Leverage research EXCELLence and INNOVation potential of Instituto de Medicina Molecular (IMM) through translational biomedical research in immunity and infection.

Deliverables

Re-evaluation of current state of IMM towards ERA priorities
Publications in the research field of immunity and infection of the Instituto de Medicina Molecular

A one-page statement that the task has been completed.

Acquisition of the pre-clinical molecular and imaging equipment
Organisation of thematic Workshops – first period

Organisation of thematic Workshops held during the first period

Organisation of thematic Workshops – second period

Organisation of thematic Workshops held during the second reporting period

Self-assessment after 2-year period of strategy implementation
Organisation of thematic Workshops – third period

Organisation of thematic Workshops held during the third reporting period

Launch of website
Development of the project logo/brand
Forum for overseas discussion in translational immunity and infection
Brochure and flyer development

Publications

Controlling the pandemic during the SARS-CoV-2 vaccination rollout

Author(s): João Viana, Christiaan H. van Dorp, Ana Nunes, Manuel C. Gomes, Michiel van Boven, Mirjam E. Kretzschmar, Marc Veldhoen, Ganna Rozhnova
Published in: Nature Communications, Issue 12/1, 2021, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-021-23938-8

Th17 Cells Require You to Chew before You Swallow

Author(s): Marc Veldhoen
Published in: Immunity, Issue 46/1, 2017, Page(s) 8-10, ISSN 1074-7613
Publisher: Cell Press
DOI: 10.1016/j.immuni.2016.12.016

Seroprevalence of anti‐SARS‐CoV‐2 antibodies in COVID‐19 patients and healthy volunteers up to 6 months post disease onset

Author(s): Patrícia Figueiredo‐Campos, Birte Blankenhaus, Catarina Mota, Andreia Gomes, Marta Serrano, Silvia Ariotti, Catarina Costa, Helena Nunes‐Cabaço, António M. Mendes, Pedro Gaspar, M. Conceição Pereira‐Santos, Fabiana Rodrigues, Jorge Condeço, M. Antonia Escoval, Matilde Santos, Mario Ramirez, José Melo‐Cristino, J. Pedro Simas, Eugenia Vasconcelos, Ângela Afonso, Marc Veldhoen
Published in: European Journal of Immunology, Issue 50/12, 2020, Page(s) 2025-2040, ISSN 0014-2980
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/eji.202048970

3-hydroxy-L-kynurenamine is an immunomodulatory biogenic amine

Author(s): Cristina C. Clement, Angelo D’Alessandro, Sangeetha Thangaswamy, Samantha Chalmers, Raquel Furtado, Sheila Spada, Giada Mondanelli, Federica Ianni, Sarah Gehrke, Marco Gargaro, Giorgia Manni, Luisa Carlota Lopez Cara, Peter Runge, Wanxia Li Tsai, Sinem Karaman, Jorge Arasa, Ruben Fernandez-Rodriguez, Amanda Beck, Antonio Macchiarulo, Massimo Gadina, Cornelia Halin, Francesca Fallarino, Mihaela S
Published in: Nature Communications, Issue 12/1, 2021, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-021-24785-3

Smarcad1 mediates microbiota-induced inflammation in mouse and coordinates gene expression in the intestinal epithelium

Author(s): Juri Kazakevych, Jérémy Denizot, Anke Liebert, Mariana Portovedo, Mia Mosavie, Payal Jain, Claudia Stellato, Claire Fraser, Renan Oliveira Corrêa, Marina Célestine, Raphaël Mattiuz, Hanneke Okkenhaug, J. Ross Miller, Marco Aurélio Ramirez Vinolo, Marc Veldhoen, Patrick Varga-Weisz
Published in: Genome Biology, Issue 21/1, 2020, ISSN 1474-760X
Publisher: BMC
DOI: 10.1186/s13059-020-01976-7

Loss of Phosphatidylinositol 3-Kinase Activity in Regulatory T Cells Leads to Neuronal Inflammation

Author(s): Anne-Katrien Stark, Elizabeth C. M. Davenport, Daniel T. Patton, Cheryl L. Scudamore, Bart Vanhaesebroeck, Marc Veldhoen, Oliver A. Garden, Klaus Okkenhaug
Published in: The Journal of Immunology, Issue 205/1, 2020, Page(s) 78-89, ISSN 0022-1767
Publisher: American Association of Immunologists
DOI: 10.4049/jimmunol.2000043

Severe COVID-19 Recovery Is Associated with Timely Acquisition of a Myeloid Cell Immune-Regulatory Phenotype

Author(s): Amelia C. Trombetta, Guilherme B. Farias, André M. C. Gomes, Ana Godinho-Santos, Pedro Rosmaninho, Carolina M. Conceição, Joel Laia, Diana F. Santos, Afonso R. M. Almeida, Catarina Mota, Andreia Gomes, Marta Serrano, Marc Veldhoen, Ana E. Sousa, Susana M. Fernandes
Published in: Frontiers in Immunology, Issue 12, 2021, ISSN 1664-3224
Publisher: FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2021.691725

Feeding immunity: skepticism, delicacies and delights

Author(s): Marc Veldhoen, Henrique Veiga-Fernandes
Published in: Nature Immunology, Issue 16/3, 2015, Page(s) 215-219, ISSN 1529-2908
Publisher: Nature Publishing Group
DOI: 10.1038/ni.3100

Type 1 Treg cells promote the generation of CD8+ tissue-resident memory T cells

Author(s): Cristina Ferreira, Leandro Barros, Marta Baptista, Birte Blankenhaus, André Barros, Patrícia Figueiredo-Campos, Špela Konjar, Alexandra Lainé, Nadine Kamenjarin, Ana Stojanovic, Adelheid Cerwenka, Hans C. Probst, Julien C. Marie, Marc Veldhoen
Published in: Nature Immunology, Issue 21/7, 2020, Page(s) 766-776, ISSN 1529-2908
Publisher: Nature Publishing Group
DOI: 10.1038/s41590-020-0674-9

Pulmonary paracoccidioidomycosis in AhR deficient hosts is severe and associated with defective Treg and Th22 responses

Author(s): Eliseu Frank de Araújo, Nycolas Willian Preite, Marc Veldhoen, Flávio Vieira Loures, Vera Lúcia Garcia Calich
Published in: Scientific Reports, Issue 10/1, 2020, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-020-68322-6

Humoral Immune Response of SARS‐CoV ‐2–Infected Patients with Cancer: Influencing Factors and Mechanisms

Author(s): Miguel Esperança‐Martins, Lisa Gonçalves, Inês Soares‐Pinho, Andreia Gomes, Marta Serrano, Birte Blankenhaus, Patrícia Figueiredo‐Campos, Ana Catarina‐Marques, Ana Castro‐Barbosa, Ana Cardoso, Pedro Antunes‐Meireles, Henrique Atalaia‐Barbacena, Pedro Gaspar, Patrícia Howell‐Monteiro, António Pais‐de‐Lacerda, Catarina Mota, Marc Veldhoen
Published in: The Oncologist, Issue 26/9, 2021, ISSN 1083-7159
Publisher: AlphaMed Press Inc
DOI: 10.1002/onco.13828

Microbiota derived short chain fatty acids promote histone crotonylation in the colon through histone deacetylases

Author(s): Rachel Fellows, Jérémy Denizot, Claudia Stellato, Alessandro Cuomo, Payal Jain, Elena Stoyanova, Szabina Balázsi, Zoltán Hajnády, Anke Liebert, Juri Kazakevych, Hector Blackburn, Renan Oliveira Corrêa, José Luís Fachi, Fabio Takeo Sato, Willian R. Ribeiro, Caroline Marcantonio Ferreira, Hélène Perée, Mariangela Spagnuolo, Raphaël Mattiuz, Csaba Matolcsi, Joana Guedes, Jonathan Clark, M
Published in: Nature Communications, Issue 9/1, 2018, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-017-02651-5

Gut Bacterial Metabolite Urolithin A (UA) Mitigates Ca2+ Entry in T Cells by Regulating miR-10a-5p

Author(s): Shaqiu Zhang, Tamer Al-Maghout, Hang Cao, Lisann Pelzl, Madhuri S. Salker, Marc Veldhoen, Anchun Cheng, Florian Lang, Yogesh Singh
Published in: Frontiers in Immunology, Issue 10, 2019, ISSN 1664-3224
Publisher: FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2019.01737

Guidelines for the use of flow cytometry

Author(s): Marc Veldhoen
Published in: Immunity, Inflammation and Disease, Issue 5/4, 2017, Page(s) 384-385, ISSN 2050-4527
Publisher: WILEY
DOI: 10.1002/iid3.207

Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition)

Author(s): Andrea Cossarizza, Hyun‐Dong Chang, Andreas Radbruch, Andreas Acs, Dieter Adam, Sabine Adam‐Klages, William W. Agace, Nima Aghaeepour, Mübeccel Akdis, Matthieu Allez, Larissa Nogueira Almeida, Giorgia Alvisi, Graham Anderson, Immanuel Andrä, Francesco Annunziato, Achille Anselmo, Petra Bacher, Cosima T. Baldari, Sudipto Bari, Vincenzo Barnaba, Joana Barros‐Martins, Luca Battistini, Wolfgan
Published in: European Journal of Immunology, Issue 49/10, 2019, Page(s) 1457-1973, ISSN 0014-2980
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/eji.201970107

Cellular Stress in the Context of an Inflammatory Environment Supports TGF-β-Independent T Helper-17 Differentiation

Author(s): Verena Brucklacher-Waldert, Cristina Ferreira, Marisa Stebegg, Olivier Fesneau, Silvia Innocentin, Julien C. Marie, Marc Veldhoen
Published in: Cell Reports, Issue 19/11, 2017, Page(s) 2357-2370, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2017.05.052

Intestinal Barrier Interactions with Specialized CD8 T Cells

Author(s): Špela Konjar, Cristina Ferreira, Birte Blankenhaus, Marc Veldhoen
Published in: Frontiers in Immunology, Issue 8, 2017, ISSN 1664-3224
Publisher: FRONTIERS MEDIA SA, PO BOX 110, EPFL INNOVATION PARK, BUILDING I, LAUSANNE, 1015, SWITZERLAND
DOI: 10.3389/fimmu.2017.01281

Metabolic wiring of murine T cell and intraepithelial lymphocyte maintenance and activation

