Targeting epigenetic REPROGRamming of innate immune cells in Atherosclerosis Management and other chronic inflammatory diseases

Rezultaty

Final report on knowledge exploitation results, including filed patents, spin-off initiatives, etc. during REPROGRAM and thereafter

Quality Assurance File

Report defining the working conditions based on the intaconsortium agreement and procedures defined in Annex 1: standard operation procedures, details on document, knowledge and data management, publication procedures, conflict resolution procedures, meetings arrangements and decision making structure, among other issues

Gender-specific analysis addressing distinct patterns in inflammatory activity

Report on the gender-specific analysis addressing distinct patterns in inflammatory activity, epigenetic control in men vs. women

Ex vivo analysis of monocyte phenotype/function/epigenome in patients with active vs. remissive RA

Report on ex vivo analysis of monocyte phenotype / function / epigenome in patients with active vs. remissive RA

50 BMT experiments in various mouse models

Report on 50 BMT experiments in various mouse models

Data on phenotype, function and epigenome of myeloid cells

Report on study data on phenotype, function and epigenome of myeloid cells harvested from patients with atherogenic risk factors

Roadmap for exploitation

Report incorporating extensive market research, innovation strategies, technology transfer policy, business opportunities among others ensuring swift knowledge exploitation for the expected outcomes of the project: 1. New therapeutic targets; 2. New cellular biomarkers; 3. New therapeutic strategies based on newly discovered disease pathways common to several chronic inflammatory diseases; 4. New opportunities in nanotechnology for targeted drug delivery in chronic inflammatory diseases; 5. New multimodal imaging techniques for systemic activation of innate immune cells.

Relation between gene-score and cardiovascular risk

Evaluation report of the relation between gene-score and cardiovascular risk in the general population

Young researcher training program

Report on the proposed young talent program actions during the REPROGRAM project, including complementary trainings, invited lectures, short laboratory/clinic visits.

Nanoparticle vs. unpackaged epigenetic modulator in vitro and experimental model

Report on the comparison of nanoparticle vs. unpackaged epigenetic modulators in in vitro studies and experimental models

PET/CT studies in patients with active and remissive RA

Report on in vivo PET/CT studies in patients with active and remissive RA

Local delivery strategy development for a epigenetic modulator

Feasibility report of local delivery strategy development for a epigenetic modulator

24 ldlr-/- experiments using either placebo or epigenetic modulator

Report on the 24 ldlr-/- experiments using either placebo or epigenetic modulator for 4 weeks

Validated gene score for modified epigenetic modulation

Report on the delivery of a validated gene score for modified epigenetic modulation in humans

Data management plan

Report containing: (1) detailed information on the procedures that will be implemented for data collection, use, consent, storage, protection, retention, destruction, and how the participants will be consented (2) a document from the responsible data management structure/individual stating that all planned measures comply with national and EU legislation, (3) If applicable copies of the i. notifications ii. approvals iii. opinions iv. authorisations from the relevant national data protection authorities for the proposed data collection and processing as well as reuse must be provided to the EU prior to any use.

Dissemination final report

Final report on dissemination results, including all scientific publications, newsletters, etc. during REPROGRAM and thereafter

In vitro tests of atherogenic factors on phenotype/function/epigenetics of human myeloid cells

Report on in vitro tests of atherogenic factors on phenotype/function/epigenetics of human myeloid cells

CID-associated DAMPs on human monocyte phenotype/function/epigenome

Report on in vitro tests of CID-associated DAMPs on human monocyte phenotype / function / epigenome

Epigenetic modulators on in vitro cell systems

Report on in vitro testing of the library of epigenetic modulators on in vitro cell systems

Publikacje

CCR2 expression on circulating monocytes is associated with arterial wall inflammation assessed by 18F-FDG PET/CT in patients at risk for cardiovascular disease

