Leverage research EXCELLence and INNOVation potential of Instituto de Medicina Molecular (IMM) through translational biomedical research in immunity and infection.

Livrables

Re-evaluation of current state of IMM towards ERA priorities
Publications in the research field of immunity and infection of the Instituto de Medicina Molecular

A one-page statement that the task has been completed.

Acquisition of the pre-clinical molecular and imaging equipment
Organisation of thematic Workshops – first period

Organisation of thematic Workshops held during the first period

Organisation of thematic Workshops – second period

Organisation of thematic Workshops held during the second reporting period

Self-assessment after 2-year period of strategy implementation
Organisation of thematic Workshops – third period

Organisation of thematic Workshops held during the third reporting period

Launch of website
Development of the project logo/brand
Forum for overseas discussion in translational immunity and infection
Brochure and flyer development

Publications

Controlling the pandemic during the SARS-CoV-2 vaccination rollout

Auteurs: João Viana, Christiaan H. van Dorp, Ana Nunes, Manuel C. Gomes, Michiel van Boven, Mirjam E. Kretzschmar, Marc Veldhoen, Ganna Rozhnova
Publié dans: Nature Communications, Numéro 12/1, 2021, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/s41467-021-23938-8

Th17 Cells Require You to Chew before You Swallow

Auteurs: Marc Veldhoen
Publié dans: Immunity, Numéro 46/1, 2017, Page(s) 8-10, ISSN 1074-7613
Éditeur: Cell Press
DOI: 10.1016/j.immuni.2016.12.016

Seroprevalence of anti‐SARS‐CoV‐2 antibodies in COVID‐19 patients and healthy volunteers up to 6 months post disease onset

Auteurs: Patrícia Figueiredo‐Campos, Birte Blankenhaus, Catarina Mota, Andreia Gomes, Marta Serrano, Silvia Ariotti, Catarina Costa, Helena Nunes‐Cabaço, António M. Mendes, Pedro Gaspar, M. Conceição Pereira‐Santos, Fabiana Rodrigues, Jorge Condeço, M. Antonia Escoval, Matilde Santos, Mario Ramirez, José Melo‐Cristino, J. Pedro Simas, Eugenia Vasconcelos, Ângela Afonso, Marc Veldhoen
Publié dans: European Journal of Immunology, Numéro 50/12, 2020, Page(s) 2025-2040, ISSN 0014-2980
Éditeur: John Wiley & Sons Ltd.
DOI: 10.1002/eji.202048970

3-hydroxy-L-kynurenamine is an immunomodulatory biogenic amine

Auteurs: Cristina C. Clement, Angelo D’Alessandro, Sangeetha Thangaswamy, Samantha Chalmers, Raquel Furtado, Sheila Spada, Giada Mondanelli, Federica Ianni, Sarah Gehrke, Marco Gargaro, Giorgia Manni, Luisa Carlota Lopez Cara, Peter Runge, Wanxia Li Tsai, Sinem Karaman, Jorge Arasa, Ruben Fernandez-Rodriguez, Amanda Beck, Antonio Macchiarulo, Massimo Gadina, Cornelia Halin, Francesca Fallarino, Mihaela S
Publié dans: Nature Communications, Numéro 12/1, 2021, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/s41467-021-24785-3

Smarcad1 mediates microbiota-induced inflammation in mouse and coordinates gene expression in the intestinal epithelium

Auteurs: Juri Kazakevych, Jérémy Denizot, Anke Liebert, Mariana Portovedo, Mia Mosavie, Payal Jain, Claudia Stellato, Claire Fraser, Renan Oliveira Corrêa, Marina Célestine, Raphaël Mattiuz, Hanneke Okkenhaug, J. Ross Miller, Marco Aurélio Ramirez Vinolo, Marc Veldhoen, Patrick Varga-Weisz
Publié dans: Genome Biology, Numéro 21/1, 2020, ISSN 1474-760X
Éditeur: BMC
DOI: 10.1186/s13059-020-01976-7

Loss of Phosphatidylinositol 3-Kinase Activity in Regulatory T Cells Leads to Neuronal Inflammation

Auteurs: Anne-Katrien Stark, Elizabeth C. M. Davenport, Daniel T. Patton, Cheryl L. Scudamore, Bart Vanhaesebroeck, Marc Veldhoen, Oliver A. Garden, Klaus Okkenhaug
Publié dans: The Journal of Immunology, Numéro 205/1, 2020, Page(s) 78-89, ISSN 0022-1767
Éditeur: American Association of Immunologists
DOI: 10.4049/jimmunol.2000043

Severe COVID-19 Recovery Is Associated with Timely Acquisition of a Myeloid Cell Immune-Regulatory Phenotype

Auteurs: Amelia C. Trombetta, Guilherme B. Farias, André M. C. Gomes, Ana Godinho-Santos, Pedro Rosmaninho, Carolina M. Conceição, Joel Laia, Diana F. Santos, Afonso R. M. Almeida, Catarina Mota, Andreia Gomes, Marta Serrano, Marc Veldhoen, Ana E. Sousa, Susana M. Fernandes
Publié dans: Frontiers in Immunology, Numéro 12, 2021, ISSN 1664-3224
Éditeur: FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2021.691725

Feeding immunity: skepticism, delicacies and delights

Auteurs: Marc Veldhoen, Henrique Veiga-Fernandes
Publié dans: Nature Immunology, Numéro 16/3, 2015, Page(s) 215-219, ISSN 1529-2908
Éditeur: Nature Publishing Group
DOI: 10.1038/ni.3100

Type 1 Treg cells promote the generation of CD8+ tissue-resident memory T cells

Auteurs: Cristina Ferreira, Leandro Barros, Marta Baptista, Birte Blankenhaus, André Barros, Patrícia Figueiredo-Campos, Špela Konjar, Alexandra Lainé, Nadine Kamenjarin, Ana Stojanovic, Adelheid Cerwenka, Hans C. Probst, Julien C. Marie, Marc Veldhoen
Publié dans: Nature Immunology, Numéro 21/7, 2020, Page(s) 766-776, ISSN 1529-2908
Éditeur: Nature Publishing Group
DOI: 10.1038/s41590-020-0674-9

Pulmonary paracoccidioidomycosis in AhR deficient hosts is severe and associated with defective Treg and Th22 responses

Auteurs: Eliseu Frank de Araújo, Nycolas Willian Preite, Marc Veldhoen, Flávio Vieira Loures, Vera Lúcia Garcia Calich
Publié dans: Scientific Reports, Numéro 10/1, 2020, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/s41598-020-68322-6

Humoral Immune Response of SARS‐CoV ‐2–Infected Patients with Cancer: Influencing Factors and Mechanisms

Auteurs: Miguel Esperança‐Martins, Lisa Gonçalves, Inês Soares‐Pinho, Andreia Gomes, Marta Serrano, Birte Blankenhaus, Patrícia Figueiredo‐Campos, Ana Catarina‐Marques, Ana Castro‐Barbosa, Ana Cardoso, Pedro Antunes‐Meireles, Henrique Atalaia‐Barbacena, Pedro Gaspar, Patrícia Howell‐Monteiro, António Pais‐de‐Lacerda, Catarina Mota, Marc Veldhoen
Publié dans: The Oncologist, Numéro 26/9, 2021, ISSN 1083-7159
Éditeur: AlphaMed Press Inc
DOI: 10.1002/onco.13828

Microbiota derived short chain fatty acids promote histone crotonylation in the colon through histone deacetylases

Auteurs: Rachel Fellows, Jérémy Denizot, Claudia Stellato, Alessandro Cuomo, Payal Jain, Elena Stoyanova, Szabina Balázsi, Zoltán Hajnády, Anke Liebert, Juri Kazakevych, Hector Blackburn, Renan Oliveira Corrêa, José Luís Fachi, Fabio Takeo Sato, Willian R. Ribeiro, Caroline Marcantonio Ferreira, Hélène Perée, Mariangela Spagnuolo, Raphaël Mattiuz, Csaba Matolcsi, Joana Guedes, Jonathan Clark, M
Publié dans: Nature Communications, Numéro 9/1, 2018, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/s41467-017-02651-5

Gut Bacterial Metabolite Urolithin A (UA) Mitigates Ca2+ Entry in T Cells by Regulating miR-10a-5p

Auteurs: Shaqiu Zhang, Tamer Al-Maghout, Hang Cao, Lisann Pelzl, Madhuri S. Salker, Marc Veldhoen, Anchun Cheng, Florian Lang, Yogesh Singh
Publié dans: Frontiers in Immunology, Numéro 10, 2019, ISSN 1664-3224
Éditeur: FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2019.01737

Guidelines for the use of flow cytometry

Auteurs: Marc Veldhoen
Publié dans: Immunity, Inflammation and Disease, Numéro 5/4, 2017, Page(s) 384-385, ISSN 2050-4527
Éditeur: WILEY
DOI: 10.1002/iid3.207

Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition)

Auteurs: Andrea Cossarizza, Hyun‐Dong Chang, Andreas Radbruch, Andreas Acs, Dieter Adam, Sabine Adam‐Klages, William W. Agace, Nima Aghaeepour, Mübeccel Akdis, Matthieu Allez, Larissa Nogueira Almeida, Giorgia Alvisi, Graham Anderson, Immanuel Andrä, Francesco Annunziato, Achille Anselmo, Petra Bacher, Cosima T. Baldari, Sudipto Bari, Vincenzo Barnaba, Joana Barros‐Martins, Luca Battistini, Wolfgan
Publié dans: European Journal of Immunology, Numéro 49/10, 2019, Page(s) 1457-1973, ISSN 0014-2980
Éditeur: John Wiley & Sons Ltd.
DOI: 10.1002/eji.201970107

Cellular Stress in the Context of an Inflammatory Environment Supports TGF-β-Independent T Helper-17 Differentiation

Auteurs: Verena Brucklacher-Waldert, Cristina Ferreira, Marisa Stebegg, Olivier Fesneau, Silvia Innocentin, Julien C. Marie, Marc Veldhoen
Publié dans: Cell Reports, Numéro 19/11, 2017, Page(s) 2357-2370, ISSN 2211-1247
Éditeur: Cell Press
DOI: 10.1016/j.celrep.2017.05.052

Intestinal Barrier Interactions with Specialized CD8 T Cells

Auteurs: Špela Konjar, Cristina Ferreira, Birte Blankenhaus, Marc Veldhoen
Publié dans: Frontiers in Immunology, Numéro 8, 2017, ISSN 1664-3224
Éditeur: FRONTIERS MEDIA SA, PO BOX 110, EPFL INNOVATION PARK, BUILDING I, LAUSANNE, 1015, SWITZERLAND
DOI: 10.3389/fimmu.2017.01281

Metabolic wiring of murine T cell and intraepithelial lymphocyte maintenance and activation

Auteurs: Marc Veldhoen, Birte Blankenhaus, Špela Konjar, Cristina Ferreira
Publié dans: European Journal of Immunology, 2018, ISSN 0014-2980
Éditeur: John Wiley & Sons Ltd.
DOI: 10.1002/eji.201646745