Author(s): Marc Veldhoen, Birte Blankenhaus, Špela Konjar, Cristina Ferreira
Published in: European Journal of Immunology, 2018, ISSN 0014-2980
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/eji.201646745

Oxygen starvation during T cell priming boosts cancer-killing potential

Author(s): Špela Konjar, Birte Blankenhaus, Marc Veldhoen
Published in: Translational Cancer Research, Issue 7/S1, 2018, Page(s) S34-S37, ISSN 2218-676X
Publisher: AME PUBL CO, FLAT-RM C 16F, KINGS WING PLAZA 1, NO 3 KWAN ST, SHATIN, HONG KONG 00000, PEOPLES R CHINA
DOI: 10.21037/tcr.2017.12.07

Interleukin 17 is a chief orchestrator of immunity

Author(s): Marc Veldhoen
Published in: Nature Immunology, Issue 18/6, 2017, Page(s) 612-621, ISSN 1529-2908
Publisher: Nature Publishing Group
DOI: 10.1038/ni.3742

PD-1 and its ligand PD-L1 are progressively up-regulated on CD4 and CD8 T-cells in HIV-2 infection irrespective of the presence of viremia

Author(s): Rita Tendeiro, Russell B. Foxall, António P. Baptista, Francisco Pinto, Rui S. Soares, Rita Cavaleiro, Emília Valadas, Perpétua Gomes, Rui M.M. Victorino, Ana E. Sousa
Published in: AIDS, Issue 02699370, 2012, Page(s) 1065-1071, ISSN 0269-9370
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/QAD.0b013e32835374db

Memory B-cell depletion is a feature of HIV-2 infection even in the absence of detectable viremia

Author(s): Rita Tendeiro, Sofia Fernandes, Russell B. Foxall, José M. Marcelino, Nuno Taveira, Rui S. Soares, António P. Baptista, Rita Cavaleiro, Perpétua Gomes, Rui M.M. Victorino, Ana E. Sousa
Published in: AIDS, Issue 02699370, 2012, Page(s) 1607-1617, ISSN 0269-9370
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/QAD.0b013e3283568849

Gold nanoparticle-based fluorescence immunoassay for malaria antigen detection

Author(s): Bassem S. S. Guirgis, Cláudia Sá e Cunha, Inês Gomes, Miguel Cavadas, Isabel Silva, Gonçalo Doria, Gregory L. Blatch, Pedro V. Baptista, Eulália Pereira, Hassan M. E. Azzazy, Maria M. Mota, Miguel Prudêncio, Ricardo Franco
Published in: Analytical and Bioanalytical Chemistry, Issue 16182642, 2012, Page(s) 1019-1027, ISSN 1618-2642
Publisher: Springer Verlag
DOI: 10.1007/s00216-011-5489-y

Haemozoin detection in infected erythrocytes for Plasmodium falciparum malaria diagnosis—Prospects and limitations

Author(s): Maria Rebelo, Howard M. Shapiro, Teresa Amaral, José Melo-Cristino, Thomas Hänscheid
Published in: Acta Tropica, Issue 0001706X, 2012, Page(s) 58-61, ISSN 0001-706X
Publisher: Elsevier BV
DOI: 10.1016/j.actatropica.2012.03.005

A Novel Carbon Monoxide-Releasing Molecule Fully Protects Mice from Severe Malaria

Author(s): A. C. Pena, N. Penacho, L. Mancio-Silva, R. Neres, J. D. Seixas, A. C. Fernandes, C. C. Romao, M. M. Mota, G. J. L. Bernardes, A. Pamplona
Published in: Antimicrobial Agents and Chemotherapy, Issue 00664804, 2012, Page(s) 1281-1290, ISSN 0066-4804
Publisher: American Society for Microbiology
DOI: 10.1128/AAC.05571-11

PHYLOViZ: phylogenetic inference and data visualization for sequence based typing methods

Author(s): Alexandre P Francisco, Cátia Vaz, Pedro T Monteiro, José Melo-Cristino, Mário Ramirez, João A Carriço
Published in: BMC Bioinformatics, Issue 14712105, 2012, Page(s) 87, ISSN 1471-2105
Publisher: BioMed Central
DOI: 10.1186/1471-2105-13-87

Engagement of NKp30 on V 1 T cells induces the production of CCL3, CCL4, and CCL5 and suppresses HIV-1 replication

Author(s): K. Hudspeth, M. Fogli, D. V. Correia, J. Mikulak, A. Roberto, S. Della Bella, B. Silva-Santos, D. Mavilio
Published in: Blood, Issue 00064971, 2012, Page(s) 4013-4016, ISSN 0006-4971
Publisher: American Society of Hematology
DOI: 10.1182/blood-2011-11-390153

Differences between Macrolide-Resistant and -Susceptible Streptococcus pyogenes: Importance of Clonal Properties in Addition to Antibiotic Consumption

Author(s): C. Silva-Costa, A. Friaes, M. Ramirez, J. Melo-Cristino
Published in: Antimicrobial Agents and Chemotherapy, Issue 00664804, 2012, Page(s) 5661-5666, ISSN 0066-4804
Publisher: American Society for Microbiology
DOI: 10.1128/AAC.01133-12

Novel Potent Metallocenes against Liver Stage Malaria

Author(s): J. Matos, F. P. da Cruz, E. Cabrita, J. Gut, F. Nogueira, V. E. do Rosario, R. Moreira, P. J. Rosenthal, M. Prudencio, P. Gomes
Published in: Antimicrobial Agents and Chemotherapy, Issue 00664804, 2012, Page(s) 1564-1570, ISSN 0066-4804
Publisher: American Society for Microbiology
DOI: 10.1128/AAC.05345-11

Group A streptococci clones associated with invasive infections and pharyngitis in Portugal present differences in emm types, superantigen gene content and antimicrobial resistance

Author(s): Ana Friães, Francisco R Pinto, Catarina Silva-Costa, Mario Ramirez, José Melo-Cristino
Published in: BMC Microbiology, Issue 14712180, 2012, Page(s) 280, ISSN 1471-2180
Publisher: BioMed Central
DOI: 10.1186/1471-2180-12-280

Monocyte activation is a feature of common variable immunodeficiency irrespective of plasma lipopolysaccharide levels

Author(s): R. R. Barbosa, S. P. Silva, S. L. Silva, R. Tendeiro, A. C. Melo, E. Pedro, M. P. Barbosa, M. C. P. Santos, R. M. M. Victorino, A. E. Sousa
Published in: Clinical & Experimental Immunology, Issue 00099104, 2012, Page(s) 263-272, ISSN 0009-9104
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/j.1365-2249.2012.04620.x

CD8+ T Cells from Mice Transnuclear for a TCR that Recognizes a Single H-2Kb-Restricted MHV68 Epitope Derived from gB-ORF8 Help Control Infection

Author(s): Sharvan Sehrawat, Oktay Kirak, Paul-Albert Koenig, Marisa K. Isaacson, Sofia Marques, Gunes Bozkurt, J. Pedro Simas, Rudolph Jaenisch, Hidde L. Ploegh
Published in: Cell Reports, Issue 22111247, 2012, Page(s) 461-471, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2012.03.009

Early skin immunological disturbance after Plasmodium-infected mosquito bites

Author(s): Henrique Borges da Silva, Susana S. Caetano, Isadora Monteiro, Iván Gómez-Conde, Kirsten Hanson, Carlos Penha-Gonçalves, David N. Olivieri, Maria M. Mota, Cláudio R. Marinho, Maria R. D’Imperio Lima, Carlos E. Tadokoro
Published in: Cellular Immunology, Issue 00088749, 2012, Page(s) 22-32, ISSN 0008-8749
Publisher: Academic Press
DOI: 10.1016/j.cellimm.2012.06.003

γδ T-cell conference 2012: Close encounters for the fifth time

Author(s): Bruno Silva-Santos, Wolfgang W. A. Schamel, Paul Fisch, Matthias Eberl
Published in: European Journal of Immunology, Issue 00142980, 2012, Page(s) 3101-3105, ISSN 0014-2980
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/eji.201270101

Driving IL-17+ γδ T-cell migration in allergic reactions: A new “inflammatory” role for the “homeostatic” chemokine CCL25

Author(s): Bruno Silva-Santos
Published in: European Journal of Immunology, Issue 00142980, 2012, Page(s) 1097-1101, ISSN 0014-2980
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/eji.201242545

Persistence of uropathogenic Escherichia coli strains in the host for long periods of time: relationship between phylogenetic groups and virulence factors

Author(s): A. Narciso, F. Nunes, T. Amores, L. Lito, J. Melo-Cristino, A. Duarte
Published in: European Journal of Clinical Microbiology & Infectious Diseases, Issue 09349723, 2012, Page(s) 1211-1217, ISSN 0934-9723
Publisher: Springer Verlag
DOI: 10.1007/s10096-011-1431-7

Innate recognition of malarial parasites by mammalian hosts

Author(s): Peter Liehl, Maria M. Mota
Published in: International Journal for Parasitology, Issue 00207519, 2012, Page(s) 557-566, ISSN 0020-7519
Publisher: Elsevier BV
DOI: 10.1016/j.ijpara.2012.04.006

Targeting the Liver Stage of Malaria Parasites: A Yet Unmet Goal

Author(s): Tiago Rodrigues, Miguel Prudêncio, Rui Moreira, Maria M. Mota, Francisca Lopes
Published in: Journal of Medicinal Chemistry, Issue 00222623, 2012, Page(s) 995-1012, ISSN 0022-2623
Publisher: American Chemical Society
DOI: 10.1021/jm201095h

Murine Gammaherpesvirus 68 LANA Acts on Terminal Repeat DNA To Mediate Episome Persistence

Author(s): A. C. Habison, C. Beauchemin, J. P. Simas, E. J. Usherwood, K. M. Kaye
Published in: Journal of Virology, Issue 0022538X, 2012, Page(s) 11863-11876, ISSN 0022-538X
Publisher: American Society for Microbiology
DOI: 10.1128/JVI.01656-12

T Cell Apoptosis and Induction of Foxp3+ Regulatory T Cells Underlie the Therapeutic Efficacy of CD4 Blockade in Experimental Autoimmune Encephalomyelitis

Author(s): J. Duarte, N. Carrie, V. G. Oliveira, C. Almeida, A. Agua-Doce, L. Rodrigues, J. P. Simas, L. T. Mars, L. Graca
Published in: The Journal of Immunology, Issue 00221767, 2012, Page(s) 1680-1688, ISSN 0022-1767
Publisher: American Association of Immunologists
DOI: 10.4049/jimmunol.1201269

