Leverage research EXCELLence and INNOVation potential of Instituto de Medicina Molecular (IMM) through translational biomedical research in immunity and infection.

Risultati finali

Re-evaluation of current state of IMM towards ERA priorities
Publications in the research field of immunity and infection of the Instituto de Medicina Molecular

A one-page statement that the task has been completed.

Acquisition of the pre-clinical molecular and imaging equipment
Organisation of thematic Workshops – first period

Organisation of thematic Workshops held during the first period

Organisation of thematic Workshops – second period

Organisation of thematic Workshops held during the second reporting period

Self-assessment after 2-year period of strategy implementation
Organisation of thematic Workshops – third period

Organisation of thematic Workshops held during the third reporting period

Launch of website
Development of the project logo/brand
Forum for overseas discussion in translational immunity and infection
Brochure and flyer development

Pubblicazioni

Controlling the pandemic during the SARS-CoV-2 vaccination rollout

Autori: João Viana, Christiaan H. van Dorp, Ana Nunes, Manuel C. Gomes, Michiel van Boven, Mirjam E. Kretzschmar, Marc Veldhoen, Ganna Rozhnova
Pubblicato in: Nature Communications, Numero 12/1, 2021, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-021-23938-8

Th17 Cells Require You to Chew before You Swallow

Autori: Marc Veldhoen
Pubblicato in: Immunity, Numero 46/1, 2017, Pagina/e 8-10, ISSN 1074-7613
Editore: Cell Press
DOI: 10.1016/j.immuni.2016.12.016

Seroprevalence of anti‐SARS‐CoV‐2 antibodies in COVID‐19 patients and healthy volunteers up to 6 months post disease onset

Autori: Patrícia Figueiredo‐Campos, Birte Blankenhaus, Catarina Mota, Andreia Gomes, Marta Serrano, Silvia Ariotti, Catarina Costa, Helena Nunes‐Cabaço, António M. Mendes, Pedro Gaspar, M. Conceição Pereira‐Santos, Fabiana Rodrigues, Jorge Condeço, M. Antonia Escoval, Matilde Santos, Mario Ramirez, José Melo‐Cristino, J. Pedro Simas, Eugenia Vasconcelos, Ângela Afonso, Marc Veldhoen
Pubblicato in: European Journal of Immunology, Numero 50/12, 2020, Pagina/e 2025-2040, ISSN 0014-2980
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/eji.202048970

3-hydroxy-L-kynurenamine is an immunomodulatory biogenic amine

Autori: Cristina C. Clement, Angelo D’Alessandro, Sangeetha Thangaswamy, Samantha Chalmers, Raquel Furtado, Sheila Spada, Giada Mondanelli, Federica Ianni, Sarah Gehrke, Marco Gargaro, Giorgia Manni, Luisa Carlota Lopez Cara, Peter Runge, Wanxia Li Tsai, Sinem Karaman, Jorge Arasa, Ruben Fernandez-Rodriguez, Amanda Beck, Antonio Macchiarulo, Massimo Gadina, Cornelia Halin, Francesca Fallarino, Mihaela S
Pubblicato in: Nature Communications, Numero 12/1, 2021, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-021-24785-3

Smarcad1 mediates microbiota-induced inflammation in mouse and coordinates gene expression in the intestinal epithelium

Autori: Juri Kazakevych, Jérémy Denizot, Anke Liebert, Mariana Portovedo, Mia Mosavie, Payal Jain, Claudia Stellato, Claire Fraser, Renan Oliveira Corrêa, Marina Célestine, Raphaël Mattiuz, Hanneke Okkenhaug, J. Ross Miller, Marco Aurélio Ramirez Vinolo, Marc Veldhoen, Patrick Varga-Weisz
Pubblicato in: Genome Biology, Numero 21/1, 2020, ISSN 1474-760X
Editore: BMC
DOI: 10.1186/s13059-020-01976-7

Loss of Phosphatidylinositol 3-Kinase Activity in Regulatory T Cells Leads to Neuronal Inflammation

Autori: Anne-Katrien Stark, Elizabeth C. M. Davenport, Daniel T. Patton, Cheryl L. Scudamore, Bart Vanhaesebroeck, Marc Veldhoen, Oliver A. Garden, Klaus Okkenhaug
Pubblicato in: The Journal of Immunology, Numero 205/1, 2020, Pagina/e 78-89, ISSN 0022-1767
Editore: American Association of Immunologists
DOI: 10.4049/jimmunol.2000043

Severe COVID-19 Recovery Is Associated with Timely Acquisition of a Myeloid Cell Immune-Regulatory Phenotype

Autori: Amelia C. Trombetta, Guilherme B. Farias, André M. C. Gomes, Ana Godinho-Santos, Pedro Rosmaninho, Carolina M. Conceição, Joel Laia, Diana F. Santos, Afonso R. M. Almeida, Catarina Mota, Andreia Gomes, Marta Serrano, Marc Veldhoen, Ana E. Sousa, Susana M. Fernandes
Pubblicato in: Frontiers in Immunology, Numero 12, 2021, ISSN 1664-3224
Editore: FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2021.691725

Feeding immunity: skepticism, delicacies and delights

Autori: Marc Veldhoen, Henrique Veiga-Fernandes
Pubblicato in: Nature Immunology, Numero 16/3, 2015, Pagina/e 215-219, ISSN 1529-2908
Editore: Nature Publishing Group
DOI: 10.1038/ni.3100

Type 1 Treg cells promote the generation of CD8+ tissue-resident memory T cells

Autori: Cristina Ferreira, Leandro Barros, Marta Baptista, Birte Blankenhaus, André Barros, Patrícia Figueiredo-Campos, Špela Konjar, Alexandra Lainé, Nadine Kamenjarin, Ana Stojanovic, Adelheid Cerwenka, Hans C. Probst, Julien C. Marie, Marc Veldhoen
Pubblicato in: Nature Immunology, Numero 21/7, 2020, Pagina/e 766-776, ISSN 1529-2908
Editore: Nature Publishing Group
DOI: 10.1038/s41590-020-0674-9

Pulmonary paracoccidioidomycosis in AhR deficient hosts is severe and associated with defective Treg and Th22 responses

Autori: Eliseu Frank de Araújo, Nycolas Willian Preite, Marc Veldhoen, Flávio Vieira Loures, Vera Lúcia Garcia Calich
Pubblicato in: Scientific Reports, Numero 10/1, 2020, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-020-68322-6

Humoral Immune Response of SARS‐CoV ‐2–Infected Patients with Cancer: Influencing Factors and Mechanisms

Autori: Miguel Esperança‐Martins, Lisa Gonçalves, Inês Soares‐Pinho, Andreia Gomes, Marta Serrano, Birte Blankenhaus, Patrícia Figueiredo‐Campos, Ana Catarina‐Marques, Ana Castro‐Barbosa, Ana Cardoso, Pedro Antunes‐Meireles, Henrique Atalaia‐Barbacena, Pedro Gaspar, Patrícia Howell‐Monteiro, António Pais‐de‐Lacerda, Catarina Mota, Marc Veldhoen
Pubblicato in: The Oncologist, Numero 26/9, 2021, ISSN 1083-7159
Editore: AlphaMed Press Inc
DOI: 10.1002/onco.13828

