Descrizione del progetto
Esiste un legame fra malattie cardiometaboliche e cancro?
Il progetto BIOMENDELIAN è finanziato dal Consiglio europeo della ricerca e intende risolvere la mancanza di integrazione fra la ricerca sulle malattie cardiometaboliche (malattia cardiovascolare, diabete mellito di tipo 2, obesità) e il cancro. Il progetto studierà i percorsi e i bersagli delle terapie che li accomunano mediante un’ampia coorte prospettica con oltre 15 anni di follow-up. I fattori causali che collegano e scollegano queste malattie, compresi i fattori di rischio genetici, saranno esaminati insieme alle interazioni fra microbiota intestinale, dieta dell’ospite e suscettibilità genetica. Inoltre, i ricercatori condurranno diversi studi di intervento utilizzando approcci basati sul genotipo, sui biomarcatori e sul microbiota intestinale. Nel complesso, l’obiettivo è quello di migliorare le strategie personalizzate di prevenzione e trattamento delle malattie per gli individui ad alto rischio.
Obiettivo
Cardiovascular disease (CVD), type 2 diabetes (T2D) and obesity, collectively referred to as cardiometabolic disease, together with cancer are the major morbidities and causes of death. With few exceptions, research on cardiometabolic disease and cancer is funded, studied and clinically applied separately without fully taking advantage of knowledge on common pathways and treatment targets through interdisciplinary synergies. The purpose of this proposal is to reveal causal factors connecting and disconnecting cardiometabolic diseases and cancer, and to understand interactions between gut microbiota, host diet and genetic susceptibility in a comprehensive prospective cohort study design to subsequently allow design of intervention strategies to guide more personalized disease prevention.
1. We investigate causality between genetic risk factors for cardiometabolic disease associated traits and future incidence of T2D, CVD, cancer (total/breast/colon/prostate) and mortality (total, CVD- and cancer mortality), searching for causal factors in a prospective cohort with >15 y follow-up (N>30,000, incident cases N=3550, 4713, 5975, 6115 for T2D, CVD, cancer, mortality)
2. For the first time in a large population (N=6000), we investigate how gut and oral microbiome are regulated by dietary factors, gut satiety peptides and host genetics, and how such connections relate to cardiometabolic disease associated traits and cancer
3. We investigate the role of diet and gene-diet interactions of importance for cardiometabolic disease and cancer
4. We perform genotype, biomarker and gut microbiota based diet intervention studies.
This inter-disciplinary project contributes to biological understanding of basic disease mechanisms and takes steps towards better possibilities to prevent and treat individuals at high risk for cardiometabolic disease, cancer and death.
Campo scientifico
- medical and health sciencesclinical medicineendocrinologydiabetes
- medical and health sciencesclinical medicinecardiologycardiovascular diseases
- medical and health sciencesclinical medicineoncology
- medical and health scienceshealth sciencesnutritionobesity
- medical and health sciencesclinical medicinenephrologykidney diseases
Programma(i)
Argomento(i)
Meccanismo di finanziamento
ERC-COG - Consolidator GrantIstituzione ospitante
22100 Lund
Svezia