Dominance of Serotype Ia among Group B Streptococci Causing Invasive Infections in Nonpregnant Adults in Portugal

Author(s): E. R. Martins, J. Melo-Cristino, M. Ramirez
Published in: Journal of Clinical Microbiology, Issue 00951137, 2012, Page(s) 1219-1227, ISSN 0095-1137
Publisher: American Society for Microbiology
DOI: 10.1128/JCM.05488-11

The split nature of tumor-infiltrating leukocytes

Author(s): Telma Lança, Bruno Silva-Santos
Published in: OncoImmunology, Issue 21624011, 2012, Page(s) 717-725, ISSN 2162-4011
Publisher: Landes Bioscience
DOI: 10.4161/onci.20068

Infection by Plasmodium changes shape and stiffness of hepatic cells

Author(s): Peter Eaton, Vanessa Zuzarte-Luis, Maria M. Mota, Nuno C. Santos, Miguel Prudêncio
Published in: Nanomedicine: Nanotechnology, Biology and Medicine, Issue 15499634, 2012, Page(s) 17-19, ISSN 1549-9634
Publisher: Elsevier BV
DOI: 10.1016/j.nano.2011.10.004

Human FOXN1-Deficiency Is Associated with αβ Double-Negative and FoxP3+ T-Cell Expansions That Are Distinctly Modulated upon Thymic Transplantation

Author(s): Adriana S. Albuquerque, José G. Marques, Susana L. Silva, Dario Ligeiro, Blythe H. Devlin, Jacques Dutrieux, Rémi Cheynier, Claudio Pignata, Rui M. M. Victorino, M. Louise Markert, Ana E. Sousa
Published in: PLoS ONE, Issue 19326203, 2012, Page(s) e37042, ISSN 1932-6203
Publisher: Public Library of Science
DOI: 10.1371/journal.pone.0037042

A Novel Way to Grow Hemozoin-Like Crystals In Vitro and Its Use to Screen for Hemozoin Inhibiting Antimalarial Compounds

Author(s): Vincent Thomas, Ana Góis, Bruce Ritts, Peter Burke, Thomas Hänscheid, Gerald McDonnell
Published in: PLoS ONE, Issue 19326203, 2012, Page(s) e41006, ISSN 1932-6203
Publisher: Public Library of Science
DOI: 10.1371/journal.pone.0041006

Highly Dynamic Host Actin Reorganization around Developing Plasmodium Inside Hepatocytes

Author(s): Carina S. S. Gomes-Santos, Maurice A. Itoe, Cristina Afonso, Ricardo Henriques, Rui Gardner, Nuno Sepúlveda, Pedro D. Simões, Helena Raquel, António Paulo Almeida, Luis F. Moita, Friedrich Frischknecht, Maria M. Mota
Published in: PLoS ONE, Issue 19326203, 2012, Page(s) e29408, ISSN 1932-6203
Publisher: Public Library of Science
DOI: 10.1371/journal.pone.0029408

RET/GFRα Signals Are Dispensable for Thymic T Cell Development In Vivo

Author(s): Afonso Rocha Martins Almeida, Sílvia Arroz-Madeira, Diogo Fonseca-Pereira, Hélder Ribeiro, Reena Lasrado, Vassilis Pachnis, Henrique Veiga-Fernandes
Published in: PLoS ONE, Issue 19326203, 2012, Page(s) e52949, ISSN 1932-6203
Publisher: Public Library of Science
DOI: 10.1371/journal.pone.0052949

PRIMACINS, N-cinnamoyl-primaquine conjugates, with improved liver-stage antimalarial activity

Author(s): Bianca Pérez, Cátia Teixeira, Inês S. Albuquerque, Jiri Gut, Philip J. Rosenthal, Miguel Prudêncio, Paula Gomes
Published in: MedChemComm, Issue 20402503, 2012, Page(s) 1170, ISSN 2040-2503
Publisher: Royal Society of Chemistry
DOI: 10.1039/c2md20113e

Differential RET Signaling Pathways Drive Development of the Enteric Lymphoid and Nervous Systems

Author(s): A. Patel, N. Harker, L. Moreira-Santos, M. Ferreira, K. Alden, J. Timmis, K. Foster, A. Garefalaki, P. Pachnis, P. Andrews, H. Enomoto, J. Milbrandt, V. Pachnis, M. C. Coles, D. Kioussis, H. Veiga-Fernandes
Published in: Science Signaling, Issue 19379145, 2012, Page(s) ra55-ra55, ISSN 1937-9145
Publisher: American Association for the Advancement of Science
DOI: 10.1126/scisignal.2002734

Liver-stage malaria parasites vulnerable to diverse chemical scaffolds

Author(s): E. R. Derbyshire, M. Prudencio, M. M. Mota, J. Clardy
Published in: Proceedings of the National Academy of Sciences, Issue 00278424, 2012, Page(s) 8511-8516, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.1118370109

Serotype changes in adult invasive pneumococcal infections in Portugal did not reduce the high fraction of potentially vaccine preventable infections

Author(s): Andreia N. Horácio, Jorge Diamantino-Miranda, Sandra I. Aguiar, Mário Ramirez, José Melo-Cristino
Published in: Vaccine, Issue 0264410X, 2012, Page(s) 218-224, ISSN 0264-410X
Publisher: Elsevier BV
DOI: 10.1016/j.vaccine.2011.11.022

B7-CD28 Costimulatory Signals Control the Survival and Proliferation of Murine and Human T Cells via IL-2 Production

Author(s): J. C. Ribot, A. deBarros, L. Mancio-Silva, A. Pamplona, B. Silva-Santos
Published in: The Journal of Immunology, Issue 00221767, 2012, Page(s) 1202-1208, ISSN 0022-1767
Publisher: American Association of Immunologists
DOI: 10.4049/jimmunol.1200268

Use of the 13-valent conjugate vaccine has the potential to eliminate pilus carrying isolates as causes of invasive pneumococcal disease

Author(s): Sandra I. Aguiar, José Melo-Cristino, Mário Ramirez
Published in: Vaccine, Issue 0264410X, 2012, Page(s) 5487-5490, ISSN 0264-410X
Publisher: Elsevier BV
DOI: 10.1016/j.vaccine.2012.06.062

Drug Screen Targeted at Plasmodium Liver Stages Identifies a Potent Multistage Antimalarial Drug

Author(s): F. P. da Cruz, C. Martin, K. Buchholz, M. J. Lafuente-Monasterio, T. Rodrigues, B. Sonnichsen, R. Moreira, F.-J. Gamo, M. Marti, M. M. Mota, M. Hannus, M. Prudencio
Published in: Journal of Infectious Diseases, Issue 00221899, 2012, Page(s) 1278-1286, ISSN 0022-1899
Publisher: University of Chicago Press
DOI: 10.1093/infdis/jis184

Tumor cell recognition by γδ T lymphocytes

Author(s): Daniel V. Correia, Antonio C. Lopes, Bruno Silva-Santos
Published in: OncoImmunology, Issue 21624011, 2013, Page(s) e22892, ISSN 2162-4011
Publisher: Landes Bioscience
DOI: 10.4161/onci.22892

Preserved CD4 T-cell telomere length during long-lasting HIV-2 infection

Author(s): Rita Tendeiro, Adriana S. Albuquerque, Russell B. Foxall, Rita Cavaleiro, Rui S. Soares, António P. Baptista, Maria V.D. Soares, Perpétua Gomes, Ana E. Sousa
Published in: AIDS, Issue 02699370, 2013, Page(s) 289-292, ISSN 0269-9370
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/QAD.0b013e32835ab234

Monocyte and Myeloid Dendritic Cell Activation Occurs Throughout HIV Type 2 Infection, an Attenuated Form of HIV Disease

Author(s): R. Cavaleiro, R. Tendeiro, R. B. Foxall, R. S. Soares, A. P. Baptista, P. Gomes, E. Valadas, R. M. M. Victorino, A. E. Sousa
Published in: Journal of Infectious Diseases, Issue 00221899, 2013, Page(s) 1730-1742, ISSN 0022-1899
Publisher: University of Chicago Press
DOI: 10.1093/infdis/jit085

Colonic patch and colonic SILT development are independent and differentially regulated events

Author(s): A P Baptista, B J Olivier, G Goverse, M Greuter, M Knippenberg, K Kusser, R G Domingues, H Veiga-Fernandes, A D Luster, A Lugering, T D Randall, T Cupedo, R E Mebius
Published in: Mucosal Immunology, Issue 19330219, 2012, Page(s) 511-521, ISSN 1933-0219
Publisher: Nature Publishing Group
DOI: 10.1038/mi.2012.90

Long-Term Immune Reconstitution of Naive and Memory T Cell Pools after Haploidentical Hematopoietic Stem Cell Transplantation

Author(s): Rita I. Azevedo, Maria V.D. Soares, Adriana S. Albuquerque, Rita Tendeiro, Rui S. Soares, Miguel Martins, Dário Ligeiro, Rui M.M. Victorino, João F. Lacerda, Ana E. Sousa
Published in: Biology of Blood and Marrow Transplantation, Issue 10838791, 2013, Page(s) 703-712, ISSN 1083-8791
Publisher: Elsevier BV
DOI: 10.1016/j.bbmt.2013.01.017

A Microscale Human Liver Platform that Supports the Hepatic Stages of Plasmodium falciparum and vivax

Author(s): Sandra March, Shengyong Ng, Soundarapandian Velmurugan, Ani Galstian, Jing Shan, David J. Logan, Anne E. Carpenter, David Thomas, B. Kim Lee Sim, Maria M. Mota, Stephen L. Hoffman, Sangeeta N. Bhatia
Published in: Cell Host & Microbe, Issue 19313128, 2013, Page(s) 104-115, ISSN 1931-3128
Publisher: Cell Press
DOI: 10.1016/j.chom.2013.06.005

Distribution of Pilus Islands in Streptococcus agalactiae That Cause Human Infections: Insights into Evolution and Implication for Vaccine Development

Author(s): E. R. Martins, A. Andreu, J. Melo-Cristino, M. Ramirez
Published in: Clinical and Vaccine Immunology, Issue 15566811, 2013, Page(s) 313-316, ISSN 1556-6811
Publisher: American Society for Microbiology
DOI: 10.1128/CVI.00529-12

Bioinformatics in bacterial molecular epidemiology and public health: databases, tools and the next-generation sequencing revolution

