Leverage research EXCELLence and INNOVation potential of Instituto de Medicina Molecular (IMM) through translational biomedical research in immunity and infection.

Resultado final

Re-evaluation of current state of IMM towards ERA priorities
Publications in the research field of immunity and infection of the Instituto de Medicina Molecular

A one-page statement that the task has been completed.

Acquisition of the pre-clinical molecular and imaging equipment
Organisation of thematic Workshops – first period

Organisation of thematic Workshops held during the first period

Organisation of thematic Workshops – second period

Organisation of thematic Workshops held during the second reporting period

Self-assessment after 2-year period of strategy implementation
Organisation of thematic Workshops – third period

Organisation of thematic Workshops held during the third reporting period

Launch of website
Development of the project logo/brand
Forum for overseas discussion in translational immunity and infection
Brochure and flyer development

Publicaciones

Controlling the pandemic during the SARS-CoV-2 vaccination rollout

Autores: João Viana, Christiaan H. van Dorp, Ana Nunes, Manuel C. Gomes, Michiel van Boven, Mirjam E. Kretzschmar, Marc Veldhoen, Ganna Rozhnova
Publicado en: Nature Communications, Edición 12/1, 2021, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-021-23938-8

Th17 Cells Require You to Chew before You Swallow

Autores: Marc Veldhoen
Publicado en: Immunity, Edición 46/1, 2017, Página(s) 8-10, ISSN 1074-7613
Editor: Cell Press
DOI: 10.1016/j.immuni.2016.12.016

Seroprevalence of anti‐SARS‐CoV‐2 antibodies in COVID‐19 patients and healthy volunteers up to 6 months post disease onset

Autores: Patrícia Figueiredo‐Campos, Birte Blankenhaus, Catarina Mota, Andreia Gomes, Marta Serrano, Silvia Ariotti, Catarina Costa, Helena Nunes‐Cabaço, António M. Mendes, Pedro Gaspar, M. Conceição Pereira‐Santos, Fabiana Rodrigues, Jorge Condeço, M. Antonia Escoval, Matilde Santos, Mario Ramirez, José Melo‐Cristino, J. Pedro Simas, Eugenia Vasconcelos, Ângela Afonso, Marc Veldhoen
Publicado en: European Journal of Immunology, Edición 50/12, 2020, Página(s) 2025-2040, ISSN 0014-2980
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/eji.202048970

3-hydroxy-L-kynurenamine is an immunomodulatory biogenic amine

Autores: Cristina C. Clement, Angelo D’Alessandro, Sangeetha Thangaswamy, Samantha Chalmers, Raquel Furtado, Sheila Spada, Giada Mondanelli, Federica Ianni, Sarah Gehrke, Marco Gargaro, Giorgia Manni, Luisa Carlota Lopez Cara, Peter Runge, Wanxia Li Tsai, Sinem Karaman, Jorge Arasa, Ruben Fernandez-Rodriguez, Amanda Beck, Antonio Macchiarulo, Massimo Gadina, Cornelia Halin, Francesca Fallarino, Mihaela S
Publicado en: Nature Communications, Edición 12/1, 2021, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-021-24785-3

Smarcad1 mediates microbiota-induced inflammation in mouse and coordinates gene expression in the intestinal epithelium

Autores: Juri Kazakevych, Jérémy Denizot, Anke Liebert, Mariana Portovedo, Mia Mosavie, Payal Jain, Claudia Stellato, Claire Fraser, Renan Oliveira Corrêa, Marina Célestine, Raphaël Mattiuz, Hanneke Okkenhaug, J. Ross Miller, Marco Aurélio Ramirez Vinolo, Marc Veldhoen, Patrick Varga-Weisz
Publicado en: Genome Biology, Edición 21/1, 2020, ISSN 1474-760X
Editor: BMC
DOI: 10.1186/s13059-020-01976-7

Loss of Phosphatidylinositol 3-Kinase Activity in Regulatory T Cells Leads to Neuronal Inflammation

Autores: Anne-Katrien Stark, Elizabeth C. M. Davenport, Daniel T. Patton, Cheryl L. Scudamore, Bart Vanhaesebroeck, Marc Veldhoen, Oliver A. Garden, Klaus Okkenhaug
Publicado en: The Journal of Immunology, Edición 205/1, 2020, Página(s) 78-89, ISSN 0022-1767
Editor: American Association of Immunologists
DOI: 10.4049/jimmunol.2000043

Severe COVID-19 Recovery Is Associated with Timely Acquisition of a Myeloid Cell Immune-Regulatory Phenotype

Autores: Amelia C. Trombetta, Guilherme B. Farias, André M. C. Gomes, Ana Godinho-Santos, Pedro Rosmaninho, Carolina M. Conceição, Joel Laia, Diana F. Santos, Afonso R. M. Almeida, Catarina Mota, Andreia Gomes, Marta Serrano, Marc Veldhoen, Ana E. Sousa, Susana M. Fernandes
Publicado en: Frontiers in Immunology, Edición 12, 2021, ISSN 1664-3224
Editor: FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2021.691725

Feeding immunity: skepticism, delicacies and delights

Autores: Marc Veldhoen, Henrique Veiga-Fernandes
Publicado en: Nature Immunology, Edición 16/3, 2015, Página(s) 215-219, ISSN 1529-2908
Editor: Nature Publishing Group
DOI: 10.1038/ni.3100

Type 1 Treg cells promote the generation of CD8+ tissue-resident memory T cells

Autores: Cristina Ferreira, Leandro Barros, Marta Baptista, Birte Blankenhaus, André Barros, Patrícia Figueiredo-Campos, Špela Konjar, Alexandra Lainé, Nadine Kamenjarin, Ana Stojanovic, Adelheid Cerwenka, Hans C. Probst, Julien C. Marie, Marc Veldhoen
Publicado en: Nature Immunology, Edición 21/7, 2020, Página(s) 766-776, ISSN 1529-2908
Editor: Nature Publishing Group
DOI: 10.1038/s41590-020-0674-9

Pulmonary paracoccidioidomycosis in AhR deficient hosts is severe and associated with defective Treg and Th22 responses

Autores: Eliseu Frank de Araújo, Nycolas Willian Preite, Marc Veldhoen, Flávio Vieira Loures, Vera Lúcia Garcia Calich
Publicado en: Scientific Reports, Edición 10/1, 2020, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-020-68322-6

Humoral Immune Response of SARS‐CoV ‐2–Infected Patients with Cancer: Influencing Factors and Mechanisms

Autores: Miguel Esperança‐Martins, Lisa Gonçalves, Inês Soares‐Pinho, Andreia Gomes, Marta Serrano, Birte Blankenhaus, Patrícia Figueiredo‐Campos, Ana Catarina‐Marques, Ana Castro‐Barbosa, Ana Cardoso, Pedro Antunes‐Meireles, Henrique Atalaia‐Barbacena, Pedro Gaspar, Patrícia Howell‐Monteiro, António Pais‐de‐Lacerda, Catarina Mota, Marc Veldhoen
Publicado en: The Oncologist, Edición 26/9, 2021, ISSN 1083-7159
Editor: AlphaMed Press Inc
DOI: 10.1002/onco.13828

Microbiota derived short chain fatty acids promote histone crotonylation in the colon through histone deacetylases

Autores: Rachel Fellows, Jérémy Denizot, Claudia Stellato, Alessandro Cuomo, Payal Jain, Elena Stoyanova, Szabina Balázsi, Zoltán Hajnády, Anke Liebert, Juri Kazakevych, Hector Blackburn, Renan Oliveira Corrêa, José Luís Fachi, Fabio Takeo Sato, Willian R. Ribeiro, Caroline Marcantonio Ferreira, Hélène Perée, Mariangela Spagnuolo, Raphaël Mattiuz, Csaba Matolcsi, Joana Guedes, Jonathan Clark, M
Publicado en: Nature Communications, Edición 9/1, 2018, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-017-02651-5

Gut Bacterial Metabolite Urolithin A (UA) Mitigates Ca2+ Entry in T Cells by Regulating miR-10a-5p

Autores: Shaqiu Zhang, Tamer Al-Maghout, Hang Cao, Lisann Pelzl, Madhuri S. Salker, Marc Veldhoen, Anchun Cheng, Florian Lang, Yogesh Singh
Publicado en: Frontiers in Immunology, Edición 10, 2019, ISSN 1664-3224
Editor: FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2019.01737

Guidelines for the use of flow cytometry

Autores: Marc Veldhoen
Publicado en: Immunity, Inflammation and Disease, Edición 5/4, 2017, Página(s) 384-385, ISSN 2050-4527
Editor: WILEY
DOI: 10.1002/iid3.207

Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition)

Autores: Andrea Cossarizza, Hyun‐Dong Chang, Andreas Radbruch, Andreas Acs, Dieter Adam, Sabine Adam‐Klages, William W. Agace, Nima Aghaeepour, Mübeccel Akdis, Matthieu Allez, Larissa Nogueira Almeida, Giorgia Alvisi, Graham Anderson, Immanuel Andrä, Francesco Annunziato, Achille Anselmo, Petra Bacher, Cosima T. Baldari, Sudipto Bari, Vincenzo Barnaba, Joana Barros‐Martins, Luca Battistini, Wolfgan
Publicado en: European Journal of Immunology, Edición 49/10, 2019, Página(s) 1457-1973, ISSN 0014-2980
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/eji.201970107

Cellular Stress in the Context of an Inflammatory Environment Supports TGF-β-Independent T Helper-17 Differentiation

Autores: Verena Brucklacher-Waldert, Cristina Ferreira, Marisa Stebegg, Olivier Fesneau, Silvia Innocentin, Julien C. Marie, Marc Veldhoen
Publicado en: Cell Reports, Edición 19/11, 2017, Página(s) 2357-2370, ISSN 2211-1247
Editor: Cell Press
DOI: 10.1016/j.celrep.2017.05.052

Intestinal Barrier Interactions with Specialized CD8 T Cells

Autores: Špela Konjar, Cristina Ferreira, Birte Blankenhaus, Marc Veldhoen
Publicado en: Frontiers in Immunology, Edición 8, 2017, ISSN 1664-3224
Editor: FRONTIERS MEDIA SA, PO BOX 110, EPFL INNOVATION PARK, BUILDING I, LAUSANNE, 1015, SWITZERLAND
DOI: 10.3389/fimmu.2017.01281

Metabolic wiring of murine T cell and intraepithelial lymphocyte maintenance and activation

Autores: Marc Veldhoen, Birte Blankenhaus, Špela Konjar, Cristina Ferreira
Publicado en: European Journal of Immunology, 2018, ISSN 0014-2980
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/eji.201646745