Microbiota derived short chain fatty acids promote histone crotonylation in the colon through histone deacetylases

Autori: Rachel Fellows, Jérémy Denizot, Claudia Stellato, Alessandro Cuomo, Payal Jain, Elena Stoyanova, Szabina Balázsi, Zoltán Hajnády, Anke Liebert, Juri Kazakevych, Hector Blackburn, Renan Oliveira Corrêa, José Luís Fachi, Fabio Takeo Sato, Willian R. Ribeiro, Caroline Marcantonio Ferreira, Hélène Perée, Mariangela Spagnuolo, Raphaël Mattiuz, Csaba Matolcsi, Joana Guedes, Jonathan Clark, M
Pubblicato in: Nature Communications, Numero 9/1, 2018, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-017-02651-5

Gut Bacterial Metabolite Urolithin A (UA) Mitigates Ca2+ Entry in T Cells by Regulating miR-10a-5p

Autori: Shaqiu Zhang, Tamer Al-Maghout, Hang Cao, Lisann Pelzl, Madhuri S. Salker, Marc Veldhoen, Anchun Cheng, Florian Lang, Yogesh Singh
Pubblicato in: Frontiers in Immunology, Numero 10, 2019, ISSN 1664-3224
Editore: FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2019.01737

Guidelines for the use of flow cytometry

Autori: Marc Veldhoen
Pubblicato in: Immunity, Inflammation and Disease, Numero 5/4, 2017, Pagina/e 384-385, ISSN 2050-4527
Editore: WILEY
DOI: 10.1002/iid3.207

Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition)

Autori: Andrea Cossarizza, Hyun‐Dong Chang, Andreas Radbruch, Andreas Acs, Dieter Adam, Sabine Adam‐Klages, William W. Agace, Nima Aghaeepour, Mübeccel Akdis, Matthieu Allez, Larissa Nogueira Almeida, Giorgia Alvisi, Graham Anderson, Immanuel Andrä, Francesco Annunziato, Achille Anselmo, Petra Bacher, Cosima T. Baldari, Sudipto Bari, Vincenzo Barnaba, Joana Barros‐Martins, Luca Battistini, Wolfgan
Pubblicato in: European Journal of Immunology, Numero 49/10, 2019, Pagina/e 1457-1973, ISSN 0014-2980
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/eji.201970107

Cellular Stress in the Context of an Inflammatory Environment Supports TGF-β-Independent T Helper-17 Differentiation

Autori: Verena Brucklacher-Waldert, Cristina Ferreira, Marisa Stebegg, Olivier Fesneau, Silvia Innocentin, Julien C. Marie, Marc Veldhoen
Pubblicato in: Cell Reports, Numero 19/11, 2017, Pagina/e 2357-2370, ISSN 2211-1247
Editore: Cell Press
DOI: 10.1016/j.celrep.2017.05.052

Intestinal Barrier Interactions with Specialized CD8 T Cells

Autori: Špela Konjar, Cristina Ferreira, Birte Blankenhaus, Marc Veldhoen
Pubblicato in: Frontiers in Immunology, Numero 8, 2017, ISSN 1664-3224
Editore: FRONTIERS MEDIA SA, PO BOX 110, EPFL INNOVATION PARK, BUILDING I, LAUSANNE, 1015, SWITZERLAND
DOI: 10.3389/fimmu.2017.01281

Metabolic wiring of murine T cell and intraepithelial lymphocyte maintenance and activation

Autori: Marc Veldhoen, Birte Blankenhaus, Špela Konjar, Cristina Ferreira
Pubblicato in: European Journal of Immunology, 2018, ISSN 0014-2980
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/eji.201646745

Oxygen starvation during T cell priming boosts cancer-killing potential

Autori: Špela Konjar, Birte Blankenhaus, Marc Veldhoen
Pubblicato in: Translational Cancer Research, Numero 7/S1, 2018, Pagina/e S34-S37, ISSN 2218-676X
Editore: AME PUBL CO, FLAT-RM C 16F, KINGS WING PLAZA 1, NO 3 KWAN ST, SHATIN, HONG KONG 00000, PEOPLES R CHINA
DOI: 10.21037/tcr.2017.12.07

Interleukin 17 is a chief orchestrator of immunity

Autori: Marc Veldhoen
Pubblicato in: Nature Immunology, Numero 18/6, 2017, Pagina/e 612-621, ISSN 1529-2908
Editore: Nature Publishing Group
DOI: 10.1038/ni.3742

PD-1 and its ligand PD-L1 are progressively up-regulated on CD4 and CD8 T-cells in HIV-2 infection irrespective of the presence of viremia

Autori: Rita Tendeiro, Russell B. Foxall, António P. Baptista, Francisco Pinto, Rui S. Soares, Rita Cavaleiro, Emília Valadas, Perpétua Gomes, Rui M.M. Victorino, Ana E. Sousa
Pubblicato in: AIDS, Numero 02699370, 2012, Pagina/e 1065-1071, ISSN 0269-9370
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/QAD.0b013e32835374db

Memory B-cell depletion is a feature of HIV-2 infection even in the absence of detectable viremia

Autori: Rita Tendeiro, Sofia Fernandes, Russell B. Foxall, José M. Marcelino, Nuno Taveira, Rui S. Soares, António P. Baptista, Rita Cavaleiro, Perpétua Gomes, Rui M.M. Victorino, Ana E. Sousa
Pubblicato in: AIDS, Numero 02699370, 2012, Pagina/e 1607-1617, ISSN 0269-9370
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/QAD.0b013e3283568849

Gold nanoparticle-based fluorescence immunoassay for malaria antigen detection

Autori: Bassem S. S. Guirgis, Cláudia Sá e Cunha, Inês Gomes, Miguel Cavadas, Isabel Silva, Gonçalo Doria, Gregory L. Blatch, Pedro V. Baptista, Eulália Pereira, Hassan M. E. Azzazy, Maria M. Mota, Miguel Prudêncio, Ricardo Franco
Pubblicato in: Analytical and Bioanalytical Chemistry, Numero 16182642, 2012, Pagina/e 1019-1027, ISSN 1618-2642
Editore: Springer Verlag
DOI: 10.1007/s00216-011-5489-y

Haemozoin detection in infected erythrocytes for Plasmodium falciparum malaria diagnosis—Prospects and limitations

Autori: Maria Rebelo, Howard M. Shapiro, Teresa Amaral, José Melo-Cristino, Thomas Hänscheid
Pubblicato in: Acta Tropica, Numero 0001706X, 2012, Pagina/e 58-61, ISSN 0001-706X
Editore: Elsevier BV
DOI: 10.1016/j.actatropica.2012.03.005

A Novel Carbon Monoxide-Releasing Molecule Fully Protects Mice from Severe Malaria