Author(s): J. A. Carriço, A. J. Sabat, A.W. Friedrich, Mário Ramirez
Published in: Eurosurveillance, 2013, ISSN 1560-7917
Publisher: EUR CENTRE DIS PREVENTION & CONTROL

Repairing thymic function

Author(s): Helena Nunes-Cabaço, Ana E. Sousa
Published in: Current Opinion in Organ Transplantation, Issue 10872418, 2013, Page(s) 1, ISSN 1087-2418
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/MOT.0b013e3283615df9

Functional development of γδ T cells

Author(s): Immo Prinz, Bruno Silva-Santos, Daniel J. Pennington
Published in: European Journal of Immunology, Issue 00142980, 2013, Page(s) 1988-1994, ISSN 0014-2980
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/eji.201343759

Targeting Host Factors to Circumvent Anti-Malarial Drug Resistance

Author(s): Miguel Prudencio, Maria M. Mota
Published in: Current Pharmaceutical Design, Issue 13816128, 2013, Page(s) 290-299, ISSN 1381-6128
Publisher: Bentham Science Publishers
DOI: 10.2174/138161213804070276

Superantigen gene complement of Streptococcus pyogenes—relationship with other typing methods and short-term stability

Author(s): A. Friães, F. R. Pinto, C. Silva-Costa, M. Ramirez, J. Melo-Cristino
Published in: European Journal of Clinical Microbiology & Infectious Diseases, Issue 09349723, 2013, Page(s) 115-125, ISSN 0934-9723
Publisher: Springer Verlag
DOI: 10.1007/s10096-012-1726-3

Flavones as isosteres of 4(1H)-quinolones: Discovery of ligand efficient and dual stage antimalarial lead compounds

Author(s): Tiago Rodrigues, Ana S. Ressurreição, Filipa P. da Cruz, Inês S. Albuquerque, Jiri Gut, Marta P. Carrasco, Daniel Gonçalves, Rita C. Guedes, Daniel J.V.A. dos Santos, Maria M. Mota, Philip J. Rosenthal, Rui Moreira, Miguel Prudêncio, Francisca Lopes
Published in: European Journal of Medicinal Chemistry, Issue 02235234, 2013, Page(s) 872-880, ISSN 0223-5234
Publisher: Elsevier BV
DOI: 10.1016/j.ejmech.2013.09.008

Anthracyclines Induce DNA Damage Response-Mediated Protection against Severe Sepsis

Author(s): Nuno Figueiredo, Angelo Chora, Helena Raquel, Nadja Pejanovic, Pedro Pereira, Björn Hartleben, Ana Neves-Costa, Catarina Moita, Dora Pedroso, Andreia Pinto, Sofia Marques, Hafeez Faridi, Paulo Costa, Raffaella Gozzelino, Jimmy L. Zhao, Miguel P. Soares, Margarida Gama-Carvalho, Jennifer Martinez, Qingshuo Zhang, Gerd Döring, Markus Grompe, J. Pedro Simas, Tobias B. Huber, David Baltimore, Vineet Gupta, Douglas R. Green, João A. Ferreira, Luis F. Moita
Published in: Immunity, Issue 10747613, 2013, Page(s) 874-884, ISSN 1074-7613
Publisher: Cell Press
DOI: 10.1016/j.immuni.2013.08.039

The fate of CD4+ T cells under tolerance-inducing stimulation: a modeling perspective

Author(s): Marta Caridade, Vanessa G Oliveira, Ana Agua-Doce, Luis Graca, Ruy M Ribeiro
Published in: Immunology and Cell Biology, Issue 08189641, 2013, Page(s) 652-660, ISSN 0818-9641
Publisher: Blackwell Publishing Inc.
DOI: 10.1038/icb.2013.63

Changes in Streptococcus pyogenes causing invasive disease in Portugal: Evidence for superantigen gene loss and acquisition

Author(s): Ana Friães, Joana P. Lopes, José Melo-Cristino, Mario Ramirez
Published in: International Journal of Medical Microbiology, Issue 14384221, 2013, Page(s) 505-513, ISSN 1438-4221
Publisher: Elsevier BV
DOI: 10.1016/j.ijmm.2013.07.004

Insight into lymphoid tissue morphogenesis

Author(s): Mark Coles, Henrique Veiga-Fernandes
Published in: Immunology Letters, Issue 01652478, 2013, Page(s) 46-53, ISSN 0165-2478
Publisher: Elsevier BV
DOI: 10.1016/j.imlet.2013.08.001

Description of plasmid pSM52, harbouring the gene for the Smr efflux pump, and its involvement in resistance to biocides in a meticillin-resistant Staphylococcus aureus strain

Author(s): Sofia Santos Costa, Cláudia Mourato, Miguel Viveiros, José Melo-Cristino, Leonard Amaral, Isabel Couto
Published in: International Journal of Antimicrobial Agents, Issue 09248579, 2013, Page(s) 490-492, ISSN 0924-8579
Publisher: Elsevier BV
DOI: 10.1016/j.ijantimicag.2013.01.003

Role of Src Homology Domain Binding in Signaling Complexes Assembled by the Murid -Herpesvirus M2 Protein

Author(s): M. Pires de Miranda, F. B. Lopes, C. E. McVey, X. R. Bustelo, J. P. Simas
Published in: Journal of Biological Chemistry, Issue 00219258, 2013, Page(s) 3858-3870, ISSN 0021-9258
Publisher: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1074/jbc.M112.439810

miR-363-5p regulates endothelial cell properties and their communication with hematopoietic precursor cells

Author(s): Ana Costa, Joana Afonso, Catarina Osório, Ana L Gomes, Francisco Caiado, Joana Valente, Sandra I Aguiar, Francisco Pinto, Mário Ramirez, Sérgio Dias
Published in: Journal of Hematology & Oncology, Issue 17568722, 2013, Page(s) 87, ISSN 1756-8722
Publisher: BioMed Central
DOI: 10.1186/1756-8722-6-87

Multilocus Sequence Analysis of Streptococcus canis Confirms the Zoonotic Origin of Human Infections and Reveals Genetic Exchange with Streptococcus dysgalactiae subsp. equisimilis

Author(s): M. D. Pinho, S. C. Matos, C. Pomba, A. Lubke-Becker, L. H. Wieler, S. Preziuso, J. Melo-Cristino, M. Ramirez
Published in: Journal of Clinical Microbiology, Issue 00951137, 2013, Page(s) 1099-1109, ISSN 0095-1137
Publisher: American Society for Microbiology
DOI: 10.1128/JCM.02912-12

At the Bench: Preclinical rationale for exploiting NK cells and T lymphocytes for the treatment of high-risk leukemias

Author(s): H. Norell, A. Moretta, B. Silva-Santos, L. Moretta
Published in: Journal of Leukocyte Biology, Issue 07415400, 2013, Page(s) 1123-1139, ISSN 0741-5400
Publisher: Federation of American Societies for Experimental Biology
DOI: 10.1189/jlb.0613312

Structural Optimization of Quinolon-4(1 H )-imines as Dual-Stage Antimalarials: Toward Increased Potency and Metabolic Stability

Author(s): Ana S. Ressurreição, Daniel Gonçalves, Ana R. Sitoe, Inês S. Albuquerque, Jiri Gut, Ana Góis, Lídia M. Gonçalves, Maria R. Bronze, Thomas Hanscheid, Giancarlo A. Biagini, Philip J. Rosenthal, Miguel Prudêncio, Paul O’Neill, Maria M. Mota, Francisca Lopes, Rui Moreira
Published in: Journal of Medicinal Chemistry, Issue 00222623, 2013, Page(s) 7679-7690, ISSN 0022-2623
Publisher: American Chemical Society
DOI: 10.1021/jm4011466

How Many Sputum Culture Results Do We Need To Monitor Multidrug-Resistant-Tuberculosis (MDR-TB) Patients during Treatment?

Author(s): S. Janssen, X. Padanilam, R. Louw, R. Mahanyele, G. Coetzee, T. Hanscheid, T. Leenstra, M. P. Grobusch
Published in: Journal of Clinical Microbiology, Issue 00951137, 2013, Page(s) 644-646, ISSN 0095-1137
Publisher: American Society for Microbiology
DOI: 10.1128/JCM.02837-12

Assessment of Dual Life Stage Antiplasmodial Activity of British Seaweeds

Author(s): Jasmine Spavieri, Andrea Allmendinger, Marcel Kaiser, Maurice Itoe, Gerald Blunden, Maria Mota, Deniz Tasdemir
Published in: Marine Drugs, Issue 16603397, 2013, Page(s) 4019-4034, ISSN 1660-3397
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/md11104019

A Novel Flow Cytometric Hemozoin Detection Assay for Real-Time Sensitivity Testing of Plasmodium falciparum

Author(s): Maria Rebelo, Claudia Sousa, Howard M. Shapiro, Maria M. Mota, Martin P. Grobusch, Thomas Hänscheid
Published in: PLoS ONE, Issue 19326203, 2013, Page(s) e61606, ISSN 1932-6203
Publisher: Public Library of Science
DOI: 10.1371/journal.pone.0061606

The Majority of Adult Pneumococcal Invasive Infections in Portugal Are Still Potentially Vaccine Preventable in Spite of Significant Declines of Serotypes 1 and 5

Author(s): Andreia N. Horácio, Jorge Diamantino-Miranda, Sandra I. Aguiar, Mário Ramirez, José Melo-Cristino
Published in: PLoS ONE, Issue 19326203, 2013, Page(s) e73704, ISSN 1932-6203
Publisher: Public Library of Science
DOI: 10.1371/journal.pone.0073704

Spartan: A Comprehensive Tool for Understanding Uncertainty in Simulations of Biological Systems

Author(s): Kieran Alden, Mark Read, Jon Timmis, Paul S. Andrews, Henrique Veiga-Fernandes, Mark Coles
Published in: PLoS Computational Biology, Issue 1553734X, 2013, Page(s) e1002916, ISSN 1553-734X
Publisher: Public Library of Science
DOI: 10.1371/journal.pcbi.1002916

Export of the pneumococcal phage SV1 lysin requires choline-containing teichoic acids and is holin-independent

Author(s): Maria João Frias, José Melo-Cristino, Mário Ramirez
Published in: Molecular Microbiology, Issue 0950382X, 2013, Page(s) 430-445, ISSN 0950-382X
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/mmi.12108