Oxygen starvation during T cell priming boosts cancer-killing potential

Auteurs: Špela Konjar, Birte Blankenhaus, Marc Veldhoen
Publié dans: Translational Cancer Research, Numéro 7/S1, 2018, Page(s) S34-S37, ISSN 2218-676X
Éditeur: AME PUBL CO, FLAT-RM C 16F, KINGS WING PLAZA 1, NO 3 KWAN ST, SHATIN, HONG KONG 00000, PEOPLES R CHINA
DOI: 10.21037/tcr.2017.12.07

Interleukin 17 is a chief orchestrator of immunity

Auteurs: Marc Veldhoen
Publié dans: Nature Immunology, Numéro 18/6, 2017, Page(s) 612-621, ISSN 1529-2908
Éditeur: Nature Publishing Group
DOI: 10.1038/ni.3742

PD-1 and its ligand PD-L1 are progressively up-regulated on CD4 and CD8 T-cells in HIV-2 infection irrespective of the presence of viremia

Auteurs: Rita Tendeiro, Russell B. Foxall, António P. Baptista, Francisco Pinto, Rui S. Soares, Rita Cavaleiro, Emília Valadas, Perpétua Gomes, Rui M.M. Victorino, Ana E. Sousa
Publié dans: AIDS, Numéro 02699370, 2012, Page(s) 1065-1071, ISSN 0269-9370
Éditeur: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/QAD.0b013e32835374db

Memory B-cell depletion is a feature of HIV-2 infection even in the absence of detectable viremia

Auteurs: Rita Tendeiro, Sofia Fernandes, Russell B. Foxall, José M. Marcelino, Nuno Taveira, Rui S. Soares, António P. Baptista, Rita Cavaleiro, Perpétua Gomes, Rui M.M. Victorino, Ana E. Sousa
Publié dans: AIDS, Numéro 02699370, 2012, Page(s) 1607-1617, ISSN 0269-9370
Éditeur: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/QAD.0b013e3283568849

Gold nanoparticle-based fluorescence immunoassay for malaria antigen detection

Auteurs: Bassem S. S. Guirgis, Cláudia Sá e Cunha, Inês Gomes, Miguel Cavadas, Isabel Silva, Gonçalo Doria, Gregory L. Blatch, Pedro V. Baptista, Eulália Pereira, Hassan M. E. Azzazy, Maria M. Mota, Miguel Prudêncio, Ricardo Franco
Publié dans: Analytical and Bioanalytical Chemistry, Numéro 16182642, 2012, Page(s) 1019-1027, ISSN 1618-2642
Éditeur: Springer Verlag
DOI: 10.1007/s00216-011-5489-y

Haemozoin detection in infected erythrocytes for Plasmodium falciparum malaria diagnosis—Prospects and limitations

Auteurs: Maria Rebelo, Howard M. Shapiro, Teresa Amaral, José Melo-Cristino, Thomas Hänscheid
Publié dans: Acta Tropica, Numéro 0001706X, 2012, Page(s) 58-61, ISSN 0001-706X
Éditeur: Elsevier BV
DOI: 10.1016/j.actatropica.2012.03.005

A Novel Carbon Monoxide-Releasing Molecule Fully Protects Mice from Severe Malaria

Auteurs: A. C. Pena, N. Penacho, L. Mancio-Silva, R. Neres, J. D. Seixas, A. C. Fernandes, C. C. Romao, M. M. Mota, G. J. L. Bernardes, A. Pamplona
Publié dans: Antimicrobial Agents and Chemotherapy, Numéro 00664804, 2012, Page(s) 1281-1290, ISSN 0066-4804
Éditeur: American Society for Microbiology
DOI: 10.1128/AAC.05571-11

PHYLOViZ: phylogenetic inference and data visualization for sequence based typing methods

Auteurs: Alexandre P Francisco, Cátia Vaz, Pedro T Monteiro, José Melo-Cristino, Mário Ramirez, João A Carriço
Publié dans: BMC Bioinformatics, Numéro 14712105, 2012, Page(s) 87, ISSN 1471-2105
Éditeur: BioMed Central
DOI: 10.1186/1471-2105-13-87

Engagement of NKp30 on V 1 T cells induces the production of CCL3, CCL4, and CCL5 and suppresses HIV-1 replication

Auteurs: K. Hudspeth, M. Fogli, D. V. Correia, J. Mikulak, A. Roberto, S. Della Bella, B. Silva-Santos, D. Mavilio
Publié dans: Blood, Numéro 00064971, 2012, Page(s) 4013-4016, ISSN 0006-4971
Éditeur: American Society of Hematology
DOI: 10.1182/blood-2011-11-390153

Differences between Macrolide-Resistant and -Susceptible Streptococcus pyogenes: Importance of Clonal Properties in Addition to Antibiotic Consumption

Auteurs: C. Silva-Costa, A. Friaes, M. Ramirez, J. Melo-Cristino
Publié dans: Antimicrobial Agents and Chemotherapy, Numéro 00664804, 2012, Page(s) 5661-5666, ISSN 0066-4804
Éditeur: American Society for Microbiology
DOI: 10.1128/AAC.01133-12

Novel Potent Metallocenes against Liver Stage Malaria

Auteurs: J. Matos, F. P. da Cruz, E. Cabrita, J. Gut, F. Nogueira, V. E. do Rosario, R. Moreira, P. J. Rosenthal, M. Prudencio, P. Gomes
Publié dans: Antimicrobial Agents and Chemotherapy, Numéro 00664804, 2012, Page(s) 1564-1570, ISSN 0066-4804
Éditeur: American Society for Microbiology
DOI: 10.1128/AAC.05345-11

Group A streptococci clones associated with invasive infections and pharyngitis in Portugal present differences in emm types, superantigen gene content and antimicrobial resistance

Auteurs: Ana Friães, Francisco R Pinto, Catarina Silva-Costa, Mario Ramirez, José Melo-Cristino
Publié dans: BMC Microbiology, Numéro 14712180, 2012, Page(s) 280, ISSN 1471-2180
Éditeur: BioMed Central
DOI: 10.1186/1471-2180-12-280

Monocyte activation is a feature of common variable immunodeficiency irrespective of plasma lipopolysaccharide levels

Auteurs: R. R. Barbosa, S. P. Silva, S. L. Silva, R. Tendeiro, A. C. Melo, E. Pedro, M. P. Barbosa, M. C. P. Santos, R. M. M. Victorino, A. E. Sousa
Publié dans: Clinical & Experimental Immunology, Numéro 00099104, 2012, Page(s) 263-272, ISSN 0009-9104
Éditeur: Blackwell Publishing Inc.
DOI: 10.1111/j.1365-2249.2012.04620.x

CD8+ T Cells from Mice Transnuclear for a TCR that Recognizes a Single H-2Kb-Restricted MHV68 Epitope Derived from gB-ORF8 Help Control Infection

Auteurs: Sharvan Sehrawat, Oktay Kirak, Paul-Albert Koenig, Marisa K. Isaacson, Sofia Marques, Gunes Bozkurt, J. Pedro Simas, Rudolph Jaenisch, Hidde L. Ploegh
Publié dans: Cell Reports, Numéro 22111247, 2012, Page(s) 461-471, ISSN 2211-1247
Éditeur: Cell Press
DOI: 10.1016/j.celrep.2012.03.009

Early skin immunological disturbance after Plasmodium-infected mosquito bites

Auteurs: Henrique Borges da Silva, Susana S. Caetano, Isadora Monteiro, Iván Gómez-Conde, Kirsten Hanson, Carlos Penha-Gonçalves, David N. Olivieri, Maria M. Mota, Cláudio R. Marinho, Maria R. D’Imperio Lima, Carlos E. Tadokoro
Publié dans: Cellular Immunology, Numéro 00088749, 2012, Page(s) 22-32, ISSN 0008-8749
Éditeur: Academic Press
DOI: 10.1016/j.cellimm.2012.06.003

γδ T-cell conference 2012: Close encounters for the fifth time

Auteurs: Bruno Silva-Santos, Wolfgang W. A. Schamel, Paul Fisch, Matthias Eberl
Publié dans: European Journal of Immunology, Numéro 00142980, 2012, Page(s) 3101-3105, ISSN 0014-2980
Éditeur: John Wiley & Sons Ltd.
DOI: 10.1002/eji.201270101

Driving IL-17+ γδ T-cell migration in allergic reactions: A new “inflammatory” role for the “homeostatic” chemokine CCL25

Auteurs: Bruno Silva-Santos
Publié dans: European Journal of Immunology, Numéro 00142980, 2012, Page(s) 1097-1101, ISSN 0014-2980
Éditeur: John Wiley & Sons Ltd.
DOI: 10.1002/eji.201242545

Persistence of uropathogenic Escherichia coli strains in the host for long periods of time: relationship between phylogenetic groups and virulence factors

Auteurs: A. Narciso, F. Nunes, T. Amores, L. Lito, J. Melo-Cristino, A. Duarte
Publié dans: European Journal of Clinical Microbiology & Infectious Diseases, Numéro 09349723, 2012, Page(s) 1211-1217, ISSN 0934-9723
Éditeur: Springer Verlag
DOI: 10.1007/s10096-011-1431-7

Innate recognition of malarial parasites by mammalian hosts

Auteurs: Peter Liehl, Maria M. Mota
Publié dans: International Journal for Parasitology, Numéro 00207519, 2012, Page(s) 557-566, ISSN 0020-7519
Éditeur: Elsevier BV
DOI: 10.1016/j.ijpara.2012.04.006

Targeting the Liver Stage of Malaria Parasites: A Yet Unmet Goal

Auteurs: Tiago Rodrigues, Miguel Prudêncio, Rui Moreira, Maria M. Mota, Francisca Lopes
Publié dans: Journal of Medicinal Chemistry, Numéro 00222623, 2012, Page(s) 995-1012, ISSN 0022-2623
Éditeur: American Chemical Society
DOI: 10.1021/jm201095h

Murine Gammaherpesvirus 68 LANA Acts on Terminal Repeat DNA To Mediate Episome Persistence

Auteurs: A. C. Habison, C. Beauchemin, J. P. Simas, E. J. Usherwood, K. M. Kaye
Publié dans: Journal of Virology, Numéro 0022538X, 2012, Page(s) 11863-11876, ISSN 0022-538X
Éditeur: American Society for Microbiology
DOI: 10.1128/JVI.01656-12

T Cell Apoptosis and Induction of Foxp3+ Regulatory T Cells Underlie the Therapeutic Efficacy of CD4 Blockade in Experimental Autoimmune Encephalomyelitis

Auteurs: J. Duarte, N. Carrie, V. G. Oliveira, C. Almeida, A. Agua-Doce, L. Rodrigues, J. P. Simas, L. T. Mars, L. Graca
Publié dans: The Journal of Immunology, Numéro 00221767, 2012, Page(s) 1680-1688, ISSN 0022-1767
Éditeur: American Association of Immunologists
DOI: 10.4049/jimmunol.1201269

Dominance of Serotype Ia among Group B Streptococci Causing Invasive Infections in Nonpregnant Adults in Portugal