Oxygen starvation during T cell priming boosts cancer-killing potential

Autores: Špela Konjar, Birte Blankenhaus, Marc Veldhoen
Publicado en: Translational Cancer Research, Edición 7/S1, 2018, Página(s) S34-S37, ISSN 2218-676X
Editor: AME PUBL CO, FLAT-RM C 16F, KINGS WING PLAZA 1, NO 3 KWAN ST, SHATIN, HONG KONG 00000, PEOPLES R CHINA
DOI: 10.21037/tcr.2017.12.07

Interleukin 17 is a chief orchestrator of immunity

Autores: Marc Veldhoen
Publicado en: Nature Immunology, Edición 18/6, 2017, Página(s) 612-621, ISSN 1529-2908
Editor: Nature Publishing Group
DOI: 10.1038/ni.3742

PD-1 and its ligand PD-L1 are progressively up-regulated on CD4 and CD8 T-cells in HIV-2 infection irrespective of the presence of viremia

Autores: Rita Tendeiro, Russell B. Foxall, António P. Baptista, Francisco Pinto, Rui S. Soares, Rita Cavaleiro, Emília Valadas, Perpétua Gomes, Rui M.M. Victorino, Ana E. Sousa
Publicado en: AIDS, Edición 02699370, 2012, Página(s) 1065-1071, ISSN 0269-9370
Editor: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/QAD.0b013e32835374db

Memory B-cell depletion is a feature of HIV-2 infection even in the absence of detectable viremia

Autores: Rita Tendeiro, Sofia Fernandes, Russell B. Foxall, José M. Marcelino, Nuno Taveira, Rui S. Soares, António P. Baptista, Rita Cavaleiro, Perpétua Gomes, Rui M.M. Victorino, Ana E. Sousa
Publicado en: AIDS, Edición 02699370, 2012, Página(s) 1607-1617, ISSN 0269-9370
Editor: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/QAD.0b013e3283568849

Gold nanoparticle-based fluorescence immunoassay for malaria antigen detection

Autores: Bassem S. S. Guirgis, Cláudia Sá e Cunha, Inês Gomes, Miguel Cavadas, Isabel Silva, Gonçalo Doria, Gregory L. Blatch, Pedro V. Baptista, Eulália Pereira, Hassan M. E. Azzazy, Maria M. Mota, Miguel Prudêncio, Ricardo Franco
Publicado en: Analytical and Bioanalytical Chemistry, Edición 16182642, 2012, Página(s) 1019-1027, ISSN 1618-2642
Editor: Springer Verlag
DOI: 10.1007/s00216-011-5489-y

Haemozoin detection in infected erythrocytes for Plasmodium falciparum malaria diagnosis—Prospects and limitations

Autores: Maria Rebelo, Howard M. Shapiro, Teresa Amaral, José Melo-Cristino, Thomas Hänscheid
Publicado en: Acta Tropica, Edición 0001706X, 2012, Página(s) 58-61, ISSN 0001-706X
Editor: Elsevier BV
DOI: 10.1016/j.actatropica.2012.03.005

A Novel Carbon Monoxide-Releasing Molecule Fully Protects Mice from Severe Malaria

Autores: A. C. Pena, N. Penacho, L. Mancio-Silva, R. Neres, J. D. Seixas, A. C. Fernandes, C. C. Romao, M. M. Mota, G. J. L. Bernardes, A. Pamplona
Publicado en: Antimicrobial Agents and Chemotherapy, Edición 00664804, 2012, Página(s) 1281-1290, ISSN 0066-4804
Editor: American Society for Microbiology
DOI: 10.1128/AAC.05571-11

PHYLOViZ: phylogenetic inference and data visualization for sequence based typing methods

Autores: Alexandre P Francisco, Cátia Vaz, Pedro T Monteiro, José Melo-Cristino, Mário Ramirez, João A Carriço
Publicado en: BMC Bioinformatics, Edición 14712105, 2012, Página(s) 87, ISSN 1471-2105
Editor: BioMed Central
DOI: 10.1186/1471-2105-13-87

Engagement of NKp30 on V 1 T cells induces the production of CCL3, CCL4, and CCL5 and suppresses HIV-1 replication

Autores: K. Hudspeth, M. Fogli, D. V. Correia, J. Mikulak, A. Roberto, S. Della Bella, B. Silva-Santos, D. Mavilio
Publicado en: Blood, Edición 00064971, 2012, Página(s) 4013-4016, ISSN 0006-4971
Editor: American Society of Hematology
DOI: 10.1182/blood-2011-11-390153

Differences between Macrolide-Resistant and -Susceptible Streptococcus pyogenes: Importance of Clonal Properties in Addition to Antibiotic Consumption

Autores: C. Silva-Costa, A. Friaes, M. Ramirez, J. Melo-Cristino
Publicado en: Antimicrobial Agents and Chemotherapy, Edición 00664804, 2012, Página(s) 5661-5666, ISSN 0066-4804
Editor: American Society for Microbiology
DOI: 10.1128/AAC.01133-12

Novel Potent Metallocenes against Liver Stage Malaria

Autores: J. Matos, F. P. da Cruz, E. Cabrita, J. Gut, F. Nogueira, V. E. do Rosario, R. Moreira, P. J. Rosenthal, M. Prudencio, P. Gomes
Publicado en: Antimicrobial Agents and Chemotherapy, Edición 00664804, 2012, Página(s) 1564-1570, ISSN 0066-4804
Editor: American Society for Microbiology
DOI: 10.1128/AAC.05345-11

Group A streptococci clones associated with invasive infections and pharyngitis in Portugal present differences in emm types, superantigen gene content and antimicrobial resistance

Autores: Ana Friães, Francisco R Pinto, Catarina Silva-Costa, Mario Ramirez, José Melo-Cristino
Publicado en: BMC Microbiology, Edición 14712180, 2012, Página(s) 280, ISSN 1471-2180
Editor: BioMed Central
DOI: 10.1186/1471-2180-12-280

Monocyte activation is a feature of common variable immunodeficiency irrespective of plasma lipopolysaccharide levels

Autores: R. R. Barbosa, S. P. Silva, S. L. Silva, R. Tendeiro, A. C. Melo, E. Pedro, M. P. Barbosa, M. C. P. Santos, R. M. M. Victorino, A. E. Sousa
Publicado en: Clinical & Experimental Immunology, Edición 00099104, 2012, Página(s) 263-272, ISSN 0009-9104
Editor: Blackwell Publishing Inc.
DOI: 10.1111/j.1365-2249.2012.04620.x

CD8+ T Cells from Mice Transnuclear for a TCR that Recognizes a Single H-2Kb-Restricted MHV68 Epitope Derived from gB-ORF8 Help Control Infection

Autores: Sharvan Sehrawat, Oktay Kirak, Paul-Albert Koenig, Marisa K. Isaacson, Sofia Marques, Gunes Bozkurt, J. Pedro Simas, Rudolph Jaenisch, Hidde L. Ploegh
Publicado en: Cell Reports, Edición 22111247, 2012, Página(s) 461-471, ISSN 2211-1247
Editor: Cell Press
DOI: 10.1016/j.celrep.2012.03.009

Early skin immunological disturbance after Plasmodium-infected mosquito bites

Autores: Henrique Borges da Silva, Susana S. Caetano, Isadora Monteiro, Iván Gómez-Conde, Kirsten Hanson, Carlos Penha-Gonçalves, David N. Olivieri, Maria M. Mota, Cláudio R. Marinho, Maria R. D’Imperio Lima, Carlos E. Tadokoro
Publicado en: Cellular Immunology, Edición 00088749, 2012, Página(s) 22-32, ISSN 0008-8749
Editor: Academic Press
DOI: 10.1016/j.cellimm.2012.06.003

γδ T-cell conference 2012: Close encounters for the fifth time

Autores: Bruno Silva-Santos, Wolfgang W. A. Schamel, Paul Fisch, Matthias Eberl
Publicado en: European Journal of Immunology, Edición 00142980, 2012, Página(s) 3101-3105, ISSN 0014-2980
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/eji.201270101

Driving IL-17+ γδ T-cell migration in allergic reactions: A new “inflammatory” role for the “homeostatic” chemokine CCL25

Autores: Bruno Silva-Santos
Publicado en: European Journal of Immunology, Edición 00142980, 2012, Página(s) 1097-1101, ISSN 0014-2980
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/eji.201242545

Persistence of uropathogenic Escherichia coli strains in the host for long periods of time: relationship between phylogenetic groups and virulence factors

Autores: A. Narciso, F. Nunes, T. Amores, L. Lito, J. Melo-Cristino, A. Duarte
Publicado en: European Journal of Clinical Microbiology & Infectious Diseases, Edición 09349723, 2012, Página(s) 1211-1217, ISSN 0934-9723
Editor: Springer Verlag
DOI: 10.1007/s10096-011-1431-7

Innate recognition of malarial parasites by mammalian hosts

Autores: Peter Liehl, Maria M. Mota
Publicado en: International Journal for Parasitology, Edición 00207519, 2012, Página(s) 557-566, ISSN 0020-7519
Editor: Elsevier BV
DOI: 10.1016/j.ijpara.2012.04.006

Targeting the Liver Stage of Malaria Parasites: A Yet Unmet Goal

Autores: Tiago Rodrigues, Miguel Prudêncio, Rui Moreira, Maria M. Mota, Francisca Lopes
Publicado en: Journal of Medicinal Chemistry, Edición 00222623, 2012, Página(s) 995-1012, ISSN 0022-2623
Editor: American Chemical Society
DOI: 10.1021/jm201095h

Murine Gammaherpesvirus 68 LANA Acts on Terminal Repeat DNA To Mediate Episome Persistence

Autores: A. C. Habison, C. Beauchemin, J. P. Simas, E. J. Usherwood, K. M. Kaye
Publicado en: Journal of Virology, Edición 0022538X, 2012, Página(s) 11863-11876, ISSN 0022-538X
Editor: American Society for Microbiology
DOI: 10.1128/JVI.01656-12

T Cell Apoptosis and Induction of Foxp3+ Regulatory T Cells Underlie the Therapeutic Efficacy of CD4 Blockade in Experimental Autoimmune Encephalomyelitis

Autores: J. Duarte, N. Carrie, V. G. Oliveira, C. Almeida, A. Agua-Doce, L. Rodrigues, J. P. Simas, L. T. Mars, L. Graca
Publicado en: The Journal of Immunology, Edición 00221767, 2012, Página(s) 1680-1688, ISSN 0022-1767
Editor: American Association of Immunologists
DOI: 10.4049/jimmunol.1201269

Dominance of Serotype Ia among Group B Streptococci Causing Invasive Infections in Nonpregnant Adults in Portugal

Autores: E. R. Martins, J. Melo-Cristino, M. Ramirez
Publicado en: Journal of Clinical Microbiology, Edición 00951137, 2012, Página(s) 1219-1227, ISSN 0095-1137
Editor: American Society for Microbiology
DOI: 10.1128/JCM.05488-11