Quinolin-4(1 H )-imines are Potent Antiplasmodial Drugs Targeting the Liver Stage of Malaria

Author(s): Tiago Rodrigues, Filipa P. da Cruz, Maria J. Lafuente-Monasterio, Daniel Gonçalves, Ana S. Ressurreição, Ana R. Sitoe, Maria R. Bronze, Jiri Gut, Gisbert Schneider, Maria M. Mota, Philip J. Rosenthal, Miguel Prudêncio, Francisco-Javier Gamo, Francisca Lopes, Rui Moreira
Published in: Journal of Medicinal Chemistry, Issue 00222623, 2013, Page(s) 4811-4815, ISSN 0022-2623
Publisher: American Chemical Society
DOI: 10.1021/jm400246e

Extensive Dissemination of Methicillin-Resistant Staphylococcus aureus (MRSA) between the Hospital and the Community in a Country with a High Prevalence of Nosocomial MRSA

Author(s): Diana Espadinha, Nuno A. Faria, Maria Miragaia, Luís Marques Lito, José Melo-Cristino, Hermínia de Lencastre
Published in: PLoS ONE, Issue 19326203, 2013, Page(s) e59960, ISSN 1932-6203
Publisher: Public Library of Science
DOI: 10.1371/journal.pone.0059960

The role of human umbilical cord tissue-derived mesenchymal stromal cells (UCX®) in the treatment of inflammatory arthritis

Author(s): Jorge M Santos, Rita N Bárcia, Sandra I Simões, Manuela M Gaspar, Susana Calado, Ana Água-Doce, Sílvia CP Almeida, Joana Almeida, Mariana Filipe, Mariana Teixeira, José P Martins, Luís Graça, Maria EM Cruz, Pedro Cruz, Helder Cruz
Published in: Journal of Translational Medicine, Issue 14795876, 2013, Page(s) 18, ISSN 1479-5876
Publisher: BioMed Central
DOI: 10.1186/1479-5876-11-18

Serotype discrimination of encapsulated Streptococcus pneumoniae strains by Fourier-transform infrared spectroscopy and chemometrics

Author(s): M. Vaz, L. Meirinhos-Soares, C.C.S. Sousa, M. Ramirez, J. Melo-Cristino, J.A. Lopes
Published in: Journal of Microbiological Methods, Issue 01677012, 2013, Page(s) 102-107, ISSN 0167-7012
Publisher: Elsevier BV
DOI: 10.1016/j.mimet.2013.02.008

The Use of Machine Learning Methodologies to Analyse Antibiotic and Biocide Susceptibility in Staphylococcus aureus

Author(s): Joana Rosado Coelho, João André Carriço, Daniel Knight, Jose-Luis Martínez, Ian Morrissey, Marco Rinaldo Oggioni, Ana Teresa Freitas
Published in: PLoS ONE, Issue 19326203, 2013, Page(s) e55582, ISSN 1932-6203
Publisher: Public Library of Science
DOI: 10.1371/journal.pone.0055582

The Genetic Basis of Escherichia coli Pathoadaptation to Macrophages

Author(s): Migla Miskinyte, Ana Sousa, Ricardo S. Ramiro, Jorge A. Moura de Sousa, Jerzy Kotlinowski, Iris Caramalho, Sara Magalhães, Miguel P. Soares, Isabel Gordo
Published in: PLoS Pathogens, Issue 15537366, 2013, Page(s) e1003802, ISSN 1553-7366
Publisher: Public Library of Science
DOI: 10.1371/journal.ppat.1003802

Crystal Structure of the Gamma-2 Herpesvirus LANA DNA Binding Domain Identifies Charged Surface Residues Which Impact Viral Latency

Author(s): Bruno Correia, Sofia A. Cerqueira, Chantal Beauchemin, Marta Pires de Miranda, Shijun Li, Rajesh Ponnusamy, LÃ©nia Rodrigues, Thomas R. Schneider, Maria A. Carrondo, Kenneth M. Kaye, J. Pedro Simas, Colin E. McVey
Published in: PLoS Pathogens, Issue 15537366, 2013, Page(s) e1003673, ISSN 1553-7366
Publisher: Public Library of Science
DOI: 10.1371/journal.ppat.1003673

Recent thymic emigrants are the preferential precursors of regulatory T cells differentiated in the periphery

Author(s): R. S. Paiva, A. C. Lino, M.-L. Bergman, I. Caramalho, A. E. Sousa, S. Zelenay, J. Demengeot
Published in: Proceedings of the National Academy of Sciences, Issue 00278424, 2013, Page(s) 6494-6499, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.1221955110

Stabilization of Myc through Heterotypic Poly-Ubiquitination by mLANA Is Critical for γ-Herpesvirus Lymphoproliferation

Author(s): Lénia Rodrigues, Nikita Popov, Kenneth M. Kaye, J. Pedro Simas
Published in: PLoS Pathogens, Issue 15537366, 2013, Page(s) e1003554, ISSN 1553-7366
Publisher: Public Library of Science
DOI: 10.1371/journal.ppat.1003554

Essential, dose-dependent role for the transcription factor Gata3 in the development of IL-5+ and IL-13+ type 2 innate lymphoid cells

Author(s): R. G. J. Klein Wolterink, N. Serafini, M. van Nimwegen, C. A. J. Vosshenrich, M. J. W. de Bruijn, D. Fonseca Pereira, H. Veiga Fernandes, R. W. Hendriks, J. P. Di Santo
Published in: Proceedings of the National Academy of Sciences, Issue 00278424, 2013, Page(s) 10240-10245, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.1217158110

Induced IL-17-Producing Invariant NKT Cells Require Activation in Presence of TGF- and IL-1

Author(s): M. Monteiro, C. F. Almeida, A. Agua-Doce, L. Graca
Published in: The Journal of Immunology, Issue 00221767, 2013, Page(s) 805-811, ISSN 0022-1767
Publisher: American Association of Immunologists
DOI: 10.4049/jimmunol.1201010

Tuberculosis with malaria or HIV co-infection in a large hospital in Luanda, Angola

Author(s): Emília Valadas, Augusto Gomes,Ana Sutre, Sara Brilha, Afonso Wete, Thomas Hänscheid, Francisco Antunes
Published in: Journal of Infection in Developing Countries, Issue 6, 2013, Page(s) 269-272, ISSN 1972-2680
Publisher: Open Learning on Enteric Pathogens

Protective Role of the Inflammatory CCR2/CCL2 Chemokine Pathway through Recruitment of Type 1 Cytotoxic T Lymphocytes to Tumor Beds

Author(s): T. Lanca, M. F. Costa, N. Goncalves-Sousa, M. Rei, A. R. Grosso, C. Penido, B. Silva-Santos
Published in: The Journal of Immunology, Issue 00221767, 2013, Page(s) 6673-6680, ISSN 0022-1767
Publisher: American Association of Immunologists
DOI: 10.4049/jimmunol.1300434

Torins are potent antimalarials that block replenishment of Plasmodium liver stage parasitophorous vacuole membrane proteins

Author(s): K. K. Hanson, A. S. Ressurreicao, K. Buchholz, M. Prudencio, J. D. Herman-Ornelas, M. Rebelo, W. L. Beatty, D. F. Wirth, T. Hanscheid, R. Moreira, M. Marti, M. M. Mota
Published in: Proceedings of the National Academy of Sciences, Issue 00278424, 2013, Page(s) E2838-E2847, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.1306097110

Mechanisms Underlying CD4+ Treg Immune Regulation in the Adult: From Experiments to Models

Author(s): Marta Caridade, Luis Graca, Ruy M. Ribeiro
Published in: Frontiers in Immunology, Issue 16643224, 2013, ISSN 1664-3224
Publisher: Frontiers Editorial Office
DOI: 10.3389/fimmu.2013.00378

BAFF and TACI Gene Expression Are Increased in Patients with Untreated Very Early Rheumatoid Arthritis

Author(s): R. A. Moura, H. Canhao, J. Polido-Pereira, A. M. Rodrigues, M. Navalho, A. F. Mourao, C. Resende, R. Campanilho-Marques, J. Madruga Dias, J. A. P. da Silva, L. Graca, J. E. Fonseca
Published in: The Journal of Rheumatology, Issue 0315162X, 2013, Page(s) 1293-1302, ISSN 0315-162X
Publisher: Journal of Rheumatology Publishing Co., Ltd.
DOI: 10.3899/jrheum.121110

The hemozoin conundrum: is malaria pigment immune-activating, inhibiting, or simply a bystander?

Author(s): Márcia Boura, Rosangela Frita, Ana Góis, Tânia Carvalho, Thomas Hänscheid
Published in: Trends in Parasitology, Issue 14714922, 2013, Page(s) 469-476, ISSN 1471-4922
Publisher: Elsevier BV
DOI: 10.1016/j.pt.2013.07.005

First case of infection with vancomycin-resistant Staphylococcus aureus in Europe

Author(s): José Melo-Cristino, Cristina Resina, Viviana Manuel, Luís Lito, Mário Ramirez
Published in: The Lancet, Issue 01406736, 2013, Page(s) 205, ISSN 0140-6736
Publisher: The Lancet Publishing Group
DOI: 10.1016/S0140-6736(13)61219-2

Recruitment of γδ T lymphocytes to tumors

Author(s): Telma Lança, Bruno Silva-Santos
Published in: OncoImmunology, Issue 21624011, 2013, Page(s) e25461, ISSN 2162-4011
Publisher: Landes Bioscience
DOI: 10.4161/onci.25461

Adjuvant facilitates tolerance induction to factor VIII in hemophilic mice through a Foxp3-independent mechanism that relies on IL-10

Author(s): V. G. Oliveira, A. Agua-Doce, M. A. Curotto de Lafaille, J. J. Lafaille, L. Graca
Published in: Blood, Issue 00064971, 2013, Page(s) 3936-3945, ISSN 0006-4971
Publisher: American Society of Hematology
DOI: 10.1182/blood-2012-09-457135

Novel Endoperoxide-Based Transmission-Blocking Antimalarials with Liver- and Blood-Schizontocidal Activities

Author(s): Daniela Miranda, Rita Capela, Inês S. Albuquerque, Patrícia Meireles, Isa Paiva, Fátima Nogueira, Richard Amewu, Jiri Gut, Philip J. Rosenthal, Rudi Oliveira, Maria M. Mota, Rui Moreira, Francesc Marti, Miguel Prudêncio, Paul M. O’Neill, Francisca Lopes
Published in: ACS Medicinal Chemistry Letters, Issue 19485875, 2014, Page(s) 108-112, ISSN 1948-5875
Publisher: American Chemical Society
DOI: 10.1021/ml4002985

