnes Hotz-Wagenblatt, Marina Wuttke, Kathrin Schambeck, Lisa Schmidleithner, Sebastian Bittner, Asmita Pant, Uwe Ritter, Thomas Hehlgans, Dania Riegel, Verena Schneider, Florian Kai Groeber-Becker, Andreas Eigenberger, Claudia Gebhard, Nicholas Strieder, Alexander Fischer, Michael Rehli, Petra Hoffmann, Matthias Edinger, Till Strowig, Jochen Huehn,
Pubblicato in: Immunity, Numero 54/4, 2021, Pagina/e 702-720.e17, ISSN 1074-7613
Editore: Cell Press
DOI: 10.1016/j.immuni.2021.03.007

Recirculating IL-1R2+ Tregs fine-tune intrathymic Treg development under inflammatory conditions

Autori: Eirini Nikolouli, Yassin Elfaki, Susanne Herppich, Carsten Schelmbauer, Michael Delacher, Christine Falk, Ilgiz A. Mufazalov, Ari Waisman, Markus Feuerer, Jochen Huehn
Pubblicato in: Cellular & Molecular Immunology, Numero 18/1, 2021, Pagina/e 182-193, ISSN 1672-7681
Editore: Nature Publishing Group
DOI: 10.1038/s41423-019-0352-8