The split nature of tumor-infiltrating leukocytes

Autores: Telma Lança, Bruno Silva-Santos
Publicado en: OncoImmunology, Edición 21624011, 2012, Página(s) 717-725, ISSN 2162-4011
Editor: Landes Bioscience
DOI: 10.4161/onci.20068

Infection by Plasmodium changes shape and stiffness of hepatic cells

Autores: Peter Eaton, Vanessa Zuzarte-Luis, Maria M. Mota, Nuno C. Santos, Miguel Prudêncio
Publicado en: Nanomedicine: Nanotechnology, Biology and Medicine, Edición 15499634, 2012, Página(s) 17-19, ISSN 1549-9634
Editor: Elsevier BV
DOI: 10.1016/j.nano.2011.10.004

Human FOXN1-Deficiency Is Associated with αβ Double-Negative and FoxP3+ T-Cell Expansions That Are Distinctly Modulated upon Thymic Transplantation

Autores: Adriana S. Albuquerque, José G. Marques, Susana L. Silva, Dario Ligeiro, Blythe H. Devlin, Jacques Dutrieux, Rémi Cheynier, Claudio Pignata, Rui M. M. Victorino, M. Louise Markert, Ana E. Sousa
Publicado en: PLoS ONE, Edición 19326203, 2012, Página(s) e37042, ISSN 1932-6203
Editor: Public Library of Science
DOI: 10.1371/journal.pone.0037042

A Novel Way to Grow Hemozoin-Like Crystals In Vitro and Its Use to Screen for Hemozoin Inhibiting Antimalarial Compounds

Autores: Vincent Thomas, Ana Góis, Bruce Ritts, Peter Burke, Thomas Hänscheid, Gerald McDonnell
Publicado en: PLoS ONE, Edición 19326203, 2012, Página(s) e41006, ISSN 1932-6203
Editor: Public Library of Science
DOI: 10.1371/journal.pone.0041006

Highly Dynamic Host Actin Reorganization around Developing Plasmodium Inside Hepatocytes

Autores: Carina S. S. Gomes-Santos, Maurice A. Itoe, Cristina Afonso, Ricardo Henriques, Rui Gardner, Nuno Sepúlveda, Pedro D. Simões, Helena Raquel, António Paulo Almeida, Luis F. Moita, Friedrich Frischknecht, Maria M. Mota
Publicado en: PLoS ONE, Edición 19326203, 2012, Página(s) e29408, ISSN 1932-6203
Editor: Public Library of Science
DOI: 10.1371/journal.pone.0029408

RET/GFRα Signals Are Dispensable for Thymic T Cell Development In Vivo

Autores: Afonso Rocha Martins Almeida, Sílvia Arroz-Madeira, Diogo Fonseca-Pereira, Hélder Ribeiro, Reena Lasrado, Vassilis Pachnis, Henrique Veiga-Fernandes
Publicado en: PLoS ONE, Edición 19326203, 2012, Página(s) e52949, ISSN 1932-6203
Editor: Public Library of Science
DOI: 10.1371/journal.pone.0052949

PRIMACINS, N-cinnamoyl-primaquine conjugates, with improved liver-stage antimalarial activity

Autores: Bianca Pérez, Cátia Teixeira, Inês S. Albuquerque, Jiri Gut, Philip J. Rosenthal, Miguel Prudêncio, Paula Gomes
Publicado en: MedChemComm, Edición 20402503, 2012, Página(s) 1170, ISSN 2040-2503
Editor: Royal Society of Chemistry
DOI: 10.1039/c2md20113e

Differential RET Signaling Pathways Drive Development of the Enteric Lymphoid and Nervous Systems

Autores: A. Patel, N. Harker, L. Moreira-Santos, M. Ferreira, K. Alden, J. Timmis, K. Foster, A. Garefalaki, P. Pachnis, P. Andrews, H. Enomoto, J. Milbrandt, V. Pachnis, M. C. Coles, D. Kioussis, H. Veiga-Fernandes
Publicado en: Science Signaling, Edición 19379145, 2012, Página(s) ra55-ra55, ISSN 1937-9145
Editor: American Association for the Advancement of Science
DOI: 10.1126/scisignal.2002734

Liver-stage malaria parasites vulnerable to diverse chemical scaffolds

Autores: E. R. Derbyshire, M. Prudencio, M. M. Mota, J. Clardy
Publicado en: Proceedings of the National Academy of Sciences, Edición 00278424, 2012, Página(s) 8511-8516, ISSN 0027-8424
Editor: National Academy of Sciences
DOI: 10.1073/pnas.1118370109

Serotype changes in adult invasive pneumococcal infections in Portugal did not reduce the high fraction of potentially vaccine preventable infections

Autores: Andreia N. Horácio, Jorge Diamantino-Miranda, Sandra I. Aguiar, Mário Ramirez, José Melo-Cristino
Publicado en: Vaccine, Edición 0264410X, 2012, Página(s) 218-224, ISSN 0264-410X
Editor: Elsevier BV
DOI: 10.1016/j.vaccine.2011.11.022

B7-CD28 Costimulatory Signals Control the Survival and Proliferation of Murine and Human T Cells via IL-2 Production

Autores: J. C. Ribot, A. deBarros, L. Mancio-Silva, A. Pamplona, B. Silva-Santos
Publicado en: The Journal of Immunology, Edición 00221767, 2012, Página(s) 1202-1208, ISSN 0022-1767
Editor: American Association of Immunologists
DOI: 10.4049/jimmunol.1200268

Use of the 13-valent conjugate vaccine has the potential to eliminate pilus carrying isolates as causes of invasive pneumococcal disease

Autores: Sandra I. Aguiar, José Melo-Cristino, Mário Ramirez
Publicado en: Vaccine, Edición 0264410X, 2012, Página(s) 5487-5490, ISSN 0264-410X
Editor: Elsevier BV
DOI: 10.1016/j.vaccine.2012.06.062

Drug Screen Targeted at Plasmodium Liver Stages Identifies a Potent Multistage Antimalarial Drug

Autores: F. P. da Cruz, C. Martin, K. Buchholz, M. J. Lafuente-Monasterio, T. Rodrigues, B. Sonnichsen, R. Moreira, F.-J. Gamo, M. Marti, M. M. Mota, M. Hannus, M. Prudencio
Publicado en: Journal of Infectious Diseases, Edición 00221899, 2012, Página(s) 1278-1286, ISSN 0022-1899
Editor: University of Chicago Press
DOI: 10.1093/infdis/jis184

Tumor cell recognition by γδ T lymphocytes

Autores: Daniel V. Correia, Antonio C. Lopes, Bruno Silva-Santos
Publicado en: OncoImmunology, Edición 21624011, 2013, Página(s) e22892, ISSN 2162-4011
Editor: Landes Bioscience
DOI: 10.4161/onci.22892

Preserved CD4 T-cell telomere length during long-lasting HIV-2 infection

Autores: Rita Tendeiro, Adriana S. Albuquerque, Russell B. Foxall, Rita Cavaleiro, Rui S. Soares, António P. Baptista, Maria V.D. Soares, Perpétua Gomes, Ana E. Sousa
Publicado en: AIDS, Edición 02699370, 2013, Página(s) 289-292, ISSN 0269-9370
Editor: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/QAD.0b013e32835ab234

Monocyte and Myeloid Dendritic Cell Activation Occurs Throughout HIV Type 2 Infection, an Attenuated Form of HIV Disease

Autores: R. Cavaleiro, R. Tendeiro, R. B. Foxall, R. S. Soares, A. P. Baptista, P. Gomes, E. Valadas, R. M. M. Victorino, A. E. Sousa
Publicado en: Journal of Infectious Diseases, Edición 00221899, 2013, Página(s) 1730-1742, ISSN 0022-1899
Editor: University of Chicago Press
DOI: 10.1093/infdis/jit085

Colonic patch and colonic SILT development are independent and differentially regulated events

Autores: A P Baptista, B J Olivier, G Goverse, M Greuter, M Knippenberg, K Kusser, R G Domingues, H Veiga-Fernandes, A D Luster, A Lugering, T D Randall, T Cupedo, R E Mebius
Publicado en: Mucosal Immunology, Edición 19330219, 2012, Página(s) 511-521, ISSN 1933-0219
Editor: Nature Publishing Group
DOI: 10.1038/mi.2012.90

Long-Term Immune Reconstitution of Naive and Memory T Cell Pools after Haploidentical Hematopoietic Stem Cell Transplantation

Autores: Rita I. Azevedo, Maria V.D. Soares, Adriana S. Albuquerque, Rita Tendeiro, Rui S. Soares, Miguel Martins, Dário Ligeiro, Rui M.M. Victorino, João F. Lacerda, Ana E. Sousa
Publicado en: Biology of Blood and Marrow Transplantation, Edición 10838791, 2013, Página(s) 703-712, ISSN 1083-8791
Editor: Elsevier BV
DOI: 10.1016/j.bbmt.2013.01.017

A Microscale Human Liver Platform that Supports the Hepatic Stages of Plasmodium falciparum and vivax

Autores: Sandra March, Shengyong Ng, Soundarapandian Velmurugan, Ani Galstian, Jing Shan, David J. Logan, Anne E. Carpenter, David Thomas, B. Kim Lee Sim, Maria M. Mota, Stephen L. Hoffman, Sangeeta N. Bhatia
Publicado en: Cell Host & Microbe, Edición 19313128, 2013, Página(s) 104-115, ISSN 1931-3128
Editor: Cell Press
DOI: 10.1016/j.chom.2013.06.005

Distribution of Pilus Islands in Streptococcus agalactiae That Cause Human Infections: Insights into Evolution and Implication for Vaccine Development

Autores: E. R. Martins, A. Andreu, J. Melo-Cristino, M. Ramirez
Publicado en: Clinical and Vaccine Immunology, Edición 15566811, 2013, Página(s) 313-316, ISSN 1556-6811
Editor: American Society for Microbiology
DOI: 10.1128/CVI.00529-12

Bioinformatics in bacterial molecular epidemiology and public health: databases, tools and the next-generation sequencing revolution

Autores: J. A. Carriço, A. J. Sabat, A.W. Friedrich, Mário Ramirez
Publicado en: Eurosurveillance, 2013, ISSN 1560-7917
Editor: EUR CENTRE DIS PREVENTION & CONTROL

Repairing thymic function

Autores: Helena Nunes-Cabaço, Ana E. Sousa
Publicado en: Current Opinion in Organ Transplantation, Edición 10872418, 2013, Página(s) 1, ISSN 1087-2418
Editor: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/MOT.0b013e3283615df9

