Macroporous Polymer Monoliths as a Low-Cost Bioanalytical Platform for Biopharmaceutical Glycoprotein

Projektinformationen

PoreSelect

ID Finanzhilfevereinbarung: 656259

DOI 10.3030/656259

Abgeschlossenes Projekt

EK-Unterschriftsdatum 12 März 2015

Startdatum 15 Februar 2016

Enddatum 14 Februar 2018

Finanziert unter

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Gesamtkosten € 175 866,00

EU-Beitrag € 175 866,00

Koordiniert durch

ROYAL COLLEGE OF SURGEONS IN IRELAND
Ireland

Ziel

Glycoprotein therapeutics are widely seen as the next generation of drugs. 80% of new therapeutic drugs in phase 3 development are ‘biologics’. However, the early detection of critical glycosylation changes in biopharma pro-duction (i.e. in the drug producing cells) and the rapid and sensitive identification and separation of closely relat-ed protein-drug glycoforms presents an industry wide problem. This project aims to develop a low-cost and easy-to-produce glycopeptide separation platform. This will be based on highly porous polyHIPE structures obtained from fast and scalable polymerisation and subsequently functionalised with reactive groups. The latter will be employed in the conjugation with novel recombinant lectins that have very selective carbohydrate-binding prop-erties. The separation of closely related glycoproteins will be investigated. Moreover, the integration of the lectin conjugated porous polymers into a device format will be addressed. This is a highly interdisciplinary project at the interface of polymer and material science, biotechnology and separation science. The applicants diverse experi-ence in academic and industrially informed projects makes him an ideal match for this project. It provides a unique environment for the researcher to develop his skills supported by unique scientific and complementary training and accelerate his academic career in applied material science. The dissemination of research results will target the professional audience as well the general public through outreach activities.

Wissenschaftliches Gebiet

• natural sciences › chemical sciences › inorganic chemistry › alkali metals
• natural sciences › chemical sciences › polymer sciences
• natural sciences › biological sciences › biochemistry › biomolecules › carbohydrates
• natural sciences › chemical sciences › organic chemistry › amines
• natural sciences › chemical sciences › analytical chemistry › mass spectrometry

Programm/Programme

• H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions Main Programme
• H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility

Thema/Themen

• MSCA-IF-2014-EF - Marie Skłodowska-Curie Individual Fellowships (IF-EF)

Aufforderung zur Vorschlagseinreichung

H2020-MSCA-IF-2014

Finanzierungsplan

MSCA-IF-EF-ST - Standard EF

Koordinator

ROYAL COLLEGE OF SURGEONS IN IRELAND

• Netto-EU-Beitrag: € 175 866,00
• Adresse: ST STEPHEN'S GREEN 123 ; 2 Dublin ; Irland
• Region: Ireland › Northern and Western › Border
• Aktivitätstyp: Higher or Secondary Education Establishments
• Gesamtkosten: € 175 866,00

Beteiligte (1)

DUBLIN CITY UNIVERSITY

Beteiligung beendet

Irland

• Netto-EU-Beitrag: € 0,00
• Adresse: Glasnevin ; 9 Dublin
• Region: Ireland › Eastern and Midland › Dublin
• Aktivitätstyp: Higher or Secondary Education Establishments
• Gesamtkosten: Keine Daten