Autorzy: Simone L Verweij, Raphaël Duivenvoorden, Lotte C A Stiekema, Nick S Nurmohamed, Fleur M van der Valk, Miranda Versloot, Hein J Verberne, Erik S G Stroes, Matthias Nahrendorf, Siroon Bekkering, Sophie J Bernelot Moens
Opublikowane w: Cardiovascular Research, Numer 114/3, 2017, Strona(/y) 468-475, ISSN 0008-6363
Wydawca: Elsevier BV
DOI: 10.1093/cvr/cvx224

Targeting CD40-Induced TRAF6 Signaling in Macrophages Reduces Atherosclerosis

Autorzy: Tom T.P. Seijkens, Claudia M. van Tiel, Pascal J.H. Kusters, Dorothee Atzler, Oliver Soehnlein, Barbara Zarzycka, Suzanne A.B.M. Aarts, Marnix Lameijer, Marion J. Gijbels, Linda Beckers, Myrthe den Toom, Bram Slütter, Johan Kuiper, Johan Duchene, Maria Aslani, Remco T.A. Megens, Cornelis van ‘t Veer, Gijs Kooij, Roy Schrijver, Marten A. Hoeksema, Louis Boon, Francois Fay, Jun Tang, Samantha Bax
Opublikowane w: Journal of the American College of Cardiology, Numer 71/5, 2018, Strona(/y) 527-542, ISSN 0735-1097
Wydawca: Elsevier BV
DOI: 10.1016/j.jacc.2017.11.055

Exploring immune checkpoints as potential therapeutic targets in atherosclerosis

Autorzy: Pascal J H Kusters, Esther Lutgens, Tom T P Seijkens
Opublikowane w: Cardiovascular Research, Numer 114/3, 2017, Strona(/y) 368-377, ISSN 0008-6363
Wydawca: Elsevier BV
DOI: 10.1093/cvr/cvx248

Trained Innate Immunity as a Novel Mechanism Linking Infection and the Development of Atherosclerosis

Autorzy: Jenneke Leentjens, Siroon Bekkering, Leo A Joosten, Mihai G Netea, David P Burgner, Niels P Riksen
Opublikowane w: Circulation Research, Numer 2018 Jan 24, 2018, Strona(/y) CIRCRESAHA.117.312465, ISSN 0009-7330
Wydawca: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/CIRCRESAHA.117.312465

The maturation of a ‘neural–hematopoietic’ inflammatory axis in cardiovascular disease

Autorzy: Lotte C.A. Stiekema, Johan G. Schnitzler, Matthias Nahrendorf, Erik S.G. Stroes
Opublikowane w: Current Opinion in Lipidology, Numer 28/6, 2017, Strona(/y) 507-512, ISSN 0957-9672
Wydawca: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/MOL.0000000000000457

Monocyte and haematopoietic progenitor reprogramming as common mechanism underlying chronic inflammatory and cardiovascular diseases

Autorzy: Renate M Hoogeveen, Matthias Nahrendorf, Niels P Riksen, Mihai G Netea, Menno P J de Winther, Esther Lutgens, Børge G Nordestgaard, Michel Neidhart, Erik S G Stroes, Alberico L Catapano, Siroon Bekkering
Opublikowane w: European Heart Journal, 2017, ISSN 0195-668X
Wydawca: Oxford University Press
DOI: 10.1093/eurheartj/ehx581

Metabolic Induction of Trained Immunity through the Mevalonate Pathway

Autorzy: Siroon Bekkering, Rob J.W. Arts, Boris Novakovic, Ioannis Kourtzelis, Charlotte D.C.C. van der Heijden, Yang Li, Calin D. Popa, Rob ter Horst, Julia van Tuijl, Romana T. Netea-Maier, Frank L. van de Veerdonk, Triantafyllos Chavakis, Leo A.B. Joosten, Jos W.M. van der Meer, Henk Stunnenberg, Niels P. Riksen, Mihai G. Netea
Opublikowane w: Cell, Numer 172/1-2, 2018, Strona(/y) 135-146.e9, ISSN 0092-8674
Wydawca: Cell Press
DOI: 10.1016/j.cell.2017.11.025