Autori: A. C. Pena, N. Penacho, L. Mancio-Silva, R. Neres, J. D. Seixas, A. C. Fernandes, C. C. Romao, M. M. Mota, G. J. L. Bernardes, A. Pamplona
Pubblicato in: Antimicrobial Agents and Chemotherapy, Numero 00664804, 2012, Pagina/e 1281-1290, ISSN 0066-4804
Editore: American Society for Microbiology
DOI: 10.1128/AAC.05571-11

PHYLOViZ: phylogenetic inference and data visualization for sequence based typing methods

Autori: Alexandre P Francisco, Cátia Vaz, Pedro T Monteiro, José Melo-Cristino, Mário Ramirez, João A Carriço
Pubblicato in: BMC Bioinformatics, Numero 14712105, 2012, Pagina/e 87, ISSN 1471-2105
Editore: BioMed Central
DOI: 10.1186/1471-2105-13-87

Engagement of NKp30 on V 1 T cells induces the production of CCL3, CCL4, and CCL5 and suppresses HIV-1 replication

Autori: K. Hudspeth, M. Fogli, D. V. Correia, J. Mikulak, A. Roberto, S. Della Bella, B. Silva-Santos, D. Mavilio
Pubblicato in: Blood, Numero 00064971, 2012, Pagina/e 4013-4016, ISSN 0006-4971
Editore: American Society of Hematology
DOI: 10.1182/blood-2011-11-390153

Differences between Macrolide-Resistant and -Susceptible Streptococcus pyogenes: Importance of Clonal Properties in Addition to Antibiotic Consumption

Autori: C. Silva-Costa, A. Friaes, M. Ramirez, J. Melo-Cristino
Pubblicato in: Antimicrobial Agents and Chemotherapy, Numero 00664804, 2012, Pagina/e 5661-5666, ISSN 0066-4804
Editore: American Society for Microbiology
DOI: 10.1128/AAC.01133-12

Novel Potent Metallocenes against Liver Stage Malaria

Autori: J. Matos, F. P. da Cruz, E. Cabrita, J. Gut, F. Nogueira, V. E. do Rosario, R. Moreira, P. J. Rosenthal, M. Prudencio, P. Gomes
Pubblicato in: Antimicrobial Agents and Chemotherapy, Numero 00664804, 2012, Pagina/e 1564-1570, ISSN 0066-4804
Editore: American Society for Microbiology
DOI: 10.1128/AAC.05345-11

Group A streptococci clones associated with invasive infections and pharyngitis in Portugal present differences in emm types, superantigen gene content and antimicrobial resistance

Autori: Ana Friães, Francisco R Pinto, Catarina Silva-Costa, Mario Ramirez, José Melo-Cristino
Pubblicato in: BMC Microbiology, Numero 14712180, 2012, Pagina/e 280, ISSN 1471-2180
Editore: BioMed Central
DOI: 10.1186/1471-2180-12-280

Monocyte activation is a feature of common variable immunodeficiency irrespective of plasma lipopolysaccharide levels

Autori: R. R. Barbosa, S. P. Silva, S. L. Silva, R. Tendeiro, A. C. Melo, E. Pedro, M. P. Barbosa, M. C. P. Santos, R. M. M. Victorino, A. E. Sousa
Pubblicato in: Clinical & Experimental Immunology, Numero 00099104, 2012, Pagina/e 263-272, ISSN 0009-9104
Editore: Blackwell Publishing Inc.
DOI: 10.1111/j.1365-2249.2012.04620.x

CD8+ T Cells from Mice Transnuclear for a TCR that Recognizes a Single H-2Kb-Restricted MHV68 Epitope Derived from gB-ORF8 Help Control Infection

Autori: Sharvan Sehrawat, Oktay Kirak, Paul-Albert Koenig, Marisa K. Isaacson, Sofia Marques, Gunes Bozkurt, J. Pedro Simas, Rudolph Jaenisch, Hidde L. Ploegh
Pubblicato in: Cell Reports, Numero 22111247, 2012, Pagina/e 461-471, ISSN 2211-1247
Editore: Cell Press
DOI: 10.1016/j.celrep.2012.03.009

Early skin immunological disturbance after Plasmodium-infected mosquito bites

Autori: Henrique Borges da Silva, Susana S. Caetano, Isadora Monteiro, Iván Gómez-Conde, Kirsten Hanson, Carlos Penha-Gonçalves, David N. Olivieri, Maria M. Mota, Cláudio R. Marinho, Maria R. D’Imperio Lima, Carlos E. Tadokoro
Pubblicato in: Cellular Immunology, Numero 00088749, 2012, Pagina/e 22-32, ISSN 0008-8749
Editore: Academic Press
DOI: 10.1016/j.cellimm.2012.06.003

γδ T-cell conference 2012: Close encounters for the fifth time

Autori: Bruno Silva-Santos, Wolfgang W. A. Schamel, Paul Fisch, Matthias Eberl
Pubblicato in: European Journal of Immunology, Numero 00142980, 2012, Pagina/e 3101-3105, ISSN 0014-2980
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/eji.201270101

Driving IL-17+ γδ T-cell migration in allergic reactions: A new “inflammatory” role for the “homeostatic” chemokine CCL25

Autori: Bruno Silva-Santos
Pubblicato in: European Journal of Immunology, Numero 00142980, 2012, Pagina/e 1097-1101, ISSN 0014-2980
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/eji.201242545

Persistence of uropathogenic Escherichia coli strains in the host for long periods of time: relationship between phylogenetic groups and virulence factors

Autori: A. Narciso, F. Nunes, T. Amores, L. Lito, J. Melo-Cristino, A. Duarte
Pubblicato in: European Journal of Clinical Microbiology & Infectious Diseases, Numero 09349723, 2012, Pagina/e 1211-1217, ISSN 0934-9723
Editore: Springer Verlag
DOI: 10.1007/s10096-011-1431-7

Innate recognition of malarial parasites by mammalian hosts

Autori: Peter Liehl, Maria M. Mota
Pubblicato in: International Journal for Parasitology, Numero 00207519, 2012, Pagina/e 557-566, ISSN 0020-7519
Editore: Elsevier BV
DOI: 10.1016/j.ijpara.2012.04.006

Targeting the Liver Stage of Malaria Parasites: A Yet Unmet Goal

Autori: Tiago Rodrigues, Miguel Prudêncio, Rui Moreira, Maria M. Mota, Francisca Lopes
Pubblicato in: Journal of Medicinal Chemistry, Numero 00222623, 2012, Pagina/e 995-1012, ISSN 0022-2623
Editore: American Chemical Society
DOI: 10.1021/jm201095h

Murine Gammaherpesvirus 68 LANA Acts on Terminal Repeat DNA To Mediate Episome Persistence

Autori: A. C. Habison, C. Beauchemin, J. P. Simas, E. J. Usherwood, K. M. Kaye
Pubblicato in: Journal of Virology, Numero 0022538X, 2012, Pagina/e 11863-11876, ISSN 0022-538X
Editore: American Society for Microbiology
DOI: 10.1128/JVI.01656-12