Natural Cytotoxicity Receptors: Broader Expression Patterns and Functions in Innate and Adaptive Immune Cells

Author(s): Kelly Hudspeth, Bruno Silva-Santos, Domenico Mavilio
Published in: Frontiers in Immunology, Issue 16643224, 2013, ISSN 1664-3224
Publisher: Frontiers Editorial Office
DOI: 10.3389/fimmu.2013.00069

Molecular Mechanisms of Differentiation of Murine Pro-Inflammatory γδ T Cell Subsets

Author(s): Karine Serre, Bruno Silva-Santos
Published in: Frontiers in Immunology, Issue 16643224, 2013, ISSN 1664-3224
Publisher: Frontiers Editorial Office
DOI: 10.3389/fimmu.2013.00431

Massive hypereosinophilia and vasculitis associated with major expansion of interleukin-5-producing CD8+ T cells in HIV-1 infection

Author(s): Inês Jorge, Beatriz Amaral, Luis M.S.R. Soares-Almeida, Russell B. Foxall, Rita Tendeiro, João M. Santos, Ana E. Sousa, Rui M.M. Victorino
Published in: AIDS, Issue 02699370, 2014, Page(s) 1075-1077, ISSN 0269-9370
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/QAD.0000000000000205

Gut disruption in HIV-2 infection despite reduced viremia

Author(s): Susana M. Fernandes, Ana R. Pires, Cristina Ferreira, Rita Tendeiro, Luís Correia, Sérgio E. Paulo, Rui M.M. Victorino, Ana E. Sousa
Published in: AIDS, Issue 02699370, 2014, Page(s) 290-292, ISSN 0269-9370
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/QAD.0000000000000114

Dual-stage triterpenoids from an African medicinal plant targeting the malaria parasite

Author(s): Cátia Ramalhete, Filipa P. da Cruz, Silva Mulhovo, Inês J. Sousa, Miguel X. Fernandes, Miguel Prudêncio, Maria-José U. Ferreira
Published in: Bioorganic & Medicinal Chemistry, Issue 09680896, 2014, Page(s) 3887-3890, ISSN 0968-0896
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.bmc.2014.06.019

2-Octadecynoic acid as a dual life stage inhibitor of Plasmodium infections and plasmodial FAS-II enzymes

Author(s): Néstor M. Carballeira, Angela Gono Bwalya, Maurice Ayamba Itoe, Adriano D. Andricopulo, María Lorena Cordero-Maldonado, Marcel Kaiser, Maria M. Mota, Alexander D. Crawford, Rafael V.C. Guido, Deniz Tasdemir
Published in: Bioorganic & Medicinal Chemistry Letters, Issue 0960894X, 2014, Page(s) 4151-4157, ISSN 0960-894X
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.bmcl.2014.07.050

PCR based differentiation between Streptococcus dysgalactiae subsp. equisimilis strains isolated from humans and horses

Author(s): S. Preziuso, M.D. Pinho, A.R. Attili, J. Melo-Cristino, E. Acke, A.C. Midwinter, V. Cuteri, M. Ramirez
Published in: Comparative Immunology, Microbiology and Infectious Diseases, Issue 01479571, 2014, Page(s) 169-172, ISSN 0147-9571
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.cimid.2014.04.001

iNKT Cells: Innate Lymphocytes with a Diverse Response

Author(s): Marta Monteiro, Luis Graca
Published in: Critical Reviews in Immunology, Issue 10408401, 2014, Page(s) 81-90, ISSN 1040-8401
Publisher: Begell House
DOI: 10.1615/CritRevImmunol.2014010088

N- Cinnamoylation of Antimalarial Classics: Quinacrine Analogues with Decreased Toxicity and Dual-Stage Activity

Author(s): Ana Gomes, Bianca Pérez, Inês Albuquerque, Marta Machado, Miguel Prudêncio, Fátima Nogueira, Cátia Teixeira, Paula Gomes
Published in: ChemMedChem, Issue 18607179, 2014, Page(s) 305-310, ISSN 1860-7179
Publisher: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/cmdc.201300459

Differentiation of Type 1 ILCs from a Common Progenitor to All Helper-like Innate Lymphoid Cell Lineages

Author(s): Christoph S.N. Klose, Melanie Flach, Luisa Möhle, Leif Rogell, Thomas Hoyler, Karolina Ebert, Carola Fabiunke, Dietmar Pfeifer, Veronika Sexl, Diogo Fonseca-Pereira, Rita G. Domingues, Henrique Veiga-Fernandes, Sebastian J. Arnold, Meinrad Busslinger, Ildiko R. Dunay, Yakup Tanriver, Andreas Diefenbach
Published in: Cell, Issue 00928674, 2014, Page(s) 340-356, ISSN 0092-8674
Publisher: Cell Press
DOI: 10.1016/j.cell.2014.03.030

Chemical Interrogation of the Malaria Kinome

Author(s): Emily R. Derbyshire, Vanessa Zuzarte-Luís, Andreia D. Magalhães, Nobutaka Kato, Paul C. Sanschagrin, Jinhua Wang, Wenjun Zhou, Chandrasekhar V. Miduturu, Ralph Mazitschek, Piotr Sliz, Maria M. Mota, Nathanael S. Gray, Jon Clardy
Published in: ChemBioChem, Issue 14394227, 2014, Page(s) 1920-1930, ISSN 1439-4227
Publisher: John Wiley & Sons Ltd.
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Invasive infections due to Streptococcus pyogenes: seasonal variation of severity and clinical characteristics, Iceland, 1975 to 2012

Author(s): L B Olafsdottir, H Erlendsdóttir, J Melo-Cristino, D M Weinberger, M Ramirez, K G Kristinsson, M Gottfredsson
Published in: EuroSurveillance, Issue 52, 2014, ISSN 1560-7917
Publisher: EUR CENTRE DIS PREVENTION & CONTROL

Probing the aurone scaffold against Plasmodium falciparum: Design, synthesis and antimalarial activity

Author(s): Marta P. Carrasco, Ana S. Newton, Lídia Gonçalves, Ana Góis, Marta Machado, Jiri Gut, Fátima Nogueira, Thomas Hänscheid, Rita C. Guedes, Daniel J.V.A. dos Santos, Philip J. Rosenthal, Rui Moreira
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Decreasing incidence and changes in serotype distribution of invasive pneumococcal disease in persons aged under 18 years since introduction of 10-valent and 13-valent conjugate vaccines in Portugal, July 2008 to June 2012

Author(s): S I Aguiar, M J Brito, A N Horácio, J P Lopes, M Ramirez, J Melo-Cristino
Published in: EuroSurveillance, Issue 52, 2014, ISSN 1560-7917
Publisher: EUR CENTRE DIS PREVENTION & CONTROL

Hypoxia promotes liver-stage malaria infection in primary human hepatocytes in vitro

Author(s): S. Ng, S. March, A. Galstian, K. Hanson, T. Carvalho, M. M. Mota, S. N. Bhatia
Published in: Disease Models & Mechanisms, Issue 17548403, 2014, Page(s) 215-224, ISSN 1754-8403
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Bacillus invictae sp. nov., isolated from a health product

Author(s): R. Branquinho, C. Sousa, H. Osorio, L. Meirinhos-Soares, J. Lopes, J. A. Carrico, H.-J. Busse, A. Abdulmawjood, G. Klein, P. Kampfer, M. E. Pintado, L. V. Peixe
Published in: INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY, Issue 14665026, 2014, Page(s) 3867-3876, ISSN 1466-5026
Publisher: Society for General Microbiology
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Adult B-cell acute lymphoblastic leukemia cells display decreased PTEN activity and constitutive hyperactivation of PI3K/Akt pathway despite high PTEN protein levels

Author(s): A. M. Gomes, M. V. D. Soares, P. Ribeiro, J. Caldas, V. Povoa, L. R. Martins, A. Melao, A. Serra-Caetano, A. B. de Sousa, J. F. Lacerda, J. T. Barata
Published in: Haematologica, Issue 03906078, 2014, Page(s) 1062-1068, ISSN 0390-6078
Publisher: Ferrata Storti Foundation
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Phylogenetic and clonality analysis of Bacillus pumilus isolates uncovered a highly heterogeneous population of different closely related species and clones

Author(s): Raquel Branquinho, Luís Meirinhos-Soares, João A. Carriço, Manuela Pintado, Luísa V. Peixe
Published in: FEMS Microbiology Ecology, Issue 01686496, 2014, Page(s) 689-698, ISSN 0168-6496
Publisher: Blackwell
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Reduced BAFF-R and Increased TACI Expression in Common Variable Immunodeficiency

Author(s): Rita R. Barbosa, Susana L. Silva, Sara P. Silva, Alcinda C. Melo, M. Conceição Pereira-Santos, João T. Barata, Lennart Hammarström, Marília Cascalho, Ana E. Sousa
Published in: Journal of Clinical Immunology, Issue 02719142, 2014, Page(s) 573-583, ISSN 0271-9142
Publisher: Kluwer Academic/Plenum Publishers
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Malaria infections: What and how can mice teach us

Author(s): Vanessa Zuzarte-Luis, Maria M. Mota, Ana M. Vigário
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Novel Role of the Antimicrobial Peptide LL-37 in the Protection of Neutrophil Extracellular Traps against Degradation by Bacterial Nucleases

Author(s): Ariane Neumann, Lena Völlger, Evelien T.M. Berends, E. Margo Molhoek, Daphne A.C. Stapels, Marika Midon, Ana Friães, Alfred Pingoud, Suzan H.M. Rooijakkers, Richard L. Gallo, Matthias Mörgelin, Victor Nizet, Hassan Y. Naim, Maren von Köckritz-Blickwede
Published in: Journal of Innate Immunity, Issue 1662811X, 2014, Page(s) 860-868, ISSN 1662-811X
Publisher: Karger AG
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Simple, sensitive and quantitative bioluminescence assay for determination of malaria pre-patent period

Author(s): Vanessa Zuzarte-Luis, Joana Sales-Dias, Maria M Mota
Published in: Malaria Journal, Issue 14752875, 2014, Page(s) 15, ISSN 1475-2875
Publisher: BioMed Central
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Tetraoxane–Pyrimidine Nitrile Hybrids as Dual Stage Antimalarials