Functional development of γδ T cells

Autores: Immo Prinz, Bruno Silva-Santos, Daniel J. Pennington
Publicado en: European Journal of Immunology, Edición 00142980, 2013, Página(s) 1988-1994, ISSN 0014-2980
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/eji.201343759

Targeting Host Factors to Circumvent Anti-Malarial Drug Resistance

Autores: Miguel Prudencio, Maria M. Mota
Publicado en: Current Pharmaceutical Design, Edición 13816128, 2013, Página(s) 290-299, ISSN 1381-6128
Editor: Bentham Science Publishers
DOI: 10.2174/138161213804070276

Superantigen gene complement of Streptococcus pyogenes—relationship with other typing methods and short-term stability

Autores: A. Friães, F. R. Pinto, C. Silva-Costa, M. Ramirez, J. Melo-Cristino
Publicado en: European Journal of Clinical Microbiology & Infectious Diseases, Edición 09349723, 2013, Página(s) 115-125, ISSN 0934-9723
Editor: Springer Verlag
DOI: 10.1007/s10096-012-1726-3

Flavones as isosteres of 4(1H)-quinolones: Discovery of ligand efficient and dual stage antimalarial lead compounds

Autores: Tiago Rodrigues, Ana S. Ressurreição, Filipa P. da Cruz, Inês S. Albuquerque, Jiri Gut, Marta P. Carrasco, Daniel Gonçalves, Rita C. Guedes, Daniel J.V.A. dos Santos, Maria M. Mota, Philip J. Rosenthal, Rui Moreira, Miguel Prudêncio, Francisca Lopes
Publicado en: European Journal of Medicinal Chemistry, Edición 02235234, 2013, Página(s) 872-880, ISSN 0223-5234
Editor: Elsevier BV
DOI: 10.1016/j.ejmech.2013.09.008

Anthracyclines Induce DNA Damage Response-Mediated Protection against Severe Sepsis

Autores: Nuno Figueiredo, Angelo Chora, Helena Raquel, Nadja Pejanovic, Pedro Pereira, Björn Hartleben, Ana Neves-Costa, Catarina Moita, Dora Pedroso, Andreia Pinto, Sofia Marques, Hafeez Faridi, Paulo Costa, Raffaella Gozzelino, Jimmy L. Zhao, Miguel P. Soares, Margarida Gama-Carvalho, Jennifer Martinez, Qingshuo Zhang, Gerd Döring, Markus Grompe, J. Pedro Simas, Tobias B. Huber, David Baltimore, Vineet Gupta, Douglas R. Green, João A. Ferreira, Luis F. Moita
Publicado en: Immunity, Edición 10747613, 2013, Página(s) 874-884, ISSN 1074-7613
Editor: Cell Press
DOI: 10.1016/j.immuni.2013.08.039

The fate of CD4+ T cells under tolerance-inducing stimulation: a modeling perspective

Autores: Marta Caridade, Vanessa G Oliveira, Ana Agua-Doce, Luis Graca, Ruy M Ribeiro
Publicado en: Immunology and Cell Biology, Edición 08189641, 2013, Página(s) 652-660, ISSN 0818-9641
Editor: Blackwell Publishing Inc.
DOI: 10.1038/icb.2013.63

Changes in Streptococcus pyogenes causing invasive disease in Portugal: Evidence for superantigen gene loss and acquisition

Autores: Ana Friães, Joana P. Lopes, José Melo-Cristino, Mario Ramirez
Publicado en: International Journal of Medical Microbiology, Edición 14384221, 2013, Página(s) 505-513, ISSN 1438-4221
Editor: Elsevier BV
DOI: 10.1016/j.ijmm.2013.07.004

Insight into lymphoid tissue morphogenesis

Autores: Mark Coles, Henrique Veiga-Fernandes
Publicado en: Immunology Letters, Edición 01652478, 2013, Página(s) 46-53, ISSN 0165-2478
Editor: Elsevier BV
DOI: 10.1016/j.imlet.2013.08.001

Description of plasmid pSM52, harbouring the gene for the Smr efflux pump, and its involvement in resistance to biocides in a meticillin-resistant Staphylococcus aureus strain

Autores: Sofia Santos Costa, Cláudia Mourato, Miguel Viveiros, José Melo-Cristino, Leonard Amaral, Isabel Couto
Publicado en: International Journal of Antimicrobial Agents, Edición 09248579, 2013, Página(s) 490-492, ISSN 0924-8579
Editor: Elsevier BV
DOI: 10.1016/j.ijantimicag.2013.01.003

Role of Src Homology Domain Binding in Signaling Complexes Assembled by the Murid -Herpesvirus M2 Protein

Autores: M. Pires de Miranda, F. B. Lopes, C. E. McVey, X. R. Bustelo, J. P. Simas
Publicado en: Journal of Biological Chemistry, Edición 00219258, 2013, Página(s) 3858-3870, ISSN 0021-9258
Editor: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1074/jbc.M112.439810

miR-363-5p regulates endothelial cell properties and their communication with hematopoietic precursor cells

Autores: Ana Costa, Joana Afonso, Catarina Osório, Ana L Gomes, Francisco Caiado, Joana Valente, Sandra I Aguiar, Francisco Pinto, Mário Ramirez, Sérgio Dias
Publicado en: Journal of Hematology & Oncology, Edición 17568722, 2013, Página(s) 87, ISSN 1756-8722
Editor: BioMed Central
DOI: 10.1186/1756-8722-6-87

Multilocus Sequence Analysis of Streptococcus canis Confirms the Zoonotic Origin of Human Infections and Reveals Genetic Exchange with Streptococcus dysgalactiae subsp. equisimilis

Autores: M. D. Pinho, S. C. Matos, C. Pomba, A. Lubke-Becker, L. H. Wieler, S. Preziuso, J. Melo-Cristino, M. Ramirez
Publicado en: Journal of Clinical Microbiology, Edición 00951137, 2013, Página(s) 1099-1109, ISSN 0095-1137
Editor: American Society for Microbiology
DOI: 10.1128/JCM.02912-12

At the Bench: Preclinical rationale for exploiting NK cells and T lymphocytes for the treatment of high-risk leukemias

Autores: H. Norell, A. Moretta, B. Silva-Santos, L. Moretta
Publicado en: Journal of Leukocyte Biology, Edición 07415400, 2013, Página(s) 1123-1139, ISSN 0741-5400
Editor: Federation of American Societies for Experimental Biology
DOI: 10.1189/jlb.0613312

Structural Optimization of Quinolon-4(1 H )-imines as Dual-Stage Antimalarials: Toward Increased Potency and Metabolic Stability

Autores: Ana S. Ressurreição, Daniel Gonçalves, Ana R. Sitoe, Inês S. Albuquerque, Jiri Gut, Ana Góis, Lídia M. Gonçalves, Maria R. Bronze, Thomas Hanscheid, Giancarlo A. Biagini, Philip J. Rosenthal, Miguel Prudêncio, Paul O’Neill, Maria M. Mota, Francisca Lopes, Rui Moreira
Publicado en: Journal of Medicinal Chemistry, Edición 00222623, 2013, Página(s) 7679-7690, ISSN 0022-2623
Editor: American Chemical Society
DOI: 10.1021/jm4011466

How Many Sputum Culture Results Do We Need To Monitor Multidrug-Resistant-Tuberculosis (MDR-TB) Patients during Treatment?

Autores: S. Janssen, X. Padanilam, R. Louw, R. Mahanyele, G. Coetzee, T. Hanscheid, T. Leenstra, M. P. Grobusch
Publicado en: Journal of Clinical Microbiology, Edición 00951137, 2013, Página(s) 644-646, ISSN 0095-1137
Editor: American Society for Microbiology
DOI: 10.1128/JCM.02837-12

Assessment of Dual Life Stage Antiplasmodial Activity of British Seaweeds

Autores: Jasmine Spavieri, Andrea Allmendinger, Marcel Kaiser, Maurice Itoe, Gerald Blunden, Maria Mota, Deniz Tasdemir
Publicado en: Marine Drugs, Edición 16603397, 2013, Página(s) 4019-4034, ISSN 1660-3397
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/md11104019

A Novel Flow Cytometric Hemozoin Detection Assay for Real-Time Sensitivity Testing of Plasmodium falciparum

Autores: Maria Rebelo, Claudia Sousa, Howard M. Shapiro, Maria M. Mota, Martin P. Grobusch, Thomas Hänscheid
Publicado en: PLoS ONE, Edición 19326203, 2013, Página(s) e61606, ISSN 1932-6203
Editor: Public Library of Science
DOI: 10.1371/journal.pone.0061606

The Majority of Adult Pneumococcal Invasive Infections in Portugal Are Still Potentially Vaccine Preventable in Spite of Significant Declines of Serotypes 1 and 5

Autores: Andreia N. Horácio, Jorge Diamantino-Miranda, Sandra I. Aguiar, Mário Ramirez, José Melo-Cristino
Publicado en: PLoS ONE, Edición 19326203, 2013, Página(s) e73704, ISSN 1932-6203
Editor: Public Library of Science
DOI: 10.1371/journal.pone.0073704

Spartan: A Comprehensive Tool for Understanding Uncertainty in Simulations of Biological Systems

Autores: Kieran Alden, Mark Read, Jon Timmis, Paul S. Andrews, Henrique Veiga-Fernandes, Mark Coles
Publicado en: PLoS Computational Biology, Edición 1553734X, 2013, Página(s) e1002916, ISSN 1553-734X
Editor: Public Library of Science
DOI: 10.1371/journal.pcbi.1002916

Export of the pneumococcal phage SV1 lysin requires choline-containing teichoic acids and is holin-independent

Autores: Maria João Frias, José Melo-Cristino, Mário Ramirez
Publicado en: Molecular Microbiology, Edición 0950382X, 2013, Página(s) 430-445, ISSN 0950-382X
Editor: Blackwell Publishing Inc.
DOI: 10.1111/mmi.12108

Quinolin-4(1 H )-imines are Potent Antiplasmodial Drugs Targeting the Liver Stage of Malaria

Autores: Tiago Rodrigues, Filipa P. da Cruz, Maria J. Lafuente-Monasterio, Daniel Gonçalves, Ana S. Ressurreição, Ana R. Sitoe, Maria R. Bronze, Jiri Gut, Gisbert Schneider, Maria M. Mota, Philip J. Rosenthal, Miguel Prudêncio, Francisco-Javier Gamo, Francisca Lopes, Rui Moreira
Publicado en: Journal of Medicinal Chemistry, Edición 00222623, 2013, Página(s) 4811-4815, ISSN 0022-2623
Editor: American Chemical Society
DOI: 10.1021/jm400246e

Extensive Dissemination of Methicillin-Resistant Staphylococcus aureus (MRSA) between the Hospital and the Community in a Country with a High Prevalence of Nosocomial MRSA