Epigenetics and Trained Immunity

Autorzy: Charlotte D.C.C. van der Heijden, Marlies P. Noz, Leo A.B. Joosten, Mihai G. Netea, Niels P. Riksen, Samuel T. Keating
Opublikowane w: Antioxidants & Redox Signaling, 2017, ISSN 1523-0864
Wydawca: Mary Ann Liebert Inc.
DOI: 10.1089/ars.2017.7310

PCSK9 monoclonal antibodies reverse the pro-inflammatory profile of monocytes in familial hypercholesterolaemia

Autorzy: Sophie J. Bernelot Moens, Annette E. Neele, Jeffrey Kroon, Fleur M. van der Valk, Jan Van den Bossche, Marten A. Hoeksema, Renate M. Hoogeveen, Johan G. Schnitzler, Marie T. Baccara-Dinet, Garen Manvelian, Menno P.J. de Winther, Erik S.G. Stroes
Opublikowane w: European Heart Journal, Numer 38/20, 2017, Strona(/y) 1584-1593, ISSN 0195-668X
Wydawca: Oxford University Press
DOI: 10.1093/eurheartj/ehx002

Remnant Cholesterol Elicits Arterial Wall Inflammation and a Multilevel Cellular Immune Response in HumansHighlights

Autorzy: Sophie J. Bernelot Moens, Simone L. Verweij, Johan G. Schnitzler, Lotte C.A. Stiekema, Merijn Bos, Anne Langsted, Carlijn Kuijk, Siroon Bekkering, Carlijn Voermans, Hein J. Verberne, Børge G. Nordestgaard, Erik S.G. Stroes, Jeffrey Kroon
Opublikowane w: Arteriosclerosis, Thrombosis, and Vascular Biology, Numer 37/5, 2017, Strona(/y) 969-975, ISSN 1079-5642
Wydawca: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/ATVBAHA.116.308834

Nile Red Quantifier: a novel and quantitative tool to study lipid accumulation in patient-derived circulating monocytes using confocal microscopy

Autorzy: Johan G. Schnitzler, Sophie J. Bernelot Moens, Feiko Tiessens, Guido J. Bakker, Geesje M. Dallinga-Thie, Albert K. Groen, Max Nieuwdorp, Erik S. G. Stroes, Jeffrey Kroon
Opublikowane w: Journal of Lipid Research, Numer 58/11, 2017, Strona(/y) 2210-2219, ISSN 0022-2275
Wydawca: Lipid Research, Inc.
DOI: 10.1194/jlr.D073197

Western Diet Triggers NLRP3-Dependent Innate Immune Reprogramming

Autorzy: Anette Christ, Patrick Günther, Mario A.R. Lauterbach, Peter Duewell, Debjani Biswas, Karin Pelka, Claus J. Scholz, Marije Oosting, Kristian Haendler, Kevin Baßler, Kathrin Klee, Jonas Schulte-Schrepping, Thomas Ulas, Simone J.C.F.M. Moorlag, Vinod Kumar, Min Hi Park, Leo A.B. Joosten, Laszlo A. Groh, Niels P. Riksen, Terje Espevik, Andreas Schlitzer, Yang Li, Michael L. Fitzgerald, Mihai G. Net
Opublikowane w: Cell, Numer 172/1-2, 2018, Strona(/y) 162-175.e14, ISSN 0092-8674
Wydawca: Cell Press
DOI: 10.1016/j.cell.2017.12.013

Monocyte and macrophage immunometabolism in atherosclerosis

Autorzy: Laszlo Groh, Samuel T. Keating, Leo A. B. Joosten, Mihai G. Netea, Niels P. Riksen
Opublikowane w: Seminars in Immunopathology, Numer 40/2, 2018, Strona(/y) 203-214, ISSN 1863-2297
Wydawca: Springer Verlag
DOI: 10.1007/s00281-017-0656-7