Auteurs: E. R. Martins, J. Melo-Cristino, M. Ramirez
Publié dans: Journal of Clinical Microbiology, Numéro 00951137, 2012, Page(s) 1219-1227, ISSN 0095-1137
Éditeur: American Society for Microbiology
DOI: 10.1128/JCM.05488-11

The split nature of tumor-infiltrating leukocytes

Auteurs: Telma Lança, Bruno Silva-Santos
Publié dans: OncoImmunology, Numéro 21624011, 2012, Page(s) 717-725, ISSN 2162-4011
Éditeur: Landes Bioscience
DOI: 10.4161/onci.20068

Infection by Plasmodium changes shape and stiffness of hepatic cells

Auteurs: Peter Eaton, Vanessa Zuzarte-Luis, Maria M. Mota, Nuno C. Santos, Miguel Prudêncio
Publié dans: Nanomedicine: Nanotechnology, Biology and Medicine, Numéro 15499634, 2012, Page(s) 17-19, ISSN 1549-9634
Éditeur: Elsevier BV
DOI: 10.1016/j.nano.2011.10.004

Human FOXN1-Deficiency Is Associated with αβ Double-Negative and FoxP3+ T-Cell Expansions That Are Distinctly Modulated upon Thymic Transplantation

Auteurs: Adriana S. Albuquerque, José G. Marques, Susana L. Silva, Dario Ligeiro, Blythe H. Devlin, Jacques Dutrieux, Rémi Cheynier, Claudio Pignata, Rui M. M. Victorino, M. Louise Markert, Ana E. Sousa
Publié dans: PLoS ONE, Numéro 19326203, 2012, Page(s) e37042, ISSN 1932-6203
Éditeur: Public Library of Science
DOI: 10.1371/journal.pone.0037042

A Novel Way to Grow Hemozoin-Like Crystals In Vitro and Its Use to Screen for Hemozoin Inhibiting Antimalarial Compounds

Auteurs: Vincent Thomas, Ana Góis, Bruce Ritts, Peter Burke, Thomas Hänscheid, Gerald McDonnell
Publié dans: PLoS ONE, Numéro 19326203, 2012, Page(s) e41006, ISSN 1932-6203
Éditeur: Public Library of Science
DOI: 10.1371/journal.pone.0041006

Highly Dynamic Host Actin Reorganization around Developing Plasmodium Inside Hepatocytes

Auteurs: Carina S. S. Gomes-Santos, Maurice A. Itoe, Cristina Afonso, Ricardo Henriques, Rui Gardner, Nuno Sepúlveda, Pedro D. Simões, Helena Raquel, António Paulo Almeida, Luis F. Moita, Friedrich Frischknecht, Maria M. Mota
Publié dans: PLoS ONE, Numéro 19326203, 2012, Page(s) e29408, ISSN 1932-6203
Éditeur: Public Library of Science
DOI: 10.1371/journal.pone.0029408

RET/GFRα Signals Are Dispensable for Thymic T Cell Development In Vivo

Auteurs: Afonso Rocha Martins Almeida, Sílvia Arroz-Madeira, Diogo Fonseca-Pereira, Hélder Ribeiro, Reena Lasrado, Vassilis Pachnis, Henrique Veiga-Fernandes
Publié dans: PLoS ONE, Numéro 19326203, 2012, Page(s) e52949, ISSN 1932-6203
Éditeur: Public Library of Science
DOI: 10.1371/journal.pone.0052949

PRIMACINS, N-cinnamoyl-primaquine conjugates, with improved liver-stage antimalarial activity

Auteurs: Bianca Pérez, Cátia Teixeira, Inês S. Albuquerque, Jiri Gut, Philip J. Rosenthal, Miguel Prudêncio, Paula Gomes
Publié dans: MedChemComm, Numéro 20402503, 2012, Page(s) 1170, ISSN 2040-2503
Éditeur: Royal Society of Chemistry
DOI: 10.1039/c2md20113e

Differential RET Signaling Pathways Drive Development of the Enteric Lymphoid and Nervous Systems

Auteurs: A. Patel, N. Harker, L. Moreira-Santos, M. Ferreira, K. Alden, J. Timmis, K. Foster, A. Garefalaki, P. Pachnis, P. Andrews, H. Enomoto, J. Milbrandt, V. Pachnis, M. C. Coles, D. Kioussis, H. Veiga-Fernandes
Publié dans: Science Signaling, Numéro 19379145, 2012, Page(s) ra55-ra55, ISSN 1937-9145
Éditeur: American Association for the Advancement of Science
DOI: 10.1126/scisignal.2002734

Liver-stage malaria parasites vulnerable to diverse chemical scaffolds

Auteurs: E. R. Derbyshire, M. Prudencio, M. M. Mota, J. Clardy
Publié dans: Proceedings of the National Academy of Sciences, Numéro 00278424, 2012, Page(s) 8511-8516, ISSN 0027-8424
Éditeur: National Academy of Sciences
DOI: 10.1073/pnas.1118370109

Serotype changes in adult invasive pneumococcal infections in Portugal did not reduce the high fraction of potentially vaccine preventable infections

Auteurs: Andreia N. Horácio, Jorge Diamantino-Miranda, Sandra I. Aguiar, Mário Ramirez, José Melo-Cristino
Publié dans: Vaccine, Numéro 0264410X, 2012, Page(s) 218-224, ISSN 0264-410X
Éditeur: Elsevier BV
DOI: 10.1016/j.vaccine.2011.11.022

B7-CD28 Costimulatory Signals Control the Survival and Proliferation of Murine and Human T Cells via IL-2 Production

Auteurs: J. C. Ribot, A. deBarros, L. Mancio-Silva, A. Pamplona, B. Silva-Santos
Publié dans: The Journal of Immunology, Numéro 00221767, 2012, Page(s) 1202-1208, ISSN 0022-1767
Éditeur: American Association of Immunologists
DOI: 10.4049/jimmunol.1200268

Use of the 13-valent conjugate vaccine has the potential to eliminate pilus carrying isolates as causes of invasive pneumococcal disease

Auteurs: Sandra I. Aguiar, José Melo-Cristino, Mário Ramirez
Publié dans: Vaccine, Numéro 0264410X, 2012, Page(s) 5487-5490, ISSN 0264-410X
Éditeur: Elsevier BV
DOI: 10.1016/j.vaccine.2012.06.062

Drug Screen Targeted at Plasmodium Liver Stages Identifies a Potent Multistage Antimalarial Drug

Auteurs: F. P. da Cruz, C. Martin, K. Buchholz, M. J. Lafuente-Monasterio, T. Rodrigues, B. Sonnichsen, R. Moreira, F.-J. Gamo, M. Marti, M. M. Mota, M. Hannus, M. Prudencio
Publié dans: Journal of Infectious Diseases, Numéro 00221899, 2012, Page(s) 1278-1286, ISSN 0022-1899
Éditeur: University of Chicago Press
DOI: 10.1093/infdis/jis184

Tumor cell recognition by γδ T lymphocytes

Auteurs: Daniel V. Correia, Antonio C. Lopes, Bruno Silva-Santos
Publié dans: OncoImmunology, Numéro 21624011, 2013, Page(s) e22892, ISSN 2162-4011
Éditeur: Landes Bioscience
DOI: 10.4161/onci.22892

Preserved CD4 T-cell telomere length during long-lasting HIV-2 infection

Auteurs: Rita Tendeiro, Adriana S. Albuquerque, Russell B. Foxall, Rita Cavaleiro, Rui S. Soares, António P. Baptista, Maria V.D. Soares, Perpétua Gomes, Ana E. Sousa
Publié dans: AIDS, Numéro 02699370, 2013, Page(s) 289-292, ISSN 0269-9370
Éditeur: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/QAD.0b013e32835ab234

Monocyte and Myeloid Dendritic Cell Activation Occurs Throughout HIV Type 2 Infection, an Attenuated Form of HIV Disease

Auteurs: R. Cavaleiro, R. Tendeiro, R. B. Foxall, R. S. Soares, A. P. Baptista, P. Gomes, E. Valadas, R. M. M. Victorino, A. E. Sousa
Publié dans: Journal of Infectious Diseases, Numéro 00221899, 2013, Page(s) 1730-1742, ISSN 0022-1899
Éditeur: University of Chicago Press
DOI: 10.1093/infdis/jit085

Colonic patch and colonic SILT development are independent and differentially regulated events

Auteurs: A P Baptista, B J Olivier, G Goverse, M Greuter, M Knippenberg, K Kusser, R G Domingues, H Veiga-Fernandes, A D Luster, A Lugering, T D Randall, T Cupedo, R E Mebius
Publié dans: Mucosal Immunology, Numéro 19330219, 2012, Page(s) 511-521, ISSN 1933-0219
Éditeur: Nature Publishing Group
DOI: 10.1038/mi.2012.90

Long-Term Immune Reconstitution of Naive and Memory T Cell Pools after Haploidentical Hematopoietic Stem Cell Transplantation

Auteurs: Rita I. Azevedo, Maria V.D. Soares, Adriana S. Albuquerque, Rita Tendeiro, Rui S. Soares, Miguel Martins, Dário Ligeiro, Rui M.M. Victorino, João F. Lacerda, Ana E. Sousa
Publié dans: Biology of Blood and Marrow Transplantation, Numéro 10838791, 2013, Page(s) 703-712, ISSN 1083-8791
Éditeur: Elsevier BV
DOI: 10.1016/j.bbmt.2013.01.017

A Microscale Human Liver Platform that Supports the Hepatic Stages of Plasmodium falciparum and vivax

Auteurs: Sandra March, Shengyong Ng, Soundarapandian Velmurugan, Ani Galstian, Jing Shan, David J. Logan, Anne E. Carpenter, David Thomas, B. Kim Lee Sim, Maria M. Mota, Stephen L. Hoffman, Sangeeta N. Bhatia
Publié dans: Cell Host & Microbe, Numéro 19313128, 2013, Page(s) 104-115, ISSN 1931-3128
Éditeur: Cell Press
DOI: 10.1016/j.chom.2013.06.005

Distribution of Pilus Islands in Streptococcus agalactiae That Cause Human Infections: Insights into Evolution and Implication for Vaccine Development

Auteurs: E. R. Martins, A. Andreu, J. Melo-Cristino, M. Ramirez
Publié dans: Clinical and Vaccine Immunology, Numéro 15566811, 2013, Page(s) 313-316, ISSN 1556-6811
Éditeur: American Society for Microbiology
DOI: 10.1128/CVI.00529-12

Bioinformatics in bacterial molecular epidemiology and public health: databases, tools and the next-generation sequencing revolution

Auteurs: J. A. Carriço, A. J. Sabat, A.W. Friedrich, Mário Ramirez
Publié dans: Eurosurveillance, 2013, ISSN 1560-7917
Éditeur: EUR CENTRE DIS PREVENTION & CONTROL

Repairing thymic function

Auteurs: Helena Nunes-Cabaço, Ana E. Sousa
Publié dans: Current Opinion in Organ Transplantation, Numéro 10872418, 2013, Page(s) 1, ISSN 1087-2418
Éditeur: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/MOT.0b013e3283615df9