Autores: Diana Espadinha, Nuno A. Faria, Maria Miragaia, Luís Marques Lito, José Melo-Cristino, Hermínia de Lencastre
Publicado en: PLoS ONE, Edición 19326203, 2013, Página(s) e59960, ISSN 1932-6203
Editor: Public Library of Science
DOI: 10.1371/journal.pone.0059960

The role of human umbilical cord tissue-derived mesenchymal stromal cells (UCX®) in the treatment of inflammatory arthritis

Autores: Jorge M Santos, Rita N Bárcia, Sandra I Simões, Manuela M Gaspar, Susana Calado, Ana Água-Doce, Sílvia CP Almeida, Joana Almeida, Mariana Filipe, Mariana Teixeira, José P Martins, Luís Graça, Maria EM Cruz, Pedro Cruz, Helder Cruz
Publicado en: Journal of Translational Medicine, Edición 14795876, 2013, Página(s) 18, ISSN 1479-5876
Editor: BioMed Central
DOI: 10.1186/1479-5876-11-18

Serotype discrimination of encapsulated Streptococcus pneumoniae strains by Fourier-transform infrared spectroscopy and chemometrics

Autores: M. Vaz, L. Meirinhos-Soares, C.C.S. Sousa, M. Ramirez, J. Melo-Cristino, J.A. Lopes
Publicado en: Journal of Microbiological Methods, Edición 01677012, 2013, Página(s) 102-107, ISSN 0167-7012
Editor: Elsevier BV
DOI: 10.1016/j.mimet.2013.02.008

The Use of Machine Learning Methodologies to Analyse Antibiotic and Biocide Susceptibility in Staphylococcus aureus

Autores: Joana Rosado Coelho, João André Carriço, Daniel Knight, Jose-Luis Martínez, Ian Morrissey, Marco Rinaldo Oggioni, Ana Teresa Freitas
Publicado en: PLoS ONE, Edición 19326203, 2013, Página(s) e55582, ISSN 1932-6203
Editor: Public Library of Science
DOI: 10.1371/journal.pone.0055582

The Genetic Basis of Escherichia coli Pathoadaptation to Macrophages

Autores: Migla Miskinyte, Ana Sousa, Ricardo S. Ramiro, Jorge A. Moura de Sousa, Jerzy Kotlinowski, Iris Caramalho, Sara Magalhães, Miguel P. Soares, Isabel Gordo
Publicado en: PLoS Pathogens, Edición 15537366, 2013, Página(s) e1003802, ISSN 1553-7366
Editor: Public Library of Science
DOI: 10.1371/journal.ppat.1003802

Crystal Structure of the Gamma-2 Herpesvirus LANA DNA Binding Domain Identifies Charged Surface Residues Which Impact Viral Latency

Autores: Bruno Correia, Sofia A. Cerqueira, Chantal Beauchemin, Marta Pires de Miranda, Shijun Li, Rajesh Ponnusamy, LÃ©nia Rodrigues, Thomas R. Schneider, Maria A. Carrondo, Kenneth M. Kaye, J. Pedro Simas, Colin E. McVey
Publicado en: PLoS Pathogens, Edición 15537366, 2013, Página(s) e1003673, ISSN 1553-7366
Editor: Public Library of Science
DOI: 10.1371/journal.ppat.1003673

Recent thymic emigrants are the preferential precursors of regulatory T cells differentiated in the periphery

Autores: R. S. Paiva, A. C. Lino, M.-L. Bergman, I. Caramalho, A. E. Sousa, S. Zelenay, J. Demengeot
Publicado en: Proceedings of the National Academy of Sciences, Edición 00278424, 2013, Página(s) 6494-6499, ISSN 0027-8424
Editor: National Academy of Sciences
DOI: 10.1073/pnas.1221955110

Stabilization of Myc through Heterotypic Poly-Ubiquitination by mLANA Is Critical for γ-Herpesvirus Lymphoproliferation

Autores: Lénia Rodrigues, Nikita Popov, Kenneth M. Kaye, J. Pedro Simas
Publicado en: PLoS Pathogens, Edición 15537366, 2013, Página(s) e1003554, ISSN 1553-7366
Editor: Public Library of Science
DOI: 10.1371/journal.ppat.1003554

Essential, dose-dependent role for the transcription factor Gata3 in the development of IL-5+ and IL-13+ type 2 innate lymphoid cells

Autores: R. G. J. Klein Wolterink, N. Serafini, M. van Nimwegen, C. A. J. Vosshenrich, M. J. W. de Bruijn, D. Fonseca Pereira, H. Veiga Fernandes, R. W. Hendriks, J. P. Di Santo
Publicado en: Proceedings of the National Academy of Sciences, Edición 00278424, 2013, Página(s) 10240-10245, ISSN 0027-8424
Editor: National Academy of Sciences
DOI: 10.1073/pnas.1217158110

Induced IL-17-Producing Invariant NKT Cells Require Activation in Presence of TGF- and IL-1

Autores: M. Monteiro, C. F. Almeida, A. Agua-Doce, L. Graca
Publicado en: The Journal of Immunology, Edición 00221767, 2013, Página(s) 805-811, ISSN 0022-1767
Editor: American Association of Immunologists
DOI: 10.4049/jimmunol.1201010

Tuberculosis with malaria or HIV co-infection in a large hospital in Luanda, Angola

Autores: Emília Valadas, Augusto Gomes,Ana Sutre, Sara Brilha, Afonso Wete, Thomas Hänscheid, Francisco Antunes
Publicado en: Journal of Infection in Developing Countries, Edición 6, 2013, Página(s) 269-272, ISSN 1972-2680
Editor: Open Learning on Enteric Pathogens

Protective Role of the Inflammatory CCR2/CCL2 Chemokine Pathway through Recruitment of Type 1 Cytotoxic T Lymphocytes to Tumor Beds

Autores: T. Lanca, M. F. Costa, N. Goncalves-Sousa, M. Rei, A. R. Grosso, C. Penido, B. Silva-Santos
Publicado en: The Journal of Immunology, Edición 00221767, 2013, Página(s) 6673-6680, ISSN 0022-1767
Editor: American Association of Immunologists
DOI: 10.4049/jimmunol.1300434

Torins are potent antimalarials that block replenishment of Plasmodium liver stage parasitophorous vacuole membrane proteins

Autores: K. K. Hanson, A. S. Ressurreicao, K. Buchholz, M. Prudencio, J. D. Herman-Ornelas, M. Rebelo, W. L. Beatty, D. F. Wirth, T. Hanscheid, R. Moreira, M. Marti, M. M. Mota
Publicado en: Proceedings of the National Academy of Sciences, Edición 00278424, 2013, Página(s) E2838-E2847, ISSN 0027-8424
Editor: National Academy of Sciences
DOI: 10.1073/pnas.1306097110

Mechanisms Underlying CD4+ Treg Immune Regulation in the Adult: From Experiments to Models

Autores: Marta Caridade, Luis Graca, Ruy M. Ribeiro
Publicado en: Frontiers in Immunology, Edición 16643224, 2013, ISSN 1664-3224
Editor: Frontiers Editorial Office
DOI: 10.3389/fimmu.2013.00378

BAFF and TACI Gene Expression Are Increased in Patients with Untreated Very Early Rheumatoid Arthritis

Autores: R. A. Moura, H. Canhao, J. Polido-Pereira, A. M. Rodrigues, M. Navalho, A. F. Mourao, C. Resende, R. Campanilho-Marques, J. Madruga Dias, J. A. P. da Silva, L. Graca, J. E. Fonseca
Publicado en: The Journal of Rheumatology, Edición 0315162X, 2013, Página(s) 1293-1302, ISSN 0315-162X
Editor: Journal of Rheumatology Publishing Co., Ltd.
DOI: 10.3899/jrheum.121110

The hemozoin conundrum: is malaria pigment immune-activating, inhibiting, or simply a bystander?

Autores: Márcia Boura, Rosangela Frita, Ana Góis, Tânia Carvalho, Thomas Hänscheid
Publicado en: Trends in Parasitology, Edición 14714922, 2013, Página(s) 469-476, ISSN 1471-4922
Editor: Elsevier BV
DOI: 10.1016/j.pt.2013.07.005

First case of infection with vancomycin-resistant Staphylococcus aureus in Europe

Autores: José Melo-Cristino, Cristina Resina, Viviana Manuel, Luís Lito, Mário Ramirez
Publicado en: The Lancet, Edición 01406736, 2013, Página(s) 205, ISSN 0140-6736
Editor: The Lancet Publishing Group
DOI: 10.1016/S0140-6736(13)61219-2

Recruitment of γδ T lymphocytes to tumors

Autores: Telma Lança, Bruno Silva-Santos
Publicado en: OncoImmunology, Edición 21624011, 2013, Página(s) e25461, ISSN 2162-4011
Editor: Landes Bioscience
DOI: 10.4161/onci.25461

Adjuvant facilitates tolerance induction to factor VIII in hemophilic mice through a Foxp3-independent mechanism that relies on IL-10

Autores: V. G. Oliveira, A. Agua-Doce, M. A. Curotto de Lafaille, J. J. Lafaille, L. Graca
Publicado en: Blood, Edición 00064971, 2013, Página(s) 3936-3945, ISSN 0006-4971
Editor: American Society of Hematology
DOI: 10.1182/blood-2012-09-457135

Novel Endoperoxide-Based Transmission-Blocking Antimalarials with Liver- and Blood-Schizontocidal Activities

Autores: Daniela Miranda, Rita Capela, Inês S. Albuquerque, Patrícia Meireles, Isa Paiva, Fátima Nogueira, Richard Amewu, Jiri Gut, Philip J. Rosenthal, Rudi Oliveira, Maria M. Mota, Rui Moreira, Francesc Marti, Miguel Prudêncio, Paul M. O’Neill, Francisca Lopes
Publicado en: ACS Medicinal Chemistry Letters, Edición 19485875, 2014, Página(s) 108-112, ISSN 1948-5875
Editor: American Chemical Society
DOI: 10.1021/ml4002985

Natural Cytotoxicity Receptors: Broader Expression Patterns and Functions in Innate and Adaptive Immune Cells

Autores: Kelly Hudspeth, Bruno Silva-Santos, Domenico Mavilio
Publicado en: Frontiers in Immunology, Edición 16643224, 2013, ISSN 1664-3224
Editor: Frontiers Editorial Office
DOI: 10.3389/fimmu.2013.00069

Molecular Mechanisms of Differentiation of Murine Pro-Inflammatory γδ T Cell Subsets

Autores: Karine Serre, Bruno Silva-Santos
Publicado en: Frontiers in Immunology, Edición 16643224, 2013, ISSN 1664-3224
Editor: Frontiers Editorial Office
DOI: 10.3389/fimmu.2013.00431