T Cell Apoptosis and Induction of Foxp3+ Regulatory T Cells Underlie the Therapeutic Efficacy of CD4 Blockade in Experimental Autoimmune Encephalomyelitis

Autori: J. Duarte, N. Carrie, V. G. Oliveira, C. Almeida, A. Agua-Doce, L. Rodrigues, J. P. Simas, L. T. Mars, L. Graca
Pubblicato in: The Journal of Immunology, Numero 00221767, 2012, Pagina/e 1680-1688, ISSN 0022-1767
Editore: American Association of Immunologists
DOI: 10.4049/jimmunol.1201269

Dominance of Serotype Ia among Group B Streptococci Causing Invasive Infections in Nonpregnant Adults in Portugal

Autori: E. R. Martins, J. Melo-Cristino, M. Ramirez
Pubblicato in: Journal of Clinical Microbiology, Numero 00951137, 2012, Pagina/e 1219-1227, ISSN 0095-1137
Editore: American Society for Microbiology
DOI: 10.1128/JCM.05488-11

The split nature of tumor-infiltrating leukocytes

Autori: Telma Lança, Bruno Silva-Santos
Pubblicato in: OncoImmunology, Numero 21624011, 2012, Pagina/e 717-725, ISSN 2162-4011
Editore: Landes Bioscience
DOI: 10.4161/onci.20068

Infection by Plasmodium changes shape and stiffness of hepatic cells

Autori: Peter Eaton, Vanessa Zuzarte-Luis, Maria M. Mota, Nuno C. Santos, Miguel Prudêncio
Pubblicato in: Nanomedicine: Nanotechnology, Biology and Medicine, Numero 15499634, 2012, Pagina/e 17-19, ISSN 1549-9634
Editore: Elsevier BV
DOI: 10.1016/j.nano.2011.10.004

Human FOXN1-Deficiency Is Associated with αβ Double-Negative and FoxP3+ T-Cell Expansions That Are Distinctly Modulated upon Thymic Transplantation

Autori: Adriana S. Albuquerque, José G. Marques, Susana L. Silva, Dario Ligeiro, Blythe H. Devlin, Jacques Dutrieux, Rémi Cheynier, Claudio Pignata, Rui M. M. Victorino, M. Louise Markert, Ana E. Sousa
Pubblicato in: PLoS ONE, Numero 19326203, 2012, Pagina/e e37042, ISSN 1932-6203
Editore: Public Library of Science
DOI: 10.1371/journal.pone.0037042

A Novel Way to Grow Hemozoin-Like Crystals In Vitro and Its Use to Screen for Hemozoin Inhibiting Antimalarial Compounds

Autori: Vincent Thomas, Ana Góis, Bruce Ritts, Peter Burke, Thomas Hänscheid, Gerald McDonnell
Pubblicato in: PLoS ONE, Numero 19326203, 2012, Pagina/e e41006, ISSN 1932-6203
Editore: Public Library of Science
DOI: 10.1371/journal.pone.0041006

Highly Dynamic Host Actin Reorganization around Developing Plasmodium Inside Hepatocytes

Autori: Carina S. S. Gomes-Santos, Maurice A. Itoe, Cristina Afonso, Ricardo Henriques, Rui Gardner, Nuno Sepúlveda, Pedro D. Simões, Helena Raquel, António Paulo Almeida, Luis F. Moita, Friedrich Frischknecht, Maria M. Mota
Pubblicato in: PLoS ONE, Numero 19326203, 2012, Pagina/e e29408, ISSN 1932-6203
Editore: Public Library of Science
DOI: 10.1371/journal.pone.0029408

RET/GFRα Signals Are Dispensable for Thymic T Cell Development In Vivo

Autori: Afonso Rocha Martins Almeida, Sílvia Arroz-Madeira, Diogo Fonseca-Pereira, Hélder Ribeiro, Reena Lasrado, Vassilis Pachnis, Henrique Veiga-Fernandes
Pubblicato in: PLoS ONE, Numero 19326203, 2012, Pagina/e e52949, ISSN 1932-6203
Editore: Public Library of Science
DOI: 10.1371/journal.pone.0052949

PRIMACINS, N-cinnamoyl-primaquine conjugates, with improved liver-stage antimalarial activity

Autori: Bianca Pérez, Cátia Teixeira, Inês S. Albuquerque, Jiri Gut, Philip J. Rosenthal, Miguel Prudêncio, Paula Gomes
Pubblicato in: MedChemComm, Numero 20402503, 2012, Pagina/e 1170, ISSN 2040-2503
Editore: Royal Society of Chemistry
DOI: 10.1039/c2md20113e

Differential RET Signaling Pathways Drive Development of the Enteric Lymphoid and Nervous Systems

Autori: A. Patel, N. Harker, L. Moreira-Santos, M. Ferreira, K. Alden, J. Timmis, K. Foster, A. Garefalaki, P. Pachnis, P. Andrews, H. Enomoto, J. Milbrandt, V. Pachnis, M. C. Coles, D. Kioussis, H. Veiga-Fernandes
Pubblicato in: Science Signaling, Numero 19379145, 2012, Pagina/e ra55-ra55, ISSN 1937-9145
Editore: American Association for the Advancement of Science
DOI: 10.1126/scisignal.2002734

Liver-stage malaria parasites vulnerable to diverse chemical scaffolds

Autori: E. R. Derbyshire, M. Prudencio, M. M. Mota, J. Clardy
Pubblicato in: Proceedings of the National Academy of Sciences, Numero 00278424, 2012, Pagina/e 8511-8516, ISSN 0027-8424
Editore: National Academy of Sciences
DOI: 10.1073/pnas.1118370109

Serotype changes in adult invasive pneumococcal infections in Portugal did not reduce the high fraction of potentially vaccine preventable infections

Autori: Andreia N. Horácio, Jorge Diamantino-Miranda, Sandra I. Aguiar, Mário Ramirez, José Melo-Cristino
Pubblicato in: Vaccine, Numero 0264410X, 2012, Pagina/e 218-224, ISSN 0264-410X
Editore: Elsevier BV
DOI: 10.1016/j.vaccine.2011.11.022

B7-CD28 Costimulatory Signals Control the Survival and Proliferation of Murine and Human T Cells via IL-2 Production

Autori: J. C. Ribot, A. deBarros, L. Mancio-Silva, A. Pamplona, B. Silva-Santos
Pubblicato in: The Journal of Immunology, Numero 00221767, 2012, Pagina/e 1202-1208, ISSN 0022-1767
Editore: American Association of Immunologists
DOI: 10.4049/jimmunol.1200268

Use of the 13-valent conjugate vaccine has the potential to eliminate pilus carrying isolates as causes of invasive pneumococcal disease

Autori: Sandra I. Aguiar, José Melo-Cristino, Mário Ramirez
Pubblicato in: Vaccine, Numero 0264410X, 2012, Pagina/e 5487-5490, ISSN 0264-410X
Editore: Elsevier BV
DOI: 10.1016/j.vaccine.2012.06.062

Drug Screen Targeted at Plasmodium Liver Stages Identifies a Potent Multistage Antimalarial Drug