Functional development of γδ T cells

Auteurs: Immo Prinz, Bruno Silva-Santos, Daniel J. Pennington
Publié dans: European Journal of Immunology, Numéro 00142980, 2013, Page(s) 1988-1994, ISSN 0014-2980
Éditeur: John Wiley & Sons Ltd.
DOI: 10.1002/eji.201343759

Targeting Host Factors to Circumvent Anti-Malarial Drug Resistance

Auteurs: Miguel Prudencio, Maria M. Mota
Publié dans: Current Pharmaceutical Design, Numéro 13816128, 2013, Page(s) 290-299, ISSN 1381-6128
Éditeur: Bentham Science Publishers
DOI: 10.2174/138161213804070276

Superantigen gene complement of Streptococcus pyogenes—relationship with other typing methods and short-term stability

Auteurs: A. Friães, F. R. Pinto, C. Silva-Costa, M. Ramirez, J. Melo-Cristino
Publié dans: European Journal of Clinical Microbiology & Infectious Diseases, Numéro 09349723, 2013, Page(s) 115-125, ISSN 0934-9723
Éditeur: Springer Verlag
DOI: 10.1007/s10096-012-1726-3

Flavones as isosteres of 4(1H)-quinolones: Discovery of ligand efficient and dual stage antimalarial lead compounds

Auteurs: Tiago Rodrigues, Ana S. Ressurreição, Filipa P. da Cruz, Inês S. Albuquerque, Jiri Gut, Marta P. Carrasco, Daniel Gonçalves, Rita C. Guedes, Daniel J.V.A. dos Santos, Maria M. Mota, Philip J. Rosenthal, Rui Moreira, Miguel Prudêncio, Francisca Lopes
Publié dans: European Journal of Medicinal Chemistry, Numéro 02235234, 2013, Page(s) 872-880, ISSN 0223-5234
Éditeur: Elsevier BV
DOI: 10.1016/j.ejmech.2013.09.008

Anthracyclines Induce DNA Damage Response-Mediated Protection against Severe Sepsis

Auteurs: Nuno Figueiredo, Angelo Chora, Helena Raquel, Nadja Pejanovic, Pedro Pereira, Björn Hartleben, Ana Neves-Costa, Catarina Moita, Dora Pedroso, Andreia Pinto, Sofia Marques, Hafeez Faridi, Paulo Costa, Raffaella Gozzelino, Jimmy L. Zhao, Miguel P. Soares, Margarida Gama-Carvalho, Jennifer Martinez, Qingshuo Zhang, Gerd Döring, Markus Grompe, J. Pedro Simas, Tobias B. Huber, David Baltimore, Vineet Gupta, Douglas R. Green, João A. Ferreira, Luis F. Moita
Publié dans: Immunity, Numéro 10747613, 2013, Page(s) 874-884, ISSN 1074-7613
Éditeur: Cell Press
DOI: 10.1016/j.immuni.2013.08.039

The fate of CD4+ T cells under tolerance-inducing stimulation: a modeling perspective

Auteurs: Marta Caridade, Vanessa G Oliveira, Ana Agua-Doce, Luis Graca, Ruy M Ribeiro
Publié dans: Immunology and Cell Biology, Numéro 08189641, 2013, Page(s) 652-660, ISSN 0818-9641
Éditeur: Blackwell Publishing Inc.
DOI: 10.1038/icb.2013.63

Changes in Streptococcus pyogenes causing invasive disease in Portugal: Evidence for superantigen gene loss and acquisition

Auteurs: Ana Friães, Joana P. Lopes, José Melo-Cristino, Mario Ramirez
Publié dans: International Journal of Medical Microbiology, Numéro 14384221, 2013, Page(s) 505-513, ISSN 1438-4221
Éditeur: Elsevier BV
DOI: 10.1016/j.ijmm.2013.07.004

Insight into lymphoid tissue morphogenesis

Auteurs: Mark Coles, Henrique Veiga-Fernandes
Publié dans: Immunology Letters, Numéro 01652478, 2013, Page(s) 46-53, ISSN 0165-2478
Éditeur: Elsevier BV
DOI: 10.1016/j.imlet.2013.08.001

Description of plasmid pSM52, harbouring the gene for the Smr efflux pump, and its involvement in resistance to biocides in a meticillin-resistant Staphylococcus aureus strain

Auteurs: Sofia Santos Costa, Cláudia Mourato, Miguel Viveiros, José Melo-Cristino, Leonard Amaral, Isabel Couto
Publié dans: International Journal of Antimicrobial Agents, Numéro 09248579, 2013, Page(s) 490-492, ISSN 0924-8579
Éditeur: Elsevier BV
DOI: 10.1016/j.ijantimicag.2013.01.003

Role of Src Homology Domain Binding in Signaling Complexes Assembled by the Murid -Herpesvirus M2 Protein

Auteurs: M. Pires de Miranda, F. B. Lopes, C. E. McVey, X. R. Bustelo, J. P. Simas
Publié dans: Journal of Biological Chemistry, Numéro 00219258, 2013, Page(s) 3858-3870, ISSN 0021-9258
Éditeur: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1074/jbc.M112.439810

miR-363-5p regulates endothelial cell properties and their communication with hematopoietic precursor cells

Auteurs: Ana Costa, Joana Afonso, Catarina Osório, Ana L Gomes, Francisco Caiado, Joana Valente, Sandra I Aguiar, Francisco Pinto, Mário Ramirez, Sérgio Dias
Publié dans: Journal of Hematology & Oncology, Numéro 17568722, 2013, Page(s) 87, ISSN 1756-8722
Éditeur: BioMed Central
DOI: 10.1186/1756-8722-6-87

Multilocus Sequence Analysis of Streptococcus canis Confirms the Zoonotic Origin of Human Infections and Reveals Genetic Exchange with Streptococcus dysgalactiae subsp. equisimilis

Auteurs: M. D. Pinho, S. C. Matos, C. Pomba, A. Lubke-Becker, L. H. Wieler, S. Preziuso, J. Melo-Cristino, M. Ramirez
Publié dans: Journal of Clinical Microbiology, Numéro 00951137, 2013, Page(s) 1099-1109, ISSN 0095-1137
Éditeur: American Society for Microbiology
DOI: 10.1128/JCM.02912-12

At the Bench: Preclinical rationale for exploiting NK cells and T lymphocytes for the treatment of high-risk leukemias

Auteurs: H. Norell, A. Moretta, B. Silva-Santos, L. Moretta
Publié dans: Journal of Leukocyte Biology, Numéro 07415400, 2013, Page(s) 1123-1139, ISSN 0741-5400
Éditeur: Federation of American Societies for Experimental Biology
DOI: 10.1189/jlb.0613312

Structural Optimization of Quinolon-4(1 H )-imines as Dual-Stage Antimalarials: Toward Increased Potency and Metabolic Stability

Auteurs: Ana S. Ressurreição, Daniel Gonçalves, Ana R. Sitoe, Inês S. Albuquerque, Jiri Gut, Ana Góis, Lídia M. Gonçalves, Maria R. Bronze, Thomas Hanscheid, Giancarlo A. Biagini, Philip J. Rosenthal, Miguel Prudêncio, Paul O’Neill, Maria M. Mota, Francisca Lopes, Rui Moreira
Publié dans: Journal of Medicinal Chemistry, Numéro 00222623, 2013, Page(s) 7679-7690, ISSN 0022-2623
Éditeur: American Chemical Society
DOI: 10.1021/jm4011466

How Many Sputum Culture Results Do We Need To Monitor Multidrug-Resistant-Tuberculosis (MDR-TB) Patients during Treatment?

Auteurs: S. Janssen, X. Padanilam, R. Louw, R. Mahanyele, G. Coetzee, T. Hanscheid, T. Leenstra, M. P. Grobusch
Publié dans: Journal of Clinical Microbiology, Numéro 00951137, 2013, Page(s) 644-646, ISSN 0095-1137
Éditeur: American Society for Microbiology
DOI: 10.1128/JCM.02837-12

Assessment of Dual Life Stage Antiplasmodial Activity of British Seaweeds

Auteurs: Jasmine Spavieri, Andrea Allmendinger, Marcel Kaiser, Maurice Itoe, Gerald Blunden, Maria Mota, Deniz Tasdemir
Publié dans: Marine Drugs, Numéro 16603397, 2013, Page(s) 4019-4034, ISSN 1660-3397
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/md11104019

A Novel Flow Cytometric Hemozoin Detection Assay for Real-Time Sensitivity Testing of Plasmodium falciparum

Auteurs: Maria Rebelo, Claudia Sousa, Howard M. Shapiro, Maria M. Mota, Martin P. Grobusch, Thomas Hänscheid
Publié dans: PLoS ONE, Numéro 19326203, 2013, Page(s) e61606, ISSN 1932-6203
Éditeur: Public Library of Science
DOI: 10.1371/journal.pone.0061606

The Majority of Adult Pneumococcal Invasive Infections in Portugal Are Still Potentially Vaccine Preventable in Spite of Significant Declines of Serotypes 1 and 5

Auteurs: Andreia N. Horácio, Jorge Diamantino-Miranda, Sandra I. Aguiar, Mário Ramirez, José Melo-Cristino
Publié dans: PLoS ONE, Numéro 19326203, 2013, Page(s) e73704, ISSN 1932-6203
Éditeur: Public Library of Science
DOI: 10.1371/journal.pone.0073704

Spartan: A Comprehensive Tool for Understanding Uncertainty in Simulations of Biological Systems

Auteurs: Kieran Alden, Mark Read, Jon Timmis, Paul S. Andrews, Henrique Veiga-Fernandes, Mark Coles
Publié dans: PLoS Computational Biology, Numéro 1553734X, 2013, Page(s) e1002916, ISSN 1553-734X
Éditeur: Public Library of Science
DOI: 10.1371/journal.pcbi.1002916

Export of the pneumococcal phage SV1 lysin requires choline-containing teichoic acids and is holin-independent

Auteurs: Maria João Frias, José Melo-Cristino, Mário Ramirez
Publié dans: Molecular Microbiology, Numéro 0950382X, 2013, Page(s) 430-445, ISSN 0950-382X
Éditeur: Blackwell Publishing Inc.
DOI: 10.1111/mmi.12108

Quinolin-4(1 H )-imines are Potent Antiplasmodial Drugs Targeting the Liver Stage of Malaria

Auteurs: Tiago Rodrigues, Filipa P. da Cruz, Maria J. Lafuente-Monasterio, Daniel Gonçalves, Ana S. Ressurreição, Ana R. Sitoe, Maria R. Bronze, Jiri Gut, Gisbert Schneider, Maria M. Mota, Philip J. Rosenthal, Miguel Prudêncio, Francisco-Javier Gamo, Francisca Lopes, Rui Moreira
Publié dans: Journal of Medicinal Chemistry, Numéro 00222623, 2013, Page(s) 4811-4815, ISSN 0022-2623
Éditeur: American Chemical Society
DOI: 10.1021/jm400246e

Extensive Dissemination of Methicillin-Resistant Staphylococcus aureus (MRSA) between the Hospital and the Community in a Country with a High Prevalence of Nosocomial MRSA