Epigenetics in diabetic nephropathy, immunity and metabolism

Autorzy: Samuel T. Keating, Janna A. van Diepen, Niels P. Riksen, Assam El-Osta
Opublikowane w: Diabetologia, Numer 61/1, 2018, Strona(/y) 6-20, ISSN 0012-186X
Wydawca: Springer Verlag
DOI: 10.1007/s00125-017-4490-1

Diabetes propels the risk for cardiovascular disease: sweet monocytes becoming aggressive?

Autorzy: Janna A. van Diepen, Kathrin Thiem, Rinke Stienstra, Niels P. Riksen, Cees J. Tack, Mihai G. Netea
Opublikowane w: Cellular and Molecular Life Sciences, 2016, ISSN 1420-682X
Wydawca: Birkhauser Verlag
DOI: 10.1007/s00018-016-2316-9

Oxidized Phospholipids on Lipoprotein(a) Elicit Arterial Wall Inflammation and an Inflammatory Monocyte Response in HumansClinical Perspective

Autorzy: Fleur M. van der Valk, Siroon Bekkering, Jeffrey Kroon, Calvin Yeang, Jan Van den Bossche, Jaap D. van Buul, Amir Ravandi, Aart J. Nederveen, Hein J. Verberne, Corey Scipione, Max Nieuwdorp, Leo A.B. Joosten, Mihai G. Netea, Marlys L. Koschinsky, Joseph L. Witztum, Sotirios Tsimikas, Niels P. Riksen, Erik S.G. Stroes
Opublikowane w: Circulation, Numer 134/8, 2016, Strona(/y) 611-624, ISSN 0009-7322
Wydawca: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/CIRCULATIONAHA.116.020838

Unexpected arterial wall and cellular inflammation in patients with rheumatoid arthritis in remission using biological therapy: a cross-sectional study

Autorzy: Sophie J. Bernelot Moens, Fleur M. van der Valk, Aart C. Strang, Jeffrey Kroon, Loek P. Smits, Eva L. Kneepkens, Hein J. Verberne, Jaap D. van Buul, Michael T. Nurmohamed, Erik S. G. Stroes
Opublikowane w: Arthritis Research & Therapy, Numer 18/1, 2016, ISSN 1478-6362
Wydawca: BioMed Central
DOI: 10.1186/s13075-016-1008-z

Erratum to: Unexpected arterial wall and cellular inflammation in patients with rheumatoid arthritis in remission using biological therapy: a cross-sectional study

Myeloid apolipoprotein E controls dendritic cell antigen presentation and T cell activation

Autorzy: Fabrizia Bonacina, David Coe, Guosu Wang, Maria P. Longhi, Andrea Baragetti, Annalisa Moregola, Katia Garlaschelli, Patrizia Uboldi, Fabio Pellegatta, Liliana Grigore, Lorenzo Da Dalt, Andrea Annoni, Silvia Gregori, Qingzhong Xiao, Donatella Caruso, Nico Mitro, Alberico L. Catapano, Federica M. Marelli-Berg, Giuseppe D. Norata
Opublikowane w: Nature Communications, Numer 9/1, 2018, ISSN 2041-1723
Wydawca: Nature Publishing Group
DOI: 10.1038/s41467-018-05322-1

Anti-PCSK9 antibodies for the treatment of heterozygous familial hypercholesterolemia: patient selection and perspectives

Autorzy: Alberico Catapano, Angela Pirillo, Giuseppe Danilo Norata
Opublikowane w: Vascular Health and Risk Management, Numer Volume 13, 2017, Strona(/y) 343-351, ISSN 1178-2048
Wydawca: Dovepress
DOI: 10.2147/VHRM.S130338