Author(s): Rudi Oliveira, Rita C. Guedes, Patrícia Meireles, Inês S. Albuquerque, Lídia M. Gonçalves, Elisabete Pires, Maria Rosário Bronze, Jiri Gut, Philip J. Rosenthal, Miguel Prudêncio, Rui Moreira, Paul M. O’Neill, Francisca Lopes
Published in: Journal of Medicinal Chemistry, Issue 00222623, 2014, Page(s) 4916-4923, ISSN 0022-2623
Publisher: American Chemical Society
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Methaemoglobin and COHb in patients with malaria

Author(s): Thomas Hänscheid, Tom Gresnigt, Sascha Löhr, Arnaud Flamen, Thomas Zoller, José Melo-Cristino, Martin P Grobusch
Published in: Malaria Journal, Issue 14752875, 2014, Page(s) 285, ISSN 1475-2875
Publisher: BioMed Central
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T rypanosoma brucei histone H1 inhibits RNA polymerase I transcription and is important for parasite fitness in vivo

Author(s): Ana C. Pena, Mafalda R. Pimentel, Helena Manso, Rita Vaz-Drago, Daniel Pinto-Neves, Francisco Aresta-Branco, Filipa Rijo-Ferreira, Fabien Guegan, Luis Pedro Coelho, Maria Carmo-Fonseca, Nuno L. Barbosa-Morais, Luisa M. Figueiredo
Published in: Molecular Microbiology, Issue 0950382X, 2014, Page(s) 645-663, ISSN 0950-382X
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Development of functionalized nanoparticles for vaccine delivery to dendritic cells: a mechanistic approach

Author(s): Joana M Silva, Gaëlle Vandermeulen, Vanessa G Oliveira, Sandra N Pinto, Catarina Rodrigues, Ana Salgado, Carlos A Afonso, Ana S Viana, Christine Jérôme, Liana C Silva, Luis Graca, Véronique Préat, Helena F Florindo
Published in: Nanomedicine, Issue 17435889, 2014, Page(s) 2639-2656, ISSN 1743-5889
Publisher: Future Medicine Ltd.
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Classification of current anticancer immunotherapies

Author(s): Lorenzo Galluzzi, Erika Vacchelli, José-Manuel Bravo-San Pedro, Aitziber Buqué, Laura Senovilla, Elisa Elena Baracco, Norma Bloy, Francesca Castoldi, Jean-Pierre Abastado, Patrizia Agostinis, Ron N. Apte, Fernando Aranda, Maha Ayyoub, Philipp Beckhove, Jean-Yves Blay, Laura Bracci, Anne Caignard, Chiara Castelli, Federica Cavallo, Estaban Celis, Vincenzo Cerundolo, Aled Clayton, Mario P. Colombo, Lisa Coussens, Madhav V. Dhodapkar, Alexander M. Eggermont, Douglas T. Fearon, Wolf H. Fridman, Jitka Fučíková, Dmitry I. Gabrilovich, Jérôme Galon, Abhishek Garg, François Ghiringhelli, Giuseppe Giaccone, Eli Gilboa, Sacha Gnjatic, Axel Hoos, Anne Hosmalin, Dirk Jäger, Pawel Kalinski, Klas Kärre, Oliver Kepp, Rolf Kiessling, John M. Kirkwood, Eva Klein, Alexander Knuth, Claire E. Lewis, Roland Liblau, Michael T. Lotze, Enrico Lugli, Jean-Pierre Mach, Fabrizio Mattei, Domenico Mavilio, Ignacio Melero, Cornelis J. Melief, Elizabeth A. Mittendorf, Lorenzo Moretta, Adekunke Odunsi, Hideho Okada, Anna Karolina Palucka, Marcus E. Peter, Kenneth J. Pienta, Angel Porgador, George C. Prendergast, Gabriel A. Rabinovich, Nicholas P. Restifo, Naiyer Rizvi, Catherine Sautès-Fridman, Hans Schreiber, Barbara Seliger, Hiroshi Shiku, Bruno Silva-Santos, Mark J. Smyth, Daniel E. Speiser, Radek Spisek, Pramod K. Srivastava, James E. Talmadge, Eric Tartour, Sjoerd H. Van Der Burg, Benoît J. Van Den Eynde, Richard Vile, Hermann Wagner, Jeffrey S. Weber, Theresa L. Whiteside, Jedd D. Wolchok, Laurence Zitvogel, Weiping Zou, Guido Kroemer
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Publisher: Impact Journals
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Host-cell sensors for Plasmodium activate innate immunity against liver-stage infection

Author(s): Peter Liehl, Vanessa Zuzarte-Luís, Jennie Chan, Thomas Zillinger, Fernanda Baptista, Daniel Carapau, Madlen Konert, Kirsten K Hanson, Céline Carret, Caroline Lassnig, Mathias Müller, Ulrich Kalinke, Mohsan Saeed, Angelo Ferreira Chora, Douglas T Golenbock, Birgit Strobl, Miguel Prudêncio, Luis P Coelho, Stefan H Kappe, Giulio Superti-Furga, Andreas Pichlmair, Ana M Vigário, Charles M Rice, Katherine A Fitzgerald, Winfried Barchet, Maria M Mota
Published in: Nature Medicine, Issue 10788956, 2013, Page(s) 47-53, ISSN 1078-8956
Publisher: Nature Publishing Group
DOI: 10.1038/nm.3424

Maternal retinoids control type 3 innate lymphoid cells and set the offspring immunity

Author(s): Serge A. van de Pavert, Manuela Ferreira, Rita G. Domingues, Hélder Ribeiro, Rosalie Molenaar, Lara Moreira-Santos, Francisca F. Almeida, Sales Ibiza, Inês Barbosa, Gera Goverse, Carlos Labão-Almeida, Cristina Godinho-Silva, Tanja Konijn, Dennis Schooneman, Tom O’Toole, Mark R. Mizee, Yasmin Habani, Esther Haak, Fabio R. Santori, Dan R. Littman, Stefan Schulte-Merker, Elaine Dzierzak, J. Pedro Simas, Reina E. Mebius, Henrique Veiga-Fernandes
Published in: Nature, Issue 00280836, 2014, Page(s) 123-127, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/nature13158

The neurotrophic factor receptor RET drives haematopoietic stem cell survival and function

Author(s): Diogo Fonseca-Pereira, Sílvia Arroz-Madeira, Mariana Rodrigues-Campos, Inês A. M. Barbosa, Rita G. Domingues, Teresa Bento, Afonso R. M. Almeida, Hélder Ribeiro, Alexandre J. Potocnik, Hideki Enomoto, Henrique Veiga-Fernandes
Published in: Nature, Issue 00280836, 2014, Page(s) 98-101, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/nature13498

Pherotype Influences Biofilm Growth and Recombination in Streptococcus pneumoniae

Author(s): Margarida Carrolo, Francisco Rodrigues Pinto, José Melo-Cristino, Mário Ramirez
Published in: PLoS ONE, Issue 19326203, 2014, Page(s) e92138, ISSN 1932-6203
Publisher: Public Library of Science
DOI: 10.1371/journal.pone.0092138

Non-Invasive Pneumococcal Pneumonia in Portugal—Serotype Distribution and Antimicrobial Resistance

Author(s): Andreia N. Horácio, Joana P. Lopes, Mário Ramirez, José Melo-Cristino
Published in: PLoS ONE, Issue 19326203, 2014, Page(s) e103092, ISSN 1932-6203
Publisher: Public Library of Science
DOI: 10.1371/journal.pone.0103092

Evaluation of a Novel Magneto-Optical Method for the Detection of Malaria Parasites

Author(s): Ágnes Orbán, Ádám Butykai, András Molnár, Zsófia Pröhle, Gergö Fülöp, Tivadar Zelles, Wasan Forsyth, Danika Hill, Ivo Müller, Louis Schofield, Maria Rebelo, Thomas Hänscheid, Stephan Karl, István Kézsmárki
Published in: PLoS ONE, Issue 19326203, 2014, Page(s) e96981, ISSN 1932-6203
Publisher: Public Library of Science
DOI: 10.1371/journal.pone.0096981

Scarlet Fever Is Caused By a Limited Number of Streptococcus pyogenes Lineages and Is Associated with the Exotoxin Genes ssa, speA and speC

Author(s): Catarina Silva-Costa, Joao A. Carriço, Mario Ramirez, Jose Melo-Cristino
Published in: The Pediatric Infectious Disease Journal, Issue 08913668, 2014, Page(s) 306-310, ISSN 0891-3668
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/INF.0000000000000088

Defining Immune Engagement Thresholds for In Vivo Control of Virus-Driven Lymphoproliferation

Author(s): Cristina Godinho-Silva, Sofia Marques, Diana Fontinha, Henrique Veiga-Fernandes, Philip G. Stevenson, J. Pedro Simas
Published in: PLoS Pathogens, Issue 15537366, 2014, Page(s) e1004220, ISSN 1553-7366
Publisher: Public Library of Science
DOI: 10.1371/journal.ppat.1004220

Establishment of Murine Gammaherpesvirus Latency in B Cells Is Not a Stochastic Event

Author(s): Jérémie Decalf, Cristina Godinho-Silva, Diana Fontinha, Sofia Marques, J. Pedro Simas
Published in: PLoS Pathogens, Issue 15537366, 2014, Page(s) e1004269, ISSN 1553-7366
Publisher: Public Library of Science
DOI: 10.1371/journal.ppat.1004269

Induction of Prophages by Fluoroquinolones in Streptococcus pneumoniae: Implications for Emergence of Resistance in Genetically-Related Clones

Author(s): Elena López, Arnau Domenech, María-José Ferrándiz, Maria João Frias, Carmen Ardanuy, Mario Ramirez, Ernesto García, Josefina Liñares, Adela G. de la Campa
Published in: PLoS ONE, Issue 19326203, 2014, Page(s) e94358, ISSN 1932-6203
Publisher: Public Library of Science
DOI: 10.1371/journal.pone.0094358

Murine CD27(-) V 6(+) T cells producing IL-17A promote ovarian cancer growth via mobilization of protumor small peritoneal macrophages

Author(s): M. Rei, N. Goncalves-Sousa, T. Lanca, R. G. Thompson, S. Mensurado, F. R. Balkwill, H. Kulbe, D. J. Pennington, B. Silva-Santos
Published in: Proceedings of the National Academy of Sciences, Issue 00278424, 2014, Page(s) E3562-E3570, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.1403424111