Auteurs: Diana Espadinha, Nuno A. Faria, Maria Miragaia, Luís Marques Lito, José Melo-Cristino, Hermínia de Lencastre
Publié dans: PLoS ONE, Numéro 19326203, 2013, Page(s) e59960, ISSN 1932-6203
Éditeur: Public Library of Science
DOI: 10.1371/journal.pone.0059960

The role of human umbilical cord tissue-derived mesenchymal stromal cells (UCX®) in the treatment of inflammatory arthritis

Auteurs: Jorge M Santos, Rita N Bárcia, Sandra I Simões, Manuela M Gaspar, Susana Calado, Ana Água-Doce, Sílvia CP Almeida, Joana Almeida, Mariana Filipe, Mariana Teixeira, José P Martins, Luís Graça, Maria EM Cruz, Pedro Cruz, Helder Cruz
Publié dans: Journal of Translational Medicine, Numéro 14795876, 2013, Page(s) 18, ISSN 1479-5876
Éditeur: BioMed Central
DOI: 10.1186/1479-5876-11-18

Serotype discrimination of encapsulated Streptococcus pneumoniae strains by Fourier-transform infrared spectroscopy and chemometrics

Auteurs: M. Vaz, L. Meirinhos-Soares, C.C.S. Sousa, M. Ramirez, J. Melo-Cristino, J.A. Lopes
Publié dans: Journal of Microbiological Methods, Numéro 01677012, 2013, Page(s) 102-107, ISSN 0167-7012
Éditeur: Elsevier BV
DOI: 10.1016/j.mimet.2013.02.008

The Use of Machine Learning Methodologies to Analyse Antibiotic and Biocide Susceptibility in Staphylococcus aureus

Auteurs: Joana Rosado Coelho, João André Carriço, Daniel Knight, Jose-Luis Martínez, Ian Morrissey, Marco Rinaldo Oggioni, Ana Teresa Freitas
Publié dans: PLoS ONE, Numéro 19326203, 2013, Page(s) e55582, ISSN 1932-6203
Éditeur: Public Library of Science
DOI: 10.1371/journal.pone.0055582

The Genetic Basis of Escherichia coli Pathoadaptation to Macrophages

Auteurs: Migla Miskinyte, Ana Sousa, Ricardo S. Ramiro, Jorge A. Moura de Sousa, Jerzy Kotlinowski, Iris Caramalho, Sara Magalhães, Miguel P. Soares, Isabel Gordo
Publié dans: PLoS Pathogens, Numéro 15537366, 2013, Page(s) e1003802, ISSN 1553-7366
Éditeur: Public Library of Science
DOI: 10.1371/journal.ppat.1003802

Crystal Structure of the Gamma-2 Herpesvirus LANA DNA Binding Domain Identifies Charged Surface Residues Which Impact Viral Latency

Auteurs: Bruno Correia, Sofia A. Cerqueira, Chantal Beauchemin, Marta Pires de Miranda, Shijun Li, Rajesh Ponnusamy, LÃ©nia Rodrigues, Thomas R. Schneider, Maria A. Carrondo, Kenneth M. Kaye, J. Pedro Simas, Colin E. McVey
Publié dans: PLoS Pathogens, Numéro 15537366, 2013, Page(s) e1003673, ISSN 1553-7366
Éditeur: Public Library of Science
DOI: 10.1371/journal.ppat.1003673

Recent thymic emigrants are the preferential precursors of regulatory T cells differentiated in the periphery

Auteurs: R. S. Paiva, A. C. Lino, M.-L. Bergman, I. Caramalho, A. E. Sousa, S. Zelenay, J. Demengeot
Publié dans: Proceedings of the National Academy of Sciences, Numéro 00278424, 2013, Page(s) 6494-6499, ISSN 0027-8424
Éditeur: National Academy of Sciences
DOI: 10.1073/pnas.1221955110

Stabilization of Myc through Heterotypic Poly-Ubiquitination by mLANA Is Critical for γ-Herpesvirus Lymphoproliferation

Auteurs: Lénia Rodrigues, Nikita Popov, Kenneth M. Kaye, J. Pedro Simas
Publié dans: PLoS Pathogens, Numéro 15537366, 2013, Page(s) e1003554, ISSN 1553-7366
Éditeur: Public Library of Science
DOI: 10.1371/journal.ppat.1003554

Essential, dose-dependent role for the transcription factor Gata3 in the development of IL-5+ and IL-13+ type 2 innate lymphoid cells

Auteurs: R. G. J. Klein Wolterink, N. Serafini, M. van Nimwegen, C. A. J. Vosshenrich, M. J. W. de Bruijn, D. Fonseca Pereira, H. Veiga Fernandes, R. W. Hendriks, J. P. Di Santo
Publié dans: Proceedings of the National Academy of Sciences, Numéro 00278424, 2013, Page(s) 10240-10245, ISSN 0027-8424
Éditeur: National Academy of Sciences
DOI: 10.1073/pnas.1217158110

Induced IL-17-Producing Invariant NKT Cells Require Activation in Presence of TGF- and IL-1

Auteurs: M. Monteiro, C. F. Almeida, A. Agua-Doce, L. Graca
Publié dans: The Journal of Immunology, Numéro 00221767, 2013, Page(s) 805-811, ISSN 0022-1767
Éditeur: American Association of Immunologists
DOI: 10.4049/jimmunol.1201010

Tuberculosis with malaria or HIV co-infection in a large hospital in Luanda, Angola

Auteurs: Emília Valadas, Augusto Gomes,Ana Sutre, Sara Brilha, Afonso Wete, Thomas Hänscheid, Francisco Antunes
Publié dans: Journal of Infection in Developing Countries, Numéro 6, 2013, Page(s) 269-272, ISSN 1972-2680
Éditeur: Open Learning on Enteric Pathogens

Protective Role of the Inflammatory CCR2/CCL2 Chemokine Pathway through Recruitment of Type 1 Cytotoxic T Lymphocytes to Tumor Beds

Auteurs: T. Lanca, M. F. Costa, N. Goncalves-Sousa, M. Rei, A. R. Grosso, C. Penido, B. Silva-Santos
Publié dans: The Journal of Immunology, Numéro 00221767, 2013, Page(s) 6673-6680, ISSN 0022-1767
Éditeur: American Association of Immunologists
DOI: 10.4049/jimmunol.1300434

Torins are potent antimalarials that block replenishment of Plasmodium liver stage parasitophorous vacuole membrane proteins

Auteurs: K. K. Hanson, A. S. Ressurreicao, K. Buchholz, M. Prudencio, J. D. Herman-Ornelas, M. Rebelo, W. L. Beatty, D. F. Wirth, T. Hanscheid, R. Moreira, M. Marti, M. M. Mota
Publié dans: Proceedings of the National Academy of Sciences, Numéro 00278424, 2013, Page(s) E2838-E2847, ISSN 0027-8424
Éditeur: National Academy of Sciences
DOI: 10.1073/pnas.1306097110

Mechanisms Underlying CD4+ Treg Immune Regulation in the Adult: From Experiments to Models

Auteurs: Marta Caridade, Luis Graca, Ruy M. Ribeiro
Publié dans: Frontiers in Immunology, Numéro 16643224, 2013, ISSN 1664-3224
Éditeur: Frontiers Editorial Office
DOI: 10.3389/fimmu.2013.00378

BAFF and TACI Gene Expression Are Increased in Patients with Untreated Very Early Rheumatoid Arthritis

Auteurs: R. A. Moura, H. Canhao, J. Polido-Pereira, A. M. Rodrigues, M. Navalho, A. F. Mourao, C. Resende, R. Campanilho-Marques, J. Madruga Dias, J. A. P. da Silva, L. Graca, J. E. Fonseca
Publié dans: The Journal of Rheumatology, Numéro 0315162X, 2013, Page(s) 1293-1302, ISSN 0315-162X
Éditeur: Journal of Rheumatology Publishing Co., Ltd.
DOI: 10.3899/jrheum.121110

The hemozoin conundrum: is malaria pigment immune-activating, inhibiting, or simply a bystander?

Auteurs: Márcia Boura, Rosangela Frita, Ana Góis, Tânia Carvalho, Thomas Hänscheid
Publié dans: Trends in Parasitology, Numéro 14714922, 2013, Page(s) 469-476, ISSN 1471-4922
Éditeur: Elsevier BV
DOI: 10.1016/j.pt.2013.07.005

First case of infection with vancomycin-resistant Staphylococcus aureus in Europe

Auteurs: José Melo-Cristino, Cristina Resina, Viviana Manuel, Luís Lito, Mário Ramirez
Publié dans: The Lancet, Numéro 01406736, 2013, Page(s) 205, ISSN 0140-6736
Éditeur: The Lancet Publishing Group
DOI: 10.1016/S0140-6736(13)61219-2

Recruitment of γδ T lymphocytes to tumors

Auteurs: Telma Lança, Bruno Silva-Santos
Publié dans: OncoImmunology, Numéro 21624011, 2013, Page(s) e25461, ISSN 2162-4011
Éditeur: Landes Bioscience
DOI: 10.4161/onci.25461

Adjuvant facilitates tolerance induction to factor VIII in hemophilic mice through a Foxp3-independent mechanism that relies on IL-10

Auteurs: V. G. Oliveira, A. Agua-Doce, M. A. Curotto de Lafaille, J. J. Lafaille, L. Graca
Publié dans: Blood, Numéro 00064971, 2013, Page(s) 3936-3945, ISSN 0006-4971
Éditeur: American Society of Hematology
DOI: 10.1182/blood-2012-09-457135

Novel Endoperoxide-Based Transmission-Blocking Antimalarials with Liver- and Blood-Schizontocidal Activities

Auteurs: Daniela Miranda, Rita Capela, Inês S. Albuquerque, Patrícia Meireles, Isa Paiva, Fátima Nogueira, Richard Amewu, Jiri Gut, Philip J. Rosenthal, Rudi Oliveira, Maria M. Mota, Rui Moreira, Francesc Marti, Miguel Prudêncio, Paul M. O’Neill, Francisca Lopes
Publié dans: ACS Medicinal Chemistry Letters, Numéro 19485875, 2014, Page(s) 108-112, ISSN 1948-5875
Éditeur: American Chemical Society
DOI: 10.1021/ml4002985

Natural Cytotoxicity Receptors: Broader Expression Patterns and Functions in Innate and Adaptive Immune Cells

Auteurs: Kelly Hudspeth, Bruno Silva-Santos, Domenico Mavilio
Publié dans: Frontiers in Immunology, Numéro 16643224, 2013, ISSN 1664-3224
Éditeur: Frontiers Editorial Office
DOI: 10.3389/fimmu.2013.00069

Molecular Mechanisms of Differentiation of Murine Pro-Inflammatory γδ T Cell Subsets

Auteurs: Karine Serre, Bruno Silva-Santos
Publié dans: Frontiers in Immunology, Numéro 16643224, 2013, ISSN 1664-3224
Éditeur: Frontiers Editorial Office
DOI: 10.3389/fimmu.2013.00431