Macrophages and Cardiovascular Health

Autorzy: Vanessa Frodermann, Matthias Nahrendorf
Opublikowane w: Physiological Reviews, Numer 98/4, 2018, Strona(/y) 2523-2569, ISSN 0031-9333
Wydawca: American Physiological Society
DOI: 10.1152/physrev.00068.2017

Myeloid cell contributions to cardiovascular health and disease

Autorzy: Matthias Nahrendorf
Opublikowane w: Nature Medicine, Numer 24/6, 2018, Strona(/y) 711-720, ISSN 1078-8956
Wydawca: Nature Publishing Group
DOI: 10.1038/s41591-018-0064-0

Imaging the Vascular Bone Marrow Niche During Inflammatory Stress

Autorzy: Katrien Vandoorne, David Rohde, Hye-Yeong Kim, Gabriel Courties, Gregory Wojtkiewicz, Lisa Honold, Friedrich Felix Hoyer, Vanessa Frodermann, Ribhu Nayar, Fanny Herisson, Yookyung Jung, Pauline A. Désogère, Claudio Vinegoni, Peter Caravan, Ralph Weissleder, David E. Sosnovik, Charles P. Lin, Filip K. Swirski, Matthias Nahrendorf
Opublikowane w: Circulation Research, Numer 123/4, 2018, Strona(/y) 415-427, ISSN 0009-7330
Wydawca: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/circresaha.118.313302

Myeloid Kdm6b deficiency results in advanced atherosclerosis

Autorzy: Annette E. Neele, Marion J.J. Gijbels, Saskia van der Velden, Marten A. Hoeksema, Marieke C.S. Boshuizen, Koen H.M. Prange, Hung-Jen Chen, Jan Van den Bossche, Cindy P.P.A. van Roomen, Annelie Shami, Johannes H.M. Levels, Jeffrey Kroon, Tina Lucas, Stefanie Dimmeler, Esther Lutgens, Menno P.J. de Winther
Opublikowane w: Atherosclerosis, Numer 275, 2018, Strona(/y) 156-165, ISSN 0021-9150
Wydawca: Elsevier BV
DOI: 10.1016/j.atherosclerosis.2018.05.052

CD40L Deficiency Protects Against Aneurysm Formation

Autorzy: Pascal J.H. Kusters, Tom T.P. Seijkens, Linda Beckers, Dirk Lievens, Holger Winkels, Vivian de Waard, Adriaan Duijvestijn, Moritz Lindquist Liljeqvist, Joy Roy, Alan Daugherty, Andrew Newby, Norbert Gerdes, Esther Lutgens
Opublikowane w: Arteriosclerosis, Thrombosis, and Vascular Biology, Numer 38/5, 2018, Strona(/y) 1076-1085, ISSN 1079-5642
Wydawca: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/atvbaha.117.310640

2016 Jeffrey M. Hoeg Award Lecture

Autorzy: Ellen Rouwet, Esther Lutgens
Opublikowane w: Arteriosclerosis, Thrombosis, and Vascular Biology, Numer 38/8, 2018, Strona(/y) 1678-1688, ISSN 1079-5642
Wydawca: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/atvbaha.118.307742

Future directions for therapeutic strategies in post-ischaemic vascularization: a position paper from European Society of Cardiology Working Group on Atherosclerosis and Vascular Biology

Autorzy: Andrea Caporali, Magnus Bäck, Mat J Daemen, Imo E Hoefer, Elizabeth A Jones, Esther Lutgens, Christian M Matter, Marie-Luce Bochaton-Piallat, Arndt F Siekmann, Judith C Sluimer, Sabine Steffens, José Tuñón, Cecile Vindis, Jolanda J Wentzel, Seppo Ylä-Herttuala, Paul C Evans
Opublikowane w: Cardiovascular Research, Numer 114/11, 2018, Strona(/y) 1411-1421, ISSN 0008-6363
Wydawca: Elsevier BV
DOI: 10.1093/cvr/cvy184

