Projektbeschreibung
Gibt es einen Zusammenhang zwischen kardiometabolischen Erkrankungen und Krebs?
Das vom Europäischen Forschungsrat finanzierte Projekt BIOMENDELIAN zielt darauf ab, die mangelnde Integration zwischen der Forschung zu kardiometabolischen Krankheiten (Herz-Kreislauf-Erkrankungen, Diabetes Typ 2, Adipositas) und Krebs zu beheben. Im Rahmen des Projekts werden ihre gemeinsamen Krankheitsverläufe und Behandlungsziele anhand einer großen zukünftigen Kohorte mit einer Nachbeobachtungszeit von über 15 Jahren untersucht. Die ursächlichen Faktoren, die diese Krankheiten miteinander verbinden und voneinander trennen, einschließlich genetischer Risikofaktoren, werden ebenso untersucht wie die Wechselwirkungen zwischen Darmmikrobiota, Wirtsernährung und genetischer Anfälligkeit. Darüber hinaus werden die Forschenden verschiedene Interventionsstudien mithilfe von Genotypen, Biomarkern und auf der Darmmikrobiota basierenden Ansätzen durchführen. Insgesamt geht es darum, personalisierte Präventions- und Behandlungsstrategien für Personen mit hohem Risiko zu verbessern.
Ziel
Cardiovascular disease (CVD), type 2 diabetes (T2D) and obesity, collectively referred to as cardiometabolic disease, together with cancer are the major morbidities and causes of death. With few exceptions, research on cardiometabolic disease and cancer is funded, studied and clinically applied separately without fully taking advantage of knowledge on common pathways and treatment targets through interdisciplinary synergies. The purpose of this proposal is to reveal causal factors connecting and disconnecting cardiometabolic diseases and cancer, and to understand interactions between gut microbiota, host diet and genetic susceptibility in a comprehensive prospective cohort study design to subsequently allow design of intervention strategies to guide more personalized disease prevention.
1. We investigate causality between genetic risk factors for cardiometabolic disease associated traits and future incidence of T2D, CVD, cancer (total/breast/colon/prostate) and mortality (total, CVD- and cancer mortality), searching for causal factors in a prospective cohort with >15 y follow-up (N>30,000, incident cases N=3550, 4713, 5975, 6115 for T2D, CVD, cancer, mortality)
2. For the first time in a large population (N=6000), we investigate how gut and oral microbiome are regulated by dietary factors, gut satiety peptides and host genetics, and how such connections relate to cardiometabolic disease associated traits and cancer
3. We investigate the role of diet and gene-diet interactions of importance for cardiometabolic disease and cancer
4. We perform genotype, biomarker and gut microbiota based diet intervention studies.
This inter-disciplinary project contributes to biological understanding of basic disease mechanisms and takes steps towards better possibilities to prevent and treat individuals at high risk for cardiometabolic disease, cancer and death.
Wissenschaftliches Gebiet
- medical and health sciencesclinical medicineendocrinologydiabetes
- medical and health sciencesclinical medicinecardiologycardiovascular diseases
- medical and health sciencesclinical medicineoncology
- medical and health scienceshealth sciencesnutritionobesity
- medical and health sciencesclinical medicinenephrologykidney diseases
Programm/Programme
Thema/Themen
Finanzierungsplan
ERC-COG - Consolidator GrantGastgebende Einrichtung
22100 Lund
Schweden