Intra Erythrocyte Dexamethasone in the treatment of Ataxia Telangiectasia

Informations projet

IEDAT

N° de convention de subvention: 667946

DOI 10.3030/667946

Projet clôturé

Date de signature de la CE 9 Decembre 2015

Date de début 1 Janvier 2016

Date de fin 31 Août 2021

Financé au titre de

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Coût total € 5 871 825,00

Contribution de l’UE € 5 871 825,00

Coordonné par

ERYDEL SPA
Italy

Livrables

Documents, reports (5)

First evaluation workshop
Report on AT NEST definition, guidelines and SOPs
Registration number of clinical study in approved registry

Registration number of clinical study in approved registry Informed Consents Forms and/or Data Protection Forms (in their final version) will be included here. The authorisation for the use of personal data for specified purposes for a specified duration, and if applicable data transfers to third countries will be part of the content of these forms. Mandatory deliverable

Statistical report of comparison
Final evaluation workshop

Websites, patent fillings, videos etc. (2)

Project website (IEDAT)
Dissemination materials

Other (1)

Registry database

Publications

Peer reviewed articles (7)

DDIT4 gene expression is switched on by a new HDAC4 function in ataxia telangiectasia

Auteurs: Anastasia Ricci, Luca Galluzzi, Mauro Magnani, Michele Menotta
Publié dans: The FASEB Journal, Numéro 34/1, 2020, Page(s) 1802-1818, ISSN 0892-6638
Éditeur: Federation of American Societies for Experimental Biology
DOI: 10.1096/fj.201902039r

The nucleoplasmic interactions among Lamin A/C-pRB-LAP2α-E2F1 are modulated by dexamethasone

Auteurs: Anastasia Ricci, Sara Orazi, Federica Biancucci, Mauro Magnani, Michele Menotta
Publié dans: Scientific Reports, Numéro 11/1, 2021, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/s41598-021-89608-3

Proteomics and transcriptomics analyses of ataxia telangiectasia cells treated with Dexamethasone

Auteurs: Michele Menotta, Sara Orazi, Anna Maria Gioacchini, Chiara Spapperi, Anastasia Ricci, Luciana Chessa, Mauro Magnani
Publié dans: PLOS ONE, Numéro 13/4, 2018, Page(s) e0195388, ISSN 1932-6203
Éditeur: Public Library of Science
DOI: 10.1371/journal.pone.0195388

ATM splicing variants as biomarkers for low dose dexamethasone treatment of A-T

Auteurs: Michele Menotta, Sara Biagiotti, Chiara Spapperi, Sara Orazi, Luigia Rossi, Luciana Chessa, Vincenzo Leuzzi, Daniela D’Agnano, Annarosa Soresina, Roberto Micheli, Mauro Magnani
Publié dans: Orphanet Journal of Rare Diseases, Numéro 12/1, 2017, ISSN 1750-1172
Éditeur: BioMed Central
DOI: 10.1186/s13023-017-0669-2

Ex vivo encapsulation of dexamethasone sodium phosphate into human autologous erythrocytes using fully automated biomedical equipment

Auteurs: Giovanni Mambrini, Marco Mandolini, Luigia Rossi, Francesca Pierigè, Giovanni Capogrossi, Patricia Salvati, Sonja Serafini, Luca Benatti, Mauro Magnani
Publié dans: International Journal of Pharmaceutics, Numéro 517/1-2, 2017, Page(s) 175-184, ISSN 0378-5173
Éditeur: Elsevier BV
DOI: 10.1016/j.ijpharm.2016.12.011

In vivo effects of dexamethasone on blood gene expression in ataxia telangiectasia

Auteurs: Michele Menotta, Sara Biagiotti, Sara Orazi, Luigia Rossi, Luciana Chessa, Vincenzo Leuzzi, Daniela D’Agnano, Alessandro Plebani, Annarosa Soresina, Mauro Magnani
Publié dans: Molecular and Cellular Biochemistry, Numéro 438/1-2, 2018, Page(s) 153-166, ISSN 0300-8177
Éditeur: Kluwer Academic/Plenum Publishers
DOI: 10.1007/s11010-017-3122-x

Transcriptomic profile of ataxia telangiectasia cells treated for 30 days with a low dose of dexamethasone

Auteurs: Anastasia Ricci, Federica Biancucci, Mauro Magnani, Michele Menotta
Publié dans: All Life, Numéro 14/1, 2021, Page(s) 277-286, ISSN 2689-5293
Éditeur: all life
DOI: 10.1080/26895293.2021.1911863