Macrophage CD40 plays a minor role in obesity-induced metabolic dysfunction

Autorzy: Suzanne A. B. M. Aarts, Myrthe E. Reiche, Myrthe den Toom, Linda Beckers, Marion J. J. Gijbels, Norbert Gerdes, Menno P. J. de Winther, Esther Lutgens
Opublikowane w: PLOS ONE, Numer 13/8, 2018, Strona(/y) e0202150, ISSN 1932-6203
Wydawca: Public Library of Science
DOI: 10.1371/journal.pone.0202150

Innate immune cell activation and epigenetic remodeling in symptomatic and asymptomatic atherosclerosis in humans in vivo

Autorzy: Siroon Bekkering, Inge van den Munckhof, Tim Nielen, Evert Lamfers, Charles Dinarello, Joost Rutten, Jacqueline de Graaf, Leo A.B. Joosten, Mihai G. Netea, Marc E.R. Gomes, Niels P. Riksen
Opublikowane w: Atherosclerosis, Numer 254, 2016, Strona(/y) 228-236, ISSN 0021-9150
Wydawca: Elsevier BV
DOI: 10.1016/j.atherosclerosis.2016.10.019

Glutaminolysis and Fumarate Accumulation Integrate Immunometabolic and Epigenetic Programs in Trained Immunity

Autorzy: Rob J.W. Arts, Boris Novakovic, Rob ter Horst, Agostinho Carvalho, Siroon Bekkering, Ekta Lachmandas, Fernando Rodrigues, Ricardo Silvestre, Shih-Chin Cheng, Shuang-Yin Wang, Ehsan Habibi, Luís G. Gonçalves, Inês Mesquita, Cristina Cunha, Arjan van Laarhoven, Frank L. van de Veerdonk, David L. Williams, Jos W.M. van der Meer, Colin Logie, Luke A. O'Neill, Charles A. Dinarello, Niels P. Riksen,
Opublikowane w: Cell Metabolism, Numer 24/6, 2016, Strona(/y) 807-819, ISSN 1550-4131
Wydawca: Cell Press
DOI: 10.1016/j.cmet.2016.10.008

In Vitro Experimental Model of Trained Innate Immunity in Human Primary Monocytes

Autorzy: Siroon Bekkering, Bastiaan A. Blok, Leo A. B. Joosten, Niels P. Riksen, Reinout van Crevel, Mihai G. Netea
Opublikowane w: Clinical and Vaccine Immunology, Numer 23/12, 2016, Strona(/y) 926-933, ISSN 1556-6811
Wydawca: American Society for Microbiology
DOI: 10.1128/CVI.00349-16

Long-term activation of the innate immune system in atherosclerosis

Autorzy: Anette Christ, Siroon Bekkering, Eicke Latz, Niels P. Riksen
Opublikowane w: Seminars in Immunology, Numer 28/4, 2016, Strona(/y) 384-393, ISSN 1044-5323
Wydawca: Academic Press
DOI: 10.1016/j.smim.2016.04.004

Biology of proprotein convertase subtilisin kexin 9: beyond low-density lipoprotein cholesterol lowering

Autorzy: Giuseppe Danilo Norata, Hagai Tavori, Angela Pirillo, Sergio Fazio, Alberico L. Catapano
Opublikowane w: Cardiovascular Research, Numer 112/1, 2016, Strona(/y) 429-442, ISSN 0008-6363
Wydawca: Elsevier BV
DOI: 10.1093/cvr/cvw194

TET1 is an important transcriptional activator of TNFα expression in macrophages

Autorzy: Fangfang Sun, Irene Abreu-Rodriguez, Shuang Ye, Steffen Gay, Oliver Distler, Michel Neidhart, Emmanuel Karouzakis
Opublikowane w: PLOS ONE, Numer 14/6, 2019, Strona(/y) e0218551, ISSN 1932-6203
Wydawca: Public Library of Science
DOI: 10.1371/journal.pone.0218551