Massive hypereosinophilia and vasculitis associated with major expansion of interleukin-5-producing CD8+ T cells in HIV-1 infection

Autores: Inês Jorge, Beatriz Amaral, Luis M.S.R. Soares-Almeida, Russell B. Foxall, Rita Tendeiro, João M. Santos, Ana E. Sousa, Rui M.M. Victorino
Publicado en: AIDS, Edición 02699370, 2014, Página(s) 1075-1077, ISSN 0269-9370
Editor: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/QAD.0000000000000205

Gut disruption in HIV-2 infection despite reduced viremia

Autores: Susana M. Fernandes, Ana R. Pires, Cristina Ferreira, Rita Tendeiro, Luís Correia, Sérgio E. Paulo, Rui M.M. Victorino, Ana E. Sousa
Publicado en: AIDS, Edición 02699370, 2014, Página(s) 290-292, ISSN 0269-9370
Editor: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/QAD.0000000000000114

Dual-stage triterpenoids from an African medicinal plant targeting the malaria parasite

Autores: Cátia Ramalhete, Filipa P. da Cruz, Silva Mulhovo, Inês J. Sousa, Miguel X. Fernandes, Miguel Prudêncio, Maria-José U. Ferreira
Publicado en: Bioorganic & Medicinal Chemistry, Edición 09680896, 2014, Página(s) 3887-3890, ISSN 0968-0896
Editor: Pergamon Press Ltd.
DOI: 10.1016/j.bmc.2014.06.019

2-Octadecynoic acid as a dual life stage inhibitor of Plasmodium infections and plasmodial FAS-II enzymes

Autores: Néstor M. Carballeira, Angela Gono Bwalya, Maurice Ayamba Itoe, Adriano D. Andricopulo, María Lorena Cordero-Maldonado, Marcel Kaiser, Maria M. Mota, Alexander D. Crawford, Rafael V.C. Guido, Deniz Tasdemir
Publicado en: Bioorganic & Medicinal Chemistry Letters, Edición 0960894X, 2014, Página(s) 4151-4157, ISSN 0960-894X
Editor: Pergamon Press Ltd.
DOI: 10.1016/j.bmcl.2014.07.050

PCR based differentiation between Streptococcus dysgalactiae subsp. equisimilis strains isolated from humans and horses

Autores: S. Preziuso, M.D. Pinho, A.R. Attili, J. Melo-Cristino, E. Acke, A.C. Midwinter, V. Cuteri, M. Ramirez
Publicado en: Comparative Immunology, Microbiology and Infectious Diseases, Edición 01479571, 2014, Página(s) 169-172, ISSN 0147-9571
Editor: Pergamon Press Ltd.
DOI: 10.1016/j.cimid.2014.04.001

iNKT Cells: Innate Lymphocytes with a Diverse Response

Autores: Marta Monteiro, Luis Graca
Publicado en: Critical Reviews in Immunology, Edición 10408401, 2014, Página(s) 81-90, ISSN 1040-8401
Editor: Begell House
DOI: 10.1615/CritRevImmunol.2014010088

N- Cinnamoylation of Antimalarial Classics: Quinacrine Analogues with Decreased Toxicity and Dual-Stage Activity

Autores: Ana Gomes, Bianca Pérez, Inês Albuquerque, Marta Machado, Miguel Prudêncio, Fátima Nogueira, Cátia Teixeira, Paula Gomes
Publicado en: ChemMedChem, Edición 18607179, 2014, Página(s) 305-310, ISSN 1860-7179
Editor: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/cmdc.201300459

Differentiation of Type 1 ILCs from a Common Progenitor to All Helper-like Innate Lymphoid Cell Lineages

Autores: Christoph S.N. Klose, Melanie Flach, Luisa Möhle, Leif Rogell, Thomas Hoyler, Karolina Ebert, Carola Fabiunke, Dietmar Pfeifer, Veronika Sexl, Diogo Fonseca-Pereira, Rita G. Domingues, Henrique Veiga-Fernandes, Sebastian J. Arnold, Meinrad Busslinger, Ildiko R. Dunay, Yakup Tanriver, Andreas Diefenbach
Publicado en: Cell, Edición 00928674, 2014, Página(s) 340-356, ISSN 0092-8674
Editor: Cell Press
DOI: 10.1016/j.cell.2014.03.030

Chemical Interrogation of the Malaria Kinome

Autores: Emily R. Derbyshire, Vanessa Zuzarte-Luís, Andreia D. Magalhães, Nobutaka Kato, Paul C. Sanschagrin, Jinhua Wang, Wenjun Zhou, Chandrasekhar V. Miduturu, Ralph Mazitschek, Piotr Sliz, Maria M. Mota, Nathanael S. Gray, Jon Clardy
Publicado en: ChemBioChem, Edición 14394227, 2014, Página(s) 1920-1930, ISSN 1439-4227
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/cbic.201400025

Invasive infections due to Streptococcus pyogenes: seasonal variation of severity and clinical characteristics, Iceland, 1975 to 2012

Autores: L B Olafsdottir, H Erlendsdóttir, J Melo-Cristino, D M Weinberger, M Ramirez, K G Kristinsson, M Gottfredsson
Publicado en: EuroSurveillance, Edición 52, 2014, ISSN 1560-7917
Editor: EUR CENTRE DIS PREVENTION & CONTROL

Probing the aurone scaffold against Plasmodium falciparum: Design, synthesis and antimalarial activity

Autores: Marta P. Carrasco, Ana S. Newton, Lídia Gonçalves, Ana Góis, Marta Machado, Jiri Gut, Fátima Nogueira, Thomas Hänscheid, Rita C. Guedes, Daniel J.V.A. dos Santos, Philip J. Rosenthal, Rui Moreira
Publicado en: European Journal of Medicinal Chemistry, Edición 02235234, 2014, Página(s) 523-534, ISSN 0223-5234
Editor: Elsevier BV
DOI: 10.1016/j.ejmech.2014.04.076

Decreasing incidence and changes in serotype distribution of invasive pneumococcal disease in persons aged under 18 years since introduction of 10-valent and 13-valent conjugate vaccines in Portugal, July 2008 to June 2012

Autores: S I Aguiar, M J Brito, A N Horácio, J P Lopes, M Ramirez, J Melo-Cristino
Publicado en: EuroSurveillance, Edición 52, 2014, ISSN 1560-7917
Editor: EUR CENTRE DIS PREVENTION & CONTROL

Hypoxia promotes liver-stage malaria infection in primary human hepatocytes in vitro

Autores: S. Ng, S. March, A. Galstian, K. Hanson, T. Carvalho, M. M. Mota, S. N. Bhatia
Publicado en: Disease Models & Mechanisms, Edición 17548403, 2014, Página(s) 215-224, ISSN 1754-8403
Editor: The Company of Biologists Ltd.
DOI: 10.1242/dmm.013490

Bacillus invictae sp. nov., isolated from a health product

Autores: R. Branquinho, C. Sousa, H. Osorio, L. Meirinhos-Soares, J. Lopes, J. A. Carrico, H.-J. Busse, A. Abdulmawjood, G. Klein, P. Kampfer, M. E. Pintado, L. V. Peixe
Publicado en: INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY, Edición 14665026, 2014, Página(s) 3867-3876, ISSN 1466-5026
Editor: Society for General Microbiology
DOI: 10.1099/ijs.0.067850-0

Adult B-cell acute lymphoblastic leukemia cells display decreased PTEN activity and constitutive hyperactivation of PI3K/Akt pathway despite high PTEN protein levels

Autores: A. M. Gomes, M. V. D. Soares, P. Ribeiro, J. Caldas, V. Povoa, L. R. Martins, A. Melao, A. Serra-Caetano, A. B. de Sousa, J. F. Lacerda, J. T. Barata
Publicado en: Haematologica, Edición 03906078, 2014, Página(s) 1062-1068, ISSN 0390-6078
Editor: Ferrata Storti Foundation
DOI: 10.3324/haematol.2013.096438

Phylogenetic and clonality analysis of Bacillus pumilus isolates uncovered a highly heterogeneous population of different closely related species and clones

Autores: Raquel Branquinho, Luís Meirinhos-Soares, João A. Carriço, Manuela Pintado, Luísa V. Peixe
Publicado en: FEMS Microbiology Ecology, Edición 01686496, 2014, Página(s) 689-698, ISSN 0168-6496
Editor: Blackwell
DOI: 10.1111/1574-6941.12426

Reduced BAFF-R and Increased TACI Expression in Common Variable Immunodeficiency

Autores: Rita R. Barbosa, Susana L. Silva, Sara P. Silva, Alcinda C. Melo, M. Conceição Pereira-Santos, João T. Barata, Lennart Hammarström, Marília Cascalho, Ana E. Sousa
Publicado en: Journal of Clinical Immunology, Edición 02719142, 2014, Página(s) 573-583, ISSN 0271-9142
Editor: Kluwer Academic/Plenum Publishers
DOI: 10.1007/s10875-014-0047-y

Malaria infections: What and how can mice teach us

Autores: Vanessa Zuzarte-Luis, Maria M. Mota, Ana M. Vigário
Publicado en: Journal of Immunological Methods, Edición 00221759, 2014, Página(s) 113-122, ISSN 0022-1759
Editor: Elsevier BV
DOI: 10.1016/j.jim.2014.05.001

Novel Role of the Antimicrobial Peptide LL-37 in the Protection of Neutrophil Extracellular Traps against Degradation by Bacterial Nucleases

Autores: Ariane Neumann, Lena Völlger, Evelien T.M. Berends, E. Margo Molhoek, Daphne A.C. Stapels, Marika Midon, Ana Friães, Alfred Pingoud, Suzan H.M. Rooijakkers, Richard L. Gallo, Matthias Mörgelin, Victor Nizet, Hassan Y. Naim, Maren von Köckritz-Blickwede
Publicado en: Journal of Innate Immunity, Edición 1662811X, 2014, Página(s) 860-868, ISSN 1662-811X
Editor: Karger AG
DOI: 10.1159/000363699

Simple, sensitive and quantitative bioluminescence assay for determination of malaria pre-patent period

Autores: Vanessa Zuzarte-Luis, Joana Sales-Dias, Maria M Mota
Publicado en: Malaria Journal, Edición 14752875, 2014, Página(s) 15, ISSN 1475-2875
Editor: BioMed Central
DOI: 10.1186/1475-2875-13-15

Tetraoxane–Pyrimidine Nitrile Hybrids as Dual Stage Antimalarials

Autores: Rudi Oliveira, Rita C. Guedes, Patrícia Meireles, Inês S. Albuquerque, Lídia M. Gonçalves, Elisabete Pires, Maria Rosário Bronze, Jiri Gut, Philip J. Rosenthal, Miguel Prudêncio, Rui Moreira, Paul M. O’Neill, Francisca Lopes
Publicado en: Journal of Medicinal Chemistry, Edición 00222623, 2014, Página(s) 4916-4923, ISSN 0022-2623
Editor: American Chemical Society
DOI: 10.1021/jm5004528