Autori: F. P. da Cruz, C. Martin, K. Buchholz, M. J. Lafuente-Monasterio, T. Rodrigues, B. Sonnichsen, R. Moreira, F.-J. Gamo, M. Marti, M. M. Mota, M. Hannus, M. Prudencio
Pubblicato in: Journal of Infectious Diseases, Numero 00221899, 2012, Pagina/e 1278-1286, ISSN 0022-1899
Editore: University of Chicago Press
DOI: 10.1093/infdis/jis184

Tumor cell recognition by γδ T lymphocytes

Autori: Daniel V. Correia, Antonio C. Lopes, Bruno Silva-Santos
Pubblicato in: OncoImmunology, Numero 21624011, 2013, Pagina/e e22892, ISSN 2162-4011
Editore: Landes Bioscience
DOI: 10.4161/onci.22892

Preserved CD4 T-cell telomere length during long-lasting HIV-2 infection

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A Microscale Human Liver Platform that Supports the Hepatic Stages of Plasmodium falciparum and vivax

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Distribution of Pilus Islands in Streptococcus agalactiae That Cause Human Infections: Insights into Evolution and Implication for Vaccine Development

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Bioinformatics in bacterial molecular epidemiology and public health: databases, tools and the next-generation sequencing revolution

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Repairing thymic function

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Targeting Host Factors to Circumvent Anti-Malarial Drug Resistance

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Flavones as isosteres of 4(1H)-quinolones: Discovery of ligand efficient and dual stage antimalarial lead compounds

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Anthracyclines Induce DNA Damage Response-Mediated Protection against Severe Sepsis

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Changes in Streptococcus pyogenes causing invasive disease in Portugal: Evidence for superantigen gene loss and acquisition

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Insight into lymphoid tissue morphogenesis

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Description of plasmid pSM52, harbouring the gene for the Smr efflux pump, and its involvement in resistance to biocides in a meticillin-resistant Staphylococcus aureus strain

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Role of Src Homology Domain Binding in Signaling Complexes Assembled by the Murid -Herpesvirus M2 Protein

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miR-363-5p regulates endothelial cell properties and their communication with hematopoietic precursor cells

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Multilocus Sequence Analysis of Streptococcus canis Confirms the Zoonotic Origin of Human Infections and Reveals Genetic Exchange with Streptococcus dysgalactiae subsp. equisimilis

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At the Bench: Preclinical rationale for exploiting NK cells and T lymphocytes for the treatment of high-risk leukemias

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Structural Optimization of Quinolon-4(1 H )-imines as Dual-Stage Antimalarials: Toward Increased Potency and Metabolic Stability

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How Many Sputum Culture Results Do We Need To Monitor Multidrug-Resistant-Tuberculosis (MDR-TB) Patients during Treatment?

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Assessment of Dual Life Stage Antiplasmodial Activity of British Seaweeds

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A Novel Flow Cytometric Hemozoin Detection Assay for Real-Time Sensitivity Testing of Plasmodium falciparum

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The Majority of Adult Pneumococcal Invasive Infections in Portugal Are Still Potentially Vaccine Preventable in Spite of Significant Declines of Serotypes 1 and 5

Autori: Andreia N. Horácio, Jorge Diamantino-Miranda, Sandra I. Aguiar, Mário Ramirez, José Melo-Cristino
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Spartan: A Comprehensive Tool for Understanding Uncertainty in Simulations of Biological Systems

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Export of the pneumococcal phage SV1 lysin requires choline-containing teichoic acids and is holin-independent

Autori: Maria João Frias, José Melo-Cristino, Mário Ramirez
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Quinolin-4(1 H )-imines are Potent Antiplasmodial Drugs Targeting the Liver Stage of Malaria

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Extensive Dissemination of Methicillin-Resistant Staphylococcus aureus (MRSA) between the Hospital and the Community in a Country with a High Prevalence of Nosocomial MRSA

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The role of human umbilical cord tissue-derived mesenchymal stromal cells (UCX®) in the treatment of inflammatory arthritis

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Serotype discrimination of encapsulated Streptococcus pneumoniae strains by Fourier-transform infrared spectroscopy and chemometrics

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The Use of Machine Learning Methodologies to Analyse Antibiotic and Biocide Susceptibility in Staphylococcus aureus

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The Genetic Basis of Escherichia coli Pathoadaptation to Macrophages

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Crystal Structure of the Gamma-2 Herpesvirus LANA DNA Binding Domain Identifies Charged Surface Residues Which Impact Viral Latency

Autori: Bruno Correia, Sofia A. Cerqueira, Chantal Beauchemin, Marta Pires de Miranda, Shijun Li, Rajesh Ponnusamy, LÃ©nia Rodrigues, Thomas R. Schneider, Maria A. Carrondo, Kenneth M. Kaye, J. Pedro Simas, Colin E. McVey
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Recent thymic emigrants are the preferential precursors of regulatory T cells differentiated in the periphery

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Stabilization of Myc through Heterotypic Poly-Ubiquitination by mLANA Is Critical for γ-Herpesvirus Lymphoproliferation

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Essential, dose-dependent role for the transcription factor Gata3 in the development of IL-5+ and IL-13+ type 2 innate lymphoid cells

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Induced IL-17-Producing Invariant NKT Cells Require Activation in Presence of TGF- and IL-1

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Tuberculosis with malaria or HIV co-infection in a large hospital in Luanda, Angola

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Protective Role of the Inflammatory CCR2/CCL2 Chemokine Pathway through Recruitment of Type 1 Cytotoxic T Lymphocytes to Tumor Beds

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Torins are potent antimalarials that block replenishment of Plasmodium liver stage parasitophorous vacuole membrane proteins

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Mechanisms Underlying CD4+ Treg Immune Regulation in the Adult: From Experiments to Models

Autori: Marta Caridade, Luis Graca, Ruy M. Ribeiro
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BAFF and TACI Gene Expression Are Increased in Patients with Untreated Very Early Rheumatoid Arthritis

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The hemozoin conundrum: is malaria pigment immune-activating, inhibiting, or simply a bystander?