Massive hypereosinophilia and vasculitis associated with major expansion of interleukin-5-producing CD8+ T cells in HIV-1 infection

Auteurs: Inês Jorge, Beatriz Amaral, Luis M.S.R. Soares-Almeida, Russell B. Foxall, Rita Tendeiro, João M. Santos, Ana E. Sousa, Rui M.M. Victorino
Publié dans: AIDS, Numéro 02699370, 2014, Page(s) 1075-1077, ISSN 0269-9370
Éditeur: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/QAD.0000000000000205

Gut disruption in HIV-2 infection despite reduced viremia

Auteurs: Susana M. Fernandes, Ana R. Pires, Cristina Ferreira, Rita Tendeiro, Luís Correia, Sérgio E. Paulo, Rui M.M. Victorino, Ana E. Sousa
Publié dans: AIDS, Numéro 02699370, 2014, Page(s) 290-292, ISSN 0269-9370
Éditeur: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/QAD.0000000000000114

Dual-stage triterpenoids from an African medicinal plant targeting the malaria parasite

Auteurs: Cátia Ramalhete, Filipa P. da Cruz, Silva Mulhovo, Inês J. Sousa, Miguel X. Fernandes, Miguel Prudêncio, Maria-José U. Ferreira
Publié dans: Bioorganic & Medicinal Chemistry, Numéro 09680896, 2014, Page(s) 3887-3890, ISSN 0968-0896
Éditeur: Pergamon Press Ltd.
DOI: 10.1016/j.bmc.2014.06.019

2-Octadecynoic acid as a dual life stage inhibitor of Plasmodium infections and plasmodial FAS-II enzymes

Auteurs: Néstor M. Carballeira, Angela Gono Bwalya, Maurice Ayamba Itoe, Adriano D. Andricopulo, María Lorena Cordero-Maldonado, Marcel Kaiser, Maria M. Mota, Alexander D. Crawford, Rafael V.C. Guido, Deniz Tasdemir
Publié dans: Bioorganic & Medicinal Chemistry Letters, Numéro 0960894X, 2014, Page(s) 4151-4157, ISSN 0960-894X
Éditeur: Pergamon Press Ltd.
DOI: 10.1016/j.bmcl.2014.07.050

PCR based differentiation between Streptococcus dysgalactiae subsp. equisimilis strains isolated from humans and horses

Auteurs: S. Preziuso, M.D. Pinho, A.R. Attili, J. Melo-Cristino, E. Acke, A.C. Midwinter, V. Cuteri, M. Ramirez
Publié dans: Comparative Immunology, Microbiology and Infectious Diseases, Numéro 01479571, 2014, Page(s) 169-172, ISSN 0147-9571
Éditeur: Pergamon Press Ltd.
DOI: 10.1016/j.cimid.2014.04.001

iNKT Cells: Innate Lymphocytes with a Diverse Response

Auteurs: Marta Monteiro, Luis Graca
Publié dans: Critical Reviews in Immunology, Numéro 10408401, 2014, Page(s) 81-90, ISSN 1040-8401
Éditeur: Begell House
DOI: 10.1615/CritRevImmunol.2014010088

N- Cinnamoylation of Antimalarial Classics: Quinacrine Analogues with Decreased Toxicity and Dual-Stage Activity

Auteurs: Ana Gomes, Bianca Pérez, Inês Albuquerque, Marta Machado, Miguel Prudêncio, Fátima Nogueira, Cátia Teixeira, Paula Gomes
Publié dans: ChemMedChem, Numéro 18607179, 2014, Page(s) 305-310, ISSN 1860-7179
Éditeur: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/cmdc.201300459

Differentiation of Type 1 ILCs from a Common Progenitor to All Helper-like Innate Lymphoid Cell Lineages

Auteurs: Christoph S.N. Klose, Melanie Flach, Luisa Möhle, Leif Rogell, Thomas Hoyler, Karolina Ebert, Carola Fabiunke, Dietmar Pfeifer, Veronika Sexl, Diogo Fonseca-Pereira, Rita G. Domingues, Henrique Veiga-Fernandes, Sebastian J. Arnold, Meinrad Busslinger, Ildiko R. Dunay, Yakup Tanriver, Andreas Diefenbach
Publié dans: Cell, Numéro 00928674, 2014, Page(s) 340-356, ISSN 0092-8674
Éditeur: Cell Press
DOI: 10.1016/j.cell.2014.03.030

Chemical Interrogation of the Malaria Kinome

Auteurs: Emily R. Derbyshire, Vanessa Zuzarte-Luís, Andreia D. Magalhães, Nobutaka Kato, Paul C. Sanschagrin, Jinhua Wang, Wenjun Zhou, Chandrasekhar V. Miduturu, Ralph Mazitschek, Piotr Sliz, Maria M. Mota, Nathanael S. Gray, Jon Clardy
Publié dans: ChemBioChem, Numéro 14394227, 2014, Page(s) 1920-1930, ISSN 1439-4227
Éditeur: John Wiley & Sons Ltd.
DOI: 10.1002/cbic.201400025

Invasive infections due to Streptococcus pyogenes: seasonal variation of severity and clinical characteristics, Iceland, 1975 to 2012

Auteurs: L B Olafsdottir, H Erlendsdóttir, J Melo-Cristino, D M Weinberger, M Ramirez, K G Kristinsson, M Gottfredsson
Publié dans: EuroSurveillance, Numéro 52, 2014, ISSN 1560-7917
Éditeur: EUR CENTRE DIS PREVENTION & CONTROL

Probing the aurone scaffold against Plasmodium falciparum: Design, synthesis and antimalarial activity

Auteurs: Marta P. Carrasco, Ana S. Newton, Lídia Gonçalves, Ana Góis, Marta Machado, Jiri Gut, Fátima Nogueira, Thomas Hänscheid, Rita C. Guedes, Daniel J.V.A. dos Santos, Philip J. Rosenthal, Rui Moreira
Publié dans: European Journal of Medicinal Chemistry, Numéro 02235234, 2014, Page(s) 523-534, ISSN 0223-5234
Éditeur: Elsevier BV
DOI: 10.1016/j.ejmech.2014.04.076

Decreasing incidence and changes in serotype distribution of invasive pneumococcal disease in persons aged under 18 years since introduction of 10-valent and 13-valent conjugate vaccines in Portugal, July 2008 to June 2012

Auteurs: S I Aguiar, M J Brito, A N Horácio, J P Lopes, M Ramirez, J Melo-Cristino
Publié dans: EuroSurveillance, Numéro 52, 2014, ISSN 1560-7917
Éditeur: EUR CENTRE DIS PREVENTION & CONTROL

Hypoxia promotes liver-stage malaria infection in primary human hepatocytes in vitro

Auteurs: S. Ng, S. March, A. Galstian, K. Hanson, T. Carvalho, M. M. Mota, S. N. Bhatia
Publié dans: Disease Models & Mechanisms, Numéro 17548403, 2014, Page(s) 215-224, ISSN 1754-8403
Éditeur: The Company of Biologists Ltd.
DOI: 10.1242/dmm.013490

Bacillus invictae sp. nov., isolated from a health product

Auteurs: R. Branquinho, C. Sousa, H. Osorio, L. Meirinhos-Soares, J. Lopes, J. A. Carrico, H.-J. Busse, A. Abdulmawjood, G. Klein, P. Kampfer, M. E. Pintado, L. V. Peixe
Publié dans: INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY, Numéro 14665026, 2014, Page(s) 3867-3876, ISSN 1466-5026
Éditeur: Society for General Microbiology
DOI: 10.1099/ijs.0.067850-0

Adult B-cell acute lymphoblastic leukemia cells display decreased PTEN activity and constitutive hyperactivation of PI3K/Akt pathway despite high PTEN protein levels

Auteurs: A. M. Gomes, M. V. D. Soares, P. Ribeiro, J. Caldas, V. Povoa, L. R. Martins, A. Melao, A. Serra-Caetano, A. B. de Sousa, J. F. Lacerda, J. T. Barata
Publié dans: Haematologica, Numéro 03906078, 2014, Page(s) 1062-1068, ISSN 0390-6078
Éditeur: Ferrata Storti Foundation
DOI: 10.3324/haematol.2013.096438

Phylogenetic and clonality analysis of Bacillus pumilus isolates uncovered a highly heterogeneous population of different closely related species and clones

Auteurs: Raquel Branquinho, Luís Meirinhos-Soares, João A. Carriço, Manuela Pintado, Luísa V. Peixe
Publié dans: FEMS Microbiology Ecology, Numéro 01686496, 2014, Page(s) 689-698, ISSN 0168-6496
Éditeur: Blackwell
DOI: 10.1111/1574-6941.12426

Reduced BAFF-R and Increased TACI Expression in Common Variable Immunodeficiency

Auteurs: Rita R. Barbosa, Susana L. Silva, Sara P. Silva, Alcinda C. Melo, M. Conceição Pereira-Santos, João T. Barata, Lennart Hammarström, Marília Cascalho, Ana E. Sousa
Publié dans: Journal of Clinical Immunology, Numéro 02719142, 2014, Page(s) 573-583, ISSN 0271-9142
Éditeur: Kluwer Academic/Plenum Publishers
DOI: 10.1007/s10875-014-0047-y

Malaria infections: What and how can mice teach us

Auteurs: Vanessa Zuzarte-Luis, Maria M. Mota, Ana M. Vigário
Publié dans: Journal of Immunological Methods, Numéro 00221759, 2014, Page(s) 113-122, ISSN 0022-1759
Éditeur: Elsevier BV
DOI: 10.1016/j.jim.2014.05.001

Novel Role of the Antimicrobial Peptide LL-37 in the Protection of Neutrophil Extracellular Traps against Degradation by Bacterial Nucleases

Auteurs: Ariane Neumann, Lena Völlger, Evelien T.M. Berends, E. Margo Molhoek, Daphne A.C. Stapels, Marika Midon, Ana Friães, Alfred Pingoud, Suzan H.M. Rooijakkers, Richard L. Gallo, Matthias Mörgelin, Victor Nizet, Hassan Y. Naim, Maren von Köckritz-Blickwede
Publié dans: Journal of Innate Immunity, Numéro 1662811X, 2014, Page(s) 860-868, ISSN 1662-811X
Éditeur: Karger AG
DOI: 10.1159/000363699

Simple, sensitive and quantitative bioluminescence assay for determination of malaria pre-patent period

Auteurs: Vanessa Zuzarte-Luis, Joana Sales-Dias, Maria M Mota
Publié dans: Malaria Journal, Numéro 14752875, 2014, Page(s) 15, ISSN 1475-2875
Éditeur: BioMed Central
DOI: 10.1186/1475-2875-13-15

Tetraoxane–Pyrimidine Nitrile Hybrids as Dual Stage Antimalarials

Auteurs: Rudi Oliveira, Rita C. Guedes, Patrícia Meireles, Inês S. Albuquerque, Lídia M. Gonçalves, Elisabete Pires, Maria Rosário Bronze, Jiri Gut, Philip J. Rosenthal, Miguel Prudêncio, Rui Moreira, Paul M. O’Neill, Francisca Lopes
Publié dans: Journal of Medicinal Chemistry, Numéro 00222623, 2014, Page(s) 4916-4923, ISSN 0022-2623
Éditeur: American Chemical Society
DOI: 10.1021/jm5004528