Methaemoglobin and COHb in patients with malaria

Autores: Thomas Hänscheid, Tom Gresnigt, Sascha Löhr, Arnaud Flamen, Thomas Zoller, José Melo-Cristino, Martin P Grobusch
Publicado en: Malaria Journal, Edición 14752875, 2014, Página(s) 285, ISSN 1475-2875
Editor: BioMed Central
DOI: 10.1186/1475-2875-13-285

T rypanosoma brucei histone H1 inhibits RNA polymerase I transcription and is important for parasite fitness in vivo

Autores: Ana C. Pena, Mafalda R. Pimentel, Helena Manso, Rita Vaz-Drago, Daniel Pinto-Neves, Francisco Aresta-Branco, Filipa Rijo-Ferreira, Fabien Guegan, Luis Pedro Coelho, Maria Carmo-Fonseca, Nuno L. Barbosa-Morais, Luisa M. Figueiredo
Publicado en: Molecular Microbiology, Edición 0950382X, 2014, Página(s) 645-663, ISSN 0950-382X
Editor: Blackwell Publishing Inc.
DOI: 10.1111/mmi.12677

Development of functionalized nanoparticles for vaccine delivery to dendritic cells: a mechanistic approach

Autores: Joana M Silva, Gaëlle Vandermeulen, Vanessa G Oliveira, Sandra N Pinto, Catarina Rodrigues, Ana Salgado, Carlos A Afonso, Ana S Viana, Christine Jérôme, Liana C Silva, Luis Graca, Véronique Préat, Helena F Florindo
Publicado en: Nanomedicine, Edición 17435889, 2014, Página(s) 2639-2656, ISSN 1743-5889
Editor: Future Medicine Ltd.
DOI: 10.2217/nnm.14.135

Classification of current anticancer immunotherapies

Autores: Lorenzo Galluzzi, Erika Vacchelli, José-Manuel Bravo-San Pedro, Aitziber Buqué, Laura Senovilla, Elisa Elena Baracco, Norma Bloy, Francesca Castoldi, Jean-Pierre Abastado, Patrizia Agostinis, Ron N. Apte, Fernando Aranda, Maha Ayyoub, Philipp Beckhove, Jean-Yves Blay, Laura Bracci, Anne Caignard, Chiara Castelli, Federica Cavallo, Estaban Celis, Vincenzo Cerundolo, Aled Clayton, Mario P. Colombo, Lisa Coussens, Madhav V. Dhodapkar, Alexander M. Eggermont, Douglas T. Fearon, Wolf H. Fridman, Jitka Fučíková, Dmitry I. Gabrilovich, Jérôme Galon, Abhishek Garg, François Ghiringhelli, Giuseppe Giaccone, Eli Gilboa, Sacha Gnjatic, Axel Hoos, Anne Hosmalin, Dirk Jäger, Pawel Kalinski, Klas Kärre, Oliver Kepp, Rolf Kiessling, John M. Kirkwood, Eva Klein, Alexander Knuth, Claire E. Lewis, Roland Liblau, Michael T. Lotze, Enrico Lugli, Jean-Pierre Mach, Fabrizio Mattei, Domenico Mavilio, Ignacio Melero, Cornelis J. Melief, Elizabeth A. Mittendorf, Lorenzo Moretta, Adekunke Odunsi, Hideho Okada, Anna Karolina Palucka, Marcus E. Peter, Kenneth J. Pienta, Angel Porgador, George C. Prendergast, Gabriel A. Rabinovich, Nicholas P. Restifo, Naiyer Rizvi, Catherine Sautès-Fridman, Hans Schreiber, Barbara Seliger, Hiroshi Shiku, Bruno Silva-Santos, Mark J. Smyth, Daniel E. Speiser, Radek Spisek, Pramod K. Srivastava, James E. Talmadge, Eric Tartour, Sjoerd H. Van Der Burg, Benoît J. Van Den Eynde, Richard Vile, Hermann Wagner, Jeffrey S. Weber, Theresa L. Whiteside, Jedd D. Wolchok, Laurence Zitvogel, Weiping Zou, Guido Kroemer
Publicado en: Oncotarget, Edición 19492553, 2015, Página(s) 12472-12508, ISSN 1949-2553
Editor: Impact Journals
DOI: 10.18632/oncotarget.2998

Host-cell sensors for Plasmodium activate innate immunity against liver-stage infection

Autores: Peter Liehl, Vanessa Zuzarte-Luís, Jennie Chan, Thomas Zillinger, Fernanda Baptista, Daniel Carapau, Madlen Konert, Kirsten K Hanson, Céline Carret, Caroline Lassnig, Mathias Müller, Ulrich Kalinke, Mohsan Saeed, Angelo Ferreira Chora, Douglas T Golenbock, Birgit Strobl, Miguel Prudêncio, Luis P Coelho, Stefan H Kappe, Giulio Superti-Furga, Andreas Pichlmair, Ana M Vigário, Charles M Rice, Katherine A Fitzgerald, Winfried Barchet, Maria M Mota
Publicado en: Nature Medicine, Edición 10788956, 2013, Página(s) 47-53, ISSN 1078-8956
Editor: Nature Publishing Group
DOI: 10.1038/nm.3424

Maternal retinoids control type 3 innate lymphoid cells and set the offspring immunity

Autores: Serge A. van de Pavert, Manuela Ferreira, Rita G. Domingues, Hélder Ribeiro, Rosalie Molenaar, Lara Moreira-Santos, Francisca F. Almeida, Sales Ibiza, Inês Barbosa, Gera Goverse, Carlos Labão-Almeida, Cristina Godinho-Silva, Tanja Konijn, Dennis Schooneman, Tom O’Toole, Mark R. Mizee, Yasmin Habani, Esther Haak, Fabio R. Santori, Dan R. Littman, Stefan Schulte-Merker, Elaine Dzierzak, J. Pedro Simas, Reina E. Mebius, Henrique Veiga-Fernandes
Publicado en: Nature, Edición 00280836, 2014, Página(s) 123-127, ISSN 0028-0836
Editor: Nature Publishing Group
DOI: 10.1038/nature13158

The neurotrophic factor receptor RET drives haematopoietic stem cell survival and function

Autores: Diogo Fonseca-Pereira, Sílvia Arroz-Madeira, Mariana Rodrigues-Campos, Inês A. M. Barbosa, Rita G. Domingues, Teresa Bento, Afonso R. M. Almeida, Hélder Ribeiro, Alexandre J. Potocnik, Hideki Enomoto, Henrique Veiga-Fernandes
Publicado en: Nature, Edición 00280836, 2014, Página(s) 98-101, ISSN 0028-0836
Editor: Nature Publishing Group
DOI: 10.1038/nature13498

Pherotype Influences Biofilm Growth and Recombination in Streptococcus pneumoniae

Autores: Margarida Carrolo, Francisco Rodrigues Pinto, José Melo-Cristino, Mário Ramirez
Publicado en: PLoS ONE, Edición 19326203, 2014, Página(s) e92138, ISSN 1932-6203
Editor: Public Library of Science
DOI: 10.1371/journal.pone.0092138

Non-Invasive Pneumococcal Pneumonia in Portugal—Serotype Distribution and Antimicrobial Resistance

Autores: Andreia N. Horácio, Joana P. Lopes, Mário Ramirez, José Melo-Cristino
Publicado en: PLoS ONE, Edición 19326203, 2014, Página(s) e103092, ISSN 1932-6203
Editor: Public Library of Science
DOI: 10.1371/journal.pone.0103092

Evaluation of a Novel Magneto-Optical Method for the Detection of Malaria Parasites

Autores: Ágnes Orbán, Ádám Butykai, András Molnár, Zsófia Pröhle, Gergö Fülöp, Tivadar Zelles, Wasan Forsyth, Danika Hill, Ivo Müller, Louis Schofield, Maria Rebelo, Thomas Hänscheid, Stephan Karl, István Kézsmárki
Publicado en: PLoS ONE, Edición 19326203, 2014, Página(s) e96981, ISSN 1932-6203
Editor: Public Library of Science
DOI: 10.1371/journal.pone.0096981

Scarlet Fever Is Caused By a Limited Number of Streptococcus pyogenes Lineages and Is Associated with the Exotoxin Genes ssa, speA and speC

Autores: Catarina Silva-Costa, Joao A. Carriço, Mario Ramirez, Jose Melo-Cristino
Publicado en: The Pediatric Infectious Disease Journal, Edición 08913668, 2014, Página(s) 306-310, ISSN 0891-3668
Editor: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/INF.0000000000000088

Defining Immune Engagement Thresholds for In Vivo Control of Virus-Driven Lymphoproliferation

Autores: Cristina Godinho-Silva, Sofia Marques, Diana Fontinha, Henrique Veiga-Fernandes, Philip G. Stevenson, J. Pedro Simas
Publicado en: PLoS Pathogens, Edición 15537366, 2014, Página(s) e1004220, ISSN 1553-7366
Editor: Public Library of Science
DOI: 10.1371/journal.ppat.1004220

Establishment of Murine Gammaherpesvirus Latency in B Cells Is Not a Stochastic Event

Autores: Jérémie Decalf, Cristina Godinho-Silva, Diana Fontinha, Sofia Marques, J. Pedro Simas
Publicado en: PLoS Pathogens, Edición 15537366, 2014, Página(s) e1004269, ISSN 1553-7366
Editor: Public Library of Science
DOI: 10.1371/journal.ppat.1004269

Induction of Prophages by Fluoroquinolones in Streptococcus pneumoniae: Implications for Emergence of Resistance in Genetically-Related Clones

Autores: Elena López, Arnau Domenech, María-José Ferrándiz, Maria João Frias, Carmen Ardanuy, Mario Ramirez, Ernesto García, Josefina Liñares, Adela G. de la Campa
Publicado en: PLoS ONE, Edición 19326203, 2014, Página(s) e94358, ISSN 1932-6203
Editor: Public Library of Science
DOI: 10.1371/journal.pone.0094358

Murine CD27(-) V 6(+) T cells producing IL-17A promote ovarian cancer growth via mobilization of protumor small peritoneal macrophages

Autores: M. Rei, N. Goncalves-Sousa, T. Lanca, R. G. Thompson, S. Mensurado, F. R. Balkwill, H. Kulbe, D. J. Pennington, B. Silva-Santos
Publicado en: Proceedings of the National Academy of Sciences, Edición 00278424, 2014, Página(s) E3562-E3570, ISSN 0027-8424
Editor: National Academy of Sciences
DOI: 10.1073/pnas.1403424111