Oligomeric S100A4 Is Associated With Monocyte Innate Immune Memory and Bypass of Tolerance to Subsequent Stimulation With Lipopolysaccharides

Autorzy: Michel Neidhart, Agnieszka Pajak, Katerina Laskari, Niels P. Riksen, Leo A. B. Joosten, Mihai G. Netea, Esther Lutgens, Eric S. G. Stroes, Adrian Ciurea, Oliver Distler, Mariam Grigorian, Emmanuel Karouzakis
Opublikowane w: Frontiers in Immunology, Numer 10, 2019, ISSN 1664-3224
Wydawca: Frontiers
DOI: 10.3389/fimmu.2019.00791

Role of gut microbiota in chronic low-grade inflammation as potential driver for atherosclerotic cardiovascular disease: a systematic review of human studies

Autorzy: I. C. L. van den Munckhof, A. Kurilshikov, R. ter Horst, N. P. Riksen, L. A. B. Joosten, A. Zhernakova, J. Fu, S. T. Keating, M. G. Netea, J. de Graaf, J. H. W. Rutten
Opublikowane w: Obesity Reviews, Numer 19/12, 2018, Strona(/y) 1719-1734, ISSN 1467-7881
Wydawca: Blackwell Publishing Inc.
DOI: 10.1111/obr.12750

Immunometabolism orchestrates training of innate immunity in atherosclerosis

Autorzy: Julia van Tuijl, Leo A B Joosten, Mihai G Netea, Siroon Bekkering, Niels P Riksen
Opublikowane w: Cardiovascular Research, Numer 115/9, 2019, Strona(/y) 1416-1424, ISSN 0008-6363
Wydawca: Elsevier BV
DOI: 10.1093/cvr/cvz107

Plant-based sterols and stanols in health & disease: “Consequences of human development in a plant-based environment?”

Autorzy: J. Plat, S. Baumgartner, T. Vanmierlo, D. Lütjohann, K.L. Calkins, D.G. Burrin, G. Guthrie, C. Thijs, A.A. Te Velde, A.C.E. Vreugdenhil, R. Sverdlov, J. Garssen, K. Wouters, E.A. Trautwein, T.G. Wolfs, C. van Gorp, M.T. Mulder, N.P. Riksen, A.K. Groen, R.P. Mensink
Opublikowane w: Progress in Lipid Research, Numer 74, 2019, Strona(/y) 87-102, ISSN 0163-7827
Wydawca: Pergamon Press Ltd.
DOI: 10.1016/j.plipres.2019.02.003

Getting to the marrow of trained immunity

Autorzy: Laszlo Groh, Mihai G Netea, Niels P Riksen, Samuel T Keating
Opublikowane w: Epigenomics, Numer 10/9, 2018, Strona(/y) 1151-1154, ISSN 1750-1911
Wydawca: Future Medicine Ltd.
DOI: 10.2217/epi-2018-0098

Be aware, innate immune cells remember

Autorzy: Niels P. Riksen, Mihai G. Netea
Opublikowane w: Aging, Numer 10/9, 2018, Strona(/y) 2218-2219, ISSN 1945-4589
Wydawca: Aging
DOI: 10.18632/aging.101552

Metabolism of innate immune cells

Autorzy: Niels P. Riksen, Rinke Stienstra
Opublikowane w: Current Opinion in Lipidology, Numer 29/5, 2018, Strona(/y) 359-367, ISSN 0957-9672
Wydawca: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/mol.0000000000000539

Aldosterone induces trained immunity: the role of fatty acid synthesis

Autorzy: Charlotte D C C van der Heijden, Samuel T Keating, Laszlo Groh, Leo A B Joosten, Mihai G Netea, Niels P Riksen
Opublikowane w: Cardiovascular Research, 2019, ISSN 0008-6363
Wydawca: Elsevier BV
DOI: 10.1093/cvr/cvz137