Methaemoglobin and COHb in patients with malaria

Auteurs: Thomas Hänscheid, Tom Gresnigt, Sascha Löhr, Arnaud Flamen, Thomas Zoller, José Melo-Cristino, Martin P Grobusch
Publié dans: Malaria Journal, Numéro 14752875, 2014, Page(s) 285, ISSN 1475-2875
Éditeur: BioMed Central
DOI: 10.1186/1475-2875-13-285

T rypanosoma brucei histone H1 inhibits RNA polymerase I transcription and is important for parasite fitness in vivo

Auteurs: Ana C. Pena, Mafalda R. Pimentel, Helena Manso, Rita Vaz-Drago, Daniel Pinto-Neves, Francisco Aresta-Branco, Filipa Rijo-Ferreira, Fabien Guegan, Luis Pedro Coelho, Maria Carmo-Fonseca, Nuno L. Barbosa-Morais, Luisa M. Figueiredo
Publié dans: Molecular Microbiology, Numéro 0950382X, 2014, Page(s) 645-663, ISSN 0950-382X
Éditeur: Blackwell Publishing Inc.
DOI: 10.1111/mmi.12677

Development of functionalized nanoparticles for vaccine delivery to dendritic cells: a mechanistic approach

Auteurs: Joana M Silva, Gaëlle Vandermeulen, Vanessa G Oliveira, Sandra N Pinto, Catarina Rodrigues, Ana Salgado, Carlos A Afonso, Ana S Viana, Christine Jérôme, Liana C Silva, Luis Graca, Véronique Préat, Helena F Florindo
Publié dans: Nanomedicine, Numéro 17435889, 2014, Page(s) 2639-2656, ISSN 1743-5889
Éditeur: Future Medicine Ltd.
DOI: 10.2217/nnm.14.135

Classification of current anticancer immunotherapies

Auteurs: Lorenzo Galluzzi, Erika Vacchelli, José-Manuel Bravo-San Pedro, Aitziber Buqué, Laura Senovilla, Elisa Elena Baracco, Norma Bloy, Francesca Castoldi, Jean-Pierre Abastado, Patrizia Agostinis, Ron N. Apte, Fernando Aranda, Maha Ayyoub, Philipp Beckhove, Jean-Yves Blay, Laura Bracci, Anne Caignard, Chiara Castelli, Federica Cavallo, Estaban Celis, Vincenzo Cerundolo, Aled Clayton, Mario P. Colombo, Lisa Coussens, Madhav V. Dhodapkar, Alexander M. Eggermont, Douglas T. Fearon, Wolf H. Fridman, Jitka Fučíková, Dmitry I. Gabrilovich, Jérôme Galon, Abhishek Garg, François Ghiringhelli, Giuseppe Giaccone, Eli Gilboa, Sacha Gnjatic, Axel Hoos, Anne Hosmalin, Dirk Jäger, Pawel Kalinski, Klas Kärre, Oliver Kepp, Rolf Kiessling, John M. Kirkwood, Eva Klein, Alexander Knuth, Claire E. Lewis, Roland Liblau, Michael T. Lotze, Enrico Lugli, Jean-Pierre Mach, Fabrizio Mattei, Domenico Mavilio, Ignacio Melero, Cornelis J. Melief, Elizabeth A. Mittendorf, Lorenzo Moretta, Adekunke Odunsi, Hideho Okada, Anna Karolina Palucka, Marcus E. Peter, Kenneth J. Pienta, Angel Porgador, George C. Prendergast, Gabriel A. Rabinovich, Nicholas P. Restifo, Naiyer Rizvi, Catherine Sautès-Fridman, Hans Schreiber, Barbara Seliger, Hiroshi Shiku, Bruno Silva-Santos, Mark J. Smyth, Daniel E. Speiser, Radek Spisek, Pramod K. Srivastava, James E. Talmadge, Eric Tartour, Sjoerd H. Van Der Burg, Benoît J. Van Den Eynde, Richard Vile, Hermann Wagner, Jeffrey S. Weber, Theresa L. Whiteside, Jedd D. Wolchok, Laurence Zitvogel, Weiping Zou, Guido Kroemer
Publié dans: Oncotarget, Numéro 19492553, 2015, Page(s) 12472-12508, ISSN 1949-2553
Éditeur: Impact Journals
DOI: 10.18632/oncotarget.2998

Host-cell sensors for Plasmodium activate innate immunity against liver-stage infection

Auteurs: Peter Liehl, Vanessa Zuzarte-Luís, Jennie Chan, Thomas Zillinger, Fernanda Baptista, Daniel Carapau, Madlen Konert, Kirsten K Hanson, Céline Carret, Caroline Lassnig, Mathias Müller, Ulrich Kalinke, Mohsan Saeed, Angelo Ferreira Chora, Douglas T Golenbock, Birgit Strobl, Miguel Prudêncio, Luis P Coelho, Stefan H Kappe, Giulio Superti-Furga, Andreas Pichlmair, Ana M Vigário, Charles M Rice, Katherine A Fitzgerald, Winfried Barchet, Maria M Mota
Publié dans: Nature Medicine, Numéro 10788956, 2013, Page(s) 47-53, ISSN 1078-8956
Éditeur: Nature Publishing Group
DOI: 10.1038/nm.3424

Maternal retinoids control type 3 innate lymphoid cells and set the offspring immunity

Auteurs: Serge A. van de Pavert, Manuela Ferreira, Rita G. Domingues, Hélder Ribeiro, Rosalie Molenaar, Lara Moreira-Santos, Francisca F. Almeida, Sales Ibiza, Inês Barbosa, Gera Goverse, Carlos Labão-Almeida, Cristina Godinho-Silva, Tanja Konijn, Dennis Schooneman, Tom O’Toole, Mark R. Mizee, Yasmin Habani, Esther Haak, Fabio R. Santori, Dan R. Littman, Stefan Schulte-Merker, Elaine Dzierzak, J. Pedro Simas, Reina E. Mebius, Henrique Veiga-Fernandes
Publié dans: Nature, Numéro 00280836, 2014, Page(s) 123-127, ISSN 0028-0836
Éditeur: Nature Publishing Group
DOI: 10.1038/nature13158

The neurotrophic factor receptor RET drives haematopoietic stem cell survival and function

Auteurs: Diogo Fonseca-Pereira, Sílvia Arroz-Madeira, Mariana Rodrigues-Campos, Inês A. M. Barbosa, Rita G. Domingues, Teresa Bento, Afonso R. M. Almeida, Hélder Ribeiro, Alexandre J. Potocnik, Hideki Enomoto, Henrique Veiga-Fernandes
Publié dans: Nature, Numéro 00280836, 2014, Page(s) 98-101, ISSN 0028-0836
Éditeur: Nature Publishing Group
DOI: 10.1038/nature13498

Pherotype Influences Biofilm Growth and Recombination in Streptococcus pneumoniae

Auteurs: Margarida Carrolo, Francisco Rodrigues Pinto, José Melo-Cristino, Mário Ramirez
Publié dans: PLoS ONE, Numéro 19326203, 2014, Page(s) e92138, ISSN 1932-6203
Éditeur: Public Library of Science
DOI: 10.1371/journal.pone.0092138

Non-Invasive Pneumococcal Pneumonia in Portugal—Serotype Distribution and Antimicrobial Resistance

Auteurs: Andreia N. Horácio, Joana P. Lopes, Mário Ramirez, José Melo-Cristino
Publié dans: PLoS ONE, Numéro 19326203, 2014, Page(s) e103092, ISSN 1932-6203
Éditeur: Public Library of Science
DOI: 10.1371/journal.pone.0103092

Evaluation of a Novel Magneto-Optical Method for the Detection of Malaria Parasites

Auteurs: Ágnes Orbán, Ádám Butykai, András Molnár, Zsófia Pröhle, Gergö Fülöp, Tivadar Zelles, Wasan Forsyth, Danika Hill, Ivo Müller, Louis Schofield, Maria Rebelo, Thomas Hänscheid, Stephan Karl, István Kézsmárki
Publié dans: PLoS ONE, Numéro 19326203, 2014, Page(s) e96981, ISSN 1932-6203
Éditeur: Public Library of Science
DOI: 10.1371/journal.pone.0096981

Scarlet Fever Is Caused By a Limited Number of Streptococcus pyogenes Lineages and Is Associated with the Exotoxin Genes ssa, speA and speC

Auteurs: Catarina Silva-Costa, Joao A. Carriço, Mario Ramirez, Jose Melo-Cristino
Publié dans: The Pediatric Infectious Disease Journal, Numéro 08913668, 2014, Page(s) 306-310, ISSN 0891-3668
Éditeur: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/INF.0000000000000088

Defining Immune Engagement Thresholds for In Vivo Control of Virus-Driven Lymphoproliferation

Auteurs: Cristina Godinho-Silva, Sofia Marques, Diana Fontinha, Henrique Veiga-Fernandes, Philip G. Stevenson, J. Pedro Simas
Publié dans: PLoS Pathogens, Numéro 15537366, 2014, Page(s) e1004220, ISSN 1553-7366
Éditeur: Public Library of Science
DOI: 10.1371/journal.ppat.1004220

Establishment of Murine Gammaherpesvirus Latency in B Cells Is Not a Stochastic Event

Auteurs: Jérémie Decalf, Cristina Godinho-Silva, Diana Fontinha, Sofia Marques, J. Pedro Simas
Publié dans: PLoS Pathogens, Numéro 15537366, 2014, Page(s) e1004269, ISSN 1553-7366
Éditeur: Public Library of Science
DOI: 10.1371/journal.ppat.1004269

Induction of Prophages by Fluoroquinolones in Streptococcus pneumoniae: Implications for Emergence of Resistance in Genetically-Related Clones

Auteurs: Elena López, Arnau Domenech, María-José Ferrándiz, Maria João Frias, Carmen Ardanuy, Mario Ramirez, Ernesto García, Josefina Liñares, Adela G. de la Campa
Publié dans: PLoS ONE, Numéro 19326203, 2014, Page(s) e94358, ISSN 1932-6203
Éditeur: Public Library of Science
DOI: 10.1371/journal.pone.0094358

Murine CD27(-) V 6(+) T cells producing IL-17A promote ovarian cancer growth via mobilization of protumor small peritoneal macrophages

Auteurs: M. Rei, N. Goncalves-Sousa, T. Lanca, R. G. Thompson, S. Mensurado, F. R. Balkwill, H. Kulbe, D. J. Pennington, B. Silva-Santos
Publié dans: Proceedings of the National Academy of Sciences, Numéro 00278424, 2014, Page(s) E3562-E3570, ISSN 0027-8424
Éditeur: National Academy of Sciences
DOI: 10.1073/pnas.1403424111

Towards an advanced therapy medicinal product based on mesenchymal stromal cells isolated from the umbilical cord tissue: quality and safety data