Autori: Márcia Boura, Rosangela Frita, Ana Góis, Tânia Carvalho, Thomas Hänscheid
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First case of infection with vancomycin-resistant Staphylococcus aureus in Europe

Autori: José Melo-Cristino, Cristina Resina, Viviana Manuel, Luís Lito, Mário Ramirez
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Recruitment of γδ T lymphocytes to tumors

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Adjuvant facilitates tolerance induction to factor VIII in hemophilic mice through a Foxp3-independent mechanism that relies on IL-10

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Novel Endoperoxide-Based Transmission-Blocking Antimalarials with Liver- and Blood-Schizontocidal Activities

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Natural Cytotoxicity Receptors: Broader Expression Patterns and Functions in Innate and Adaptive Immune Cells

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Molecular Mechanisms of Differentiation of Murine Pro-Inflammatory γδ T Cell Subsets

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Massive hypereosinophilia and vasculitis associated with major expansion of interleukin-5-producing CD8+ T cells in HIV-1 infection

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Gut disruption in HIV-2 infection despite reduced viremia

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Dual-stage triterpenoids from an African medicinal plant targeting the malaria parasite

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2-Octadecynoic acid as a dual life stage inhibitor of Plasmodium infections and plasmodial FAS-II enzymes

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PCR based differentiation between Streptococcus dysgalactiae subsp. equisimilis strains isolated from humans and horses

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iNKT Cells: Innate Lymphocytes with a Diverse Response

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N- Cinnamoylation of Antimalarial Classics: Quinacrine Analogues with Decreased Toxicity and Dual-Stage Activity

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Autori: Christoph S.N. Klose, Melanie Flach, Luisa Möhle, Leif Rogell, Thomas Hoyler, Karolina Ebert, Carola Fabiunke, Dietmar Pfeifer, Veronika Sexl, Diogo Fonseca-Pereira, Rita G. Domingues, Henrique Veiga-Fernandes, Sebastian J. Arnold, Meinrad Busslinger, Ildiko R. Dunay, Yakup Tanriver, Andreas Diefenbach
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Chemical Interrogation of the Malaria Kinome

Autori: Emily R. Derbyshire, Vanessa Zuzarte-Luís, Andreia D. Magalhães, Nobutaka Kato, Paul C. Sanschagrin, Jinhua Wang, Wenjun Zhou, Chandrasekhar V. Miduturu, Ralph Mazitschek, Piotr Sliz, Maria M. Mota, Nathanael S. Gray, Jon Clardy
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Invasive infections due to Streptococcus pyogenes: seasonal variation of severity and clinical characteristics, Iceland, 1975 to 2012

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Probing the aurone scaffold against Plasmodium falciparum: Design, synthesis and antimalarial activity

Autori: Marta P. Carrasco, Ana S. Newton, Lídia Gonçalves, Ana Góis, Marta Machado, Jiri Gut, Fátima Nogueira, Thomas Hänscheid, Rita C. Guedes, Daniel J.V.A. dos Santos, Philip J. Rosenthal, Rui Moreira
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Decreasing incidence and changes in serotype distribution of invasive pneumococcal disease in persons aged under 18 years since introduction of 10-valent and 13-valent conjugate vaccines in Portugal, July 2008 to June 2012

Autori: S I Aguiar, M J Brito, A N Horácio, J P Lopes, M Ramirez, J Melo-Cristino
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Hypoxia promotes liver-stage malaria infection in primary human hepatocytes in vitro

Autori: S. Ng, S. March, A. Galstian, K. Hanson, T. Carvalho, M. M. Mota, S. N. Bhatia
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Adult B-cell acute lymphoblastic leukemia cells display decreased PTEN activity and constitutive hyperactivation of PI3K/Akt pathway despite high PTEN protein levels

Autori: A. M. Gomes, M. V. D. Soares, P. Ribeiro, J. Caldas, V. Povoa, L. R. Martins, A. Melao, A. Serra-Caetano, A. B. de Sousa, J. F. Lacerda, J. T. Barata
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Phylogenetic and clonality analysis of Bacillus pumilus isolates uncovered a highly heterogeneous population of different closely related species and clones

Autori: Raquel Branquinho, Luís Meirinhos-Soares, João A. Carriço, Manuela Pintado, Luísa V. Peixe
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Reduced BAFF-R and Increased TACI Expression in Common Variable Immunodeficiency

Autori: Rita R. Barbosa, Susana L. Silva, Sara P. Silva, Alcinda C. Melo, M. Conceição Pereira-Santos, João T. Barata, Lennart Hammarström, Marília Cascalho, Ana E. Sousa
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Malaria infections: What and how can mice teach us

Autori: Vanessa Zuzarte-Luis, Maria M. Mota, Ana M. Vigário
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Novel Role of the Antimicrobial Peptide LL-37 in the Protection of Neutrophil Extracellular Traps against Degradation by Bacterial Nucleases

Autori: Ariane Neumann, Lena Völlger, Evelien T.M. Berends, E. Margo Molhoek, Daphne A.C. Stapels, Marika Midon, Ana Friães, Alfred Pingoud, Suzan H.M. Rooijakkers, Richard L. Gallo, Matthias Mörgelin, Victor Nizet, Hassan Y. Naim, Maren von Köckritz-Blickwede
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Simple, sensitive and quantitative bioluminescence assay for determination of malaria pre-patent period

Autori: Vanessa Zuzarte-Luis, Joana Sales-Dias, Maria M Mota
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Tetraoxane–Pyrimidine Nitrile Hybrids as Dual Stage Antimalarials

Autori: Rudi Oliveira, Rita C. Guedes, Patrícia Meireles, Inês S. Albuquerque, Lídia M. Gonçalves, Elisabete Pires, Maria Rosário Bronze, Jiri Gut, Philip J. Rosenthal, Miguel Prudêncio, Rui Moreira, Paul M. O’Neill, Francisca Lopes
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Methaemoglobin and COHb in patients with malaria

Autori: Thomas Hänscheid, Tom Gresnigt, Sascha Löhr, Arnaud Flamen, Thomas Zoller, José Melo-Cristino, Martin P Grobusch
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T rypanosoma brucei histone H1 inhibits RNA polymerase I transcription and is important for parasite fitness in vivo

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Development of functionalized nanoparticles for vaccine delivery to dendritic cells: a mechanistic approach

Autori: Joana M Silva, Gaëlle Vandermeulen, Vanessa G Oliveira, Sandra N Pinto, Catarina Rodrigues, Ana Salgado, Carlos A Afonso, Ana S Viana, Christine Jérôme, Liana C Silva, Luis Graca, Véronique Préat, Helena F Florindo
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Classification of current anticancer immunotherapies

Autori: Lorenzo Galluzzi, Erika Vacchelli, José-Manuel Bravo-San Pedro, Aitziber Buqué, Laura Senovilla, Elisa Elena Baracco, Norma Bloy, Francesca Castoldi, Jean-Pierre Abastado, Patrizia Agostinis, Ron N. Apte, Fernando Aranda, Maha Ayyoub, Philipp Beckhove, Jean-Yves Blay, Laura Bracci, Anne Caignard, Chiara Castelli, Federica Cavallo, Estaban Celis, Vincenzo Cerundolo, Aled Clayton, Mario P. Colombo, Lisa Coussens, Madhav V. Dhodapkar, Alexander M. Eggermont, Douglas T. Fearon, Wolf H. Fridman, Jitka Fučíková, Dmitry I. Gabrilovich, Jérôme Galon, Abhishek Garg, François Ghiringhelli, Giuseppe Giaccone, Eli Gilboa, Sacha Gnjatic, Axel Hoos, Anne Hosmalin, Dirk Jäger, Pawel Kalinski, Klas Kärre, Oliver Kepp, Rolf Kiessling, John M. Kirkwood, Eva Klein, Alexander Knuth, Claire E. Lewis, Roland Liblau, Michael T. Lotze, Enrico Lugli, Jean-Pierre Mach, Fabrizio Mattei, Domenico Mavilio, Ignacio Melero, Cornelis J. Melief, Elizabeth A. Mittendorf, Lorenzo Moretta, Adekunke Odunsi, Hideho Okada, Anna Karolina Palucka, Marcus E. Peter, Kenneth J. Pienta, Angel Porgador, George C. Prendergast, Gabriel A. Rabinovich, Nicholas P. Restifo, Naiyer Rizvi, Catherine Sautès-Fridman, Hans Schreiber, Barbara Seliger, Hiroshi Shiku, Bruno Silva-Santos, Mark J. Smyth, Daniel E. Speiser, Radek Spisek, Pramod K. Srivastava, James E. Talmadge, Eric Tartour, Sjoerd H. Van Der Burg, Benoît J. Van Den Eynde, Richard Vile, Hermann Wagner, Jeffrey S. Weber, Theresa L. Whiteside, Jedd D. Wolchok, Laurence Zitvogel, Weiping Zou, Guido Kroemer
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Host-cell sensors for Plasmodium activate innate immunity against liver-stage infection