The mineralocorticoid receptor as a modulator of innate immunity and atherosclerosis

Autorzy: Charlotte D C C van der Heijden, Jaap Deinum, Leo A B Joosten, Mihai G Netea, Niels P Riksen
Opublikowane w: Cardiovascular Research, Numer 114/7, 2018, Strona(/y) 944-953, ISSN 0008-6363
Wydawca: Elsevier BV
DOI: 10.1093/cvr/cvy092

Treatment with Statins Does Not Revert Trained Immunity in Patients with Familial Hypercholesterolemia

Autorzy: Siroon Bekkering, Lotte C.A. Stiekema, Sophie Bernelot Moens, Simone L. Verweij, Boris Novakovic, Koen Prange, Miranda Versloot, Jeanine E. Roeters van Lennep, Henk Stunnenberg, Menno de Winther, Erik S.G. Stroes, Leo A.B. Joosten, Mihai G. Netea, Niels P. Riksen
Opublikowane w: Cell Metabolism, Numer 30/1, 2019, Strona(/y) 1-2, ISSN 1550-4131
Wydawca: Cell Press
DOI: 10.1016/j.cmet.2019.05.014

Trained immunity and atherosclerotic cardiovascular disease

Autorzy: Niels P. Riksen
Opublikowane w: Current Opinion in Lipidology, Numer 30/5, 2019, Strona(/y) 395-400, ISSN 0957-9672
Wydawca: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/mol.0000000000000628

Deficiency of the T cell regulator Casitas B-cell lymphoma-B aggravates atherosclerosis by inducing CD8+ T cell-mediated macrophage death

Autorzy: Tom T P Seijkens, Kikkie Poels, Svenja Meiler, Claudia M van Tiel, Pascal J H Kusters, Myrthe Reiche, Dorothee Atzler, Holger Winkels, Marc Tjwa, Hessel Poelman, Bram Slütter, Johan Kuiper, Marion Gijbels, Jan Albert Kuivenhoven, Ljubica Perisic Matic, Gabrielle Paulsson-Berne, Ulf Hedin, Göran K Hansson, Gerry A F Nicolaes, Mat J A P Daemen, Christian Weber, Norbert Gerdes, Menno P J de Winther
Opublikowane w: European Heart Journal, Numer 40/4, 2018, Strona(/y) 372-382, ISSN 0195-668X
Wydawca: Oxford University Press
DOI: 10.1093/eurheartj/ehy714

Identifying the anti-inflammatory response to lipid lowering therapy: a position paper from the working group on atherosclerosis and vascular biology of the European Society of Cardiology

Autorzy: José Tuñón, Lina Badimón, Marie-Luce Bochaton-Piallat, Bertrand Cariou, Mat J Daemen, Jesus Egido, Paul C Evans, Imo E Hoefer, Daniel F J Ketelhuth, Esther Lutgens, Christian M Matter, Claudia Monaco, Sabine Steffens, Erik Stroes, Cécile Vindis, Christian Weber, Magnus Bäck
Opublikowane w: Cardiovascular Research, Numer 115/1, 2018, Strona(/y) 10-19, ISSN 0008-6363
Wydawca: Elsevier BV
DOI: 10.1093/cvr/cvy293

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Inhibitors of CD40-TRAF6 Interaction

Numer wniosku/publikacji: US 20160228408 A1
Data: 2016-02-09

Inhibitors of CD40-TRAF6 Interaction

Numer wniosku/publikacji: US 20160228408 A1
Data: 2016-02-09

Inhibitors of CD40-TRAF6 Interaction

Numer wniosku/publikacji: US 20160228408 A1
Data: 2016-02-09
Wnioskodawca/wnioskodawcy: LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN

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