Auteurs: José Paulo Martins, Jorge Miguel Santos, Joana Marto de Almeida, Mariana Alves Filipe, Mariana Vargas Teixeira de Almeida, Sílvia Cristina Paiva Almeida, Ana Água-Doce, Alexandre Varela, Mari Gilljam, Birgitta Stellan, Susanne Pohl, Kurt Dittmar, Werner Lindenmaier, Evren Alici, Luís Graça, Pedro Estilita Cruz, Helder Joaquim Cruz, Rita Nogueira Bárcia
Publié dans: Stem Cell Research & Therapy, Numéro 17576512, 2014, Page(s) 9, ISSN 1757-6512
Éditeur: BioMed Central
DOI: 10.1186/scrt398

Enteric Mucosa Integrity in the Presence of a Preserved Innate Interleukin 22 Compartment in HIV Type 1-Treated Individuals

Auteurs: S. M. Fernandes, A. R. Pires, C. Ferreira, R. B. Foxall, J. Rino, C. Santos, L. Correia, J. Pocas, H. Veiga-Fernandes, A. E. Sousa
Publié dans: Journal of Infectious Diseases, Numéro 00221899, 2014, Page(s) 630-640, ISSN 0022-1899
Éditeur: University of Chicago Press
DOI: 10.1093/infdis/jiu126

Delta-like 1-Mediated Notch Signaling Enhances the In Vitro Conversion of Human Memory CD4 T Cells into FOXP3-Expressing Regulatory T Cells

Auteurs: C. Mota, V. Nunes-Silva, A. R. Pires, P. Matoso, R. M. M. Victorino, A. E. Sousa, I. Caramalho
Publié dans: The Journal of Immunology, Numéro 00221767, 2014, Page(s) 5854-5862, ISSN 0022-1767
Éditeur: American Association of Immunologists
DOI: 10.4049/jimmunol.1400198

TACI deficiency enhances antibody avidity and clearance of an intestinal pathogen

Auteurs: Shoichiro Tsuji, Lucas Stein, Nobuhiko Kamada, Gabriel Nuñez, Richard Bram, Bruce A. Vallance, Ana E. Sousa, Jeffrey L. Platt, Marilia Cascalho
Publié dans: Journal of Clinical Investigation, Numéro 00219738, 2014, Page(s) 4857-4866, ISSN 0021-9738
Éditeur: American Society for Clinical Investigation
DOI: 10.1172/JCI74428

Human Thymocytes Are Functionally Immature and Differentiate into Cytotoxic Type 1 Effector T Cells upon IL-2/IL-15 Signaling

Auteurs: J. C. Ribot, S. T. Ribeiro, D. V. Correia, A. E. Sousa, B. Silva-Santos
Publié dans: The Journal of Immunology, Numéro 00221767, 2014, Page(s) 2237-2243, ISSN 0022-1767
Éditeur: American Association of Immunologists
DOI: 10.4049/jimmunol.1303119

In Vitro Alterations Do Not Reflect a Requirement for Host Cell Cycle Progression during Plasmodium Liver Stage Infection

Auteurs: Kirsten K. Hanson, Sandra March, Shengyong Ng, Sangeeta N. Bhatia, Maria M. Mota
Publié dans: Eukaryotic Cell, Numéro 15359778, 2014, Page(s) 96-103, ISSN 1535-9778
Éditeur: American Society for Microbiology
DOI: 10.1128/EC.00166-14

The Emerging Protumor Role of T Lymphocytes: Implications for Cancer Immunotherapy

Auteurs: M. Rei, D. J. Pennington, B. Silva-Santos
Publié dans: Cancer Research, Numéro 00085472, 2015, Page(s) 798-802, ISSN 0008-5472
Éditeur: American Association for Cancer Research
DOI: 10.1158/0008-5472.CAN-14-3228

Chicago 2014 – 30years of γδ T cells

Auteurs: Marc Bonneville, Zheng W. Chen, Julie Déchanet-Merville, Matthias Eberl, Jean Jacques Fournié, Julie M. Jameson, Richard D. Lopez, Massimo Massaia, Bruno Silva-Santos
Publié dans: Cellular Immunology, Numéro 00088749, 2015, Page(s) 3-9, ISSN 0008-8749
Éditeur: Academic Press
DOI: 10.1016/j.cellimm.2014.11.001

Human regulatory T-cell development is dictated by Interleukin-2 and -15 expressed in a non-overlapping pattern in the thymus

Auteurs: Iris Caramalho, Vânia Nunes-Silva, Ana R. Pires, Catarina Mota, Ana I. Pinto, Helena Nunes-Cabaço, Russell B. Foxall, Ana E. Sousa
Publié dans: Journal of Autoimmunity, Numéro 08968411, 2015, Page(s) 98-110, ISSN 0896-8411
Éditeur: Academic Press
DOI: 10.1016/j.jaut.2014.11.002

Thymic HIV-2 Infection Uncovers Posttranscriptional Control of Viral Replication in Human Thymocytes

Auteurs: Helena Nunes-Cabaço, Paula Matoso, Russell B. Foxall, Rita Tendeiro, Ana R. Pires, Tânia Carvalho, Ana I. Pinheiro, Rui S. Soares, Ana E. Sousa
Publié dans: Journal of Virology, Numéro 0022538X, 2015, Page(s) 2201-2208, ISSN 0022-538X
Éditeur: American Society for Microbiology
DOI: 10.1128/JVI.03047-14

In vivo delivery of peptides and Toll-like receptor ligands by mannose-functionalized polymeric nanoparticles induces prophylactic and therapeutic anti-tumor immune responses in a melanoma model

Auteurs: Joana M. Silva, Eva Zupancic, Gaëlle Vandermeulen, Vanessa G. Oliveira, Ana Salgado, Mafalda Videira, Manuela Gaspar, Luis Graca, Véronique Préat, Helena F. Florindo
Publié dans: Journal of Controlled Release, Numéro 01683659, 2015, Page(s) 91-103, ISSN 0168-3659
Éditeur: Elsevier BV
DOI: 10.1016/j.jconrel.2014.11.033

Point-of-care tests: where is the point?

Auteurs: Thomas Hänscheid, Maria Rebelo, Martin P Grobusch
Publié dans: The Lancet Infectious Diseases, Numéro 14733099, 2014, Page(s) 922, ISSN 1473-3099
Éditeur: The Lancet Publishing Group
DOI: 10.1016/S1473-3099(14)70914-4

Eimeria vermiformis Infection Model of Murine Small Intestine

Auteurs: Patrícia Figueiredo-Campos, Cristina Ferreira, Birte Blankenhaus, Marc Veldhoen
Publié dans: BIO-PROTOCOL, Numéro 8/24, 2018, ISSN 2331-8325
Éditeur: BIO-PROTOCOL
DOI: 10.21769/bioprotoc.3122

Dynamic Metabolic State of Tissue Resident CD8 T Cells

Auteurs: Špela Konjar, Marc Veldhoen
Publié dans: Frontiers in Immunology, Numéro 10, 2019, ISSN 1664-3224
Éditeur: FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2019.01683

Effector γδ T Cell Differentiation Relies on Master but Not Auxiliary Th Cell Transcription Factors

Auteurs: Joana Barros-Martins, Nina Schmolka, Diana Fontinha, Marta Pires de Miranda, J. Pedro Simas, Ingrid Brok, Cristina Ferreira, Marc Veldhoen, Bruno Silva-Santos, Karine Serre
Publié dans: The Journal of Immunology, Numéro 196/9, 2016, Page(s) 3642-3652, ISSN 0022-1767
Éditeur: American Association of Immunologists
DOI: 10.4049/jimmunol.1501921

Mitochondria maintain controlled activation state of epithelial-resident T lymphocytes

Auteurs: Špela Konjar, Ulrika C. Frising, Cristina Ferreira, Reinhard Hinterleitner, Toufic Mayassi, Qifeng Zhang, Birte Blankenhaus, Nejc Haberman, Yunhua Loo, Joana Guedes, Marta Baptista, Silvia Innocentin, Joerg Stange, Douglas Strathdee, Bana Jabri, Marc Veldhoen
Publié dans: Science Immunology, Numéro 3/24, 2018, Page(s) eaan2543, ISSN 2470-9468
Éditeur: AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/sciimmunol.aan2543

Immunology: Skin T Cells Switch Identity to Protect and Heal

Auteurs: Silvia Ariotti, Marc Veldhoen
Publié dans: Current Biology, Numéro 29/6, 2019, Page(s) R220-R223, ISSN 0960-9822
Éditeur: Cell Press
DOI: 10.1016/j.cub.2019.01.055

Guidelines for the use of flow cytometry and cell sorting in immunological studies *

Auteurs: Andrea Cossarizza, Hyun‐Dong Chang, Andreas Radbruch, Mübeccel Akdis, Immanuel Andrä, Francesco Annunziato, Petra Bacher, Vincenzo Barnaba, Luca Battistini, Wolfgang M. Bauer, Sabine Baumgart, Burkhard Becher, Wolfgang Beisker, Claudia Berek, Alfonso Blanco, Giovanna Borsellino, Philip E. Boulais, Ryan R. Brinkman, Martin Büscher, Dirk H. Busch, Timothy P. Bushnell, Xuetao Cao, Andrea Cavani,
Publié dans: European Journal of Immunology, Numéro 47/10, 2017, Page(s) 1584-1797, ISSN 0014-2980
Éditeur: John Wiley & Sons Ltd.
DOI: 10.1002/eji.201646632

Quantification of Sporozoite Invasion, Migration, and Development by Microscopy and Flow Cytometry

Auteurs: Photini Sinnis, Patricia De La Vega, Alida Coppi, Urszula Krzych, Maria M. Mota
Publié dans: Malaria, 2013, Page(s) 385-400, ISBN 978-1-62703-026-7
Éditeur: Humana Press
DOI: 10.1007/978-1-62703-026-7_27

Differentiation and Activation of γδ T Lymphocytes: Focus on CD27 and CD28 Costimulatory Receptors

Auteurs: Julie C. Ribot, Bruno Silva-Santos
Publié dans: Crossroads Between Innate and Adaptive Immunity IV, 2013, Page(s) 95-105, ISBN 978-1-4614-6217-0
Éditeur: Springer New York
DOI: 10.1007/978-1-4614-6217-0_11

Endemic SARS-CoV-2 will maintain post-pandemic immunity

Auteurs: Marc Veldhoen, J. Pedro Simas
Publié dans: Nature Reviews Immunology, Numéro 21/3, 2021, Page(s) 131-132, ISSN 1474-1733
Éditeur: Nature Publishing Group
DOI: 10.1038/s41577-020-00493-9

Academic labs supporting COVID‐19 diagnostics

Auteurs: Marc Veldhoen, Vanessa Zuzarte‐Luis
Publié dans: European Journal of Immunology, Numéro 51/1, 2021, Page(s) 13-16, ISSN 0014-2980
Éditeur: John Wiley & Sons Ltd.
DOI: 10.1002/eji.202170015

Recherche de données OpenAIRE...

Livrables

Publications

Partager cette page

Télécharger