Towards an advanced therapy medicinal product based on mesenchymal stromal cells isolated from the umbilical cord tissue: quality and safety data

Autores: José Paulo Martins, Jorge Miguel Santos, Joana Marto de Almeida, Mariana Alves Filipe, Mariana Vargas Teixeira de Almeida, Sílvia Cristina Paiva Almeida, Ana Água-Doce, Alexandre Varela, Mari Gilljam, Birgitta Stellan, Susanne Pohl, Kurt Dittmar, Werner Lindenmaier, Evren Alici, Luís Graça, Pedro Estilita Cruz, Helder Joaquim Cruz, Rita Nogueira Bárcia
Publicado en: Stem Cell Research & Therapy, Edición 17576512, 2014, Página(s) 9, ISSN 1757-6512
Editor: BioMed Central
DOI: 10.1186/scrt398

Enteric Mucosa Integrity in the Presence of a Preserved Innate Interleukin 22 Compartment in HIV Type 1-Treated Individuals

Autores: S. M. Fernandes, A. R. Pires, C. Ferreira, R. B. Foxall, J. Rino, C. Santos, L. Correia, J. Pocas, H. Veiga-Fernandes, A. E. Sousa
Publicado en: Journal of Infectious Diseases, Edición 00221899, 2014, Página(s) 630-640, ISSN 0022-1899
Editor: University of Chicago Press
DOI: 10.1093/infdis/jiu126

Delta-like 1-Mediated Notch Signaling Enhances the In Vitro Conversion of Human Memory CD4 T Cells into FOXP3-Expressing Regulatory T Cells

Autores: C. Mota, V. Nunes-Silva, A. R. Pires, P. Matoso, R. M. M. Victorino, A. E. Sousa, I. Caramalho
Publicado en: The Journal of Immunology, Edición 00221767, 2014, Página(s) 5854-5862, ISSN 0022-1767
Editor: American Association of Immunologists
DOI: 10.4049/jimmunol.1400198

TACI deficiency enhances antibody avidity and clearance of an intestinal pathogen

Autores: Shoichiro Tsuji, Lucas Stein, Nobuhiko Kamada, Gabriel Nuñez, Richard Bram, Bruce A. Vallance, Ana E. Sousa, Jeffrey L. Platt, Marilia Cascalho
Publicado en: Journal of Clinical Investigation, Edición 00219738, 2014, Página(s) 4857-4866, ISSN 0021-9738
Editor: American Society for Clinical Investigation
DOI: 10.1172/JCI74428

Human Thymocytes Are Functionally Immature and Differentiate into Cytotoxic Type 1 Effector T Cells upon IL-2/IL-15 Signaling

Autores: J. C. Ribot, S. T. Ribeiro, D. V. Correia, A. E. Sousa, B. Silva-Santos
Publicado en: The Journal of Immunology, Edición 00221767, 2014, Página(s) 2237-2243, ISSN 0022-1767
Editor: American Association of Immunologists
DOI: 10.4049/jimmunol.1303119

In Vitro Alterations Do Not Reflect a Requirement for Host Cell Cycle Progression during Plasmodium Liver Stage Infection

Autores: Kirsten K. Hanson, Sandra March, Shengyong Ng, Sangeeta N. Bhatia, Maria M. Mota
Publicado en: Eukaryotic Cell, Edición 15359778, 2014, Página(s) 96-103, ISSN 1535-9778
Editor: American Society for Microbiology
DOI: 10.1128/EC.00166-14

The Emerging Protumor Role of T Lymphocytes: Implications for Cancer Immunotherapy

Autores: M. Rei, D. J. Pennington, B. Silva-Santos
Publicado en: Cancer Research, Edición 00085472, 2015, Página(s) 798-802, ISSN 0008-5472
Editor: American Association for Cancer Research
DOI: 10.1158/0008-5472.CAN-14-3228

Chicago 2014 – 30years of γδ T cells

Autores: Marc Bonneville, Zheng W. Chen, Julie Déchanet-Merville, Matthias Eberl, Jean Jacques Fournié, Julie M. Jameson, Richard D. Lopez, Massimo Massaia, Bruno Silva-Santos
Publicado en: Cellular Immunology, Edición 00088749, 2015, Página(s) 3-9, ISSN 0008-8749
Editor: Academic Press
DOI: 10.1016/j.cellimm.2014.11.001

Human regulatory T-cell development is dictated by Interleukin-2 and -15 expressed in a non-overlapping pattern in the thymus

Autores: Iris Caramalho, Vânia Nunes-Silva, Ana R. Pires, Catarina Mota, Ana I. Pinto, Helena Nunes-Cabaço, Russell B. Foxall, Ana E. Sousa
Publicado en: Journal of Autoimmunity, Edición 08968411, 2015, Página(s) 98-110, ISSN 0896-8411
Editor: Academic Press
DOI: 10.1016/j.jaut.2014.11.002

Thymic HIV-2 Infection Uncovers Posttranscriptional Control of Viral Replication in Human Thymocytes

Autores: Helena Nunes-Cabaço, Paula Matoso, Russell B. Foxall, Rita Tendeiro, Ana R. Pires, Tânia Carvalho, Ana I. Pinheiro, Rui S. Soares, Ana E. Sousa
Publicado en: Journal of Virology, Edición 0022538X, 2015, Página(s) 2201-2208, ISSN 0022-538X
Editor: American Society for Microbiology
DOI: 10.1128/JVI.03047-14

In vivo delivery of peptides and Toll-like receptor ligands by mannose-functionalized polymeric nanoparticles induces prophylactic and therapeutic anti-tumor immune responses in a melanoma model

Autores: Joana M. Silva, Eva Zupancic, Gaëlle Vandermeulen, Vanessa G. Oliveira, Ana Salgado, Mafalda Videira, Manuela Gaspar, Luis Graca, Véronique Préat, Helena F. Florindo
Publicado en: Journal of Controlled Release, Edición 01683659, 2015, Página(s) 91-103, ISSN 0168-3659
Editor: Elsevier BV
DOI: 10.1016/j.jconrel.2014.11.033

Point-of-care tests: where is the point?

Autores: Thomas Hänscheid, Maria Rebelo, Martin P Grobusch
Publicado en: The Lancet Infectious Diseases, Edición 14733099, 2014, Página(s) 922, ISSN 1473-3099
Editor: The Lancet Publishing Group
DOI: 10.1016/S1473-3099(14)70914-4

Eimeria vermiformis Infection Model of Murine Small Intestine

Autores: Patrícia Figueiredo-Campos, Cristina Ferreira, Birte Blankenhaus, Marc Veldhoen
Publicado en: BIO-PROTOCOL, Edición 8/24, 2018, ISSN 2331-8325
Editor: BIO-PROTOCOL
DOI: 10.21769/bioprotoc.3122

Dynamic Metabolic State of Tissue Resident CD8 T Cells

Autores: Špela Konjar, Marc Veldhoen
Publicado en: Frontiers in Immunology, Edición 10, 2019, ISSN 1664-3224
Editor: FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2019.01683

Effector γδ T Cell Differentiation Relies on Master but Not Auxiliary Th Cell Transcription Factors

Autores: Joana Barros-Martins, Nina Schmolka, Diana Fontinha, Marta Pires de Miranda, J. Pedro Simas, Ingrid Brok, Cristina Ferreira, Marc Veldhoen, Bruno Silva-Santos, Karine Serre
Publicado en: The Journal of Immunology, Edición 196/9, 2016, Página(s) 3642-3652, ISSN 0022-1767
Editor: American Association of Immunologists
DOI: 10.4049/jimmunol.1501921

Mitochondria maintain controlled activation state of epithelial-resident T lymphocytes

Autores: Špela Konjar, Ulrika C. Frising, Cristina Ferreira, Reinhard Hinterleitner, Toufic Mayassi, Qifeng Zhang, Birte Blankenhaus, Nejc Haberman, Yunhua Loo, Joana Guedes, Marta Baptista, Silvia Innocentin, Joerg Stange, Douglas Strathdee, Bana Jabri, Marc Veldhoen
Publicado en: Science Immunology, Edición 3/24, 2018, Página(s) eaan2543, ISSN 2470-9468
Editor: AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/sciimmunol.aan2543

Immunology: Skin T Cells Switch Identity to Protect and Heal

Autores: Silvia Ariotti, Marc Veldhoen
Publicado en: Current Biology, Edición 29/6, 2019, Página(s) R220-R223, ISSN 0960-9822
Editor: Cell Press
DOI: 10.1016/j.cub.2019.01.055

Guidelines for the use of flow cytometry and cell sorting in immunological studies *

Autores: Andrea Cossarizza, Hyun‐Dong Chang, Andreas Radbruch, Mübeccel Akdis, Immanuel Andrä, Francesco Annunziato, Petra Bacher, Vincenzo Barnaba, Luca Battistini, Wolfgang M. Bauer, Sabine Baumgart, Burkhard Becher, Wolfgang Beisker, Claudia Berek, Alfonso Blanco, Giovanna Borsellino, Philip E. Boulais, Ryan R. Brinkman, Martin Büscher, Dirk H. Busch, Timothy P. Bushnell, Xuetao Cao, Andrea Cavani,
Publicado en: European Journal of Immunology, Edición 47/10, 2017, Página(s) 1584-1797, ISSN 0014-2980
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/eji.201646632

Quantification of Sporozoite Invasion, Migration, and Development by Microscopy and Flow Cytometry

Autores: Photini Sinnis, Patricia De La Vega, Alida Coppi, Urszula Krzych, Maria M. Mota
Publicado en: Malaria, 2013, Página(s) 385-400, ISBN 978-1-62703-026-7
Editor: Humana Press
DOI: 10.1007/978-1-62703-026-7_27

Differentiation and Activation of γδ T Lymphocytes: Focus on CD27 and CD28 Costimulatory Receptors

Autores: Julie C. Ribot, Bruno Silva-Santos
Publicado en: Crossroads Between Innate and Adaptive Immunity IV, 2013, Página(s) 95-105, ISBN 978-1-4614-6217-0
Editor: Springer New York
DOI: 10.1007/978-1-4614-6217-0_11

Endemic SARS-CoV-2 will maintain post-pandemic immunity

Autores: Marc Veldhoen, J. Pedro Simas
Publicado en: Nature Reviews Immunology, Edición 21/3, 2021, Página(s) 131-132, ISSN 1474-1733
Editor: Nature Publishing Group
DOI: 10.1038/s41577-020-00493-9

Academic labs supporting COVID‐19 diagnostics

Autores: Marc Veldhoen, Vanessa Zuzarte‐Luis
Publicado en: European Journal of Immunology, Edición 51/1, 2021, Página(s) 13-16, ISSN 0014-2980
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/eji.202170015

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