Towards an advanced therapy medicinal product based on mesenchymal stromal cells isolated from the umbilical cord tissue: quality and safety data

Author(s): José Paulo Martins, Jorge Miguel Santos, Joana Marto de Almeida, Mariana Alves Filipe, Mariana Vargas Teixeira de Almeida, Sílvia Cristina Paiva Almeida, Ana Água-Doce, Alexandre Varela, Mari Gilljam, Birgitta Stellan, Susanne Pohl, Kurt Dittmar, Werner Lindenmaier, Evren Alici, Luís Graça, Pedro Estilita Cruz, Helder Joaquim Cruz, Rita Nogueira Bárcia
Published in: Stem Cell Research & Therapy, Issue 17576512, 2014, Page(s) 9, ISSN 1757-6512
Publisher: BioMed Central
DOI: 10.1186/scrt398

Enteric Mucosa Integrity in the Presence of a Preserved Innate Interleukin 22 Compartment in HIV Type 1-Treated Individuals

Author(s): S. M. Fernandes, A. R. Pires, C. Ferreira, R. B. Foxall, J. Rino, C. Santos, L. Correia, J. Pocas, H. Veiga-Fernandes, A. E. Sousa
Published in: Journal of Infectious Diseases, Issue 00221899, 2014, Page(s) 630-640, ISSN 0022-1899
Publisher: University of Chicago Press
DOI: 10.1093/infdis/jiu126

Delta-like 1-Mediated Notch Signaling Enhances the In Vitro Conversion of Human Memory CD4 T Cells into FOXP3-Expressing Regulatory T Cells

Author(s): C. Mota, V. Nunes-Silva, A. R. Pires, P. Matoso, R. M. M. Victorino, A. E. Sousa, I. Caramalho
Published in: The Journal of Immunology, Issue 00221767, 2014, Page(s) 5854-5862, ISSN 0022-1767
Publisher: American Association of Immunologists
DOI: 10.4049/jimmunol.1400198

TACI deficiency enhances antibody avidity and clearance of an intestinal pathogen

Author(s): Shoichiro Tsuji, Lucas Stein, Nobuhiko Kamada, Gabriel Nuñez, Richard Bram, Bruce A. Vallance, Ana E. Sousa, Jeffrey L. Platt, Marilia Cascalho
Published in: Journal of Clinical Investigation, Issue 00219738, 2014, Page(s) 4857-4866, ISSN 0021-9738
Publisher: American Society for Clinical Investigation
DOI: 10.1172/JCI74428

Human Thymocytes Are Functionally Immature and Differentiate into Cytotoxic Type 1 Effector T Cells upon IL-2/IL-15 Signaling

Author(s): J. C. Ribot, S. T. Ribeiro, D. V. Correia, A. E. Sousa, B. Silva-Santos
Published in: The Journal of Immunology, Issue 00221767, 2014, Page(s) 2237-2243, ISSN 0022-1767
Publisher: American Association of Immunologists
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In Vitro Alterations Do Not Reflect a Requirement for Host Cell Cycle Progression during Plasmodium Liver Stage Infection

Author(s): Kirsten K. Hanson, Sandra March, Shengyong Ng, Sangeeta N. Bhatia, Maria M. Mota
Published in: Eukaryotic Cell, Issue 15359778, 2014, Page(s) 96-103, ISSN 1535-9778
Publisher: American Society for Microbiology
DOI: 10.1128/EC.00166-14

The Emerging Protumor Role of T Lymphocytes: Implications for Cancer Immunotherapy

Author(s): M. Rei, D. J. Pennington, B. Silva-Santos
Published in: Cancer Research, Issue 00085472, 2015, Page(s) 798-802, ISSN 0008-5472
Publisher: American Association for Cancer Research
DOI: 10.1158/0008-5472.CAN-14-3228

Chicago 2014 – 30years of γδ T cells

Author(s): Marc Bonneville, Zheng W. Chen, Julie Déchanet-Merville, Matthias Eberl, Jean Jacques Fournié, Julie M. Jameson, Richard D. Lopez, Massimo Massaia, Bruno Silva-Santos
Published in: Cellular Immunology, Issue 00088749, 2015, Page(s) 3-9, ISSN 0008-8749
Publisher: Academic Press
DOI: 10.1016/j.cellimm.2014.11.001

Human regulatory T-cell development is dictated by Interleukin-2 and -15 expressed in a non-overlapping pattern in the thymus

Author(s): Iris Caramalho, Vânia Nunes-Silva, Ana R. Pires, Catarina Mota, Ana I. Pinto, Helena Nunes-Cabaço, Russell B. Foxall, Ana E. Sousa
Published in: Journal of Autoimmunity, Issue 08968411, 2015, Page(s) 98-110, ISSN 0896-8411
Publisher: Academic Press
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Thymic HIV-2 Infection Uncovers Posttranscriptional Control of Viral Replication in Human Thymocytes

Author(s): Helena Nunes-Cabaço, Paula Matoso, Russell B. Foxall, Rita Tendeiro, Ana R. Pires, Tânia Carvalho, Ana I. Pinheiro, Rui S. Soares, Ana E. Sousa
Published in: Journal of Virology, Issue 0022538X, 2015, Page(s) 2201-2208, ISSN 0022-538X
Publisher: American Society for Microbiology
DOI: 10.1128/JVI.03047-14

In vivo delivery of peptides and Toll-like receptor ligands by mannose-functionalized polymeric nanoparticles induces prophylactic and therapeutic anti-tumor immune responses in a melanoma model

Author(s): Joana M. Silva, Eva Zupancic, Gaëlle Vandermeulen, Vanessa G. Oliveira, Ana Salgado, Mafalda Videira, Manuela Gaspar, Luis Graca, Véronique Préat, Helena F. Florindo
Published in: Journal of Controlled Release, Issue 01683659, 2015, Page(s) 91-103, ISSN 0168-3659
Publisher: Elsevier BV
DOI: 10.1016/j.jconrel.2014.11.033

Point-of-care tests: where is the point?

Author(s): Thomas Hänscheid, Maria Rebelo, Martin P Grobusch
Published in: The Lancet Infectious Diseases, Issue 14733099, 2014, Page(s) 922, ISSN 1473-3099
Publisher: The Lancet Publishing Group
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Eimeria vermiformis Infection Model of Murine Small Intestine

Author(s): Patrícia Figueiredo-Campos, Cristina Ferreira, Birte Blankenhaus, Marc Veldhoen
Published in: BIO-PROTOCOL, Issue 8/24, 2018, ISSN 2331-8325
Publisher: BIO-PROTOCOL
DOI: 10.21769/bioprotoc.3122

Dynamic Metabolic State of Tissue Resident CD8 T Cells

Author(s): Špela Konjar, Marc Veldhoen
Published in: Frontiers in Immunology, Issue 10, 2019, ISSN 1664-3224
Publisher: FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2019.01683

Effector γδ T Cell Differentiation Relies on Master but Not Auxiliary Th Cell Transcription Factors

Author(s): Joana Barros-Martins, Nina Schmolka, Diana Fontinha, Marta Pires de Miranda, J. Pedro Simas, Ingrid Brok, Cristina Ferreira, Marc Veldhoen, Bruno Silva-Santos, Karine Serre
Published in: The Journal of Immunology, Issue 196/9, 2016, Page(s) 3642-3652, ISSN 0022-1767
Publisher: American Association of Immunologists
DOI: 10.4049/jimmunol.1501921

Mitochondria maintain controlled activation state of epithelial-resident T lymphocytes

Author(s): Špela Konjar, Ulrika C. Frising, Cristina Ferreira, Reinhard Hinterleitner, Toufic Mayassi, Qifeng Zhang, Birte Blankenhaus, Nejc Haberman, Yunhua Loo, Joana Guedes, Marta Baptista, Silvia Innocentin, Joerg Stange, Douglas Strathdee, Bana Jabri, Marc Veldhoen
Published in: Science Immunology, Issue 3/24, 2018, Page(s) eaan2543, ISSN 2470-9468
Publisher: AMER ASSOC ADVANCEMENT SCIENCE
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Immunology: Skin T Cells Switch Identity to Protect and Heal

Author(s): Silvia Ariotti, Marc Veldhoen
Published in: Current Biology, Issue 29/6, 2019, Page(s) R220-R223, ISSN 0960-9822
Publisher: Cell Press
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Guidelines for the use of flow cytometry and cell sorting in immunological studies *

Author(s): Andrea Cossarizza, Hyun‐Dong Chang, Andreas Radbruch, Mübeccel Akdis, Immanuel Andrä, Francesco Annunziato, Petra Bacher, Vincenzo Barnaba, Luca Battistini, Wolfgang M. Bauer, Sabine Baumgart, Burkhard Becher, Wolfgang Beisker, Claudia Berek, Alfonso Blanco, Giovanna Borsellino, Philip E. Boulais, Ryan R. Brinkman, Martin Büscher, Dirk H. Busch, Timothy P. Bushnell, Xuetao Cao, Andrea Cavani,
Published in: European Journal of Immunology, Issue 47/10, 2017, Page(s) 1584-1797, ISSN 0014-2980
Publisher: John Wiley & Sons Ltd.
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Quantification of Sporozoite Invasion, Migration, and Development by Microscopy and Flow Cytometry

Author(s): Photini Sinnis, Patricia De La Vega, Alida Coppi, Urszula Krzych, Maria M. Mota
Published in: Malaria, 2013, Page(s) 385-400, ISBN 978-1-62703-026-7
Publisher: Humana Press
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Differentiation and Activation of γδ T Lymphocytes: Focus on CD27 and CD28 Costimulatory Receptors

Author(s): Julie C. Ribot, Bruno Silva-Santos
Published in: Crossroads Between Innate and Adaptive Immunity IV, 2013, Page(s) 95-105, ISBN 978-1-4614-6217-0
Publisher: Springer New York
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Endemic SARS-CoV-2 will maintain post-pandemic immunity

Author(s): Marc Veldhoen, J. Pedro Simas
Published in: Nature Reviews Immunology, Issue 21/3, 2021, Page(s) 131-132, ISSN 1474-1733
Publisher: Nature Publishing Group
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Academic labs supporting COVID‐19 diagnostics

Author(s): Marc Veldhoen, Vanessa Zuzarte‐Luis
Published in: European Journal of Immunology, Issue 51/1, 2021, Page(s) 13-16, ISSN 0014-2980
Publisher: John Wiley & Sons Ltd.
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