Autori: Peter Liehl, Vanessa Zuzarte-Luís, Jennie Chan, Thomas Zillinger, Fernanda Baptista, Daniel Carapau, Madlen Konert, Kirsten K Hanson, Céline Carret, Caroline Lassnig, Mathias Müller, Ulrich Kalinke, Mohsan Saeed, Angelo Ferreira Chora, Douglas T Golenbock, Birgit Strobl, Miguel Prudêncio, Luis P Coelho, Stefan H Kappe, Giulio Superti-Furga, Andreas Pichlmair, Ana M Vigário, Charles M Rice, Katherine A Fitzgerald, Winfried Barchet, Maria M Mota
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Maternal retinoids control type 3 innate lymphoid cells and set the offspring immunity

Autori: Serge A. van de Pavert, Manuela Ferreira, Rita G. Domingues, Hélder Ribeiro, Rosalie Molenaar, Lara Moreira-Santos, Francisca F. Almeida, Sales Ibiza, Inês Barbosa, Gera Goverse, Carlos Labão-Almeida, Cristina Godinho-Silva, Tanja Konijn, Dennis Schooneman, Tom O’Toole, Mark R. Mizee, Yasmin Habani, Esther Haak, Fabio R. Santori, Dan R. Littman, Stefan Schulte-Merker, Elaine Dzierzak, J. Pedro Simas, Reina E. Mebius, Henrique Veiga-Fernandes
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The neurotrophic factor receptor RET drives haematopoietic stem cell survival and function

Autori: Diogo Fonseca-Pereira, Sílvia Arroz-Madeira, Mariana Rodrigues-Campos, Inês A. M. Barbosa, Rita G. Domingues, Teresa Bento, Afonso R. M. Almeida, Hélder Ribeiro, Alexandre J. Potocnik, Hideki Enomoto, Henrique Veiga-Fernandes
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Pherotype Influences Biofilm Growth and Recombination in Streptococcus pneumoniae

Autori: Margarida Carrolo, Francisco Rodrigues Pinto, José Melo-Cristino, Mário Ramirez
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Non-Invasive Pneumococcal Pneumonia in Portugal—Serotype Distribution and Antimicrobial Resistance

Autori: Andreia N. Horácio, Joana P. Lopes, Mário Ramirez, José Melo-Cristino
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Evaluation of a Novel Magneto-Optical Method for the Detection of Malaria Parasites

Autori: Ágnes Orbán, Ádám Butykai, András Molnár, Zsófia Pröhle, Gergö Fülöp, Tivadar Zelles, Wasan Forsyth, Danika Hill, Ivo Müller, Louis Schofield, Maria Rebelo, Thomas Hänscheid, Stephan Karl, István Kézsmárki
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Scarlet Fever Is Caused By a Limited Number of Streptococcus pyogenes Lineages and Is Associated with the Exotoxin Genes ssa, speA and speC

Autori: Catarina Silva-Costa, Joao A. Carriço, Mario Ramirez, Jose Melo-Cristino
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Defining Immune Engagement Thresholds for In Vivo Control of Virus-Driven Lymphoproliferation

Autori: Cristina Godinho-Silva, Sofia Marques, Diana Fontinha, Henrique Veiga-Fernandes, Philip G. Stevenson, J. Pedro Simas
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Establishment of Murine Gammaherpesvirus Latency in B Cells Is Not a Stochastic Event

Autori: Jérémie Decalf, Cristina Godinho-Silva, Diana Fontinha, Sofia Marques, J. Pedro Simas
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Induction of Prophages by Fluoroquinolones in Streptococcus pneumoniae: Implications for Emergence of Resistance in Genetically-Related Clones

Autori: Elena López, Arnau Domenech, María-José Ferrándiz, Maria João Frias, Carmen Ardanuy, Mario Ramirez, Ernesto García, Josefina Liñares, Adela G. de la Campa
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Murine CD27(-) V 6(+) T cells producing IL-17A promote ovarian cancer growth via mobilization of protumor small peritoneal macrophages

Autori: M. Rei, N. Goncalves-Sousa, T. Lanca, R. G. Thompson, S. Mensurado, F. R. Balkwill, H. Kulbe, D. J. Pennington, B. Silva-Santos
Pubblicato in: Proceedings of the National Academy of Sciences, Numero 00278424, 2014, Pagina/e E3562-E3570, ISSN 0027-8424
Editore: National Academy of Sciences
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Towards an advanced therapy medicinal product based on mesenchymal stromal cells isolated from the umbilical cord tissue: quality and safety data

Autori: José Paulo Martins, Jorge Miguel Santos, Joana Marto de Almeida, Mariana Alves Filipe, Mariana Vargas Teixeira de Almeida, Sílvia Cristina Paiva Almeida, Ana Água-Doce, Alexandre Varela, Mari Gilljam, Birgitta Stellan, Susanne Pohl, Kurt Dittmar, Werner Lindenmaier, Evren Alici, Luís Graça, Pedro Estilita Cruz, Helder Joaquim Cruz, Rita Nogueira Bárcia
Pubblicato in: Stem Cell Research & Therapy, Numero 17576512, 2014, Pagina/e 9, ISSN 1757-6512
Editore: BioMed Central
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Enteric Mucosa Integrity in the Presence of a Preserved Innate Interleukin 22 Compartment in HIV Type 1-Treated Individuals

Autori: S. M. Fernandes, A. R. Pires, C. Ferreira, R. B. Foxall, J. Rino, C. Santos, L. Correia, J. Pocas, H. Veiga-Fernandes, A. E. Sousa
Pubblicato in: Journal of Infectious Diseases, Numero 00221899, 2014, Pagina/e 630-640, ISSN 0022-1899
Editore: University of Chicago Press
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Delta-like 1-Mediated Notch Signaling Enhances the In Vitro Conversion of Human Memory CD4 T Cells into FOXP3-Expressing Regulatory T Cells

