Intra Erythrocyte Dexamethasone in the treatment of Ataxia Telangiectasia

Información del proyecto

IEDAT

Identificador del acuerdo de subvención: 667946

DOI 10.3030/667946

Proyecto cerrado

Fecha de la firma de la CE 9 Diciembre 2015

Fecha de inicio 1 Enero 2016

Fecha de finalización 31 Agosto 2021

Financiado con arreglo a

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Coste total € 5 871 825,00

Aportación de la UE € 5 871 825,00

Coordinado por

ERYDEL SPA
Italy

Resultado final

Documents, reports (5)

First evaluation workshop
Report on AT NEST definition, guidelines and SOPs
Registration number of clinical study in approved registry

Registration number of clinical study in approved registry Informed Consents Forms and/or Data Protection Forms (in their final version) will be included here. The authorisation for the use of personal data for specified purposes for a specified duration, and if applicable data transfers to third countries will be part of the content of these forms. Mandatory deliverable

Statistical report of comparison
Final evaluation workshop

Websites, patent fillings, videos etc. (2)

Project website (IEDAT)
Dissemination materials

Other (1)

Registry database

Publicaciones

Peer reviewed articles (7)

DDIT4 gene expression is switched on by a new HDAC4 function in ataxia telangiectasia

Autores: Anastasia Ricci, Luca Galluzzi, Mauro Magnani, Michele Menotta
Publicado en: The FASEB Journal, Edición 34/1, 2020, Página(s) 1802-1818, ISSN 0892-6638
Editor: Federation of American Societies for Experimental Biology
DOI: 10.1096/fj.201902039r

The nucleoplasmic interactions among Lamin A/C-pRB-LAP2α-E2F1 are modulated by dexamethasone

Autores: Anastasia Ricci, Sara Orazi, Federica Biancucci, Mauro Magnani, Michele Menotta
Publicado en: Scientific Reports, Edición 11/1, 2021, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-021-89608-3

Proteomics and transcriptomics analyses of ataxia telangiectasia cells treated with Dexamethasone

Autores: Michele Menotta, Sara Orazi, Anna Maria Gioacchini, Chiara Spapperi, Anastasia Ricci, Luciana Chessa, Mauro Magnani
Publicado en: PLOS ONE, Edición 13/4, 2018, Página(s) e0195388, ISSN 1932-6203
Editor: Public Library of Science
DOI: 10.1371/journal.pone.0195388

ATM splicing variants as biomarkers for low dose dexamethasone treatment of A-T

Autores: Michele Menotta, Sara Biagiotti, Chiara Spapperi, Sara Orazi, Luigia Rossi, Luciana Chessa, Vincenzo Leuzzi, Daniela D’Agnano, Annarosa Soresina, Roberto Micheli, Mauro Magnani
Publicado en: Orphanet Journal of Rare Diseases, Edición 12/1, 2017, ISSN 1750-1172
Editor: BioMed Central
DOI: 10.1186/s13023-017-0669-2

Ex vivo encapsulation of dexamethasone sodium phosphate into human autologous erythrocytes using fully automated biomedical equipment

Autores: Giovanni Mambrini, Marco Mandolini, Luigia Rossi, Francesca Pierigè, Giovanni Capogrossi, Patricia Salvati, Sonja Serafini, Luca Benatti, Mauro Magnani
Publicado en: International Journal of Pharmaceutics, Edición 517/1-2, 2017, Página(s) 175-184, ISSN 0378-5173
Editor: Elsevier BV
DOI: 10.1016/j.ijpharm.2016.12.011

In vivo effects of dexamethasone on blood gene expression in ataxia telangiectasia

Autores: Michele Menotta, Sara Biagiotti, Sara Orazi, Luigia Rossi, Luciana Chessa, Vincenzo Leuzzi, Daniela D’Agnano, Alessandro Plebani, Annarosa Soresina, Mauro Magnani
Publicado en: Molecular and Cellular Biochemistry, Edición 438/1-2, 2018, Página(s) 153-166, ISSN 0300-8177
Editor: Kluwer Academic/Plenum Publishers
DOI: 10.1007/s11010-017-3122-x

Transcriptomic profile of ataxia telangiectasia cells treated for 30 days with a low dose of dexamethasone

Autores: Anastasia Ricci, Federica Biancucci, Mauro Magnani, Michele Menotta
Publicado en: All Life, Edición 14/1, 2021, Página(s) 277-286, ISSN 2689-5293
Editor: all life
DOI: 10.1080/26895293.2021.1911863