Autori: C. Mota, V. Nunes-Silva, A. R. Pires, P. Matoso, R. M. M. Victorino, A. E. Sousa, I. Caramalho
Pubblicato in: The Journal of Immunology, Numero 00221767, 2014, Pagina/e 5854-5862, ISSN 0022-1767
Editore: American Association of Immunologists
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TACI deficiency enhances antibody avidity and clearance of an intestinal pathogen

Autori: Shoichiro Tsuji, Lucas Stein, Nobuhiko Kamada, Gabriel Nuñez, Richard Bram, Bruce A. Vallance, Ana E. Sousa, Jeffrey L. Platt, Marilia Cascalho
Pubblicato in: Journal of Clinical Investigation, Numero 00219738, 2014, Pagina/e 4857-4866, ISSN 0021-9738
Editore: American Society for Clinical Investigation
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Human Thymocytes Are Functionally Immature and Differentiate into Cytotoxic Type 1 Effector T Cells upon IL-2/IL-15 Signaling

Autori: J. C. Ribot, S. T. Ribeiro, D. V. Correia, A. E. Sousa, B. Silva-Santos
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Editore: American Association of Immunologists
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In Vitro Alterations Do Not Reflect a Requirement for Host Cell Cycle Progression during Plasmodium Liver Stage Infection

Autori: Kirsten K. Hanson, Sandra March, Shengyong Ng, Sangeeta N. Bhatia, Maria M. Mota
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Editore: American Society for Microbiology
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The Emerging Protumor Role of T Lymphocytes: Implications for Cancer Immunotherapy

Autori: M. Rei, D. J. Pennington, B. Silva-Santos
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Editore: American Association for Cancer Research
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Chicago 2014 – 30years of γδ T cells

Autori: Marc Bonneville, Zheng W. Chen, Julie Déchanet-Merville, Matthias Eberl, Jean Jacques Fournié, Julie M. Jameson, Richard D. Lopez, Massimo Massaia, Bruno Silva-Santos
Pubblicato in: Cellular Immunology, Numero 00088749, 2015, Pagina/e 3-9, ISSN 0008-8749
Editore: Academic Press
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Human regulatory T-cell development is dictated by Interleukin-2 and -15 expressed in a non-overlapping pattern in the thymus

Autori: Iris Caramalho, Vânia Nunes-Silva, Ana R. Pires, Catarina Mota, Ana I. Pinto, Helena Nunes-Cabaço, Russell B. Foxall, Ana E. Sousa
Pubblicato in: Journal of Autoimmunity, Numero 08968411, 2015, Pagina/e 98-110, ISSN 0896-8411
Editore: Academic Press
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Thymic HIV-2 Infection Uncovers Posttranscriptional Control of Viral Replication in Human Thymocytes

Autori: Helena Nunes-Cabaço, Paula Matoso, Russell B. Foxall, Rita Tendeiro, Ana R. Pires, Tânia Carvalho, Ana I. Pinheiro, Rui S. Soares, Ana E. Sousa
Pubblicato in: Journal of Virology, Numero 0022538X, 2015, Pagina/e 2201-2208, ISSN 0022-538X
Editore: American Society for Microbiology
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In vivo delivery of peptides and Toll-like receptor ligands by mannose-functionalized polymeric nanoparticles induces prophylactic and therapeutic anti-tumor immune responses in a melanoma model

Autori: Joana M. Silva, Eva Zupancic, Gaëlle Vandermeulen, Vanessa G. Oliveira, Ana Salgado, Mafalda Videira, Manuela Gaspar, Luis Graca, Véronique Préat, Helena F. Florindo
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Point-of-care tests: where is the point?

Autori: Thomas Hänscheid, Maria Rebelo, Martin P Grobusch
Pubblicato in: The Lancet Infectious Diseases, Numero 14733099, 2014, Pagina/e 922, ISSN 1473-3099
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Eimeria vermiformis Infection Model of Murine Small Intestine

Autori: Patrícia Figueiredo-Campos, Cristina Ferreira, Birte Blankenhaus, Marc Veldhoen
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Dynamic Metabolic State of Tissue Resident CD8 T Cells

Autori: Špela Konjar, Marc Veldhoen
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Editore: FRONTIERS MEDIA SA
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Effector γδ T Cell Differentiation Relies on Master but Not Auxiliary Th Cell Transcription Factors

Autori: Joana Barros-Martins, Nina Schmolka, Diana Fontinha, Marta Pires de Miranda, J. Pedro Simas, Ingrid Brok, Cristina Ferreira, Marc Veldhoen, Bruno Silva-Santos, Karine Serre
Pubblicato in: The Journal of Immunology, Numero 196/9, 2016, Pagina/e 3642-3652, ISSN 0022-1767
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Mitochondria maintain controlled activation state of epithelial-resident T lymphocytes

Autori: Špela Konjar, Ulrika C. Frising, Cristina Ferreira, Reinhard Hinterleitner, Toufic Mayassi, Qifeng Zhang, Birte Blankenhaus, Nejc Haberman, Yunhua Loo, Joana Guedes, Marta Baptista, Silvia Innocentin, Joerg Stange, Douglas Strathdee, Bana Jabri, Marc Veldhoen
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Immunology: Skin T Cells Switch Identity to Protect and Heal

Autori: Silvia Ariotti, Marc Veldhoen
Pubblicato in: Current Biology, Numero 29/6, 2019, Pagina/e R220-R223, ISSN 0960-9822
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Guidelines for the use of flow cytometry and cell sorting in immunological studies *

Autori: Andrea Cossarizza, Hyun‐Dong Chang, Andreas Radbruch, Mübeccel Akdis, Immanuel Andrä, Francesco Annunziato, Petra Bacher, Vincenzo Barnaba, Luca Battistini, Wolfgang M. Bauer, Sabine Baumgart, Burkhard Becher, Wolfgang Beisker, Claudia Berek, Alfonso Blanco, Giovanna Borsellino, Philip E. Boulais, Ryan R. Brinkman, Martin Büscher, Dirk H. Busch, Timothy P. Bushnell, Xuetao Cao, Andrea Cavani,
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Quantification of Sporozoite Invasion, Migration, and Development by Microscopy and Flow Cytometry

Autori: Photini Sinnis, Patricia De La Vega, Alida Coppi, Urszula Krzych, Maria M. Mota
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Editore: Humana Press
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Differentiation and Activation of γδ T Lymphocytes: Focus on CD27 and CD28 Costimulatory Receptors

Autori: Julie C. Ribot, Bruno Silva-Santos
Pubblicato in: Crossroads Between Innate and Adaptive Immunity IV, 2013, Pagina/e 95-105, ISBN 978-1-4614-6217-0
Editore: Springer New York
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Endemic SARS-CoV-2 will maintain post-pandemic immunity

Autori: Marc Veldhoen, J. Pedro Simas
Pubblicato in: Nature Reviews Immunology, Numero 21/3, 2021, Pagina/e 131-132, ISSN 1474-1733
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Academic labs supporting COVID‐19 diagnostics

Autori: Marc Veldhoen, Vanessa Zuzarte‐Luis
Pubblicato in: European Journal of Immunology, Numero 51/1, 2021, Pagina/e 13-16, ISSN 0014-2980
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